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University of Sheffield

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307 Projects, page 1 of 62
  • Project . 2006 - 2008
    Funder: WT Project Code: 081398
    Funder Contribution: 200,000 GBP
    Partners: University of Sheffield
  • Funder: NIH Project Code: 5R01AA024443-03
    Funder Contribution: 461,888 USD
    Partners: University of Sheffield
  • Project . 2009 - 2009
    Funder: WT Project Code: 089879
    Funder Contribution: 8,280 GBP
    Partners: University of Sheffield
  • Open Access mandate for Publications
    Funder: WT Project Code: 216405
    Funder Contribution: 1,110,950 GBP
    Partners: University of Sheffield

    In biomedical science, there is a growing realisation that the mechanisms of ageing underlie many major debilitating age-related diseases. Interventions in the ageing process therefore have the potential to make an immense impact on our healthspan. The most potent of these interventions is dietary restriction (DR) – decreasing dietary intake but avoiding malnutrition. Translation of DR to humans is impeded by our lack of knowledge on exact mechanisms and the optimal diet. DR is thought to result from a reduced intake of the macronutrient protein. Recent data in from my lab, however, suggests that restriction of micronutrients results in similar benefits to healthspan. I propose that by studying the restriction of micronutrients, translation is facilitated and more specific insight into mechanism is gained, as it provides a more precise intervention. I will elucidate the mechanisms of how dietary micronutrients affect ageing and disease using a systematic and comprehensive research program using the fly. I will screen for micronutrients that improve health and will test specific mechanisms based on my previous work connecting phosphate, copper and mitochondrial oxidative stress. Work in two disease models will complement these approaches, together providing key novel insight into the connections between diet, disease and ageing. Ageing is a major challenge in our society. Many age-related diseases, such as cancer, cardiovascular disease and dementia are thought to share mechanisms fundamental to the ageing process. Interventions into ageing itself therefore have the potential to transform our well-being. The most potent of these interventions is dietary restriction (DR): reducing food intake but avoiding malnutrition. Previous research has suggested intake of protein is responsible for these effects. In my lab I recently found that restriction of micronutrients can have similar effects. I propose that the restriction of micronutrients is easier to apply in humans and will also provide us more information on the underlying mechanisms that could be used to develop drugs. My fellowship will use a comprehensive study in the fruit fly to test the effects of micronutrients on lifespan and disease. These studies will together provide novel insights on how to reap the health benefits of DR.

  • Funder: WT Project Code: 065267
    Funder Contribution: 3,100 GBP
    Partners: University of Sheffield