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UPO

Pablo de Olavide University
42 Projects, page 1 of 9
  • Open Access mandate for Publications and Research data
    Funder: EC Project Code: 101029581
    Overall Budget: 172,932 EURFunder Contribution: 172,932 EUR
    Partners: UPO

    Centuries-long societal relations uniting Euro-African territories have modulated the forest history. Grazing and use of wood as an essential material have led to overexploitation of woodlands with lagged environmental problems like deforestation, severe flooding, encroaching deserts and declining ecosystems productivity. These human-environment interactions are well presented in the centre of these linkages, the Strait of Gibraltar, where the legacy of such history has survived in millennial forests and timber in archaeological sites or historical buildings. The project's objectives are: 1) to characterize historical exploitation of forests and its relation with the past forest dynamics using dendrochronology in ancient Andalusian and Moroccan forests 2) to explore the potential of deriving post-medieval ecological and societal changes from archaeological and historical timber 3) to apply emerging proxies (wood traits, DNA, chemical composition) to develop novel tools for identification of timber origin that may explain past human-environment interactions. To achieve these objectives, the project will be implemented in three stages: 1) Collection of ancient trees samples in Baetic mountains and Moroccan Rif and Atlas to analyse the forest history and unlock the wooden archive containing the key for understanding the historical exploitation of resources. Tree-growth chronologies and wood traits will be estimated by wood scanning and measurement of tree-ring widths. 2) The legacy of forest history and wood trade between trans-Mediterranean continents will be analysed through multi-century ring series preserved in archaeological and post-medieval historical wood material. Old buildings will be explored to analyse wood origin in relation to the magnitude of historical use of forests. 3) Application of a battery of novel techniques (blue intensity, wood anatomy, elemental composition and stable isotopes) for developing a new timber provenancing tool – dendroscapes.

  • Open Access mandate for Publications and Research data
    Funder: EC Project Code: 845675
    Overall Budget: 259,399 EURFunder Contribution: 259,399 EUR
    Partners: UPO

    This project studies the historical relationship between military technology, globalization and the rise of European overseas empires by focusing on the provisioning system of cannons in the first political entity which ever connected the four parts of the world: the Iberian Union (1580-1640). If cannons have become a symbol of early modern European expansion, no study has tackled their contribution in sustaining overseas conquests. In defence of dozens of sea-fortresses and on board of hundreds of ships spread around the globe, cannons played a crucial role in the first globalization as key infrastructures of the Iberian empires. The project aims to shed light on this world-wide deployment of artillery technology by revealing the emergence of a system combining gun-manufactures in Europe, America and Asia, all connected through circulations of weapons, raw material and technical experts. The special attention granted to the actors of the system intends to highlight the importance of human capital in the imperial state-building and globalizing processes. The project implements a twofold interdisciplinary methodology: while computer software is used in order to quantify and map the system, archival sources are crossed with material evidence coming from the wide collections of cannons hold in museums so as to reveal circulations and hybridizations of knowledge. Complemented by thorough archival work on case studies about the gun-foundries in Mexico, Cuba, Manila and Macau, this research addresses the issue of technological asymmetries between centres and peripheries inside the Iberian empires and questions the role of European colonial spaces in the globalization of the military revolution. By doing so, this project contributes to two EU priorities as it provides a reflection, from a historical perspective, on Europe’s place in a global context and generates knowledge on the cultural heritage of European coastal areas regarding their proto-industrial developments.

  • Funder: EC Project Code: 281691
    Partners: UPO
  • Open Access mandate for Publications and Research data
    Funder: EC Project Code: 101061171
    Funder Contribution: 181,153 EUR
    Partners: UPO

    Brain plasticity and neuronal network oscillations are crucial brain processes that depend on the timing precision of neuronal activity. These processes change during healthy brain development and are disrupted early on Alzheimer’s disease (AD) with controversies on the onset of their impairment. Thus, comprehensive studies of plasticity considering the state of the neuronal network during development and AD progression are missing. Here we will address the mechanisms underlying timing-dependent plasticity by the convergent study of spike timing-dependent plasticity and neuronal networks rhythms in mice hippocampal slices. The work plan includes logical sequential sets of experiments involving ex-vivo electrophysiology combined with multiphoton imaging, optogenetic, calcium dynamics, molecular biology, and immunohistochemistry during healthy development in wild-type mice and the progressive impairment of neuronal circuits dynamic in an AD mice model. The action will be implemented during 2 years in the Laboratory of Cellular Neuroscience and Plasticity (LCNP) lead by Professor Antonio Rodríguez Moreno (supervisor) and hosted by University Pablo de Olavide (UPO) in Seville, Spain. All the premises and infrastructures owned by UPO are at full disposal for both the candidate and the supervisor (Manager of the Infrastructure of Multiphoton Unit). During the action the researcher will acquire intellectual skills and learn sophisticated and cutting-edge approaches to assess synaptic plasticity supported by his previous skills and the strong supervisor's background. The expected outcomes from the insertion in a suitable scientific and academic environment at LCNP and UPO will lead the candidate to establish as a young PI within the Spanish Science System. LCNP and UPO will establish the study of neuronal dynamics in a highly convergent way and nurture from the candidate's expertise acquired in both the KI and during the fellowship.

  • Open Access mandate for Publications
    Funder: EC Project Code: 737559
    Overall Budget: 150,000 EURFunder Contribution: 150,000 EUR
    Partners: UPO

    Fertility decline is the largest contributor to population ageing in the world today, and infertility negatively impacts on the mental a social wellness of the population affected. One of the causes of birth rate tumbling is the trend of later motherhood in modern societies and the infertility associated to diabetes and polycystic ovary syndrome (PCOS). PCOS is the leading cause for ovulatory infertility, being the most common endocrine and metabolic disorder, affecting women in reproductive age. Women suffering from diabetes frequently suffer from infertility and PCOS, while two-thirds of adult women with PCOS suffer from insulin resistance and hyperinsulinemia. The ERC-StG MitoSigAge funds research directed to understand the process of ageing with a focus on insulin/IGF-1 signalling (IIS) and its interaction with mitochondrial metabolism. PCOS blocks oocyte maturation and ovulation, suggesting a tight link between mitochondrial energy metabolism and oocyte development mediated by IIS. One of the applications emanating from this research lies in the identification of molecular targets to combat diabetes-associated sterility. The objective of the ERC-PoC is four-fold: First, identify evolutionarily conserved molecular targets that, when inactivated, suppress sterility associated to defective IIS. Second, identify existing drugs for the identified targets and ascertain which compounds have the best therapeutic potential. Third, perform the necessary patenting of the compounds for this new application and the initial steps towards the valorisation of the identified products and their commercial potential. Fourth, market studies to evaluate the commercial potential of our technology. These steps will bridge a scientific idea from basic research to therapeutic applications. If successful, it will provide important societal and economical benefits, helping combating the downsides associated to our modern ageing society.