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Other literature type . 2012
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Other literature type . 2012
License: CC BY
Data sources: Datacite
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Nature Precedings
Article . Preprint . 2012 . Peer-reviewed
License: CC BY
https://doi.org/10.48550/arxiv...
Article . 2012
License: CC BY NC SA
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Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex

Authors: Cooper, Don; Cooper, Donald C.; Baratta, Michael; Dolzani, Samuel D.; Dobelis, Peter; Nakamura, Shinya;

Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex

Abstract

A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the routing of information among prefrontal neuronal subtypes is the inability to manipulate the electrical activity of genetically defined cell types over behaviorally relevant timescales and activity patterns. To address these constraints, we present here a simple approach for selective activation of prefrontal excitatory neurons in both in vitro and in vivo preparations. Rat prelimbic pyramidal neurons were genetically targeted to express a light-activated nonselective cation channel, channelrhodopsin-2, or a light-driven inward chloride pump, halorhodopsin, which enabled them to be rapidly and reversibly activated or inhibited by pulses of light. These light responsive tools provide a spatially and temporally precise means of studying how different cell types contribute to information processing in cortical circuits. Our customized optrodes and optical commutators for in vivo recording allow for efficient light delivery and recording and can be requested at www.neuro-cloud.net/nature-precedings/baratta.

Comment: 2 pages, 2 figures Posted on http://www.neuro-cloud.net/nature-precedings/baratta

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Subjects by Vocabulary

Microsoft Academic Graph classification: Cell type Pyramidal Neuron Biology Optogenetics Light delivery Halorhodopsin In vivo Excitatory postsynaptic potential Prefrontal cortex Neuroscience

Keywords

Genetics & Genomics, Quantitative Biology - Neurons and Cognition, FOS: Biological sciences, Cell Behavior (q-bio.CB), Quantitative Biology - Cell Behavior, Neurons and Cognition (q-bio.NC), General Materials Science, Biotechnology, Neuroscience

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    1
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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