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description Publicationkeyboard_double_arrow_right Article 2021 FinlandPublisher:Elsevier BV Funded by:NHMRC | Follow up of the 1985 Aus..., NIH | EVOLUTION OF CARDIOVASCUL..., NIH | Childhood Growth, Biologi... +3 projectsNHMRC| Follow up of the 1985 Australian Schools Health and Fitness Survey Cohort ,NIH| EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGING ,NIH| Childhood Growth, Biological Aging and Midlife Cardio-Metabolic Outcomes ,NHMRC| Inter-relationships between life-stage transitions, depression and cardio-metabolic health in young adults ,NHMRC| Cardiometabolic risk trajectories from childhood to midlife: finding pathways to better health ,NIH| Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-upVerity Cleland; Jing Tian; Marie-Jeanne Buscot; Costan G. Magnussen; Lydia Bazzano; Trudy L. Burns; Stephen Daniels; Terence Dwyer; Nina Hutri-Kahonen; Johanna Ikonen; David Jacobs; Markus Juonala; Ronald Prineas; Olli Raitakari; Alan Sinaiko; Julia Steinberger; Elaine M. Urbina; Jessica G. Woo; Alison Venn;Background: Understanding lifecourse trajectories of body-mass index (BMI) is important for identifying groups at high risk of poor health and potential target points for intervention. This study aimed to describe BMI trajectories from childhood to mid-adulthood in four population-based cohorts established in the 1970s and 1980s and to identify childhood sociodemographic factors related to trajectory membership. Methods: Between Dec 17, 1970 and Dec 15, 1994, data were collected at the first visit from 9830 participants from the International Childhood Cardiovascular Cohort (i3C) Consortium, which includes participants from Australia (1985), Finland (1980) and the USA (1970–1994). Participants had at least three measures of height and weight, including one in childhood (6–18 years) and one in adulthood (>18 years), and were aged 30–49 years at last measurement. Latent Class Growth Mixture Modelling was used to identify lifecourse BMI trajectory groups and log multinomial regression models were fit to identify their childhood sociodemographic predictors. Findings: Five consistent BMI trajectory groups were identified amongst the four cohorts: persistently low (35.9–58.6%), improving from high (0.7–4.8%), progressing to moderate (9.3–43.7%), progressing to high (1.1–6.0%), and progressing to very high (0.7–1.3%). An additional three BMI trajectory groups were identified in some, but not all, cohorts: adult onset high (three cohorts; 1.8–20.7%), progressing to moderate-high (two cohorts; 5.2–13.8%), and relapsing yo-yoers (alternating upward and downward; one cohort; 1.3%). In pooled analyses, each predictor variable in childhood, including age, gender, parental education and race, was associated with increased likelihood of belonging to the most (e.g., improving from high) and least (e.g., progressing to very high) favourable BMI trajectory groups, suggesting a U-shaped (or inverse U-shaped) pattern of association. Interpretation: Five consistent BMI trajectory groups were identified across four cohorts from Australia, Finland, and the USA, mainly across two eras of birth. While most participants remained on a persistently low trajectory (50%), many demonstrated worsening BMI trajectories (47%), with only few demonstrating improving trajectories (<5%). Age, gender, parental education, and race appear to be important predictors of BMI trajectory group membership and need consideration in preventive and management strategies. Funding: This study was supported by funding from the National Institutes of Health, National Heart, Lung and Blood Institute (grant number R01 HL121230). Peer reviewed
EClinicalMedicine arrow_drop_down Trepo - Institutional Repository of Tampere UniversityArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Trepo - Institutional Repository of Tampere Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert EClinicalMedicine arrow_drop_down Trepo - Institutional Repository of Tampere UniversityArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Trepo - Institutional Repository of Tampere Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 Finland, Italy, ItalyPublisher:Springer Science and Business Media LLC Funded by:NIH | VITAMIN INTERVENTION FOR ..., NIH | Genetics of ischemic stro..., WT | Understanding the genetic... +19 projectsNIH| VITAMIN INTERVENTION FOR STROKE PREVENTION ,NIH| Genetics of ischemic stroke in the SiGN Consortium ,WT| Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics. ,NHMRC| Australian Stroke Genetics Collaborative - Genome-wide association study in ischaemic stroke ,NIH| THE BALTIMORE LONGITUDINAL STUDY OF HUMAN AGING ,NIH| ISGS: The Ischemic Stroke Genetics Study ,NIH| MULTICENTERED STUDY OF STROKE GENETICS ,NIH| Genetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic Groups ,NIH| Genetics Of Stroke ,EC| GEUVADIS ,NIH| Data Mgmt &Analysis Core - The NINDS International Stroke Genetics Consortium St ,WT| A genome wide association study in ischaemic stroke. ,NIH| GWAS of Hormone Treatment and CVD and Metabolic Outcomes in the WHI ,NIH| A Center for GEI Association Studies ,NIH| Genetics of Early Onset-Stroke ,NIH| Genome Wide Association Coordinating Center ,NIH| Genetics of Early-Onset Ischemic Stroke Consortium ,NIH| Research Training in the Epidemiology of Aging ,WT| WTCCC2 core activities ,NIH| CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS ,NIH| Randomized Clinical Trials - Whole Genome Studies Coordinating Center ,NIH| A Genome-wide Association Study for Early-Onset Myocardial InfarctionAuthors: Stefano Mammola; Diego Fontaneto; Alejandro Martínez; Filipe Chichorro;Stefano Mammola; Diego Fontaneto; Alejandro Martínez; Filipe Chichorro;handle: 10138/326141
Many believe that the quality of a scientific publication is as good as the science it cites. However, quantifications of how features of reference lists affect citations remain sparse. We examined seven numerical characteristics of reference lists of 50,878 research articles published in 17 ecological journals between 1997 and 2017. Over this period, significant changes occurred in reference lists' features. On average, more recent papers have longer reference lists and cite more high Impact Factor papers and fewer non-journal publications. We also show that highly cited articles across the ecological literature have longer reference lists, cite more recent and impactful references, and include more self-citations. Conversely, the proportion of 'classic' papers and non-journal publications cited, as well as the temporal span of the reference list, have no significant influence on articles' citations. From this analysis, we distill a recipe for crafting impactful reference lists, at least in ecology. Peer reviewed
CNR ExploRA arrow_drop_down HELDA - Digital Repository of the University of HelsinkiArticle . 2021 . Peer-reviewedData sources: HELDA - Digital Repository of the University of Helsinkiadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11192-020-03759-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 28 citations 28 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert CNR ExploRA arrow_drop_down HELDA - Digital Repository of the University of HelsinkiArticle . 2021 . Peer-reviewedData sources: HELDA - Digital Repository of the University of Helsinkiadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11192-020-03759-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 AustraliaPublisher:University Library System, University of Pittsburgh Funded by:NHMRC | Evidence Innovation: tran...NHMRC| Evidence Innovation: transforming the efficiency of systematic reviewJustin Michael Clark; Sharon Sanders; Matthew Carter; David Honeyman; Gina Cleo; Yvonne Auld; Debbie Booth; Patrick Condron; Christine Dalais; Sarah Bateup; Bronwyn Linthwaite; Nikki May; Jo Munn; Lindy Ramsay; Kirsty Rickett; Cameron Rutter; Angela Smith; Peter Sondergeld; Margie Wallin; Mark Jones; Elaine Beller;Background: Searching for studies to include in a systematic review (SR) is a time- and labor-intensive process with searches of multiple databases recommended. To reduce the time spent translating search strings across databases, a tool called the Polyglot Search Translator (PST) was developed. The authors evaluated whether using the PST as a search translation aid reduces the time required to translate search strings without increasing errors.Methods: In a randomized trial, twenty participants were randomly allocated ten database search strings and then randomly assigned to translate five with the assistance of the PST (PST-A method) and five without the assistance of the PST (manual method). We compared the time taken to translate search strings, the number of errors made, and how close the number of references retrieved by a translated search was to the number retrieved by a reference standard translation.Results: Sixteen participants performed 174 translations using the PST-A method and 192 translations using the manual method. The mean time taken to translate a search string with the PST-A method was 31 minutes versus 45 minutes by the manual method (mean difference: 14 minutes). The mean number of errors made per translation by the PST-A method was 8.6 versus 14.6 by the manual method. Large variation in the number of references retrieved makes results for this outcome unreliable, although the number of references retrieved by the PST-A method was closer to the reference standard translation than the manual method.Conclusion: When used to assist with translating search strings across databases, the PST can increase the speed of translation without increasing errors. Errors in search translations can still be a problem, and search specialists should be aware of this.
ACU Research Bank arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7069833Data sources: PubMed CentralJournal of the Medical Library AssociationArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 197 citations 197 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert ACU Research Bank arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7069833Data sources: PubMed CentralJournal of the Medical Library AssociationArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5195/jmla.2020.834&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Australia, Netherlands, Finland, Netherlands, Denmark, Belgium, Netherlands, Belgium, United KingdomPublisher:Elsevier BV Funded by:NIH | University of Washington ..., NIH | Methodologies to Enhance ..., WT | Global Atlas of Podoconio... +12 projectsNIH| University of Washington Center for Demography and Economics of Aging-Overall ,NIH| Methodologies to Enhance Understanding of HIV-Associated Social Determinants ,WT| Global Atlas of Podoconiosis ,NIH| Implementing mental health interventions for pregnant adolescents in primary care LMIC contexts ,NIH| Long term outcomes of therapy in women initiated on lifelong ART because of pregnancy in DR Congo ,NHMRC| Increasing knowledge about substance use, mental health and harms, and interventions to prevent and reduce harm ,FCT| Associated Laboratory for Green Chemistry - Clean Technologies and Processes ,NIH| Can HIV Hot-Spots be eradicated? An intervention to decrease HIV transmission to young women in rural KwaZulu-Natal South Africa ,MESTD| Functional, Functionalized and Advanced Nanomaterials ,NIH| Causal Pathways to population health impact of HIV antiretroviral treatment ,NIH| Central Africa IeDEA ,NIH| CARDIOMETABOLIC DISEASE & RISK FACTORS AMONG OLDER ADULTS IN SUB-SAHARAN AFRICA ,NIH| Training Tanzanian Researchers for HIV/AIDS Implementation Science ,NHMRC| Assessing the population health impact of illicit drug use: prevalence, trajectories, and contributions to disease burden ,NIH| New Methods for the design and evaluation of large HIV prevention interventionsFrank, Tahvi D; Carter, Austin; Jahagirdar, Deepa; Biehl, Molly H; Douwes-Schultz, Dirk; Larson, Samantha Leigh; Arora, Megha; Dwyer-Lindgren, Laura; Steuben, Krista M; Abbastabar, Hedayat; Abu-Raddad, Laith Jamal; Abyu, Direslgne Misker; Adabi, Maryam; Adebayo, Oladimeji M; Adekanmbi, Victor; Adetokunboh, Olatunji O; Ahmadi, Alireza; Ahmadi, Keivan; Ahmadian, Elham; Ahmadpour, Ehsan; Ahmed, Muktar Beshir; Akal, Chalachew Genet; Alahdab, Fares; Alam, Noore; Albertson, Samuel B; Alemnew, Birhan Tamene T; Alene, Kefyalew Addis; Alipour, Vahid; Alvis-Guzman, Nelson; Amini, Saeed; Anbari, Zohreh; Anber, Nahla Hamed; Anjomshoa, Mina; Antonio, Carl Abelardo T; Arabloo, Jalal; Aremu, Olatunde; Areri, Habtamu Abera; Asfaw, Ephrem Tsegay; Ashagre, Alebachew Fasil; Asmelash, Daniel; Asrat, Anemaw A; Avokpaho, Euripide FGA; Awasthi, Ashish; Awoke, Nefsu; Ayanore, Martin Amogre; Azari, Samad; Badawi, Alaa; Bagherzadeh, Mojtaba; Banach, Maciej; Barac, Aleksandra; Bärnighausen, Till Winfried; Basu, Sanjay; Bedi, Neeraj; Behzadifar, Masoud; Bekele, Bayu Begashaw; Belay, Saba Abraham; Belay, Yared Belete; Belayneh, Yaschilal Muche; Berhane, Adugnaw; Bhat, Anusha Ganapati; Bhattacharyya, Krittika; Biadgo, Belete; Bijani, Ali; Bin Sayeed, Muhammad Shahdaat; Bitew, Helen; Blinov, Andrew; Bogale, Kassawmar Angaw; Bojia, Hunduma Amensisa; Burugina Nagaraja, Sharath BN; Butt, Zahid A; Cahuana-Hurtado, Lucero; Campuzano Rincon, Julio Cesar; Carvalho, Félix; Chattu, Vijay Kumar; Christopher, Devasahayam J; Chu, Dinh-Toi; Crider, Raquel; Dahiru, Tukur; Dandona, Lalit; Dandona, Rakhi; Daryani, Ahmad; das Neves, José; De Neve, Jan-Walter; Degenhardt, Louisa; Demeke, Feleke Mekonnen; Demis, Asmamaw Bizuneh; Demissie, Dereje Bayissa; Demoz, Gebre Teklemariam; Deribe, Kebede; Des Jarlais, Don; Dhungana, Govinda Prasad; Diaz, Daniel; Djalalinia, Shirin; Do, Huyen Phuc; Doan, Linh Phuong; Duber, Herbert; Dubey, Manisha; Dubljanin, Eleonora; Duken, Eyasu Ejeta; Duko Adema, Bereket; Effiong, Andem; Eftekhari, Aziz; El Sayed Zaki, Maysaa; El-Jaafary, Shaimaa I; El-Khatib, Ziad; Elsharkawy, Aisha; Endries, Aman Yesuf; Eskandarieh, Sharareh; Eyawo, Oghenowede; Farzadfar, Farshad; Fatima, Batool; Fentahun, Netsanet; Fernandes, Eduarda; Filip, Irina; Fischer, Florian; Folayan, Morenike Oluwatoyin; Foroutan, Masoud; Fukumoto, Takeshi; Fullman, Nancy; Garcia-Basteiro, Alberto L; Gayesa, Reta Tsegaye; Gebremedhin, Ketema Bizuwork; Gebremeskel, Gebreamlak Gebremedhn Gebremedhn; Gebreyohannes, Kelali Kalaye; Gedefaw, Getnet Azeze; Gelaw, Belayneh K; Gesesew, Hailay Abrha; Geta, Birhanu; Gezae, Kebede Embaye; Ghadiri, Keyghobad; Ghashghaee, Ahmad; Ginindza, Themba TG; Gugnani, Harish Chander; Guimarães, Rafael Alves; Haile, Michael Tamene; Hailu, Gessessew Bugssa; Haj-Mirzaian, Arvin; Haj-Mirzaian, Arya; Hamidi, Samer; Handanagic, Senad; Handiso, Demelash Woldeyohannes; Hanfore, Lolemo Kelbiso; Hasanzadeh, Amir; Hassankhani, Hadi; Hassen, Hamid Yimam; Hay, Simon I; Henok, Andualem; Hoang, Chi Linh; Hosgood, H Dean; Hosseinzadeh, Mehdi; Hsairi, Mohamed; Ibitoye, Segun Emmanuel; Idrisov, Bulat; Ikuta, Kevin S; Ilesanmi, Olayinka Stephen; Irvani, Seyed Sina Naghibi; Iwu, Chinwe Juliana; Jacobsen, Kathryn H; James, Spencer L; Jenabi, Ensiyeh; Jha, Ravi Prakash; Jonas, Jost B; Jorjoran Shushtari, Zahra; Kabir, Ali; Kabir, Zubair; Kadel, Rajendra; Kasaeian, Amir; Kassa, Belete; Kassa, Getachew Mullu; Kassa, Tesfaye Dessale; Kayode, Gbenga A; Kebede, Mihiretu M; Kefale, Adane Teshome; Kengne, Andre Pascal; Khader, Yousef Saleh; Khafaie, Morteza Abdullatif; Khalid, Nauman; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khan, Junaid; Khang, Young-Ho; Khatab, Khaled; Khazaei, Salman; Khoja, Abdullah T; Kiadaliri, Aliasghar A; Kim, Yun Jin; Kisa, Adnan; Kisa, Sezer; Kochhar, Sonali; Komaki, Hamidreza; Koul, Parvaiz A; Koyanagi, Ai; Kuate Defo, Barthelemy; Kumar, G Anil; Kumar, Manasi; Kuupiel, Desmond; Lal, Dharmesh Kumar; Lee, Jane Jean-Hee; Lenjebo, Tsegaye Lolaso; Leshargie, Cheru Tesema; Magdy Abd El Razek, Hassan; Mahasha, Phetole Walter; Majeed, Azeem; Manafi, Navid; Martins-Melo, Francisco Rogerlândio; Meles, Gebrekiros Gebremichael; Meles, Hagazi Gebre; Meretoja, Tuomo J; Miller, Ted R; Moazen, Babak; Mohammad, Karzan Abdulmuhsin; Mohammed, Shafiu; Mohebi, Farnam; Mokdad, Ali H; Moodley, Yoshan; Moradi, Ghobad; Mossie, Tilahun Belete; Mousavi, Seyyed Meysam; Muthupandian, Saravanan; Nazari, Javad; Ndwandwe, Duduzile Edith; Ningrum, Dina Nur Anggraini; Nnaji, Chukwudi A; Noubiap, Jean Jacques; Nourollahpour Shiadeh, Malihe; Obsa, Mohammed Suleiman; Olagunju, Andrew T; Olagunju, Tinuke O; Olum, Solomon; Padubidri, Jagadish Rao; Pakhale, Smita; Pakpour, Amir H; Paulos, Kebreab; Pepito, Veincent Christian Filipino; Pourshams, Akram; Rabiee, Mohammad; Rabiee, Navid; Rafiei, Alireza; Rahim, Fakher; Rahimi-Movaghar, Vafa; Renjith, Vishnu; Reta, Melese Abate; Rezai, Mohammad Sadegh; Rostami, Ali; Saeedi Moghaddam, Sahar; Safari, Saeed; Sagar, Rajesh; Salomon, Joshua A; Samy, Abdallah M; Schutte, Aletta Elisabeth; Shabaninejad, Hosein; Shamsizadeh, Morteza; Sharifi, Hamid; Shibuya, Kenji; Silva, Diego Augusto Santos; Sisay, Mekonnen; Sokhan, Anton; Soshnikov, Sergey; Stein, Dan J; Sufiyan, Mu'awiyyah Babale; Sunguya, Bruno F; Tadesse, Birkneh Tilahun; Tadesse, Degena Bahrey; Taveira, Nuno; Tesfay, Fisaha Haile; Thapa, Subash; Topp, Stephanie M; Tran, Bach Xuan; Tran, Khanh Bao; Ullah, Irfan; Unnikrishnan, Bhaskaran; Uthman, Olalekan A; Waheed, Yasir; Wijeratne, Tissa; Wolde, Haileab Fekadu; Wonde, Tewodros Eshete; Yotebieng, Marcel; Zaidi, Zoubida; Ziapour, Arash;pmc: PMC6934077
handle: 11541.2/33253 , 10067/1651020151162165141 , 10138/310381 , 1854/LU-8626802
Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980-2017 and forecast these estimates to 2030 for 195 countries and territories. Methods We determined a modelling strategy for each country on the basis of the availability and quality of data. For countries and territories with data from population-based seroprevalence surveys or antenatal care clinics, we estimated prevalence and incidence using an open-source version of the Estimation and Projection Package-a natural history model originally developed by the UNAIDS Reference Group on Estimates, Modelling, and Projections. For countries with cause-specific vital registration data, we corrected data for garbage coding (ie, deaths coded to an intermediate, immediate, or poorly defined cause) and HIV misclassification. We developed a process of cohort incidence bias adjustment to use information on survival and deaths recorded in vital registration to back-calculate HIV incidence. For countries without any representative data on HIV, we produced incidence estimates by pulling information from observed bias in the geographical region. We used a re-coded version of the Spectrum model (a cohort component model that uses rates of disease progression and HIV mortality on and off ART) to produce age-sex-specific incidence, prevalence, and mortality, and treatment coverage results for all countries, and forecast these measures to 2030 using Spectrum with inputs that were extended on the basis of past trends in treatment scale-up and new infections. Findings Global HIV mortality peaked in 2006 with 1.95 million deaths (95% uncertainty interval 1.87-2.04) and has since decreased to 0.95 million deaths (0.91-1.01) in 2017. New cases of HIV globally peaked in 1999 (3.16 million, 2.79-3.67) and since then have gradually decreased to 1.94 million (1.63-2.29) in 2017. These trends, along with ART scale-up, have globally resulted in increased prevalence, with 36.8 million (34.8-39.2) people living with HIV in 2017. Prevalence of HIV was highest in southern sub-Saharan Africa in 2017, and countries in the region had ART coverage ranging from 65.7% in Lesotho to 85.7% in eSwatini. Our forecasts showed that 54 countries will meet the UNAIDS target of 81% ART coverage by 2020 and 12 countries are on track to meet 90% ART coverage by 2030. Forecasted results estimate that few countries will meet the UNAIDS 2020 and 2030 mortality and incidence targets. Interpretation Despite progress in reducing HIV-related mortality over the past decade, slow decreases in incidence, combined with the current context of stagnated funding for related interventions, mean that many countries are not on track to reach the 2020 and 2030 global targets for reduction in incidence and mortality. With a growing population of people living with HIV, it will continue to be a major threat to public health for years to come. The pace of progress needs to be hastened by continuing to expand access to ART and increasing investments in proven HIV prevention initiatives that can be scaled up to have population-level impact. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd. Peer reviewed
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6934077Data sources: PubMed CentralFachrepositorium LebenswissenschaftenArticle . 2019License: CC BYData sources: Fachrepositorium Lebenswissenschaftenhttps://hdl.handle.net/10067/1...Article . 2019Data sources: Institutional Repository Universiteit AntwerpenUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryUniversity of Lincoln Institutional RepositoryArticle . 2019 . Peer-reviewedData sources: University of Lincoln Institutional RepositoryGhent University Academic BibliographyArticle . 2019Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2019 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiGhent University Academic BibliographyArticle . 2019Data sources: Ghent University Academic BibliographyUniSA Research Outputs RepositoryArticle . 2019 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 271 citations 271 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 35visibility views 35 download downloads 105 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6934077Data sources: PubMed CentralFachrepositorium LebenswissenschaftenArticle . 2019License: CC BYData sources: Fachrepositorium Lebenswissenschaftenhttps://hdl.handle.net/10067/1...Article . 2019Data sources: Institutional Repository Universiteit AntwerpenUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryUniversity of Lincoln Institutional RepositoryArticle . 2019 . Peer-reviewedData sources: University of Lincoln Institutional RepositoryGhent University Academic BibliographyArticle . 2019Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2019 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiGhent University Academic BibliographyArticle . 2019Data sources: Ghent University Academic BibliographyUniSA Research Outputs RepositoryArticle . 2019 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2018 United Kingdom, Sweden, Netherlands, United Kingdom, Denmark, Belgium, United KingdomPublisher:Cold Spring Harbor Laboratory Funded by:NHMRC | Markers of inflammation a..., NIH | Quantifying and Character..., NHMRC | Australian Prostate Cance... +22 projectsNHMRC| Markers of inflammation and prostate cancer risk ,NIH| Quantifying and Characterizing the shared genetic contribution to common cancers ,NHMRC| Australian Prostate Cancer Collaboration (APCC) Bio - Resource ,NHMRC| PRACTICAL Australia ,NHMRC| The Health 2020 Cohort Study (Health 2020) ,NIH| A genome-wide association study for breast cancer in BRCA1 mutation carriers ,NIH| Imputation-based approach to identify low frequency variants in prostate cancer ,NIH| Discovery Expansion and Replication ,NIH| Breast &Prostate Cancer &Hormone-related Gene Variants ,NIH| Breast &prostate cancer &hormone-related gene variants ,NHMRC| why do some men get prostate cancer? ,NHMRC| Platform for Young Public health researchers to Upgrade their Scientific training Experience and independent Status ,NHMRC| A case control study of risk factors for aggressive prostate cancer ,NHMRC| Epidemiology of Chronic Disease, Health Interventions and DNA Studies ,CIHR ,NIH| Integrative approaches for mapping the genetic risk of complex traits ,EC| COGS ,NIH| Leveraging functional data to predict disease risk in multi-ethnic populations ,NIH| Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI) ,NIH| Elucidating Loci Involved in Prostate Cancer Suceptibility ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer: The BPC3. ,NHMRC| The predictors of prostate cancer in the Melbourne Collaborative Cohort Study ,NHMRC| Markers of androgen action, genetic variation and prostate cancer risk ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer;the BPC3 ,NHMRC| Infections, inflammatory markers and prostate cancer riskNicholas Mancuso; Simon Gayther; Alexander Gusev; Wei Zheng; Kathryn L. Penney; Brian E. Henderson; Sara Benlloch; Fredrick R. Schumacher; Ali Amin Al Olama; Kenneth Muir; Sonja I. Berndt; David V. Conti; Fredrik Wiklund; Stephen Chanock; Victoria L. Stevens; Catherine M. Tangen; Jyotsna Batra; Judith Clements; Henrik Gronberg; Nora Pashayan; Johanna Schleutker; Demetrius Albanes; Stephanie Weinstein; Alicja Wolk; Catharine West; Lorelei Mucci; Géraldine Cancel-Tassin; Stella Koutros; Karina Dalsgaard Sorensen; Lovise Maehle; David E. Neal; Freddie C. Hamdy; Jenny L. Donovan; Ruth C. Travis; Robert J. Hamilton; Sue Ann Ingles; Barry Rosenstein; Yong-Jie Lu; Graham G. Giles; Adam S. Kibel; Ana Vega; Manolis Kogevinas; Jong Y. Park; Janet L. Stanford; Cezary Cybulski; Børge G. Nordestgaard; Hermann Brenner; Christiane Maier; Jeri Kim; Esther M. John; Manuel R. Teixeira; Susan L. Neuhausen; Kim De Ruyck; Azad Razack; Lisa F. Newcomb; Davor Lessel; Radka Kaneva; Nawaid Usmani; Frank Claessens; Paul A. Townsend; Manuela Gago-Dominguez; Monique J. Roobol; Florence Menegaux; Kay-Tee Khaw; Lisa Cannon-Albright; Hardev Pandha; Stephen N. Thibodeau; David J. Hunter; Peter Kraft; Zsofia Kote-Jarai; Rosalind Eeles; Matthew Freedman; Christopher Haiman; Bogdan Pasaniuc;pmc: PMC6172280 , PMC6325152
handle: 1765/110958
Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS (N = 142,392) with gene expression measured in 45 tissues (N = 4458), including normal and tumor prostate, to perform a multi-tissue transcriptome-wide association study (TWAS) for PrCa. We identify 217 genes at 84 independent 1 Mb regions associated with PrCa risk, 9 of which are regions with no genome-wide significant SNP within 2 Mb. 23 genes are significant in TWAS only for alternative splicing models in prostate tumor thus supporting the hypothesis of splicing driving risk for continued oncogenesis. Finally, we use a Bayesian probabilistic approach to estimate credible sets of genes containing the causal gene at a pre-defined level; this reduced the list of 217 associations to 109 genes in the 90% credible set. Overall, our findings highlight the power of integrating expression with PrCa GWAS to identify novel risk loci and prioritize putative causal genes at known risk loci. ispartof: NATURE COMMUNICATIONS vol:9 issue:1 ispartof: location:England status: published
bioRxiv arrow_drop_down bioRxivPreprint . 2018Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6172280Data sources: PubMed CentralNature CommunicationsArticle . 2019Full-Text: http://europepmc.org/articles/PMC6325152Data sources: PubMed CentralThe University of Manchester - Institutional RepositoryArticle . 2019Data sources: The University of Manchester - Institutional RepositoryThe University of Manchester - Institutional RepositoryArticle . 2018Data sources: The University of Manchester - Institutional RepositoryCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemOxford University Research Archive; Nature CommunicationsArticle . 2019 . 2018 . Peer-reviewedLicense: CC BYPublikationer från Uppsala UniversitetArticle . 2018 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold more_vert bioRxiv arrow_drop_down bioRxivPreprint . 2018Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6172280Data sources: PubMed CentralNature CommunicationsArticle . 2019Full-Text: http://europepmc.org/articles/PMC6325152Data sources: PubMed CentralThe University of Manchester - Institutional RepositoryArticle . 2019Data sources: The University of Manchester - Institutional RepositoryThe University of Manchester - Institutional RepositoryArticle . 2018Data sources: The University of Manchester - Institutional RepositoryCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemOxford University Research Archive; Nature CommunicationsArticle . 2019 . 2018 . Peer-reviewedLicense: CC BYPublikationer från Uppsala UniversitetArticle . 2018 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2021 FinlandPublisher:Elsevier BV Funded by:NHMRC | Follow up of the 1985 Aus..., NIH | EVOLUTION OF CARDIOVASCUL..., NIH | Childhood Growth, Biologi... +3 projectsNHMRC| Follow up of the 1985 Australian Schools Health and Fitness Survey Cohort ,NIH| EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGING ,NIH| Childhood Growth, Biological Aging and Midlife Cardio-Metabolic Outcomes ,NHMRC| Inter-relationships between life-stage transitions, depression and cardio-metabolic health in young adults ,NHMRC| Cardiometabolic risk trajectories from childhood to midlife: finding pathways to better health ,NIH| Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-upVerity Cleland; Jing Tian; Marie-Jeanne Buscot; Costan G. Magnussen; Lydia Bazzano; Trudy L. Burns; Stephen Daniels; Terence Dwyer; Nina Hutri-Kahonen; Johanna Ikonen; David Jacobs; Markus Juonala; Ronald Prineas; Olli Raitakari; Alan Sinaiko; Julia Steinberger; Elaine M. Urbina; Jessica G. Woo; Alison Venn;Background: Understanding lifecourse trajectories of body-mass index (BMI) is important for identifying groups at high risk of poor health and potential target points for intervention. This study aimed to describe BMI trajectories from childhood to mid-adulthood in four population-based cohorts established in the 1970s and 1980s and to identify childhood sociodemographic factors related to trajectory membership. Methods: Between Dec 17, 1970 and Dec 15, 1994, data were collected at the first visit from 9830 participants from the International Childhood Cardiovascular Cohort (i3C) Consortium, which includes participants from Australia (1985), Finland (1980) and the USA (1970–1994). Participants had at least three measures of height and weight, including one in childhood (6–18 years) and one in adulthood (>18 years), and were aged 30–49 years at last measurement. Latent Class Growth Mixture Modelling was used to identify lifecourse BMI trajectory groups and log multinomial regression models were fit to identify their childhood sociodemographic predictors. Findings: Five consistent BMI trajectory groups were identified amongst the four cohorts: persistently low (35.9–58.6%), improving from high (0.7–4.8%), progressing to moderate (9.3–43.7%), progressing to high (1.1–6.0%), and progressing to very high (0.7–1.3%). An additional three BMI trajectory groups were identified in some, but not all, cohorts: adult onset high (three cohorts; 1.8–20.7%), progressing to moderate-high (two cohorts; 5.2–13.8%), and relapsing yo-yoers (alternating upward and downward; one cohort; 1.3%). In pooled analyses, each predictor variable in childhood, including age, gender, parental education and race, was associated with increased likelihood of belonging to the most (e.g., improving from high) and least (e.g., progressing to very high) favourable BMI trajectory groups, suggesting a U-shaped (or inverse U-shaped) pattern of association. Interpretation: Five consistent BMI trajectory groups were identified across four cohorts from Australia, Finland, and the USA, mainly across two eras of birth. While most participants remained on a persistently low trajectory (50%), many demonstrated worsening BMI trajectories (47%), with only few demonstrating improving trajectories (<5%). Age, gender, parental education, and race appear to be important predictors of BMI trajectory group membership and need consideration in preventive and management strategies. Funding: This study was supported by funding from the National Institutes of Health, National Heart, Lung and Blood Institute (grant number R01 HL121230). Peer reviewed
EClinicalMedicine arrow_drop_down Trepo - Institutional Repository of Tampere UniversityArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Trepo - Institutional Repository of Tampere Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.3987080&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert EClinicalMedicine arrow_drop_down Trepo - Institutional Repository of Tampere UniversityArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Trepo - Institutional Repository of Tampere Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 Finland, Italy, ItalyPublisher:Springer Science and Business Media LLC Funded by:NIH | VITAMIN INTERVENTION FOR ..., NIH | Genetics of ischemic stro..., WT | Understanding the genetic... +19 projectsNIH| VITAMIN INTERVENTION FOR STROKE PREVENTION ,NIH| Genetics of ischemic stroke in the SiGN Consortium ,WT| Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics. ,NHMRC| Australian Stroke Genetics Collaborative - Genome-wide association study in ischaemic stroke ,NIH| THE BALTIMORE LONGITUDINAL STUDY OF HUMAN AGING ,NIH| ISGS: The Ischemic Stroke Genetics Study ,NIH| MULTICENTERED STUDY OF STROKE GENETICS ,NIH| Genetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic Groups ,NIH| Genetics Of Stroke ,EC| GEUVADIS ,NIH| Data Mgmt &Analysis Core - The NINDS International Stroke Genetics Consortium St ,WT| A genome wide association study in ischaemic stroke. ,NIH| GWAS of Hormone Treatment and CVD and Metabolic Outcomes in the WHI ,NIH| A Center for GEI Association Studies ,NIH| Genetics of Early Onset-Stroke ,NIH| Genome Wide Association Coordinating Center ,NIH| Genetics of Early-Onset Ischemic Stroke Consortium ,NIH| Research Training in the Epidemiology of Aging ,WT| WTCCC2 core activities ,NIH| CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS ,NIH| Randomized Clinical Trials - Whole Genome Studies Coordinating Center ,NIH| A Genome-wide Association Study for Early-Onset Myocardial InfarctionAuthors: Stefano Mammola; Diego Fontaneto; Alejandro Martínez; Filipe Chichorro;Stefano Mammola; Diego Fontaneto; Alejandro Martínez; Filipe Chichorro;handle: 10138/326141
Many believe that the quality of a scientific publication is as good as the science it cites. However, quantifications of how features of reference lists affect citations remain sparse. We examined seven numerical characteristics of reference lists of 50,878 research articles published in 17 ecological journals between 1997 and 2017. Over this period, significant changes occurred in reference lists' features. On average, more recent papers have longer reference lists and cite more high Impact Factor papers and fewer non-journal publications. We also show that highly cited articles across the ecological literature have longer reference lists, cite more recent and impactful references, and include more self-citations. Conversely, the proportion of 'classic' papers and non-journal publications cited, as well as the temporal span of the reference list, have no significant influence on articles' citations. From this analysis, we distill a recipe for crafting impactful reference lists, at least in ecology. Peer reviewed
CNR ExploRA arrow_drop_down HELDA - Digital Repository of the University of HelsinkiArticle . 2021 . Peer-reviewedData sources: HELDA - Digital Repository of the University of Helsinkiadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11192-020-03759-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 28 citations 28 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert CNR ExploRA arrow_drop_down HELDA - Digital Repository of the University of HelsinkiArticle . 2021 . Peer-reviewedData sources: HELDA - Digital Repository of the University of Helsinkiadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11192-020-03759-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 AustraliaPublisher:University Library System, University of Pittsburgh Funded by:NHMRC | Evidence Innovation: tran...NHMRC| Evidence Innovation: transforming the efficiency of systematic reviewJustin Michael Clark; Sharon Sanders; Matthew Carter; David Honeyman; Gina Cleo; Yvonne Auld; Debbie Booth; Patrick Condron; Christine Dalais; Sarah Bateup; Bronwyn Linthwaite; Nikki May; Jo Munn; Lindy Ramsay; Kirsty Rickett; Cameron Rutter; Angela Smith; Peter Sondergeld; Margie Wallin; Mark Jones; Elaine Beller;Background: Searching for studies to include in a systematic review (SR) is a time- and labor-intensive process with searches of multiple databases recommended. To reduce the time spent translating search strings across databases, a tool called the Polyglot Search Translator (PST) was developed. The authors evaluated whether using the PST as a search translation aid reduces the time required to translate search strings without increasing errors.Methods: In a randomized trial, twenty participants were randomly allocated ten database search strings and then randomly assigned to translate five with the assistance of the PST (PST-A method) and five without the assistance of the PST (manual method). We compared the time taken to translate search strings, the number of errors made, and how close the number of references retrieved by a translated search was to the number retrieved by a reference standard translation.Results: Sixteen participants performed 174 translations using the PST-A method and 192 translations using the manual method. The mean time taken to translate a search string with the PST-A method was 31 minutes versus 45 minutes by the manual method (mean difference: 14 minutes). The mean number of errors made per translation by the PST-A method was 8.6 versus 14.6 by the manual method. Large variation in the number of references retrieved makes results for this outcome unreliable, although the number of references retrieved by the PST-A method was closer to the reference standard translation than the manual method.Conclusion: When used to assist with translating search strings across databases, the PST can increase the speed of translation without increasing errors. Errors in search translations can still be a problem, and search specialists should be aware of this.
ACU Research Bank arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7069833Data sources: PubMed CentralJournal of the Medical Library AssociationArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5195/jmla.2020.834&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 197 citations 197 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert ACU Research Bank arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7069833Data sources: PubMed CentralJournal of the Medical Library AssociationArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5195/jmla.2020.834&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Australia, Netherlands, Finland, Netherlands, Denmark, Belgium, Netherlands, Belgium, United KingdomPublisher:Elsevier BV Funded by:NIH | University of Washington ..., NIH | Methodologies to Enhance ..., WT | Global Atlas of Podoconio... +12 projectsNIH| University of Washington Center for Demography and Economics of Aging-Overall ,NIH| Methodologies to Enhance Understanding of HIV-Associated Social Determinants ,WT| Global Atlas of Podoconiosis ,NIH| Implementing mental health interventions for pregnant adolescents in primary care LMIC contexts ,NIH| Long term outcomes of therapy in women initiated on lifelong ART because of pregnancy in DR Congo ,NHMRC| Increasing knowledge about substance use, mental health and harms, and interventions to prevent and reduce harm ,FCT| Associated Laboratory for Green Chemistry - Clean Technologies and Processes ,NIH| Can HIV Hot-Spots be eradicated? An intervention to decrease HIV transmission to young women in rural KwaZulu-Natal South Africa ,MESTD| Functional, Functionalized and Advanced Nanomaterials ,NIH| Causal Pathways to population health impact of HIV antiretroviral treatment ,NIH| Central Africa IeDEA ,NIH| CARDIOMETABOLIC DISEASE & RISK FACTORS AMONG OLDER ADULTS IN SUB-SAHARAN AFRICA ,NIH| Training Tanzanian Researchers for HIV/AIDS Implementation Science ,NHMRC| Assessing the population health impact of illicit drug use: prevalence, trajectories, and contributions to disease burden ,NIH| New Methods for the design and evaluation of large HIV prevention interventionsFrank, Tahvi D; Carter, Austin; Jahagirdar, Deepa; Biehl, Molly H; Douwes-Schultz, Dirk; Larson, Samantha Leigh; Arora, Megha; Dwyer-Lindgren, Laura; Steuben, Krista M; Abbastabar, Hedayat; Abu-Raddad, Laith Jamal; Abyu, Direslgne Misker; Adabi, Maryam; Adebayo, Oladimeji M; Adekanmbi, Victor; Adetokunboh, Olatunji O; Ahmadi, Alireza; Ahmadi, Keivan; Ahmadian, Elham; Ahmadpour, Ehsan; Ahmed, Muktar Beshir; Akal, Chalachew Genet; Alahdab, Fares; Alam, Noore; Albertson, Samuel B; Alemnew, Birhan Tamene T; Alene, Kefyalew Addis; Alipour, Vahid; Alvis-Guzman, Nelson; Amini, Saeed; Anbari, Zohreh; Anber, Nahla Hamed; Anjomshoa, Mina; Antonio, Carl Abelardo T; Arabloo, Jalal; Aremu, Olatunde; Areri, Habtamu Abera; Asfaw, Ephrem Tsegay; Ashagre, Alebachew Fasil; Asmelash, Daniel; Asrat, Anemaw A; Avokpaho, Euripide FGA; Awasthi, Ashish; Awoke, Nefsu; Ayanore, Martin Amogre; Azari, Samad; Badawi, Alaa; Bagherzadeh, Mojtaba; Banach, Maciej; Barac, Aleksandra; Bärnighausen, Till Winfried; Basu, Sanjay; Bedi, Neeraj; Behzadifar, Masoud; Bekele, Bayu Begashaw; Belay, Saba Abraham; Belay, Yared Belete; Belayneh, Yaschilal Muche; Berhane, Adugnaw; Bhat, Anusha Ganapati; Bhattacharyya, Krittika; Biadgo, Belete; Bijani, Ali; Bin Sayeed, Muhammad Shahdaat; Bitew, Helen; Blinov, Andrew; Bogale, Kassawmar Angaw; Bojia, Hunduma Amensisa; Burugina Nagaraja, Sharath BN; Butt, Zahid A; Cahuana-Hurtado, Lucero; Campuzano Rincon, Julio Cesar; Carvalho, Félix; Chattu, Vijay Kumar; Christopher, Devasahayam J; Chu, Dinh-Toi; Crider, Raquel; Dahiru, Tukur; Dandona, Lalit; Dandona, Rakhi; Daryani, Ahmad; das Neves, José; De Neve, Jan-Walter; Degenhardt, Louisa; Demeke, Feleke Mekonnen; Demis, Asmamaw Bizuneh; Demissie, Dereje Bayissa; Demoz, Gebre Teklemariam; Deribe, Kebede; Des Jarlais, Don; Dhungana, Govinda Prasad; Diaz, Daniel; Djalalinia, Shirin; Do, Huyen Phuc; Doan, Linh Phuong; Duber, Herbert; Dubey, Manisha; Dubljanin, Eleonora; Duken, Eyasu Ejeta; Duko Adema, Bereket; Effiong, Andem; Eftekhari, Aziz; El Sayed Zaki, Maysaa; El-Jaafary, Shaimaa I; El-Khatib, Ziad; Elsharkawy, Aisha; Endries, Aman Yesuf; Eskandarieh, Sharareh; Eyawo, Oghenowede; Farzadfar, Farshad; Fatima, Batool; Fentahun, Netsanet; Fernandes, Eduarda; Filip, Irina; Fischer, Florian; Folayan, Morenike Oluwatoyin; Foroutan, Masoud; Fukumoto, Takeshi; Fullman, Nancy; Garcia-Basteiro, Alberto L; Gayesa, Reta Tsegaye; Gebremedhin, Ketema Bizuwork; Gebremeskel, Gebreamlak Gebremedhn Gebremedhn; Gebreyohannes, Kelali Kalaye; Gedefaw, Getnet Azeze; Gelaw, Belayneh K; Gesesew, Hailay Abrha; Geta, Birhanu; Gezae, Kebede Embaye; Ghadiri, Keyghobad; Ghashghaee, Ahmad; Ginindza, Themba TG; Gugnani, Harish Chander; Guimarães, Rafael Alves; Haile, Michael Tamene; Hailu, Gessessew Bugssa; Haj-Mirzaian, Arvin; Haj-Mirzaian, Arya; Hamidi, Samer; Handanagic, Senad; Handiso, Demelash Woldeyohannes; Hanfore, Lolemo Kelbiso; Hasanzadeh, Amir; Hassankhani, Hadi; Hassen, Hamid Yimam; Hay, Simon I; Henok, Andualem; Hoang, Chi Linh; Hosgood, H Dean; Hosseinzadeh, Mehdi; Hsairi, Mohamed; Ibitoye, Segun Emmanuel; Idrisov, Bulat; Ikuta, Kevin S; Ilesanmi, Olayinka Stephen; Irvani, Seyed Sina Naghibi; Iwu, Chinwe Juliana; Jacobsen, Kathryn H; James, Spencer L; Jenabi, Ensiyeh; Jha, Ravi Prakash; Jonas, Jost B; Jorjoran Shushtari, Zahra; Kabir, Ali; Kabir, Zubair; Kadel, Rajendra; Kasaeian, Amir; Kassa, Belete; Kassa, Getachew Mullu; Kassa, Tesfaye Dessale; Kayode, Gbenga A; Kebede, Mihiretu M; Kefale, Adane Teshome; Kengne, Andre Pascal; Khader, Yousef Saleh; Khafaie, Morteza Abdullatif; Khalid, Nauman; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khan, Junaid; Khang, Young-Ho; Khatab, Khaled; Khazaei, Salman; Khoja, Abdullah T; Kiadaliri, Aliasghar A; Kim, Yun Jin; Kisa, Adnan; Kisa, Sezer; Kochhar, Sonali; Komaki, Hamidreza; Koul, Parvaiz A; Koyanagi, Ai; Kuate Defo, Barthelemy; Kumar, G Anil; Kumar, Manasi; Kuupiel, Desmond; Lal, Dharmesh Kumar; Lee, Jane Jean-Hee; Lenjebo, Tsegaye Lolaso; Leshargie, Cheru Tesema; Magdy Abd El Razek, Hassan; Mahasha, Phetole Walter; Majeed, Azeem; Manafi, Navid; Martins-Melo, Francisco Rogerlândio; Meles, Gebrekiros Gebremichael; Meles, Hagazi Gebre; Meretoja, Tuomo J; Miller, Ted R; Moazen, Babak; Mohammad, Karzan Abdulmuhsin; Mohammed, Shafiu; Mohebi, Farnam; Mokdad, Ali H; Moodley, Yoshan; Moradi, Ghobad; Mossie, Tilahun Belete; Mousavi, Seyyed Meysam; Muthupandian, Saravanan; Nazari, Javad; Ndwandwe, Duduzile Edith; Ningrum, Dina Nur Anggraini; Nnaji, Chukwudi A; Noubiap, Jean Jacques; Nourollahpour Shiadeh, Malihe; Obsa, Mohammed Suleiman; Olagunju, Andrew T; Olagunju, Tinuke O; Olum, Solomon; Padubidri, Jagadish Rao; Pakhale, Smita; Pakpour, Amir H; Paulos, Kebreab; Pepito, Veincent Christian Filipino; Pourshams, Akram; Rabiee, Mohammad; Rabiee, Navid; Rafiei, Alireza; Rahim, Fakher; Rahimi-Movaghar, Vafa; Renjith, Vishnu; Reta, Melese Abate; Rezai, Mohammad Sadegh; Rostami, Ali; Saeedi Moghaddam, Sahar; Safari, Saeed; Sagar, Rajesh; Salomon, Joshua A; Samy, Abdallah M; Schutte, Aletta Elisabeth; Shabaninejad, Hosein; Shamsizadeh, Morteza; Sharifi, Hamid; Shibuya, Kenji; Silva, Diego Augusto Santos; Sisay, Mekonnen; Sokhan, Anton; Soshnikov, Sergey; Stein, Dan J; Sufiyan, Mu'awiyyah Babale; Sunguya, Bruno F; Tadesse, Birkneh Tilahun; Tadesse, Degena Bahrey; Taveira, Nuno; Tesfay, Fisaha Haile; Thapa, Subash; Topp, Stephanie M; Tran, Bach Xuan; Tran, Khanh Bao; Ullah, Irfan; Unnikrishnan, Bhaskaran; Uthman, Olalekan A; Waheed, Yasir; Wijeratne, Tissa; Wolde, Haileab Fekadu; Wonde, Tewodros Eshete; Yotebieng, Marcel; Zaidi, Zoubida; Ziapour, Arash;pmc: PMC6934077
handle: 11541.2/33253 , 10067/1651020151162165141 , 10138/310381 , 1854/LU-8626802
Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980-2017 and forecast these estimates to 2030 for 195 countries and territories. Methods We determined a modelling strategy for each country on the basis of the availability and quality of data. For countries and territories with data from population-based seroprevalence surveys or antenatal care clinics, we estimated prevalence and incidence using an open-source version of the Estimation and Projection Package-a natural history model originally developed by the UNAIDS Reference Group on Estimates, Modelling, and Projections. For countries with cause-specific vital registration data, we corrected data for garbage coding (ie, deaths coded to an intermediate, immediate, or poorly defined cause) and HIV misclassification. We developed a process of cohort incidence bias adjustment to use information on survival and deaths recorded in vital registration to back-calculate HIV incidence. For countries without any representative data on HIV, we produced incidence estimates by pulling information from observed bias in the geographical region. We used a re-coded version of the Spectrum model (a cohort component model that uses rates of disease progression and HIV mortality on and off ART) to produce age-sex-specific incidence, prevalence, and mortality, and treatment coverage results for all countries, and forecast these measures to 2030 using Spectrum with inputs that were extended on the basis of past trends in treatment scale-up and new infections. Findings Global HIV mortality peaked in 2006 with 1.95 million deaths (95% uncertainty interval 1.87-2.04) and has since decreased to 0.95 million deaths (0.91-1.01) in 2017. New cases of HIV globally peaked in 1999 (3.16 million, 2.79-3.67) and since then have gradually decreased to 1.94 million (1.63-2.29) in 2017. These trends, along with ART scale-up, have globally resulted in increased prevalence, with 36.8 million (34.8-39.2) people living with HIV in 2017. Prevalence of HIV was highest in southern sub-Saharan Africa in 2017, and countries in the region had ART coverage ranging from 65.7% in Lesotho to 85.7% in eSwatini. Our forecasts showed that 54 countries will meet the UNAIDS target of 81% ART coverage by 2020 and 12 countries are on track to meet 90% ART coverage by 2030. Forecasted results estimate that few countries will meet the UNAIDS 2020 and 2030 mortality and incidence targets. Interpretation Despite progress in reducing HIV-related mortality over the past decade, slow decreases in incidence, combined with the current context of stagnated funding for related interventions, mean that many countries are not on track to reach the 2020 and 2030 global targets for reduction in incidence and mortality. With a growing population of people living with HIV, it will continue to be a major threat to public health for years to come. The pace of progress needs to be hastened by continuing to expand access to ART and increasing investments in proven HIV prevention initiatives that can be scaled up to have population-level impact. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd. Peer reviewed
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6934077Data sources: PubMed CentralFachrepositorium LebenswissenschaftenArticle . 2019License: CC BYData sources: Fachrepositorium Lebenswissenschaftenhttps://hdl.handle.net/10067/1...Article . 2019Data sources: Institutional Repository Universiteit AntwerpenUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryUniversity of Lincoln Institutional RepositoryArticle . 2019 . Peer-reviewedData sources: University of Lincoln Institutional RepositoryGhent University Academic BibliographyArticle . 2019Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2019 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiGhent University Academic BibliographyArticle . 2019Data sources: Ghent University Academic BibliographyUniSA Research Outputs RepositoryArticle . 2019 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 271 citations 271 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 35visibility views 35 download downloads 105 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6934077Data sources: PubMed CentralFachrepositorium LebenswissenschaftenArticle . 2019License: CC BYData sources: Fachrepositorium Lebenswissenschaftenhttps://hdl.handle.net/10067/1...Article . 2019Data sources: Institutional Repository Universiteit AntwerpenUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryUniversity of Lincoln Institutional RepositoryArticle . 2019 . Peer-reviewedData sources: University of Lincoln Institutional RepositoryGhent University Academic BibliographyArticle . 2019Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2019 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiGhent University Academic BibliographyArticle . 2019Data sources: Ghent University Academic BibliographyUniSA Research Outputs RepositoryArticle . 2019 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2018 United Kingdom, Sweden, Netherlands, United Kingdom, Denmark, Belgium, United KingdomPublisher:Cold Spring Harbor Laboratory Funded by:NHMRC | Markers of inflammation a..., NIH | Quantifying and Character..., NHMRC | Australian Prostate Cance... +22 projectsNHMRC| Markers of inflammation and prostate cancer risk ,NIH| Quantifying and Characterizing the shared genetic contribution to common cancers ,NHMRC| Australian Prostate Cancer Collaboration (APCC) Bio - Resource ,NHMRC| PRACTICAL Australia ,NHMRC| The Health 2020 Cohort Study (Health 2020) ,NIH| A genome-wide association study for breast cancer in BRCA1 mutation carriers ,NIH| Imputation-based approach to identify low frequency variants in prostate cancer ,NIH| Discovery Expansion and Replication ,NIH| Breast &Prostate Cancer &Hormone-related Gene Variants ,NIH| Breast &prostate cancer &hormone-related gene variants ,NHMRC| why do some men get prostate cancer? ,NHMRC| Platform for Young Public health researchers to Upgrade their Scientific training Experience and independent Status ,NHMRC| A case control study of risk factors for aggressive prostate cancer ,NHMRC| Epidemiology of Chronic Disease, Health Interventions and DNA Studies ,CIHR ,NIH| Integrative approaches for mapping the genetic risk of complex traits ,EC| COGS ,NIH| Leveraging functional data to predict disease risk in multi-ethnic populations ,NIH| Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI) ,NIH| Elucidating Loci Involved in Prostate Cancer Suceptibility ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer: The BPC3. ,NHMRC| The predictors of prostate cancer in the Melbourne Collaborative Cohort Study ,NHMRC| Markers of androgen action, genetic variation and prostate cancer risk ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer;the BPC3 ,NHMRC| Infections, inflammatory markers and prostate cancer riskNicholas Mancuso; Simon Gayther; Alexander Gusev; Wei Zheng; Kathryn L. Penney; Brian E. Henderson; Sara Benlloch; Fredrick R. Schumacher; Ali Amin Al Olama; Kenneth Muir; Sonja I. Berndt; David V. Conti; Fredrik Wiklund; Stephen Chanock; Victoria L. Stevens; Catherine M. Tangen; Jyotsna Batra; Judith Clements; Henrik Gronberg; Nora Pashayan; Johanna Schleutker; Demetrius Albanes; Stephanie Weinstein; Alicja Wolk; Catharine West; Lorelei Mucci; Géraldine Cancel-Tassin; Stella Koutros; Karina Dalsgaard Sorensen; Lovise Maehle; David E. Neal; Freddie C. Hamdy; Jenny L. Donovan; Ruth C. Travis; Robert J. Hamilton; Sue Ann Ingles; Barry Rosenstein; Yong-Jie Lu; Graham G. Giles; Adam S. Kibel; Ana Vega; Manolis Kogevinas; Jong Y. Park; Janet L. Stanford; Cezary Cybulski; Børge G. Nordestgaard; Hermann Brenner; Christiane Maier; Jeri Kim; Esther M. John; Manuel R. Teixeira; Susan L. Neuhausen; Kim De Ruyck; Azad Razack; Lisa F. Newcomb; Davor Lessel; Radka Kaneva; Nawaid Usmani; Frank Claessens; Paul A. Townsend; Manuela Gago-Dominguez; Monique J. Roobol; Florence Menegaux; Kay-Tee Khaw; Lisa Cannon-Albright; Hardev Pandha; Stephen N. Thibodeau; David J. Hunter; Peter Kraft; Zsofia Kote-Jarai; Rosalind Eeles; Matthew Freedman; Christopher Haiman; Bogdan Pasaniuc;pmc: PMC6172280 , PMC6325152
handle: 1765/110958
Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS (N = 142,392) with gene expression measured in 45 tissues (N = 4458), including normal and tumor prostate, to perform a multi-tissue transcriptome-wide association study (TWAS) for PrCa. We identify 217 genes at 84 independent 1 Mb regions associated with PrCa risk, 9 of which are regions with no genome-wide significant SNP within 2 Mb. 23 genes are significant in TWAS only for alternative splicing models in prostate tumor thus supporting the hypothesis of splicing driving risk for continued oncogenesis. Finally, we use a Bayesian probabilistic approach to estimate credible sets of genes containing the causal gene at a pre-defined level; this reduced the list of 217 associations to 109 genes in the 90% credible set. Overall, our findings highlight the power of integrating expression with PrCa GWAS to identify novel risk loci and prioritize putative causal genes at known risk loci. ispartof: NATURE COMMUNICATIONS vol:9 issue:1 ispartof: location:England status: published
bioRxiv arrow_drop_down bioRxivPreprint . 2018Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6172280Data sources: PubMed CentralNature CommunicationsArticle . 2019Full-Text: http://europepmc.org/articles/PMC6325152Data sources: PubMed CentralThe University of Manchester - Institutional RepositoryArticle . 2019Data sources: The University of Manchester - Institutional RepositoryThe University of Manchester - Institutional RepositoryArticle . 2018Data sources: The University of Manchester - Institutional RepositoryCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemOxford University Research Archive; Nature CommunicationsArticle . 2019 . 2018 . Peer-reviewedLicense: CC BYPublikationer från Uppsala UniversitetArticle . 2018 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold more_vert bioRxiv arrow_drop_down bioRxivPreprint . 2018Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6172280Data sources: PubMed CentralNature CommunicationsArticle . 2019Full-Text: http://europepmc.org/articles/PMC6325152Data sources: PubMed CentralThe University of Manchester - Institutional RepositoryArticle . 2019Data sources: The University of Manchester - Institutional RepositoryThe University of Manchester - Institutional RepositoryArticle . 2018Data sources: The University of Manchester - Institutional RepositoryCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemOxford University Research Archive; Nature CommunicationsArticle . 2019 . 2018 . Peer-reviewedLicense: CC BYPublikationer från Uppsala UniversitetArticle . 2018 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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