project . 2015 - 2020 . Closed

BIO-CHIP

BIOengineered grafts for Cartilage Healing In Patients (BIO-CHIP)
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 681103 Call for proposal: H2020-PHC-2015-single-stage_RTD
  • Funded under: H2020 | RIA Overall Budget: 5,108,270 EURFunder Contribution: 3,051,840 EUR
  • Status: Closed
  • Start Date
    01 Nov 2015
    End Date
    31 Oct 2020
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Spontaneous healing of articular cartilage injuries is poor and untreated defects predispose to osteoarthritis. Current therapies, including innovative autologous cell-based treatments, cannot predictably and reproducibly restore cartilage structure and function. BIOCHIP will carry out a multicenter, prospective phase II clinical trial to treat knee cartilage injuries using engineered grafts based on autologous nasal chondrocytes (NC). As compared to typically employed articular chondrocytes, NC have a higher and more reproducible capacity to generate mature cartilage tissues. Importantly, molecular/mechanical characterization, large size animal studies and a ph...
Description
Spontaneous healing of articular cartilage injuries is poor and untreated defects predispose to osteoarthritis. Current therapies, including innovative autologous cell-based treatments, cannot predictably and reproducibly restore cartilage structure and function. BIOCHIP will carry out a multicenter, prospective phase II clinical trial to treat knee cartilage injuries using engineered grafts based on autologous nasal chondrocytes (NC). As compared to typically employed articular chondrocytes, NC have a higher and more reproducible capacity to generate mature cartilage tissues. Importantly, molecular/mechanical characterization, large size animal studies and a ph...
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