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University of Aberdeen

Country: United Kingdom

University of Aberdeen

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1,170 Projects, page 1 of 234
  • Funder: WT Project Code: 074127
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  • Funder: WT Project Code: 059199
    Funder Contribution: 88,182 GBP
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  • Funder: UKRI Project Code: G0802567
    Funder Contribution: 89,484 GBP

    Several years ago the St Andrews laboratory isolated a very unusual enzyme in that it had the ability to form carbon-fluorine bonds from inorganic fluoride ion. This enzyme was isolated and the gene identified and over-expressed in E.coli. The enzyme has emerged as an extremely useful catalyst for incorporating the isotope F-18 into an organic molecule. Using other enzymes in combination with the fluorinase enzyme the St Andrews laboratory have been able to make several novel fluorine-18 labelled products in time scales (1-2 hours) suitable for exploring the products as imaging agents, by positron emission tomography. We have begun to collaborate with the Aberdeen lab and have some preliminary data which shows that one of these molecules is actively transported into breast cancer cells, and also that one of these compounds can suitably image a rat. This Discipline Hopping grant will give us the opportunity to combine the expertise of the labs and establish if the fluorinase mediated catalysis of 18F-C bonds can be transferred into a clinical hot laboratory environment, and to establish if some of the molecules that can be prepared enzymatically have potential as imaging agents for cancer (oncology) and/ imaging the brain (neurology).

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  • Funder: UKRI Project Code: G0200525
    Funder Contribution: 3,691 GBP

    Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

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  • Funder: EC Project Code: 754326
    Overall Budget: 1,883,520 EURFunder Contribution: 941,760 EUR

    The POLITICO PhD programme will build on the success of the interdisciplinary training provided by the University of Aberdeen’s Centre for Citizenship, Civil Society and the Rule of Law (CISRUL), which specializes in the global application of political ideas. 2 cohorts of 6 high-quality international ESRs will propose and develop their own research projects around the theme of how political concepts are deployed in the world. POLITICO ESRs will ask how, and with what consequences, policy institutes, social movements and media commentators invoke such ideas such as ‘nation’, ‘democracy’ and ‘civil society’. POLITICO will reach beyond the West to locate political ideas in South, Central and Eastern Europe, the Middle East and North Africa, South and East Asia, and Latin America and the Caribbean. Selection will be via an open, transparent, merit-based, impartial, equitable and internationally advertised process, which will take special care to allow free choice of research projects. With POLITICO’s inter-disciplinary supervision and inter-sectoral training, the ESRs will build careers not only in state-of-the-art research, but also in incisive policy design, social movement leadership, and influential media commentary. In these careers, the researchers will apply their acute awareness of how political concepts vary across contexts and are invoked in political action. To further develop the ESRs’ inter-disciplinary expertise, and to provide opportunities to present research and engage in debate, CISRUL will host a full series of seminars, workshops and conferences, all co-designed with ESRs and on topics that cross-cut POLITICO themes. POLITICO ESRs will be supported by 23 internationally-recognised partner organisations, committed to providing specific training to researchers across the POLITICO project themes. 6 of the partners are leading policy institutes that will provide inter-sectoral training to include the writing of policy briefs, expected of all ESRs.

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