project . 2019 - 2024 . On going

BALANCED LETHALS

Untangling the Evolution of a Balanced Lethal System
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 802759 Call for proposal: ERC-2018-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,499,870 EURFunder Contribution: 1,499,870 EUR
  • Status: On going
  • Start Date
    01 Feb 2019
    End Date
    31 Jul 2024
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Natural selection is supposed to keep lethal alleles (dysfunctional or deleted copies of crucial genes) in check. Yet, in a balanced lethal system the frequency of lethal alleles is inflated. Because two forms of a chromosome carry distinct lethal alleles that are reciprocally compensated for by functional genes on the alternate chromosome form, both chromosome forms – and in effect their linked lethal alleles – are required for survival. The inability of natural selection to purge balanced lethal systems appears to defy evolutionary theory. How do balanced lethal systems originate and persist in nature? I suspect the answer to this pressing but neglected resear...
Link existing DMPs with this project or start a new DMP in Argos.
Description
Natural selection is supposed to keep lethal alleles (dysfunctional or deleted copies of crucial genes) in check. Yet, in a balanced lethal system the frequency of lethal alleles is inflated. Because two forms of a chromosome carry distinct lethal alleles that are reciprocally compensated for by functional genes on the alternate chromosome form, both chromosome forms – and in effect their linked lethal alleles – are required for survival. The inability of natural selection to purge balanced lethal systems appears to defy evolutionary theory. How do balanced lethal systems originate and persist in nature? I suspect the answer to this pressing but neglected resear...
Link existing DMPs with this project or start a new DMP in Argos.
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