project . 2015 - 2021 . Closed

DUT-signal

dUTPase Signalling: from Phage to Eukaryotes
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 670932 Call for proposal: ERC-2014-ADG
  • Funded under: H2020 | ERC | ERC-ADG Overall Budget: 2,246,190 EURFunder Contribution: 2,246,190 EUR
  • Status: Closed
  • Start Date
    01 Dec 2015
    End Date
    30 Nov 2021
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
dUTPases (DUTs) are enzymes that regulate cellular dUTP levels to prevent the misincorporation of uracil into DNA. Recently however, DUTs have been involved in the control of relevant cellular processes. How these regulatory functions are controlled remains unsolved. The recent elucidation of the mechanistic role of DUTs in the transfer of staphylococcal pathogenicity islands (SaPIs) by our group has revealed an entirely novel and surprising strategy involving DUTs in signalling. Namely, we have demonstrated that in addition to the 5 classical domains present in all the trimeric DUTs, staphylococcal phage-encoded DUT proteins possess an extra region (Motif VI) i...
Description
dUTPases (DUTs) are enzymes that regulate cellular dUTP levels to prevent the misincorporation of uracil into DNA. Recently however, DUTs have been involved in the control of relevant cellular processes. How these regulatory functions are controlled remains unsolved. The recent elucidation of the mechanistic role of DUTs in the transfer of staphylococcal pathogenicity islands (SaPIs) by our group has revealed an entirely novel and surprising strategy involving DUTs in signalling. Namely, we have demonstrated that in addition to the 5 classical domains present in all the trimeric DUTs, staphylococcal phage-encoded DUT proteins possess an extra region (Motif VI) i...
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