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LUNDS UNIVERSITET

Country: Sweden

LUNDS UNIVERSITET

759 Projects, page 1 of 152
  • Funder: EC Project Code: 101043587
    Overall Budget: 1,999,440 EURFunder Contribution: 1,999,440 EUR

    Gliomas are the most common brain tumors and the highest-grade glioma, glioblastoma (GBM), is arguably the most aggressive tumor type, with no long-term survivors. Patients with GBM are treated with radiotherapy, chemotherapy, surgery, and tumor treating fields. Despite initial response all tumors recur as incurable lesions; there is an urgent need for novel therapeutic approaches for this patient group. The majority of GBMs recur within the treatment field receiving high-dose radiotherapy during treatment of the primary tumor; the recurrent tumor thus forms in an irradiated microenvironment. Despite the fact that it is the recurrent tumor that ultimately kills the patient and that the majority of new therapeutic agents for GBM are tested clinically in the recurrent setting, the majority of experimental models and clinical materials for drug discovery are based on primary disease. Recent advances established a central role for the tumor microenvironment in determining the therapeutic response of GBM cells, and our lab demonstrated that standard of care radiotherapy of the primary tumor can shape the microenvironment to generate tumor-supportive conditions in the recurrent tumor; These findings suggest that there is untapped potential in targeting the irradiated microenvironment. This proposal aims to explore and exploit the recurrent brain tumor microenvironment by i) consolidating the contribution of the irradiated brain tumor microenvironment to GBM resistance by integrating spatial transcriptomics, single cell RNA sequencing, and multiplexed immunohistochemistry from state-of-the-art murine and human models of GBM treatment and recurrence, and ii) discovering and targeting novel therapeutic targets unique to the post-radiotherapy brain tumor microenvironment by high-throughput phenotypic screening, with the ultimate goal of exploiting reversible stromal radiation responses and leverage novel therapeutic opportunities unique to the irradiated brain.

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  • Funder: EC Project Code: 236106
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  • Funder: EC Project Code: 252988
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  • Funder: EC Project Code: 101078476
    Overall Budget: 1,657,190 EURFunder Contribution: 1,657,190 EUR

    Living without oxygen is challenging. To live in low-oxygen environments, some microbes exchange nutrients allowing for a division of labor among individuals in a process called ‘syntrophy’. Such interactions are often a pre-requisite for prokaryotes living in these environments. Whether syntrophy is necessary for the survival of microbial eukaryotes (protists) is unexplored and yet, critically important to discerning the roles of eukaryotes in nature and how eukaryotic cells adapt to live without oxygen. TAngO2 will test the hypothesis that syntrophic partnerships allow eukaryotes to thrive in anaerobic environments and underpin the evolution of key eukaryotic cell biological characteristics. This will be accomplished using state-of-the-art genomic, computational, and experimental approaches. I will discover genes essential for interactions between a model protist and its ectosymbiont using massively-parallelized transposon mutagenesis. This will discern the molecular mechanisms, metabolic interplay, and selective forces dictating eukaryote:prokaryote interactions. I will deliver metagenomes of cultured anaerobic eukaryote:prokaryote consortia predicted to be engaging in syntrophic interactions. This will drastically expand our knowledge of the biodiversity of eukaryotic genomes and microbial interactions from low-oxygen environments. I will interrogate the frequency and diversity of syntrophy in eukaryotes by simultaneously sequencing the genomes and transcriptomes ofindividual protist cells and their microbiota sampled from nature. This will provide the first elucidation of what communities co-exist with natural anaerobic protists. Understanding how syntrophic interactions have influenced eukaryotic cell biology will reveal hidden connections in the complicated functional networks of the eukaryotic cell. TAngO2 will open research avenues by bridging the fields of evolutionary cell biology and microbiology to understand ancient and recent symbiotic

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  • Funder: EC Project Code: 884900
    Overall Budget: 2,500,000 EURFunder Contribution: 2,500,000 EUR

    This project lies at the crossing of attosecond science, photoionization of atoms and molecules and quantum optics. Progress in the performances of the attosecond sources, in particular regarding repetition rate, now enables us to perform photoionization studies of atoms and molecules using advanced coincidence/three dimensional momentum techniques. Adding an additional dimension, the phase, which is accessible by attosecond interferometric techniques, we will able to follow in time the quantum properties of the studied processes. The aim of the present application is to perform quantum optics experiments, not with photons as in conventional quantum optics, but with electron wave-packets created by absorption of attosecond light pulses. Our objectives are - to characterize and study in the time domain the quantum coherence of attosecond electron wavepackets, - to control quantum interferences of electron wavepackets using a small number of attosecond pulses and - to create and follow in time entangled two-electron attosecond wavepackets. The experiments will use advanced laser systems, attosecond sources and electron detectors. A unique 200-kHz repetition rate laser system based on optical parametric chirped pulse amplification technology, combined with an efficient attosecond source and a three-dimensional momentum electron detector will open the door to attosecond experiments where the kinematics of the light-matter interaction can be recorded. The success in achieving the above objectives will not only lead to a major leap forward in attosecond science and atomic and molecular physics in general; it might shed new lights in fundamental quantum physics, given the originality of the studied systems, attosecond electron wave packets and the versatility of the tools, providing four dimensional information (momentum and time) for multiple particles.

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