project . 2018 - 2023 . On going

HUMAN TEXTILES

Human, Woven, Tissue-Engineered Blood Vessels (TEBV) Exclusively from Cell-Assembled Extracellular Matrix (CAM).
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 785908 Call for proposal: ERC-2017-ADG
  • Funded under: H2020 | ERC | ERC-ADG Overall Budget: 2,491,540 EURFunder Contribution: 2,491,540 EUR
  • Status: On going
  • Start Date
    01 Nov 2018
    End Date
    31 Oct 2023
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Synthetic vascular grafts perform very poorly in small diameter applications (coronary/peripheral bypass) and for dialysis access. Better vascular conduits for these applications would be life and limb-saving for a very large patient population. A biological, human, tissue-engineered blood vessel (TEBV) may be such a device. We have developed a method to produce robust sheets of cell-assembled extracellular matrix (CAM) from normal, adult, human fibroblasts in vitro. These have been rolled into TEBV and shown promising clinical results. However, this initial rolling approach is very costly, time consuming and has limited mechanical design potential. Here, we pro...
Partners
Description
Synthetic vascular grafts perform very poorly in small diameter applications (coronary/peripheral bypass) and for dialysis access. Better vascular conduits for these applications would be life and limb-saving for a very large patient population. A biological, human, tissue-engineered blood vessel (TEBV) may be such a device. We have developed a method to produce robust sheets of cell-assembled extracellular matrix (CAM) from normal, adult, human fibroblasts in vitro. These have been rolled into TEBV and shown promising clinical results. However, this initial rolling approach is very costly, time consuming and has limited mechanical design potential. Here, we pro...
Partners
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