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Translational Oncology
Article . 2023 . Peer-reviewed
License: CC BY NC ND
Data sources: Crossref
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Translational Oncology
Article . 2023
Data sources: DOAJ
SSRN Electronic Journal
Article . 2022 . Peer-reviewed
Data sources: Crossref
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CD44 Occurring Alternative Splicing Promotes Cisplatin Resistance and Evokes Tumor Immune Response in Oral Squamous Cell Carcinoma Cells

Authors: Xue Qiao; Li Zhu; Rongbo Song; Chao Shang; Yan Guo;

CD44 Occurring Alternative Splicing Promotes Cisplatin Resistance and Evokes Tumor Immune Response in Oral Squamous Cell Carcinoma Cells

Abstract

Background: Oral squamous cell carcinoma (OSCC) is the most prevalent malignant tumor in head and neck region. Platinum drug resistance limits the clinical application of chemotherapy regardless of medical development. The aim of our study is to identify cisplatin-resistant genes which can be used as new therapeutic targets and investigate the functional mechanism of OSCC chemoresistance. Methods: The OSCC Cal27 and HSC4 cisplatin-resistant cell lines were constructed to screen the differential genes/transcripts expression. GO, KEGG and GSEA were performed to reveal the relevant signaling pathways. Alternative splicing (AS) software rMATs was applied to explore AS events in chemoresistance. R package and TIMER tools were used to evaluate the linear correlation between CD44 and immune cell subpopulations. The co-culture model of dendritic cells (DCs) and OSCC cells was applied to explore the effect of CD44 on immune microenvironment and cisplatin resistance. Results: Our results showed that CD44 was differentially expressed in cisplatin-resistant OSCC cells. Through bioinformatics prediction and experimental verification, we confirmed that CD44 occurring AS was involved in tumor progression and cisplatin resistance. Moreover, CD44 could further enhance the cisplatin resistance of OSCC by activating DCs, making CD44 to be a potential intervention target. We also identified DC as a new target for platinum drugs to stimulate the growth of OSCC. Conclusion: Our findings not only make it possible to explore new therapeutic methods, such as CD44 inhibitors or antisense oligonucleotides, but also provide insights into the new mechanisms of cisplatin resistance to chemotherapy.

Keywords

Tumor immune response, Cancer Research, History, Polymers and Plastics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Dendritic cells, Industrial and Manufacturing Engineering, Oral squamous cell carcinoma, Oncology, CD44, Business and International Management, Cisplatin resistance, RC254-282, Alternative splicing

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    1
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
gold
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