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description Publicationkeyboard_double_arrow_right Article 2021 FrancePublisher:Elsevier BV van Helden, Jacques; Butler, Colin; Achaz, Guillaume; Canard, Bruno; Casane, Didier; Claverie, Jean-Michel; Colombo, Fabien; Courtier-Orgogozo, Virginie; Ebright, Richard; Graner, François; Leitenberg, Milton; Morand, Serge; Petrovsky, Nikolai; Segreto, Rossana; Decroly, Etienne; Halloy, José;pmc: PMC8448489 , PMC8448488
International audience
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8448489Data sources: PubMed CentralEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8448488Data sources: PubMed CentralHAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(21)02013-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8448489Data sources: PubMed CentralEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8448488Data sources: PubMed CentralHAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(21)02013-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 FrancePublisher:Elsevier BV Gamal Shiha; Reham Soliman; Nabiel N. H. Mikhail; Fabrice Carrat; Jessica Azzi; Ganne‐Carrié Nathalie; Hidenori Toyoda; Haruki Uojima; Akito Nozaki; Koichi Takaguchi; Atsushi Hiraoka; Masanori Atsukawa; Hiroshi Abe; Kentaro Matsuura; Shigeru Mikami; Tsunamasa Watanabe; Kunihiko Tsuji; Toru Ishikawa; Vithika Suri; Anu Osinusi; Liyun Ni; Jun Zou; Shiv Kumar Sarin; Manoj Kumar; Prasun Kumar Jalal; Mahmoud A. Hashim; Manal Hassan; Sonia Alonso Lopez; Rafael Bañares; Adriana M. Ahumada; Nasser Hamed Mousa; Mohammed Eslam; Imam Waked;pmid: 35657138
Background and Aims: We have recently demonstrated the ability of a simple predictive model (GES) score to determine the risk of hepatocellular carcinoma (HCC) after using direct-acting antivirals. However, our results were restricted to Egyptian patients with hepatitis C virus (HCV) genotype 4. Therefore, we studied a large, independent cohort of multiethnic populations through our international collaborative activity. Methods: Depending on their GES scores, patients are stratified into low risk (≤ 6/12.5), intermediate risk (> 6–7.5/12.5), and high risk (> 7.5/12.5) for HCC. A total of 12038 patients with chronic HCV were analyzed in this study, of whom 11202 were recruited from 54 centers in France, Japan, India, the U.S., and Spain, and the remaining 836 were selected from the Gilead-sponsored randomized controlled trial conducted across the U.S., Europe, Canada, and Australia. Descriptive statistics and survival analysis were performed using Kaplan–Meier and log-rank tests. The performance of the GES score was evaluated using Harrell’s C-index (HCI). Results : The GES score proved successful at stratifying all patients into 3 risk groups, namely low-risk, intermediate-risk, and high-risk. It also displayed significant predictive value for HCC development in all participants (P < 0 .0001), with HCI ranging from 0.55 to 0.76 among all cohorts after adjusting for HCV genotypes and patient ethnicities. Conclusion: The GES score can be used to stratify HCV patients into 3 categories of risk for HCC, namely low-risk, intermediate-risk, and high-risk, irrespective of their ethnicities or HCV genotypes. This international multicenter validation may allow the use of GES score in individualized HCC risk-based surveillance programs. Funding: None to declare. Declaration of Interest: None to declare. Ethical Approval: The protocol was approved by the Institutional Research Board of each participating center, as per local regulations
Journal of Viral Hep... arrow_drop_down Journal of Viral HepatitisArticle . 2022 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.3896562&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Journal of Viral Hep... arrow_drop_down Journal of Viral HepatitisArticle . 2022 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.3896562&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Article , Other literature type 2020 France, Croatia, Spain, Italy, Germany, Austria, Italy, ItalyPublisher:IOP Publishing Funded by:EC | HYMNSEC| HYMNSDomingo-Pardo; C.; Babiano-Suarez; V.; Balibrea-Correa; J.; Caballero; L.; Ladarescu; I.; Lerendegui-Marco; J.; Tain; J.L.; Calv?no; F.; Casanovas; A.; Segarr; A.; Tarife?o-Saldivia; A.E.; Guerrero; C.; Mill?n-Callado; M.A.; Quesada; J.M.; Rodr?guez-Gonz?lez; M.T.; Aberle; O.; Alcayne; V.; Amaducci; S.; Andrzejewski; J.; Audouin; L.; Bacak; M.; Barbagallo; M.; Bennett; S.; Berthoumieux; E.; Bosnar; D.; Brown; A.S.; Busso; M.; Caama?o; M.; Calviani; M.; Cano-Ott; D.; Cerutti; F.; Chiaveri; E.; Colonna; N.; Cort?s; G.P.; Cort?s-Giraldo; M.A.; Cosentino; L.; Cristallo; S.; Damone; L.A.; Davies; P.J.; Diakaki; M.; Dietz; M.; Dressler; R.; Ducasse; Q.; Dupont; E.; Dur?n; I.; Eleme; Z.; Fern?ndez-Dom?ngez; B.; Ferrari; A.; Ferro-Gon?alves; I.; Finocchiaro; P.; Furman; V.; Garg; R.; Gawlik; A.; Gilardoni; S.; G?bel; K.; Gonz?lez-Romero; E.; Gunsing; F.; Heyse; J.; Jenkins; D.G.; Jericha; E.; Jiri; U.; Junghans; A.; Kadi; Y.; K?ppeler; F.; Kimura; A.; Knapov?; I.; Kokkoris; M.; Kopatch; Y.; Krti?ka; M.; Kurtulgil; D.; Lederer-Woods; C.; Lonsdale; S.-J.; Macina; D.; Manna; A.; Mart?nez; T.; Masi; A.; Massimi; C.; Mastinua; P.F.; Mastromarco; M.; Maugeri; E.; Mazzone; A.; Mendoza; E.; Mengoni; A.; Michalopoulou; V.; Milazzo; P.M.; Mingrone; F.; Moreno-Soto; J.; Musumarra; A.; Negret; A.; Og?llar; F.; Oprea; A.; Patronis; N.; Pavlik; A.; Perkowski; J.; Petrone; C.; Piersanti; L.; Pirovano; E.; Porras; I.; Praena; J.; Doval; D.R.; Reifarth; Smith; Sosnin; Vaz; Ventura; Vescovi; Wallner;The idea of slow-neutron capture nucleosynthesis formulated in 1957 triggered a tremendous experimental effort in different laboratories worldwide to measure the relevant nuclear physics input quantities, namely (n, γ) cross sections over the stellar temperature range (from few eV up to several hundred keV) for most of the isotopes involved from Fe up to Bi. A brief historical review focused on total energy detectors will be presented to illustrate how advances in instrumentation have led to the assessment of new aspects of s-process nucleosynthesis and to the progressive refinement of stellar models. A summary will be presented on current efforts to develop new detection concepts, such as the Total-Energy Detector with γ-ray imaging capability (i-TED). The latter is based on the simultaneous combination of Compton imaging with neutron time-of-flight (TOF) techniques, in order to achieve a superior level of sensitivity and selectivity in the measurement of stellar neutron capture rates. European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (ERC Consolidator Grant project HYMNS) 681740 Instituto de Salud Carlos III Spanish Government FPA2014-52823-C2-1-P FPA2017-83946-C2-1-P Consejo Superior de Investigaciones Cientificas (CSIC) PIE-201750I26 Program Severo Ochoa SEV-2014-0398
ENEA Open Archive arrow_drop_down Permanent Hosting, Archiving and Indexing of Digital Resources and AssetsArticle . 2020License: CC BYarXiv.org e-Print ArchiveOther literature type . Preprint . 2019Data sources: arXiv.org e-Print ArchiveJournal of Physics : Conference Series; CNR ExploRA; Croatian Scientific Bibliography - CROSBIOther literature type . Article . Conference object . 2020 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTA; Repositorio Institucional Universidad de GranadaOther literature type . Article . 2021 . 2020License: CC BYHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotConference object . 2019Mémoires en Sciences de l'Information et de la Communication; HAL-CEAConference object . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/1742-6596/1668/1/012013&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert ENEA Open Archive arrow_drop_down Permanent Hosting, Archiving and Indexing of Digital Resources and AssetsArticle . 2020License: CC BYarXiv.org e-Print ArchiveOther literature type . Preprint . 2019Data sources: arXiv.org e-Print ArchiveJournal of Physics : Conference Series; CNR ExploRA; Croatian Scientific Bibliography - CROSBIOther literature type . Article . Conference object . 2020 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTA; Repositorio Institucional Universidad de GranadaOther literature type . Article . 2021 . 2020License: CC BYHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotConference object . 2019Mémoires en Sciences de l'Information et de la Communication; HAL-CEAConference object . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/1742-6596/1668/1/012013&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 FrancePublisher:Elsevier BV Funded by:ARC | ARC Future Fellowships - ..., ARC | Understanding the migrati...ARC| ARC Future Fellowships - Grant ID: FT150100215 ,ARC| Understanding the migrations of prehistoric populations through direct dating and isotopic tracking of their mobility patternsJean-Jacques Bahain; Mathieu Duval; Pierre Voinchet; Hélène Tissoux; Christophe Falguères; Rainer Grün; Davinia Moreno; Qingfeng Shao; Olivier Tombret; Guillaume Jamet; Jean-Philippe Faivre; Dominique Cliquet;– Tourville-la-Rivière (Normandy, France) is one of the rare Middle Pleistocene palaeoanthropological localities of Northern France. Electron Spin Resonance (ESR) and combined ESR/U-series dating methods were independently applied by different teams on sediments and teeth from this site. The present work provides an overview of this multi-laboratory dating work by integrating a description and discussion of the methodologies employed and results obtained.Results confirm that the ESR/U-series analyses of the teeth are greatly dependent on the U-uptake histories of the dental tissues. Although all teeth come from the same archeological level, the samples analysed by each team display two different patterns for the U-series data. This is most likely related to the different sampling areas selected by each team and may be interpreted as the result of local variations in the geochemical conditions of the surrounding environment. Concerning the ESR dating of optically bleached quartz grains, the use of the multiple centre approach seems crucial when dating such fluvial and fluvio-lacustrine sediments. Our results also confirm the great potential of the Ti-H centre to date late Middle Pleistocene deposits.Despite some (expected) discrepancies related to the independent use of parameters and approaches by the different teams involved in this multi-laboratory study, the whole ESR and ESR/U-series data set collected from Tourville-la-Rivière locality consistently correlates stratigraphic levels D1 to I and associated human occupation to MIS7. International audience
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.quaint.2019.06.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.quaint.2019.06.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, AustraliaPublisher:Elsevier BV Authors: Esther Mirjam Girsberger; Romuald Méango; Hillel Rapoport;Esther Mirjam Girsberger; Romuald Méango; Hillel Rapoport;handle: 10453/138623
© 2019 Association for Comparative Economic Studies We investigate the impact of intra-regional migration on wage inequality in the West African Economic and Monetary Union (UEMOA). We exploit unique data from a unified labour force household survey which covers natives and migrants in the seven economic capital cities of that region. We first estimate the counterfactual wage distributions of UEMOA migrants in absence of migration to evaluate the compositional effect of migration (i.e., when wages are treated as exogenous). We find that regional migration increases average wages by 1.8% and generates a decrease in inequality that ranges between −1.5% (for the Gini index) and −4.5% (for the interquartile ratio). This is essentially driven by a reduction in inequality between capital cities, while the effect of migration on within-capital cities inequality is heterogeneous across countries and remains small overall. Second, when accounting for possible general equilibrium effects of migration on stayers’ wages (i.e., when wages are treated as endogenous), we find similar to stronger effects on inequality, albeit with a smaller increase in the average wage.
Journal of Comparati... arrow_drop_down Journal of Comparative EconomicsArticle . 2020 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jce.2019.10.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Comparati... arrow_drop_down Journal of Comparative EconomicsArticle . 2020 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jce.2019.10.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 FrancePublisher:Elsevier BV Funded by:EC | NoLiMit, EC | GeoInSightEC| NoLiMit ,EC| GeoInSightLu Pan; C. Quantin-Nataf; Benoit Tauzin; Chloé Michaut; Matthew P. Golombek; P. H. Lognonné; Peter Grindrod; Benoit Langlais; Tamara Gudkova; I. E. Stepanova; Sebastien Rodriguez; Antoine Lucas;in western Elysium Planitia. The Mars crust beneath the lander is subject to complex geologic history next to the great topographic and crustal dichotomy of Mars. Understanding this part of the Martian crust in the subsurface would aid future investigations of the internal structure of the planet based on seismic datasets collected by the Seismic Experiment for Interior Structure (SEIS) instrument. Here, we investigate the subsurface structure and composition from the analysis of mineralogy and morphology of exposures in impact craters as well as on scarps and knobs in the general region of Elysium Planitia. Using a combination of orbital datasets, we identify exposures of subsurface materials with distinct composition and physical properties. We find olivine and pyroxene detections associated with small impact craters (1.5-7 km) rim in the vicinity of InSight lander, as well as in the transition unit and Elysium volcanic unit. Fe/Mg phyllosilicates have been identified in the central peak of the 51-km diameter Kalpin crater and on knobs in the transition unit between the dichotomy and the plains. In addition, eroded meter-scale layered unit subject to erosion has been identified in six impact craters to the northeast of the landing site, including Kalpin crater. Massive bedrock and layered, weak materials co-occur in the transition unit, indicating a complex origin. These results together suggest both materials with altered composition and layered deposit occur as distinct geologic units beneath the basaltic lava flow units. Through analogy with terrestrial sedimentary rocks or clay-bearing sediments, we suggest physically weak materials exist beneath the lava flow units in the general region of Elysium Planitia. The spatial distribution and continuity of these materials are unclear due to the lack of exposures within the lava flow unit where the InSight lander is located. These subsurface materials of distinct physical properties may result in increased attenuation or reverberations of seismic waves, to be collected by SEIS. The findings suggest a close investigation of the potential effects of subsurface stratigraphy on seismic data would help inform future data interpretation and understanding of the internal structure of Mars. International audience
Icarus arrow_drop_down HAL Descartes; HAL-ENS-LYON; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BY NCFull-Text: https://hal.science/hal-02346218/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.icarus.2019.113511&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 39 citations 39 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Icarus arrow_drop_down HAL Descartes; HAL-ENS-LYON; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BY NCFull-Text: https://hal.science/hal-02346218/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.icarus.2019.113511&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Australia, France, United StatesPublisher:Springer Science and Business Media LLC Funded by:NIH | Adapter-Layer RTK Signali..., EC | MYELOSHOCK, NIH | Design of Antibody Fragme... +1 projectsNIH| Adapter-Layer RTK Signaling: Basic Understanding & Targeted DrugResistance ,EC| MYELOSHOCK ,NIH| Design of Antibody Fragments Specific For Amyloidogenic Aggregates ,NSF| Collaborative Research: GOALI: Nanoparticle analysis of antibody colloidal interactions and their influence on viscoelastic properties of concentrated antibody solutionsChang-Han Lee; Tae Hyun Kang; Ophélie Godon; Makiko Watanabe; George Delidakis; Caitlin M. Gillis; Delphine Sterlin; David Hardy; Michel Cogné; Macdonald Lynn; Andrew J. Murphy; Naxin Tu; Jiwon Lee; Jonathan R. McDaniel; Emily K. Makowski; Peter M. Tessier; Aaron S. Meyer; Pierre Bruhns; George Georgiou;pmc: PMC6834678 , PMC6877538
handle: 10453/140049
The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human neonatal Fc receptor (hFcRn). Engineered Fc domains that confer a longer circulation half-life by virtue of more favorable pH-dependent binding to hFcRn are of great therapeutic interest. Here we developed a pH Toggle switch Fc variant containing the L309D/Q311H/N434S (DHS) substitutions, which exhibits markedly improved pharmacokinetics relative to both native IgG1 and widely used half-life extension variants, both in conventional hFcRn transgenic mice and in new knock-in mouse strains. engineered specifically to recapitulate all the key processes relevant to human antibody persistence in circulation, namely: (i) physiological expression of hFcRn, (ii) the impact of hFcγRs on antibody clearance and (iii) the role of competing endogenous IgG. DHS-IgG retains intact effector functions, which are important for the clearance of target pathogenic cells and also has favorable developability. International audience
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6877538Data sources: PubMed CentralNature CommunicationsArticle . 2019 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC6834678Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaHAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-019-13108-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 49 citations 49 popularity Top 1% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6877538Data sources: PubMed CentralNature CommunicationsArticle . 2019 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC6834678Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaHAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-019-13108-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 United Kingdom, United Kingdom, FrancePublisher:Elsevier BV Kennicutt, Mahlon; Bromwich, David; Liggett, Daniela; Njåstad, Birgit; Peck, Lloyd; Rintoul, Stephen; Ritz, Catherine; Siegert, Martin; Aitken, Alan; Brooks, Cassandra; Cassano, John; Chaturvedi, Sanjay; Chen, Dake; Dodds, Klaus; Golledge, Nicholas; Le Bohec, Céline; Leppe, Marcelo; Murray, Alison; Nath, P. Chandrika; Raphael, Marilyn; Rogan-Finnemore, Michelle; Schroeder, Dustin; Talley, Lynne; Travouillon, Tony; Vaughan, David; Wang, Lifan; Weatherwax, Allan; Yang, Huigen; Chown, Steven,;The view from the south is, more than ever, dominated by ominous signs of change. Antarctica and the Southern Ocean are intrinsic to the Earth system, and their evolution is intertwined with and influences the course of the Anthropocene. In turn, changes in the Antarctic affect and presage humanity's future. Growing understanding is countering popular beliefs that Antarctica is pristine, stable, isolated, and reliably frozen. An aspirational roadmap for Antarctic science has facilitated research since 2014. A renewed commitment to gathering further knowledge will quicken the pace of understanding of Earth systems and beyond. Progress is already evident, such as addressing uncertainties in the causes and pace of ice loss and global sea-level rise. However, much remains to be learned. As an iconic global “commons,” the rapidity of Antarctic change will provoke further political action. Antarctic research is more vital than ever to a sustainable future for this One Earth.
One Earth; NERC Open... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryMémoires en Sciences de l'Information et de la Communication; HAL-IRDArticle . 2019License: CC BYFull-Text: https://hal.science/hal-02353429/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.oneear.2019.08.014&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 53 citations 53 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 14visibility views 14 download downloads 43 Powered bymore_vert One Earth; NERC Open... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryMémoires en Sciences de l'Information et de la Communication; HAL-IRDArticle . 2019License: CC BYFull-Text: https://hal.science/hal-02353429/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Italy, France, FrancePublisher:John Benjamins Publishing Company Authors: Pier Marco Bertinetto; Luca Ciucci; Margherita Farina;Pier Marco Bertinetto; Luca Ciucci; Margherita Farina;doi: 10.1075/sl.17013.ber
handle: 11384/91668
AbstractThe morphological expression of non-verbal predication is a geographically widespread, although not very frequent, typological feature. This paper highlights the existence of two radically contrasting types of non-verbal predicative inflection. Construction A has already been described in the literature. It consists of attaching person-sensitive inflection markers to non-verbal predicates, possibly extending this treatment to adverbs and adverbial phrases (locational and temporal), pronouns and quantifiers. This type is well attested in Uralic, Turkic, and Paleosiberian, as well as in some Amazonian language families (most notably Chicham), but it has also been pointed out for some sparse languages of Oceania and Africa. Such non-verbal person inflections diachronically stem from incorporation of conjugated copula elements. Construction B, by contrast, is much rarer and is described here for the first time. It also consists of a dedicated morphological form of the non-verbal predicate (limited, however, to nouns and adjectives), but such form stands out as morphologically lighter than any other form to be found in nouns or adjectives in argument or attribute position. While the latter forms carry some kind of case marker, the noun/adjective predicate merely consists (or historically did) of the word’s root. This type of construction can be found in the small Zamucoan family and still survives in some Tupí-Guaraní languages. Diachronic inspection of Semitic indicates, however, that this predicative strategy was possibly adopted in some ancient varieties, although at later stages it intertwined with the expression of referential specificity. The paper compares the two construction types, highlighting similarities and differences.
Studies in Language;... arrow_drop_down Studies in Language; Archivio istituzionale della Ricerca - Scuola Normale SuperioreArticle . 2019 . Peer-reviewedMémoires en Sciences de l'Information et de la CommunicationArticle . 2019Full-Text: https://hal.science/hal-02163482/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1075/sl.17013.ber&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Studies in Language;... arrow_drop_down Studies in Language; Archivio istituzionale della Ricerca - Scuola Normale SuperioreArticle . 2019 . Peer-reviewedMémoires en Sciences de l'Information et de la CommunicationArticle . 2019Full-Text: https://hal.science/hal-02163482/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1075/sl.17013.ber&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2019 FrancePublisher:Copernicus GmbH Oswald Malcles; Philippe Vernant; Jean Chéry; Pierre Camps; Gaël Cazes; Jean-François Ritz; David Fink;The evolution of intraplate orogens is still poorly understood. Yet, it is of major importance for understanding the Earth and plate dynamics, as well as the link between surface and deep geodynamic processes. The French Massif Central is an intraplate orogen with a mean elevation of 1000 m, with the highest peak elevations ranging from 1500 to 1885 m. However, active deformation of the region is still debated due to scarce evidence either from geomorphological or geodetic and seismologic data. We focus our study on the southern part of the Massif Central, known as the Cévennes and Grands Causses, which is a key area to study the relationship between the recent geological deformation and landscape evolution. This can be done through the study of numerous karst systems with trapped sediments combined with the analysis of a high-resolution digital elevation model (DEM). Using the ability of karst to durably record morphological evolution, we first quantify the incision rates. We then investigate tilting of geomorphological benchmarks by means of a high-resolution DEM. We finally use the newly quantified incision rates to constrain numerical models and compare the results with the geomorphometric study. We show that absolute burial age (10Be∕26Al on quartz cobbles) and the paleomagnetic analysis of karstic clay deposits for multiple cave system over a large elevation range correlate consistently. This correlation indicates a regional incision rate of 83 +17/-5 m Ma−1 during the last ca. 4 Myr (Pliocene–Quaternary). Moreover, we point out through the analysis of 55 morphological benchmarks that the studied region has undergone a regional southward tilting. This tilting is expected as being due to a differential vertical motion between the northern and southern part of the studied area. Numerical models show that erosion-induced isostatic rebound can explain up to two-thirds of the regional uplift deduced from the geochronological results and are consistent with the southward tilting derived from morphological analysis. We presume that the remaining unexplained uplift is related to dynamic topography or thermal isostasy due to the Massif Central Pliocene–Quaternary magmatism. Integrating both geochronology and morphometrical results into lithospheric-scale numerical models allows a better understanding of this intraplate–orogen evolution and dynamic. We assume that the main conclusions are true to the general case of intraplate deformation. That is to say, once the topography has been generated by a triggering process, rock uplift is then enhanced by erosion and isostatic adjustment leading to a significant accumulation of mainly vertical deformation.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/se-2019-99&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2021 FrancePublisher:Elsevier BV van Helden, Jacques; Butler, Colin; Achaz, Guillaume; Canard, Bruno; Casane, Didier; Claverie, Jean-Michel; Colombo, Fabien; Courtier-Orgogozo, Virginie; Ebright, Richard; Graner, François; Leitenberg, Milton; Morand, Serge; Petrovsky, Nikolai; Segreto, Rossana; Decroly, Etienne; Halloy, José;pmc: PMC8448489 , PMC8448488
International audience
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8448489Data sources: PubMed CentralEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8448488Data sources: PubMed CentralHAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(21)02013-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8448489Data sources: PubMed CentralEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8448488Data sources: PubMed CentralHAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(21)02013-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 FrancePublisher:Elsevier BV Gamal Shiha; Reham Soliman; Nabiel N. H. Mikhail; Fabrice Carrat; Jessica Azzi; Ganne‐Carrié Nathalie; Hidenori Toyoda; Haruki Uojima; Akito Nozaki; Koichi Takaguchi; Atsushi Hiraoka; Masanori Atsukawa; Hiroshi Abe; Kentaro Matsuura; Shigeru Mikami; Tsunamasa Watanabe; Kunihiko Tsuji; Toru Ishikawa; Vithika Suri; Anu Osinusi; Liyun Ni; Jun Zou; Shiv Kumar Sarin; Manoj Kumar; Prasun Kumar Jalal; Mahmoud A. Hashim; Manal Hassan; Sonia Alonso Lopez; Rafael Bañares; Adriana M. Ahumada; Nasser Hamed Mousa; Mohammed Eslam; Imam Waked;pmid: 35657138
Background and Aims: We have recently demonstrated the ability of a simple predictive model (GES) score to determine the risk of hepatocellular carcinoma (HCC) after using direct-acting antivirals. However, our results were restricted to Egyptian patients with hepatitis C virus (HCV) genotype 4. Therefore, we studied a large, independent cohort of multiethnic populations through our international collaborative activity. Methods: Depending on their GES scores, patients are stratified into low risk (≤ 6/12.5), intermediate risk (> 6–7.5/12.5), and high risk (> 7.5/12.5) for HCC. A total of 12038 patients with chronic HCV were analyzed in this study, of whom 11202 were recruited from 54 centers in France, Japan, India, the U.S., and Spain, and the remaining 836 were selected from the Gilead-sponsored randomized controlled trial conducted across the U.S., Europe, Canada, and Australia. Descriptive statistics and survival analysis were performed using Kaplan–Meier and log-rank tests. The performance of the GES score was evaluated using Harrell’s C-index (HCI). Results : The GES score proved successful at stratifying all patients into 3 risk groups, namely low-risk, intermediate-risk, and high-risk. It also displayed significant predictive value for HCC development in all participants (P < 0 .0001), with HCI ranging from 0.55 to 0.76 among all cohorts after adjusting for HCV genotypes and patient ethnicities. Conclusion: The GES score can be used to stratify HCV patients into 3 categories of risk for HCC, namely low-risk, intermediate-risk, and high-risk, irrespective of their ethnicities or HCV genotypes. This international multicenter validation may allow the use of GES score in individualized HCC risk-based surveillance programs. Funding: None to declare. Declaration of Interest: None to declare. Ethical Approval: The protocol was approved by the Institutional Research Board of each participating center, as per local regulations
Journal of Viral Hep... arrow_drop_down Journal of Viral HepatitisArticle . 2022 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.3896562&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Journal of Viral Hep... arrow_drop_down Journal of Viral HepatitisArticle . 2022 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.3896562&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Article , Other literature type 2020 France, Croatia, Spain, Italy, Germany, Austria, Italy, ItalyPublisher:IOP Publishing Funded by:EC | HYMNSEC| HYMNSDomingo-Pardo; C.; Babiano-Suarez; V.; Balibrea-Correa; J.; Caballero; L.; Ladarescu; I.; Lerendegui-Marco; J.; Tain; J.L.; Calv?no; F.; Casanovas; A.; Segarr; A.; Tarife?o-Saldivia; A.E.; Guerrero; C.; Mill?n-Callado; M.A.; Quesada; J.M.; Rodr?guez-Gonz?lez; M.T.; Aberle; O.; Alcayne; V.; Amaducci; S.; Andrzejewski; J.; Audouin; L.; Bacak; M.; Barbagallo; M.; Bennett; S.; Berthoumieux; E.; Bosnar; D.; Brown; A.S.; Busso; M.; Caama?o; M.; Calviani; M.; Cano-Ott; D.; Cerutti; F.; Chiaveri; E.; Colonna; N.; Cort?s; G.P.; Cort?s-Giraldo; M.A.; Cosentino; L.; Cristallo; S.; Damone; L.A.; Davies; P.J.; Diakaki; M.; Dietz; M.; Dressler; R.; Ducasse; Q.; Dupont; E.; Dur?n; I.; Eleme; Z.; Fern?ndez-Dom?ngez; B.; Ferrari; A.; Ferro-Gon?alves; I.; Finocchiaro; P.; Furman; V.; Garg; R.; Gawlik; A.; Gilardoni; S.; G?bel; K.; Gonz?lez-Romero; E.; Gunsing; F.; Heyse; J.; Jenkins; D.G.; Jericha; E.; Jiri; U.; Junghans; A.; Kadi; Y.; K?ppeler; F.; Kimura; A.; Knapov?; I.; Kokkoris; M.; Kopatch; Y.; Krti?ka; M.; Kurtulgil; D.; Lederer-Woods; C.; Lonsdale; S.-J.; Macina; D.; Manna; A.; Mart?nez; T.; Masi; A.; Massimi; C.; Mastinua; P.F.; Mastromarco; M.; Maugeri; E.; Mazzone; A.; Mendoza; E.; Mengoni; A.; Michalopoulou; V.; Milazzo; P.M.; Mingrone; F.; Moreno-Soto; J.; Musumarra; A.; Negret; A.; Og?llar; F.; Oprea; A.; Patronis; N.; Pavlik; A.; Perkowski; J.; Petrone; C.; Piersanti; L.; Pirovano; E.; Porras; I.; Praena; J.; Doval; D.R.; Reifarth; Smith; Sosnin; Vaz; Ventura; Vescovi; Wallner;The idea of slow-neutron capture nucleosynthesis formulated in 1957 triggered a tremendous experimental effort in different laboratories worldwide to measure the relevant nuclear physics input quantities, namely (n, γ) cross sections over the stellar temperature range (from few eV up to several hundred keV) for most of the isotopes involved from Fe up to Bi. A brief historical review focused on total energy detectors will be presented to illustrate how advances in instrumentation have led to the assessment of new aspects of s-process nucleosynthesis and to the progressive refinement of stellar models. A summary will be presented on current efforts to develop new detection concepts, such as the Total-Energy Detector with γ-ray imaging capability (i-TED). The latter is based on the simultaneous combination of Compton imaging with neutron time-of-flight (TOF) techniques, in order to achieve a superior level of sensitivity and selectivity in the measurement of stellar neutron capture rates. European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (ERC Consolidator Grant project HYMNS) 681740 Instituto de Salud Carlos III Spanish Government FPA2014-52823-C2-1-P FPA2017-83946-C2-1-P Consejo Superior de Investigaciones Cientificas (CSIC) PIE-201750I26 Program Severo Ochoa SEV-2014-0398
ENEA Open Archive arrow_drop_down Permanent Hosting, Archiving and Indexing of Digital Resources and AssetsArticle . 2020License: CC BYarXiv.org e-Print ArchiveOther literature type . Preprint . 2019Data sources: arXiv.org e-Print ArchiveJournal of Physics : Conference Series; CNR ExploRA; Croatian Scientific Bibliography - CROSBIOther literature type . Article . Conference object . 2020 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTA; Repositorio Institucional Universidad de GranadaOther literature type . Article . 2021 . 2020License: CC BYHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotConference object . 2019Mémoires en Sciences de l'Information et de la Communication; HAL-CEAConference object . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert ENEA Open Archive arrow_drop_down Permanent Hosting, Archiving and Indexing of Digital Resources and AssetsArticle . 2020License: CC BYarXiv.org e-Print ArchiveOther literature type . Preprint . 2019Data sources: arXiv.org e-Print ArchiveJournal of Physics : Conference Series; CNR ExploRA; Croatian Scientific Bibliography - CROSBIOther literature type . Article . Conference object . 2020 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTA; Repositorio Institucional Universidad de GranadaOther literature type . Article . 2021 . 2020License: CC BYHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotConference object . 2019Mémoires en Sciences de l'Information et de la Communication; HAL-CEAConference object . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/1742-6596/1668/1/012013&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 FrancePublisher:Elsevier BV Funded by:ARC | ARC Future Fellowships - ..., ARC | Understanding the migrati...ARC| ARC Future Fellowships - Grant ID: FT150100215 ,ARC| Understanding the migrations of prehistoric populations through direct dating and isotopic tracking of their mobility patternsJean-Jacques Bahain; Mathieu Duval; Pierre Voinchet; Hélène Tissoux; Christophe Falguères; Rainer Grün; Davinia Moreno; Qingfeng Shao; Olivier Tombret; Guillaume Jamet; Jean-Philippe Faivre; Dominique Cliquet;– Tourville-la-Rivière (Normandy, France) is one of the rare Middle Pleistocene palaeoanthropological localities of Northern France. Electron Spin Resonance (ESR) and combined ESR/U-series dating methods were independently applied by different teams on sediments and teeth from this site. The present work provides an overview of this multi-laboratory dating work by integrating a description and discussion of the methodologies employed and results obtained.Results confirm that the ESR/U-series analyses of the teeth are greatly dependent on the U-uptake histories of the dental tissues. Although all teeth come from the same archeological level, the samples analysed by each team display two different patterns for the U-series data. This is most likely related to the different sampling areas selected by each team and may be interpreted as the result of local variations in the geochemical conditions of the surrounding environment. Concerning the ESR dating of optically bleached quartz grains, the use of the multiple centre approach seems crucial when dating such fluvial and fluvio-lacustrine sediments. Our results also confirm the great potential of the Ti-H centre to date late Middle Pleistocene deposits.Despite some (expected) discrepancies related to the independent use of parameters and approaches by the different teams involved in this multi-laboratory study, the whole ESR and ESR/U-series data set collected from Tourville-la-Rivière locality consistently correlates stratigraphic levels D1 to I and associated human occupation to MIS7. International audience
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.quaint.2019.06.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.quaint.2019.06.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, AustraliaPublisher:Elsevier BV Authors: Esther Mirjam Girsberger; Romuald Méango; Hillel Rapoport;Esther Mirjam Girsberger; Romuald Méango; Hillel Rapoport;handle: 10453/138623
© 2019 Association for Comparative Economic Studies We investigate the impact of intra-regional migration on wage inequality in the West African Economic and Monetary Union (UEMOA). We exploit unique data from a unified labour force household survey which covers natives and migrants in the seven economic capital cities of that region. We first estimate the counterfactual wage distributions of UEMOA migrants in absence of migration to evaluate the compositional effect of migration (i.e., when wages are treated as exogenous). We find that regional migration increases average wages by 1.8% and generates a decrease in inequality that ranges between −1.5% (for the Gini index) and −4.5% (for the interquartile ratio). This is essentially driven by a reduction in inequality between capital cities, while the effect of migration on within-capital cities inequality is heterogeneous across countries and remains small overall. Second, when accounting for possible general equilibrium effects of migration on stayers’ wages (i.e., when wages are treated as endogenous), we find similar to stronger effects on inequality, albeit with a smaller increase in the average wage.
Journal of Comparati... arrow_drop_down Journal of Comparative EconomicsArticle . 2020 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jce.2019.10.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Comparati... arrow_drop_down Journal of Comparative EconomicsArticle . 2020 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jce.2019.10.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 FrancePublisher:Elsevier BV Funded by:EC | NoLiMit, EC | GeoInSightEC| NoLiMit ,EC| GeoInSightLu Pan; C. Quantin-Nataf; Benoit Tauzin; Chloé Michaut; Matthew P. Golombek; P. H. Lognonné; Peter Grindrod; Benoit Langlais; Tamara Gudkova; I. E. Stepanova; Sebastien Rodriguez; Antoine Lucas;in western Elysium Planitia. The Mars crust beneath the lander is subject to complex geologic history next to the great topographic and crustal dichotomy of Mars. Understanding this part of the Martian crust in the subsurface would aid future investigations of the internal structure of the planet based on seismic datasets collected by the Seismic Experiment for Interior Structure (SEIS) instrument. Here, we investigate the subsurface structure and composition from the analysis of mineralogy and morphology of exposures in impact craters as well as on scarps and knobs in the general region of Elysium Planitia. Using a combination of orbital datasets, we identify exposures of subsurface materials with distinct composition and physical properties. We find olivine and pyroxene detections associated with small impact craters (1.5-7 km) rim in the vicinity of InSight lander, as well as in the transition unit and Elysium volcanic unit. Fe/Mg phyllosilicates have been identified in the central peak of the 51-km diameter Kalpin crater and on knobs in the transition unit between the dichotomy and the plains. In addition, eroded meter-scale layered unit subject to erosion has been identified in six impact craters to the northeast of the landing site, including Kalpin crater. Massive bedrock and layered, weak materials co-occur in the transition unit, indicating a complex origin. These results together suggest both materials with altered composition and layered deposit occur as distinct geologic units beneath the basaltic lava flow units. Through analogy with terrestrial sedimentary rocks or clay-bearing sediments, we suggest physically weak materials exist beneath the lava flow units in the general region of Elysium Planitia. The spatial distribution and continuity of these materials are unclear due to the lack of exposures within the lava flow unit where the InSight lander is located. These subsurface materials of distinct physical properties may result in increased attenuation or reverberations of seismic waves, to be collected by SEIS. The findings suggest a close investigation of the potential effects of subsurface stratigraphy on seismic data would help inform future data interpretation and understanding of the internal structure of Mars. International audience
Icarus arrow_drop_down HAL Descartes; HAL-ENS-LYON; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BY NCFull-Text: https://hal.science/hal-02346218/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.icarus.2019.113511&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 39 citations 39 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Icarus arrow_drop_down HAL Descartes; HAL-ENS-LYON; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BY NCFull-Text: https://hal.science/hal-02346218/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.icarus.2019.113511&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Australia, France, United StatesPublisher:Springer Science and Business Media LLC Funded by:NIH | Adapter-Layer RTK Signali..., EC | MYELOSHOCK, NIH | Design of Antibody Fragme... +1 projectsNIH| Adapter-Layer RTK Signaling: Basic Understanding & Targeted DrugResistance ,EC| MYELOSHOCK ,NIH| Design of Antibody Fragments Specific For Amyloidogenic Aggregates ,NSF| Collaborative Research: GOALI: Nanoparticle analysis of antibody colloidal interactions and their influence on viscoelastic properties of concentrated antibody solutionsChang-Han Lee; Tae Hyun Kang; Ophélie Godon; Makiko Watanabe; George Delidakis; Caitlin M. Gillis; Delphine Sterlin; David Hardy; Michel Cogné; Macdonald Lynn; Andrew J. Murphy; Naxin Tu; Jiwon Lee; Jonathan R. McDaniel; Emily K. Makowski; Peter M. Tessier; Aaron S. Meyer; Pierre Bruhns; George Georgiou;pmc: PMC6834678 , PMC6877538
handle: 10453/140049
The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human neonatal Fc receptor (hFcRn). Engineered Fc domains that confer a longer circulation half-life by virtue of more favorable pH-dependent binding to hFcRn are of great therapeutic interest. Here we developed a pH Toggle switch Fc variant containing the L309D/Q311H/N434S (DHS) substitutions, which exhibits markedly improved pharmacokinetics relative to both native IgG1 and widely used half-life extension variants, both in conventional hFcRn transgenic mice and in new knock-in mouse strains. engineered specifically to recapitulate all the key processes relevant to human antibody persistence in circulation, namely: (i) physiological expression of hFcRn, (ii) the impact of hFcγRs on antibody clearance and (iii) the role of competing endogenous IgG. DHS-IgG retains intact effector functions, which are important for the clearance of target pathogenic cells and also has favorable developability. International audience
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6877538Data sources: PubMed CentralNature CommunicationsArticle . 2019 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC6834678Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaHAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-019-13108-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 49 citations 49 popularity Top 1% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6877538Data sources: PubMed CentralNature CommunicationsArticle . 2019 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC6834678Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaHAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-019-13108-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 United Kingdom, United Kingdom, FrancePublisher:Elsevier BV Kennicutt, Mahlon; Bromwich, David; Liggett, Daniela; Njåstad, Birgit; Peck, Lloyd; Rintoul, Stephen; Ritz, Catherine; Siegert, Martin; Aitken, Alan; Brooks, Cassandra; Cassano, John; Chaturvedi, Sanjay; Chen, Dake; Dodds, Klaus; Golledge, Nicholas; Le Bohec, Céline; Leppe, Marcelo; Murray, Alison; Nath, P. Chandrika; Raphael, Marilyn; Rogan-Finnemore, Michelle; Schroeder, Dustin; Talley, Lynne; Travouillon, Tony; Vaughan, David; Wang, Lifan; Weatherwax, Allan; Yang, Huigen; Chown, Steven,;The view from the south is, more than ever, dominated by ominous signs of change. Antarctica and the Southern Ocean are intrinsic to the Earth system, and their evolution is intertwined with and influences the course of the Anthropocene. In turn, changes in the Antarctic affect and presage humanity's future. Growing understanding is countering popular beliefs that Antarctica is pristine, stable, isolated, and reliably frozen. An aspirational roadmap for Antarctic science has facilitated research since 2014. A renewed commitment to gathering further knowledge will quicken the pace of understanding of Earth systems and beyond. Progress is already evident, such as addressing uncertainties in the causes and pace of ice loss and global sea-level rise. However, much remains to be learned. As an iconic global “commons,” the rapidity of Antarctic change will provoke further political action. Antarctic research is more vital than ever to a sustainable future for this One Earth.
One Earth; NERC Open... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryMémoires en Sciences de l'Information et de la Communication; HAL-IRDArticle . 2019License: CC BYFull-Text: https://hal.science/hal-02353429/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.oneear.2019.08.014&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 53 citations 53 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 14visibility views 14 download downloads 43 Powered bymore_vert One Earth; NERC Open... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryMémoires en Sciences de l'Information et de la Communication; HAL-IRDArticle . 2019License: CC BYFull-Text: https://hal.science/hal-02353429/documentHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2019License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.oneear.2019.08.014&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Italy, France, FrancePublisher:John Benjamins Publishing Company Authors: Pier Marco Bertinetto; Luca Ciucci; Margherita Farina;Pier Marco Bertinetto; Luca Ciucci; Margherita Farina;doi: 10.1075/sl.17013.ber
handle: 11384/91668
AbstractThe morphological expression of non-verbal predication is a geographically widespread, although not very frequent, typological feature. This paper highlights the existence of two radically contrasting types of non-verbal predicative inflection. Construction A has already been described in the literature. It consists of attaching person-sensitive inflection markers to non-verbal predicates, possibly extending this treatment to adverbs and adverbial phrases (locational and temporal), pronouns and quantifiers. This type is well attested in Uralic, Turkic, and Paleosiberian, as well as in some Amazonian language families (most notably Chicham), but it has also been pointed out for some sparse languages of Oceania and Africa. Such non-verbal person inflections diachronically stem from incorporation of conjugated copula elements. Construction B, by contrast, is much rarer and is described here for the first time. It also consists of a dedicated morphological form of the non-verbal predicate (limited, however, to nouns and adjectives), but such form stands out as morphologically lighter than any other form to be found in nouns or adjectives in argument or attribute position. While the latter forms carry some kind of case marker, the noun/adjective predicate merely consists (or historically did) of the word’s root. This type of construction can be found in the small Zamucoan family and still survives in some Tupí-Guaraní languages. Diachronic inspection of Semitic indicates, however, that this predicative strategy was possibly adopted in some ancient varieties, although at later stages it intertwined with the expression of referential specificity. The paper compares the two construction types, highlighting similarities and differences.
Studies in Language;... arrow_drop_down Studies in Language; Archivio istituzionale della Ricerca - Scuola Normale SuperioreArticle . 2019 . Peer-reviewedMémoires en Sciences de l'Information et de la CommunicationArticle . 2019Full-Text: https://hal.science/hal-02163482/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1075/sl.17013.ber&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Studies in Language;... arrow_drop_down Studies in Language; Archivio istituzionale della Ricerca - Scuola Normale SuperioreArticle . 2019 . Peer-reviewedMémoires en Sciences de l'Information et de la CommunicationArticle . 2019Full-Text: https://hal.science/hal-02163482/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1075/sl.17013.ber&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2019 FrancePublisher:Copernicus GmbH Oswald Malcles; Philippe Vernant; Jean Chéry; Pierre Camps; Gaël Cazes; Jean-François Ritz; David Fink;The evolution of intraplate orogens is still poorly understood. Yet, it is of major importance for understanding the Earth and plate dynamics, as well as the link between surface and deep geodynamic processes. The French Massif Central is an intraplate orogen with a mean elevation of 1000 m, with the highest peak elevations ranging from 1500 to 1885 m. However, active deformation of the region is still debated due to scarce evidence either from geomorphological or geodetic and seismologic data. We focus our study on the southern part of the Massif Central, known as the Cévennes and Grands Causses, which is a key area to study the relationship between the recent geological deformation and landscape evolution. This can be done through the study of numerous karst systems with trapped sediments combined with the analysis of a high-resolution digital elevation model (DEM). Using the ability of karst to durably record morphological evolution, we first quantify the incision rates. We then investigate tilting of geomorphological benchmarks by means of a high-resolution DEM. We finally use the newly quantified incision rates to constrain numerical models and compare the results with the geomorphometric study. We show that absolute burial age (10Be∕26Al on quartz cobbles) and the paleomagnetic analysis of karstic clay deposits for multiple cave system over a large elevation range correlate consistently. This correlation indicates a regional incision rate of 83 +17/-5 m Ma−1 during the last ca. 4 Myr (Pliocene–Quaternary). Moreover, we point out through the analysis of 55 morphological benchmarks that the studied region has undergone a regional southward tilting. This tilting is expected as being due to a differential vertical motion between the northern and southern part of the studied area. Numerical models show that erosion-induced isostatic rebound can explain up to two-thirds of the regional uplift deduced from the geochronological results and are consistent with the southward tilting derived from morphological analysis. We presume that the remaining unexplained uplift is related to dynamic topography or thermal isostasy due to the Massif Central Pliocene–Quaternary magmatism. Integrating both geochronology and morphometrical results into lithospheric-scale numerical models allows a better understanding of this intraplate–orogen evolution and dynamic. We assume that the main conclusions are true to the general case of intraplate deformation. That is to say, once the topography has been generated by a triggering process, rock uplift is then enhanced by erosion and isostatic adjustment leading to a significant accumulation of mainly vertical deformation.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/se-2019-99&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/se-2019-99&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu