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Alma Mater Studiorum University of Bologna
Country: Italy
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785 Projects, page 1 of 157
  • Funder: EC Project Code: 883172
    Overall Budget: 257,210 EURFunder Contribution: 257,210 EUR

    Personalised medicine (PM) is a novel approach to medical care that customises each treatment not just to the disease but also to the patient. While the advantages of this framework are widely recognised and its development is acknowledged as a fundamental societal challenge by the H2020 program, clinical applications are still limited, due to the increased complexity and costs, with respect to the current standard of care. ITHACA aims at developing an innovative PM toolkit that, relying on an advanced computational simulator, innovative in-vitro techniques and standard clinical data could provide an efficient and ethical framework for the screening of different ovarian cancer therapies and the identification of the most effective for each subject. This project builds on my experience with computational modelling and multidisciplinary research environments, to develop a programmable in-silico simulator capable of reproducing the patient-specific response to standard and novel ovarian cancer treatments. This tool will be extensively validated with both standard and primary cell lines and will then be used to determine patient-specific therapy outcome (RECIST 1.1 criteria) in women affected by ovarian cancer. Additionally it will be integrated in a novel bioreactor system for the in-vitro study of metastasization in HGSC. This compound device will allow for automatic treatment optimisation within an accurate and unique experimental model for this disease, and will thus provide an effective platform for personalised treatments development. Funding of this action will be a fundamental opportunity of career development, that will support my training in a highly innovative, interdisciplinary field while fostering the achievement of professional independence. Additionally the results of ITHACA will lead to high profile, impactful publications and provide the scientific community with enabling tools for the extensive application of PM in the clinic.

  • Funder: EC Project Code: 724914
    Overall Budget: 1,997,000 EURFunder Contribution: 1,997,000 EUR

    The AlchemEast project is devoted to the study of alchemical theory and practice as it appeared and developed in distinct, albeit contiguous (both chronologically and geographically) areas: Graeco-Roman Egypt, Byzantium, and the Near East, from Ancient Babylonian times to the early Islamic Period. This project combines innovative textual investigations with experimental replications of ancient alchemical procedures. It uses sets of historically and philologically informed laboratory replications in order to reconstruct the actual practice of ancient alchemists, and it studies the texts and literary forms in which this practice was conceptualized and transmitted. It proposes new models for textual criticism in order to capture the fluidity of the transmission of ancient alchemical writings. AlchemEast is designed to carry out a comparative investigation of cuneiform tablets as well as a vast corpus of Greek, Syriac and Arabic writings. It will overcome the old, pejorative paradigm that dismissed ancient alchemy as a "pseudo-science", by proposing a new theoretical framework for comprehending the entirety of ancient alchemical practices and theories. Alongside established forms of scholarly output, such as critical editions of key texts, AlchemEast will provide an integrative, longue durée perspective on the many different phases of ancient alchemy. It will thus offer a radically new vision of this discipline as a dynamic and diversified art that developed across different technical and scholastic traditions. This new representation will allow us to connect ancient alchemy with medieval and early modern alchemy and thus fully reintegrate ancient alchemy in the history of pre-modern alchemy as well as in the history of ancient science more broadly.

  • Funder: EC Project Code: 303502
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  • Funder: EC Project Code: 101106521
    Funder Contribution: 266,318 EUR

    By investigating the development of services provided by women to cater the emotional and sexual needs of women in contemporary Japan, this project addresses the relationship and the tension between the possibility for self-expression, the role of intimacy, and its intersection with the neoliberal market from a feminist perspective. This project stands at the nexus between Japanese Studies and Gender Studies and it investigates to what extent the market for female/female commodified intimacy provides women with the chance to explore alternative ways to perform femininity outside a heteronormative frame. My contention is that occupations where female-born individuals provide emotional and/or sexual satisfaction to other women allow space for expressions of intimacy and gender performativity outside the binary male/female division for both clients and providers. When dating, meeting, or loving another woman within the frame of paid intimacy, both subjects escape the pressure generated by heteronormativity. Commodified forms of intimacy, I argue, allow women to challenge societal expectations about femininity, to obtain increased emotional satisfaction and freedom. By tackling these dimensions, I discuss the dissatisfaction of Japanese women with the dominant relational models (e.g. marriage) and provide a new understanding of the development of alternative relational models to the detriment of the traditional heteronormative family, framing these choices as a form of long-term resistance. The project fills a gap as the investigation of contexts where women are, at the same time, both clients and providers of commodified intimacy is still largely unexplored. In addition, instead of essentializing this phenomenon as a feature of Japan, this project – situated at the juncture of postindustrial consumerism and globalizing neoliberal reformation – and its findings can be applied to contemporary societies witnessing the ramifications of love on-demand.

  • Funder: EC Project Code: 101105245
    Funder Contribution: 265,099 EUR

    IDEATE aims to develop a ground-breaking class of high energy radiation direct detectors based on perovskite (PVK) and organic (OS) thin films. The target is to define and implement gender-specific medical protocols during cancer radiotherapy treatments, thanks to a beam monitoring and real-time measurement of the dose delivered to the patient. This ambitious and revolutionary result will be attained by four intermediate goals: 1) model the mechanisms of interaction between ionizing radiation and PVK and OS thin films, 2) design and fabrication of PVK/OS single pixel detectors with different device architectures, 3) validation of each material/device architecture single pixel under X-Rays and proton beams to identify the best combinations which fulfil the target specifications, 4) realization of two DEMOs formed by a 3x3 pixels matrix onto flexible substrates, of a dedicated portable read-out electronics and validation of the integrated system under relevant irradiation conditions in medical radiation therapy facilities. The final DEMOs will represent the starting prototypes to be industrialized and commercialized by a start-up that I’m going to set up at the end of the fellowship. The interdisciplinarity and intersectoral approach adopted by IDEATE will be the result of the merge of different competences offered by University of Bologna (12-months return phase, supervisor Prof. Fraboni, expert in ionizing radiation detectors and semiconductor defect states characterization), by Columbia University (23-months outgoing phase, supervisor Prof. Kymissis, expert in electronic devices based on unconventional materials) and Kairos Sensors LLC Company (1 month internship, expert in industrialization and commercialization of innovative radiation sensing technologies). I will receive excellent training during the entire action enforcing my scientific skills but also ability in communication, dissemination, technology transfer, sustainable development, and female leadership.


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