research data . Image . 2019

Additional file 3: of Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease

Konki, Mikko; Malonzo, Maia; Karlsson, Ida; Lindgren, Noora; Bishwa Ghimire; Smolander, Johannes; Scheinin, Noora; Ollikainen, Miina; Laiho, Asta; Elo, Laura; ...
  • Published: 01 Jan 2019
  • Publisher: figshare
Abstract
The effect sizes of the top-ranked differentially methylated sites. The effect sizes of the top-ranked differentially methylated sites from the monozygotic twin pairs (MZ, "Discovery set") were examined for reproducibility in the dizygotic twin pairs ("DZ, Validation set") by comparing the corresponding values in a scatterplot. A) effect size was measured as methylation difference (% estimate by RADMeth) and b) standardised effect size was measured as estimated methylation difference over standard deviation of pairwise methylation difference (n = 172, R = 0.452, p value = 4.754e-10 and R = 0.354, p value = 1.837e-6, respectively, by Pearson correlation test). The top 200 sites in the MZ cohort were initially selected (ranked by q value) of which 172 met the coverage criteria for the DZ cohort. The correlation tests indicate overall consistency in direction of methylation of the top-ranked MZ sites in the DZ cohort. (TIF 4938 kb)
Subjects
free text keywords: Biochemistry, Genetics, FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified, Inorganic Chemistry, FOS: Chemical sciences, Science Policy, Computational Biology
Communities
  • Science and Innovation Policy Studies
Funded by
AKA| Epigenetic pathways to obesity
Project
  • Funder: Academy of Finland (AKA)
  • Project Code: 297908
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