research data . Dataset . 2018

Using OWL reasoning to support the generation of novel gene sets for enrichment analysis

Osumi-Sutherland, David; Ponta, Enrico; Courtot, Melanie; Parkinson, Helen; Badi, Laura;
  • Published: 15 Feb 2018
  • Publisher: Figshare
Abstract
Abstract Background The Gene Ontology (GO) consists of over 40,000 terms for biological processes, cell components and gene product activities linked into a graph structure by over 90,000 relationships. It has been used to annotate the functions and cellular locations of several million gene products. The graph structure is used by a variety of tools to group annotated genes into sets whose products share function or location. These gene sets are widely used to interpret the results of genomics experiments by assessing which sets are significantly over- or under-represented in results lists. F Hoffmann-La Roche Ltd. has developed a bespoke, manually maintained c...
Subjects
free text keywords: Genetics, Molecular Biology, 69999 Biological Sciences not elsewhere classified, 80699 Information Systems not elsewhere classified, Cancer, FOS: Biological sciences, FOS: Computer and information sciences
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
,
NIH| Gene Ontology Consortium
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 4U41HG002273-16
  • Funding stream: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
Communities
Digital Humanities and Cultural Heritage
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Dataset . 2018
Provider: Datacite
figshare
Dataset . 2018
Provider: Datacite
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