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Universidade Nova de Lisboa
Country: Portugal
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192 Projects, page 1 of 39
  • Funder: EC Project Code: 101003374
    Overall Budget: 147,815 EURFunder Contribution: 147,815 EUR

    Currently, we face a global antibiotic resistance crisis aggravated by the slow development of more effective and anti-resistance promoting therapeutical solutions. Protein phosphorylation (PP) has recently emerged as one of the major post-translational modification in bacteria, involved in the regulation of multiple physiological processes. In this MSCA individual fellowship application we aim to bridge the current gap in the field for prokaryotes by unravelling the unknown regulatory role of PP on proteins involved in nitrosative stress (NS) detoxification in the model bacterium E.coli. We propose to examine for the first time both global protein modifications (e.g. phosphoproteomics) under nitrogen species stress, as well as characterize PP in individual proteins involved in NS response. We will construct a network model that reflect the phosphoproteomic changes upon NS in E.coli, that may pave the way for the design of new bacterial targets. Understanding how bacteria respond to the chemical weapons of the human innate system is fundamental to develop efficient therapies. We will pioneer research on the mechanism and the regulation of nitric oxide detoxification proteins already identified as phosphorylated, by analyzing how this modification influences their stability and activity in vitro and in vivo. This project opens up new research paths on bacterial detoxification systems and signalling in general, addressing for the first time the role of PP in these processes. The proposal brings together transversal and scientific skills that will enable the researcher to lead the development of this emerging field and position herself as an expert in the area, and aims at establishing the importance of PP in NO microbial response, a novelty in this field.

  • Funder: EC Project Code: 101086974
    Overall Budget: 2,492,430 EURFunder Contribution: 2,492,430 EUR

    Inequality is among the most pressing issues of our times. The world has been fast-changing in recent years and the pandemic crisis has put a spotlight on economic inequalities and fragile social safety nets that leave vulnerable communities to bear the brunt of the crisis. The outbreak of a war in Ukraine, with millions of refugees and unforeseen impacts worldwide, will most likely worsen the current situation. It is urgent to tackle inequalities in a comprehensive way, designing public policies grounded on solid knowledge. However, there is still a lack of basic information. Economic growth numbers are published every year, but they do not tell us about how growth is distributed across the population, who gains and who loses from economic policies. Besides, beyond income and wealth, it is also critical to address other dimensions of socioeconomic disparities, such as health, education, gender, or environmental inequalities. Therefore, it is urgent to advance research on inequalities, transfer knowledge to society, and contribute to well-informed, science-based public policies. EQUALNovaERA aims to position Nova School of Business & Economics (Nova SBE) as an international reference in addressing inequalities’ drivers and effects through research, education, and community engagement while contributing to deepening the European Research Area and achieving the Sustainable Development Goals. More specifically it will 1) Create a new Research Group on inequalities; 2) Set up an Institute of Public Policies with the mission of contributing to a more equal and fair society through research, education, and community engagement; 3) Position Nova SBE as an international reference institution in addressing inequalities’ drivers and effects through research and education; 4) Promote science-based awareness on inequalities’ drivers and effects to tackle societal grand challenges; 5) Introduce sustainable structural changes at Nova SBE on and beyond the inequalities’ theme.

  • Funder: EC Project Code: 275853
  • Funder: EC Project Code: 101113512
    Funder Contribution: 150,000 EUR

    As the popularity of electric vehicles continues to increase, so does the number of batteries reaching the end-of-life that are used to power them being expected that by 2030 it will reach 2 million tons worldwide. On top of this the complexity of battery production results in very high scrap rates (about 10%-30%), especially during production ramp-up, while the scarcity of raw materials in Europe are intensifying EU regulations to localize supply chains and safeguard critical raw materials. It is evident that there is strong need to increase sustainability in the batteries value chain and contributions may come from improving both their lifetime and recyclability of the cell components. In EXCELL it is proposed to prove a new concept for batteries separators based on a 100% natural cellulose nanocomposite with tuneable mesopores obtained by a mixture of nanofibers and cellulose nanocrystals. Additionally, these new separators will be suitable for the incorporation of sensing elements that will enable the new generation of smart battery cells. EXCELL will follow the outputs of NEWFUN-StG where it was demonstrated that cellulose based ionic conductive materials are possible to be recycled and reused while maintaining the electrochemical performance. The PI’s team has also demonstrated that cellulose nanocrystals are able to create mesoporous ionic conductive channels that can be tunned to specific alkali ions but proper functionalization of the crystals’ surface. EXCELL will now demonstrate the synergic effect of combining both to form hierarchical mesoporous membranes exhibiting a unique set of characteristics that can meet those ones expected for an “ideal” separator. EXCELL will follow an approach of validating the new separator concept and then implement a IPR consolidation and a business case to attract the attention of battery market stakeholders on new opportunities for cell components based on abundant natural resources that are recyclable/biodegradable.

  • Funder: EC Project Code: 101062643
    Funder Contribution: 302,451 EUR

    LUARC intends to contribute to the enhancement and revitalization of the personal archive of Angolan intellectual Mário Pinto de Andrade (MPA). In addition to working with unique documents, LUARC develops an interdisciplinary approach to the archive as a site of production of historical knowledge. Widely known for his participation in the Angolan liberation struggle, MPA is a key figure in the cultural history of Angola, and one of the most important contemporary African intellectuals. LUARC focuses on the vast and heterogeneous material that the writer collected between 1940-1990, following the life of MPA and that of Angola through the late colonial period, the anticolonial struggle, and post-independence. LUARC puts together academic institutions and non-academic organizations located in Portugal, Angola, and the US, creating international connections to animate meaningful debates on Angola’s recent past. The project uses methods and techniques of archival science and digital humanities to ensure the proper appreciation of MPA’s personal records. Treating data according to the best ethical practices, LUARC grants broad open access to the digital archive, as well as to other project results and outputs. Strongly rooted in history and postcolonial theory, LUARC situates the archive in the context of Angola’s transition from colony to independent nation, creating a framework in which personal records come to make meaning as parts of a complex collective history. In particular, records are analysed in order to trace the evolution of practices and discourses on culture and nationalism in Angola, bringing to the surface narratives that have often been neglected. At the same time, drawing from literary studies and archival art, LUARC reflects on the practice of producing and keeping records, understanding it as a performative act that intervenes in the creation of the narratives through which we come to make sense of the past.

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