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description Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United States, Spain, Netherlands, United Kingdom, United Kingdom, Argentina, PeruPublisher:Springer Science and Business Media LLC Funded by:NSF | Genes and the fertility o..., NIH | Integrative Genomics of B..., NSF | Nitric Oxide and the Micr... +7 projectsNSF| Genes and the fertility of Tibetan Women at High Altitude in Nepal ,NIH| Integrative Genomics of Body Size and Metabolism in Ethnically Diverse Africans ,NSF| Nitric Oxide and the Microcirculation in the Tibet Autonomous Region ,NIH| Population genetics and evolution of mobile elements ,NIH| Mathematical Models and Statistical Methods for Large-Scale Population Genomics ,NIH| Population mixture in evolutionary and medical genetics ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,NIH| Integrative nutrigenomic and metabolomic analyses of Africans with variable diets ,NSF| A new history and geography of human genes informed by ancient DNA ,EC| MALADAPTEDSwapan Mallick; Heng Li; Mark Lipson; Iain Mathieson; Melissa Gymrek; Fernando Racimo; Mengyao Zhao; Niru Chennagiri; Susanne Nordenfelt; Arti Tandon; Pontus Skoglund; Iosif Lazaridis; Sriram Sankararaman; Qiaomei Fu; Nadin Rohland; Gabriel Renaud; Yaniv Erlich; Thomas Willems; Carla Gallo; Jeffrey P. Spence; Yun S. Song; Giovanni Poletti; Francois Balloux; George van Driem; Peter de Knijff; Irene Gallego Romero; Aashish R. Jha; Doron M. Behar; Claudio M. Bravi; Cristian Capelli; Tor Hervig; Andrés Moreno-Estrada; Olga L. Posukh; Elena Balanovska; Oleg Balanovsky; Sena Karachanak-Yankova; Hovhannes Sahakyan; Draga Toncheva; Levon Yepiskoposyan; Chris Tyler-Smith; Yali Xue; M. Syafiq Abdullah; Andres Ruiz-Linares; Cynthia M. Beall; Anna Di Rienzo; Choongwon Jeong; Elena B. Starikovskaya; Ene Metspalu; Jüri Parik; Richard Villems; Brenna M. Henn; Ugur Hodoglugil; Robert W. Mahley; Antti Sajantila; George Stamatoyannopoulos; Joseph Wee; Rita Khusainova; Elza Khusnutdinova; Sergey Litvinov; George Ayodo; David Comas; Michael F. Hammer; Toomas Kivisild; William Klitz; Cheryl A. Winkler; Damian Labuda; Michael J. Bamshad; Lynn B. Jorde; Sarah A. Tishkoff; W. Scott Watkins; Mait Metspalu; Stanislav Dryomov; Rem I. Sukernik; Lalji Singh; Kumarasamy Thangaraj; Svante Pääbo; Janet Kelso; Nick Patterson; David Reich;The sequencing was funded by the Simons Foundation (SFARI 280376) and the US National Science Foundation (BCS-1032255). I.M. was supported by a Long Term Fellowship grant LT001095/2014 from the Human Frontier Science program. P.S. was supported by the Wenner-Gren foundation and the Swedish Research Council (VR grant 2014-453). T.W. and M.G. were supported by an NIJ grant 2014-DN-BX-K089. Y.E. was supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund and by NIJ grant 2014-DN-BX-K089. D.L. was supported by the Natural Sciences and Engineering Research Council of Canada. T.K. was supported by ERC Starting Investigator grant FP7 - 261213. R.S. received support from Russian Foundation for Basic Research (#15-04-02543). S.D. received support from the Russian Foundation for Basic Research (#16-34-00599). R.K., E.K. and S.L. were supported by the Russian Foundation for Basic Research (11-04-00725-a). E.B. was supported by the Russian Foundation for Basic Research (16-06-00303). O.B. was supported by the Russian Scientific Fund (14-04-00827) and by the Russian Foundation for Basic Research (16-04-00890). D.M.B., H.S., E.M., R.V. and M.M. were supported by Institutional Research Funding from the Estonian Research Council IUT24-1 and by the European Regional Development Fund (European Union) through the Centre of Excellence in Genomics to Estonian Biocentre and University of Tartu. D.C. was supported by the Spanish MINECO grant CGL-44351-P. L.B.J. and W.S.W. were supported by NIH grant GM59290. S.A.T. was supported by NIH grants 5DP1ES022577 05, 1R01DK104339-01, and 1R01GM113657-01. C.T.-S. and Y.X. were supported by The Wellcome Trust grant 098051. C.M.B. was supported by NSF grants 0924726 and 1153911. K.T. was supported by CSIR Network Project grant (GENESIS: BSC0121). J.P.S. and Y.S.S. were supported in part by an NIH grant R01-GM094402, and a Packard Fellowship for Science and Engineering. G.R., J.K and S.P. were funded by the Max Planck Society. N.P. and D.R. were supported by NIH grant GM100233 and D.R. is a Howard Hughes Medical Institute investigator Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.
Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5161557Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaServicio de Difusión de la Creación Intelectual; SEDICI (UNLP) - Universidad Nacional de La PlataArticle . 2016License: CC BY NC SAeScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaRepositorio Institucional Universidad Peruana Cayetano HerediaArticle . 2019 . 2016License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature18964&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routeshybrid 1K citations 1,086 popularity Top 0.01% influence Top 1% impulse Top 0.01% 
Powered by BIP!visibility 49visibility views 49 download downloads 98 Powered by
more_vert Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5161557Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaServicio de Difusión de la Creación Intelectual; SEDICI (UNLP) - Universidad Nacional de La PlataArticle . 2016License: CC BY NC SAeScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaRepositorio Institucional Universidad Peruana Cayetano HerediaArticle . 2019 . 2016License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature18964&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United States, Poland, United Kingdom, NetherlandsPublisher:Springer Science and Business Media LLC Funded by:SNSF | Characterizing migrations...SNSF| Characterizing migrations with modern and ancient genomic data: the limits of the Polynesian expansionMorten E. Allentoft; Martin Sikora; Karl-Göran Sjögren; Simon Rasmussen; Morten Rasmussen; Jesper Stenderup; Peter de Barros Damgaard; Hannes Schroeder; Torbjörn Ahlström; Lasse Vinner; Anna-Sapfo Malaspinas; Ashot Margaryan; Thomas Higham; David Chivall; Niels Lynnerup; Lise Harvig; Justyna Baron; Philippe Della Casa; Paweł Dąbrowski; Paul R. Duffy; Alexander V. Ebel; Andrey Epimakhov; Karin Margarita Frei; Mirosław Furmanek; Tomasz Gralak; Andrey Gromov; Stanisław Gronkiewicz; Gisela Grupe; Tamás Hajdu; Radosław Jarysz; Valeri Khartanovich; Alexandr Khokhlov; Viktória Kiss; Jan Kolář; Aivar Kriiska; Irena Lasak; Cristina Longhi; George McGlynn; Algimantas Merkevicius; Inga Merkyte; Mait Metspalu; Ruzan Mkrtchyan; Vyacheslav Moiseyev; László Paja; György Pálfi; Dalia Pokutta; Łukasz Pospieszny; T. Douglas Price; Lehti Saag; Mikhail V. Sablin; N. I. Shishlina; Václav Smrčka; Vasilii I. Soenov; Vajk Szeverényi; Gusztáv Tóth; Synaru V. Trifanova; Liivi Varul; Magdolna Vicze; Levon Yepiskoposyan; Vladislav S. Zhitenev; Ludovic Orlando; Thomas Sicheritz-Pontén; Søren Brunak; Rasmus Nielsen; Kristian Kristiansen; Eske Willerslev;doi: 10.1038/nature14507
pmid: 31616086
The Bronze Age of Eurasia (around 3000-1000 BC) was a period of major cultural changes. However, there is debate about whether these changes resulted from the circulation of ideas or from human migrations, potentially also facilitating the spread of languages and certain phenotypic traits. We investigated this by using new, improved methods to sequence low-coverage genomes from 101 ancient humans from across Eurasia. We show that the Bronze Age was a highly dynamic period involving large-scale population migrations and replacements, responsible for shaping major parts of present-day demographic structure in both Europe and Asia. Our findings are consistent with the hypothesized spread of Indo-European languages during the Early Bronze Age. We also demonstrate that light skin pigmentation in Europeans was already present at high frequency in the Bronze Age, but not lactose tolerance, indicating a more recent onset of positive selection on lactose tolerance than previously thought. 167-172 7555 50
Oxford University Re... arrow_drop_down Leiden University Scholarly Publications RepositoryArticle . 2015Data sources: Leiden University Scholarly Publications RepositoryeScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature14507&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesbronze 1K citations 1,025 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 25visibility views 25 download downloads 1,244 Powered bymore_vert Oxford University Re... arrow_drop_down Leiden University Scholarly Publications RepositoryArticle . 2015Data sources: Leiden University Scholarly Publications RepositoryeScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature14507&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United States, Spain, Netherlands, United Kingdom, United Kingdom, Argentina, PeruPublisher:Springer Science and Business Media LLC Funded by:NSF | Genes and the fertility o..., NIH | Integrative Genomics of B..., NSF | Nitric Oxide and the Micr... +7 projectsNSF| Genes and the fertility of Tibetan Women at High Altitude in Nepal ,NIH| Integrative Genomics of Body Size and Metabolism in Ethnically Diverse Africans ,NSF| Nitric Oxide and the Microcirculation in the Tibet Autonomous Region ,NIH| Population genetics and evolution of mobile elements ,NIH| Mathematical Models and Statistical Methods for Large-Scale Population Genomics ,NIH| Population mixture in evolutionary and medical genetics ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,NIH| Integrative nutrigenomic and metabolomic analyses of Africans with variable diets ,NSF| A new history and geography of human genes informed by ancient DNA ,EC| MALADAPTEDSwapan Mallick; Heng Li; Mark Lipson; Iain Mathieson; Melissa Gymrek; Fernando Racimo; Mengyao Zhao; Niru Chennagiri; Susanne Nordenfelt; Arti Tandon; Pontus Skoglund; Iosif Lazaridis; Sriram Sankararaman; Qiaomei Fu; Nadin Rohland; Gabriel Renaud; Yaniv Erlich; Thomas Willems; Carla Gallo; Jeffrey P. Spence; Yun S. Song; Giovanni Poletti; Francois Balloux; George van Driem; Peter de Knijff; Irene Gallego Romero; Aashish R. Jha; Doron M. Behar; Claudio M. Bravi; Cristian Capelli; Tor Hervig; Andrés Moreno-Estrada; Olga L. Posukh; Elena Balanovska; Oleg Balanovsky; Sena Karachanak-Yankova; Hovhannes Sahakyan; Draga Toncheva; Levon Yepiskoposyan; Chris Tyler-Smith; Yali Xue; M. Syafiq Abdullah; Andres Ruiz-Linares; Cynthia M. Beall; Anna Di Rienzo; Choongwon Jeong; Elena B. Starikovskaya; Ene Metspalu; Jüri Parik; Richard Villems; Brenna M. Henn; Ugur Hodoglugil; Robert W. Mahley; Antti Sajantila; George Stamatoyannopoulos; Joseph Wee; Rita Khusainova; Elza Khusnutdinova; Sergey Litvinov; George Ayodo; David Comas; Michael F. Hammer; Toomas Kivisild; William Klitz; Cheryl A. Winkler; Damian Labuda; Michael J. Bamshad; Lynn B. Jorde; Sarah A. Tishkoff; W. Scott Watkins; Mait Metspalu; Stanislav Dryomov; Rem I. Sukernik; Lalji Singh; Kumarasamy Thangaraj; Svante Pääbo; Janet Kelso; Nick Patterson; David Reich;The sequencing was funded by the Simons Foundation (SFARI 280376) and the US National Science Foundation (BCS-1032255). I.M. was supported by a Long Term Fellowship grant LT001095/2014 from the Human Frontier Science program. P.S. was supported by the Wenner-Gren foundation and the Swedish Research Council (VR grant 2014-453). T.W. and M.G. were supported by an NIJ grant 2014-DN-BX-K089. Y.E. was supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund and by NIJ grant 2014-DN-BX-K089. D.L. was supported by the Natural Sciences and Engineering Research Council of Canada. T.K. was supported by ERC Starting Investigator grant FP7 - 261213. R.S. received support from Russian Foundation for Basic Research (#15-04-02543). S.D. received support from the Russian Foundation for Basic Research (#16-34-00599). R.K., E.K. and S.L. were supported by the Russian Foundation for Basic Research (11-04-00725-a). E.B. was supported by the Russian Foundation for Basic Research (16-06-00303). O.B. was supported by the Russian Scientific Fund (14-04-00827) and by the Russian Foundation for Basic Research (16-04-00890). D.M.B., H.S., E.M., R.V. and M.M. were supported by Institutional Research Funding from the Estonian Research Council IUT24-1 and by the European Regional Development Fund (European Union) through the Centre of Excellence in Genomics to Estonian Biocentre and University of Tartu. D.C. was supported by the Spanish MINECO grant CGL-44351-P. L.B.J. and W.S.W. were supported by NIH grant GM59290. S.A.T. was supported by NIH grants 5DP1ES022577 05, 1R01DK104339-01, and 1R01GM113657-01. C.T.-S. and Y.X. were supported by The Wellcome Trust grant 098051. C.M.B. was supported by NSF grants 0924726 and 1153911. K.T. was supported by CSIR Network Project grant (GENESIS: BSC0121). J.P.S. and Y.S.S. were supported in part by an NIH grant R01-GM094402, and a Packard Fellowship for Science and Engineering. G.R., J.K and S.P. were funded by the Max Planck Society. N.P. and D.R. were supported by NIH grant GM100233 and D.R. is a Howard Hughes Medical Institute investigator Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.
Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5161557Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaServicio de Difusión de la Creación Intelectual; SEDICI (UNLP) - Universidad Nacional de La PlataArticle . 2016License: CC BY NC SAeScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaRepositorio Institucional Universidad Peruana Cayetano HerediaArticle . 2019 . 2016License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature18964&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routeshybrid 1K citations 1,086 popularity Top 0.01% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 49visibility views 49 download downloads 98 Powered bymore_vert Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5161557Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaServicio de Difusión de la Creación Intelectual; SEDICI (UNLP) - Universidad Nacional de La PlataArticle . 2016License: CC BY NC SAeScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaRepositorio Institucional Universidad Peruana Cayetano HerediaArticle . 2019 . 2016License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature18964&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United States, Poland, United Kingdom, NetherlandsPublisher:Springer Science and Business Media LLC Funded by:SNSF | Characterizing migrations...SNSF| Characterizing migrations with modern and ancient genomic data: the limits of the Polynesian expansionMorten E. Allentoft; Martin Sikora; Karl-Göran Sjögren; Simon Rasmussen; Morten Rasmussen; Jesper Stenderup; Peter de Barros Damgaard; Hannes Schroeder; Torbjörn Ahlström; Lasse Vinner; Anna-Sapfo Malaspinas; Ashot Margaryan; Thomas Higham; David Chivall; Niels Lynnerup; Lise Harvig; Justyna Baron; Philippe Della Casa; Paweł Dąbrowski; Paul R. Duffy; Alexander V. Ebel; Andrey Epimakhov; Karin Margarita Frei; Mirosław Furmanek; Tomasz Gralak; Andrey Gromov; Stanisław Gronkiewicz; Gisela Grupe; Tamás Hajdu; Radosław Jarysz; Valeri Khartanovich; Alexandr Khokhlov; Viktória Kiss; Jan Kolář; Aivar Kriiska; Irena Lasak; Cristina Longhi; George McGlynn; Algimantas Merkevicius; Inga Merkyte; Mait Metspalu; Ruzan Mkrtchyan; Vyacheslav Moiseyev; László Paja; György Pálfi; Dalia Pokutta; Łukasz Pospieszny; T. Douglas Price; Lehti Saag; Mikhail V. Sablin; N. I. Shishlina; Václav Smrčka; Vasilii I. Soenov; Vajk Szeverényi; Gusztáv Tóth; Synaru V. Trifanova; Liivi Varul; Magdolna Vicze; Levon Yepiskoposyan; Vladislav S. Zhitenev; Ludovic Orlando; Thomas Sicheritz-Pontén; Søren Brunak; Rasmus Nielsen; Kristian Kristiansen; Eske Willerslev;doi: 10.1038/nature14507
pmid: 31616086
The Bronze Age of Eurasia (around 3000-1000 BC) was a period of major cultural changes. However, there is debate about whether these changes resulted from the circulation of ideas or from human migrations, potentially also facilitating the spread of languages and certain phenotypic traits. We investigated this by using new, improved methods to sequence low-coverage genomes from 101 ancient humans from across Eurasia. We show that the Bronze Age was a highly dynamic period involving large-scale population migrations and replacements, responsible for shaping major parts of present-day demographic structure in both Europe and Asia. Our findings are consistent with the hypothesized spread of Indo-European languages during the Early Bronze Age. We also demonstrate that light skin pigmentation in Europeans was already present at high frequency in the Bronze Age, but not lactose tolerance, indicating a more recent onset of positive selection on lactose tolerance than previously thought. 167-172 7555 50
Oxford University Re... arrow_drop_down Leiden University Scholarly Publications RepositoryArticle . 2015Data sources: Leiden University Scholarly Publications RepositoryeScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature14507&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesbronze 1K citations 1,025 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 25visibility views 25 download downloads 1,244 Powered bymore_vert Oxford University Re... arrow_drop_down Leiden University Scholarly Publications RepositoryArticle . 2015Data sources: Leiden University Scholarly Publications RepositoryeScholarship - University of CaliforniaArticle . 2015Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature14507&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu