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description Publicationkeyboard_double_arrow_right Article 2024 United Kingdom, United Kingdom, United States, United KingdomPublisher:Springer Science and Business Media LLC Irving-Pease, Evan K; Refoyo-Martínez, Alba; Barrie, William; Ingason, Andrés; Pearson, Alice; Fischer, Anders; Sjögren, Karl-Göran; Halgren, Alma S; Macleod, Ruairidh; Demeter, Fabrice; Henriksen, Rasmus A; Vimala, Tharsika; McColl, Hugh; Vaughn, Andrew H; Speidel, Leo; Stern, Aaron J; Scorrano, Gabriele; Ramsøe, Abigail; Schork, Andrew J; Rosengren, Anders; Zhao, Lei; Kristiansen, Kristian; Iversen, Astrid KN; Fugger, Lars; Sudmant, Peter H; Lawson, Daniel J; Durbin, Richard; Korneliussen, Thorfinn; Werge, Thomas; Allentoft, Morten E; Sikora, Martin; Nielsen, Rasmus; Racimo, Fernando; Willerslev, Eske;AbstractThe Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes1, we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism, including that selection at the FADS cluster began earlier than previously reported and that selection near the LCT locus predates the emergence of the lactase persistence allele by thousands of years. We also find strong selection in the HLA region, possibly due to increased exposure to pathogens during the Bronze Age. Using ancient individuals to infer local ancestry tracts in over 400,000 samples from the UK Biobank, we identify widespread differences in the distribution of Mesolithic, Neolithic and Bronze Age ancestries across Eurasia. By calculating ancestry-specific polygenic risk scores, we show that height differences between Northern and Southern Europe are associated with differential Steppe ancestry, rather than selection, and that risk alleles for mood-related phenotypes are enriched for Neolithic farmer ancestry, whereas risk alleles for diabetes and Alzheimer’s disease are enriched for Western hunter-gatherer ancestry. Our results indicate that ancient selection and migration were large contributors to the distribution of phenotypic diversity in present-day Europeans.
Apollo arrow_drop_down eScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06705-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 9 citations 9 popularity Average influence Average impulse Top 10% Powered by BIP!visibility 377visibility views 377 Powered bymore_vert Apollo arrow_drop_down eScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06705-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 Denmark, United States, United KingdomPublisher:Springer Science and Business Media LLC Allentoft, Morten E; Sikora, Martin; Fischer, Anders; Sjögren, Karl-Göran; Ingason, Andrés; Macleod, Ruairidh; Rosengren, Anders; Schulz Paulsson, Bettina; Jørkov, Marie Louise Schjellerup; Novosolov, Maria; Stenderup, Jesper; Price, T Douglas; Fischer Mortensen, Morten; Nielsen, Anne Birgitte; Ulfeldt Hede, Mikkel; Sørensen, Lasse; Nielsen, Poul Otto; Rasmussen, Peter; Jensen, Theis Zetner Trolle; Refoyo-Martínez, Alba; Irving-Pease, Evan K; Barrie, William; Pearson, Alice; Sousa Da Mota, Bárbara; Demeter, Fabrice; Henriksen, Rasmus A; Vimala, Tharsika; McColl, Hugh; Vaughn, Andrew; Vinner, Lasse; Renaud, Gabriel; Stern, Aaron; Johannsen, Niels Nørkjær; Ramsøe, Abigail Daisy; Schork, Andrew Joseph; Ruter, Anthony; Gotfredsen, Anne Birgitte; Henning Nielsen, Bjarne; Brinch Petersen, Erik; Kannegaard, Esben; Hansen, Jesper; Buck Pedersen, Kristoffer; Pedersen, Lisbeth; Klassen, Lutz; Meldgaard, Morten; Johansen, Morten; Uldum, Otto Christian; Lotz, Per; Lysdahl, Per; Bangsgaard, Pernille; Petersen, Peter Vang; Maring, Rikke; Iversen, Rune; Wåhlin, Sidsel; Anker Sørensen, Søren; Andersen, Søren H; Jørgensen, Thomas; Lynnerup, Niels; Lawson, Daniel J; Rasmussen, Simon; Korneliussen, Thorfinn Sand; Kjær, Kurt H; Durbin, Richard; Nielsen, Rasmus; Delaneau, Olivier; Werge, Thomas; Kristiansen, Kristian; Willerslev, Eske;AbstractMajor migration events in Holocene Eurasia have been characterized genetically at broad regional scales1–4. However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution5–7. Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet (13C and 15N content), mobility (87Sr/86Sr ratio) and vegetation cover (pollen). We observe that Danish Mesolithic individuals of the Maglemose, Kongemose and Ertebølle cultures form a distinct genetic cluster related to other Western European hunter-gatherers. Despite shifts in material culture they displayed genetic homogeneity from around 10,500 to 5,900 calibrated years before present, when Neolithic farmers with Anatolian-derived ancestry arrived. Although the Neolithic transition was delayed by more than a millennium relative to Central Europe, it was very abrupt and resulted in a population turnover with limited genetic contribution from local hunter-gatherers. The succeeding Neolithic population, associated with the Funnel Beaker culture, persisted for only about 1,000 years before immigrants with eastern Steppe-derived ancestry arrived. This second and equally rapid population replacement gave rise to the Single Grave culture with an ancestry profile more similar to present-day Danes. In our multiproxy dataset, these major demographic events are manifested as parallel shifts in genotype, phenotype, diet and land use.
Apollo arrow_drop_down Serveur académique lausannoisArticle . 2024License: CC BYData sources: Serveur académique lausannoisCopenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information SystemOnline Research Database In TechnologyArticle . 2024Data sources: Online Research Database In TechnologyeScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06862-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 6 citations 6 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert Apollo arrow_drop_down Serveur académique lausannoisArticle . 2024License: CC BYData sources: Serveur académique lausannoisCopenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information SystemOnline Research Database In TechnologyArticle . 2024Data sources: Online Research Database In TechnologyeScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06862-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 United Kingdom, Denmark, United StatesPublisher:Springer Science and Business Media LLC Barrie, William; Yang, Yaoling; Irving-Pease, Evan K; Attfield, Kathrine E; Scorrano, Gabriele; Jensen, Lise Torp; Armen, Angelos P; Dimopoulos, Evangelos Antonios; Stern, Aaron; Refoyo-Martinez, Alba; Pearson, Alice; Ramsøe, Abigail; Gaunitz, Charleen; Demeter, Fabrice; Jørkov, Marie Louise S; Møller, Stig Bermann; Springborg, Bente; Klassen, Lutz; Hyldgård, Inger Marie; Wickmann, Niels; Vinner, Lasse; Korneliussen, Thorfinn Sand; Allentoft, Morten E; Sikora, Martin; Kristiansen, Kristian; Rodriguez, Santiago; Nielsen, Rasmus; Iversen, Astrid KN; Lawson, Daniel J; Fugger, Lars; Willerslev, Eske;AbstractMultiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1. Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age2, along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment.
Apollo arrow_drop_down eScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of CaliforniaCopenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06618-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Average influence Top 10% impulse Top 10% Powered by BIP!visibility 78visibility views 78 Powered bymore_vert Apollo arrow_drop_down eScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of CaliforniaCopenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06618-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2023 United KingdomPublisher:Springer Science and Business Media LLC Authors: Murray Shanahan; Kyle McDonell; Laria Reynolds;Murray Shanahan; Kyle McDonell; Laria Reynolds;pmid: 37938776
As dialogue agents become increasingly human-like in their performance, it is imperative that we develop effective ways to describe their behaviour in high-level terms without falling into the trap of anthropomorphism. In this paper, we foreground the concept of role-play. Casting dialogue agent behaviour in terms of role-play allows us to draw on familiar folk psychological terms, without ascribing human characteristics to language models they in fact lack. Two important cases of dialogue agent behaviour are addressed this way, namely (apparent) deception and (apparent) self-awareness.
Spiral - Imperial Co... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2023Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryPreprint . 2023Data sources: Spiral - Imperial College Digital RepositoryarXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06647-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 5 citations 5 popularity Average influence Top 10% impulse Average Powered by BIP!more_vert Spiral - Imperial Co... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2023Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryPreprint . 2023Data sources: Spiral - Imperial College Digital RepositoryarXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06647-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Juan Manuel, Parrilla;Juan Manuel, Parrilla;pmid: 37833483
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-03238-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-03238-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Will, Marshall;Will, Marshall;pmid: 37752260
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-03018-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-03018-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Richard, Van Noorden;Richard, Van Noorden;pmid: 37532856
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02470-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02470-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Karan Singhal; Shekoofeh Azizi; Tao Tu; S. Sara Mahdavi; Jason Wei; Hyung Won Chung; Nathan Scales; Ajay Tanwani; Heather Cole-Lewis; Stephen Pfohl; Perry Payne; Martin Seneviratne; Paul Gamble; Chris Kelly; Abubakr Babiker; Nathanael Schärli; Aakanksha Chowdhery; Philip Mansfield; Dina Demner-Fushman; Blaise Agüera y Arcas; Dale Webster; Greg S. Corrado; Yossi Matias; Katherine Chou; Juraj Gottweis; Nenad Tomasev; Yun Liu; Alvin Rajkomar; Joelle Barral; Christopher Semturs; Alan Karthikesalingam; Vivek Natarajan;AbstractLarge language models (LLMs) have demonstrated impressive capabilities, but the bar for clinical applications is high. Attempts to assess the clinical knowledge of models typically rely on automated evaluations based on limited benchmarks. Here, to address these limitations, we present MultiMedQA, a benchmark combining six existing medical question answering datasets spanning professional medicine, research and consumer queries and a new dataset of medical questions searched online, HealthSearchQA. We propose a human evaluation framework for model answers along multiple axes including factuality, comprehension, reasoning, possible harm and bias. In addition, we evaluate Pathways Language Model1 (PaLM, a 540-billion parameter LLM) and its instruction-tuned variant, Flan-PaLM2 on MultiMedQA. Using a combination of prompting strategies, Flan-PaLM achieves state-of-the-art accuracy on every MultiMedQA multiple-choice dataset (MedQA3, MedMCQA4, PubMedQA5 and Measuring Massive Multitask Language Understanding (MMLU) clinical topics6), including 67.6% accuracy on MedQA (US Medical Licensing Exam-style questions), surpassing the prior state of the art by more than 17%. However, human evaluation reveals key gaps. To resolve this, we introduce instruction prompt tuning, a parameter-efficient approach for aligning LLMs to new domains using a few exemplars. The resulting model, Med-PaLM, performs encouragingly, but remains inferior to clinicians. We show that comprehension, knowledge recall and reasoning improve with model scale and instruction prompt tuning, suggesting the potential utility of LLMs in medicine. Our human evaluations reveal limitations of today’s models, reinforcing the importance of both evaluation frameworks and method development in creating safe, helpful LLMs for clinical applications.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06291-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 170 citations 170 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06291-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Shotaro Kinoshita; Hiromi Yokoyama;Shotaro Kinoshita; Hiromi Yokoyama;pmid: 37433929
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02230-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02230-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Gemma, Conroy;Gemma, Conroy;pmid: 37419951
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02218-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 17 citations 17 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02218-z&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2024 United Kingdom, United Kingdom, United States, United KingdomPublisher:Springer Science and Business Media LLC Irving-Pease, Evan K; Refoyo-Martínez, Alba; Barrie, William; Ingason, Andrés; Pearson, Alice; Fischer, Anders; Sjögren, Karl-Göran; Halgren, Alma S; Macleod, Ruairidh; Demeter, Fabrice; Henriksen, Rasmus A; Vimala, Tharsika; McColl, Hugh; Vaughn, Andrew H; Speidel, Leo; Stern, Aaron J; Scorrano, Gabriele; Ramsøe, Abigail; Schork, Andrew J; Rosengren, Anders; Zhao, Lei; Kristiansen, Kristian; Iversen, Astrid KN; Fugger, Lars; Sudmant, Peter H; Lawson, Daniel J; Durbin, Richard; Korneliussen, Thorfinn; Werge, Thomas; Allentoft, Morten E; Sikora, Martin; Nielsen, Rasmus; Racimo, Fernando; Willerslev, Eske;AbstractThe Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes1, we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism, including that selection at the FADS cluster began earlier than previously reported and that selection near the LCT locus predates the emergence of the lactase persistence allele by thousands of years. We also find strong selection in the HLA region, possibly due to increased exposure to pathogens during the Bronze Age. Using ancient individuals to infer local ancestry tracts in over 400,000 samples from the UK Biobank, we identify widespread differences in the distribution of Mesolithic, Neolithic and Bronze Age ancestries across Eurasia. By calculating ancestry-specific polygenic risk scores, we show that height differences between Northern and Southern Europe are associated with differential Steppe ancestry, rather than selection, and that risk alleles for mood-related phenotypes are enriched for Neolithic farmer ancestry, whereas risk alleles for diabetes and Alzheimer’s disease are enriched for Western hunter-gatherer ancestry. Our results indicate that ancient selection and migration were large contributors to the distribution of phenotypic diversity in present-day Europeans.
Apollo arrow_drop_down eScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06705-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 9 citations 9 popularity Average influence Average impulse Top 10% Powered by BIP!visibility 377visibility views 377 Powered bymore_vert Apollo arrow_drop_down eScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06705-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 Denmark, United States, United KingdomPublisher:Springer Science and Business Media LLC Allentoft, Morten E; Sikora, Martin; Fischer, Anders; Sjögren, Karl-Göran; Ingason, Andrés; Macleod, Ruairidh; Rosengren, Anders; Schulz Paulsson, Bettina; Jørkov, Marie Louise Schjellerup; Novosolov, Maria; Stenderup, Jesper; Price, T Douglas; Fischer Mortensen, Morten; Nielsen, Anne Birgitte; Ulfeldt Hede, Mikkel; Sørensen, Lasse; Nielsen, Poul Otto; Rasmussen, Peter; Jensen, Theis Zetner Trolle; Refoyo-Martínez, Alba; Irving-Pease, Evan K; Barrie, William; Pearson, Alice; Sousa Da Mota, Bárbara; Demeter, Fabrice; Henriksen, Rasmus A; Vimala, Tharsika; McColl, Hugh; Vaughn, Andrew; Vinner, Lasse; Renaud, Gabriel; Stern, Aaron; Johannsen, Niels Nørkjær; Ramsøe, Abigail Daisy; Schork, Andrew Joseph; Ruter, Anthony; Gotfredsen, Anne Birgitte; Henning Nielsen, Bjarne; Brinch Petersen, Erik; Kannegaard, Esben; Hansen, Jesper; Buck Pedersen, Kristoffer; Pedersen, Lisbeth; Klassen, Lutz; Meldgaard, Morten; Johansen, Morten; Uldum, Otto Christian; Lotz, Per; Lysdahl, Per; Bangsgaard, Pernille; Petersen, Peter Vang; Maring, Rikke; Iversen, Rune; Wåhlin, Sidsel; Anker Sørensen, Søren; Andersen, Søren H; Jørgensen, Thomas; Lynnerup, Niels; Lawson, Daniel J; Rasmussen, Simon; Korneliussen, Thorfinn Sand; Kjær, Kurt H; Durbin, Richard; Nielsen, Rasmus; Delaneau, Olivier; Werge, Thomas; Kristiansen, Kristian; Willerslev, Eske;AbstractMajor migration events in Holocene Eurasia have been characterized genetically at broad regional scales1–4. However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution5–7. Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet (13C and 15N content), mobility (87Sr/86Sr ratio) and vegetation cover (pollen). We observe that Danish Mesolithic individuals of the Maglemose, Kongemose and Ertebølle cultures form a distinct genetic cluster related to other Western European hunter-gatherers. Despite shifts in material culture they displayed genetic homogeneity from around 10,500 to 5,900 calibrated years before present, when Neolithic farmers with Anatolian-derived ancestry arrived. Although the Neolithic transition was delayed by more than a millennium relative to Central Europe, it was very abrupt and resulted in a population turnover with limited genetic contribution from local hunter-gatherers. The succeeding Neolithic population, associated with the Funnel Beaker culture, persisted for only about 1,000 years before immigrants with eastern Steppe-derived ancestry arrived. This second and equally rapid population replacement gave rise to the Single Grave culture with an ancestry profile more similar to present-day Danes. In our multiproxy dataset, these major demographic events are manifested as parallel shifts in genotype, phenotype, diet and land use.
Apollo arrow_drop_down Serveur académique lausannoisArticle . 2024License: CC BYData sources: Serveur académique lausannoisCopenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information SystemOnline Research Database In TechnologyArticle . 2024Data sources: Online Research Database In TechnologyeScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06862-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 6 citations 6 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert Apollo arrow_drop_down Serveur académique lausannoisArticle . 2024License: CC BYData sources: Serveur académique lausannoisCopenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information SystemOnline Research Database In TechnologyArticle . 2024Data sources: Online Research Database In TechnologyeScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06862-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 United Kingdom, Denmark, United StatesPublisher:Springer Science and Business Media LLC Barrie, William; Yang, Yaoling; Irving-Pease, Evan K; Attfield, Kathrine E; Scorrano, Gabriele; Jensen, Lise Torp; Armen, Angelos P; Dimopoulos, Evangelos Antonios; Stern, Aaron; Refoyo-Martinez, Alba; Pearson, Alice; Ramsøe, Abigail; Gaunitz, Charleen; Demeter, Fabrice; Jørkov, Marie Louise S; Møller, Stig Bermann; Springborg, Bente; Klassen, Lutz; Hyldgård, Inger Marie; Wickmann, Niels; Vinner, Lasse; Korneliussen, Thorfinn Sand; Allentoft, Morten E; Sikora, Martin; Kristiansen, Kristian; Rodriguez, Santiago; Nielsen, Rasmus; Iversen, Astrid KN; Lawson, Daniel J; Fugger, Lars; Willerslev, Eske;AbstractMultiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1. Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age2, along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment.
Apollo arrow_drop_down eScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of CaliforniaCopenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06618-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Average influence Top 10% impulse Top 10% Powered by BIP!visibility 78visibility views 78 Powered bymore_vert Apollo arrow_drop_down eScholarship - University of CaliforniaArticle . 2024Data sources: eScholarship - University of CaliforniaCopenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06618-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2023 United KingdomPublisher:Springer Science and Business Media LLC Authors: Murray Shanahan; Kyle McDonell; Laria Reynolds;Murray Shanahan; Kyle McDonell; Laria Reynolds;pmid: 37938776
As dialogue agents become increasingly human-like in their performance, it is imperative that we develop effective ways to describe their behaviour in high-level terms without falling into the trap of anthropomorphism. In this paper, we foreground the concept of role-play. Casting dialogue agent behaviour in terms of role-play allows us to draw on familiar folk psychological terms, without ascribing human characteristics to language models they in fact lack. Two important cases of dialogue agent behaviour are addressed this way, namely (apparent) deception and (apparent) self-awareness.
Spiral - Imperial Co... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2023Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryPreprint . 2023Data sources: Spiral - Imperial College Digital RepositoryarXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06647-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 5 citations 5 popularity Average influence Top 10% impulse Average Powered by BIP!more_vert Spiral - Imperial Co... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2023Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryPreprint . 2023Data sources: Spiral - Imperial College Digital RepositoryarXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06647-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Juan Manuel, Parrilla;Juan Manuel, Parrilla;pmid: 37833483
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-03238-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-03238-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Will, Marshall;Will, Marshall;pmid: 37752260
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-03018-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-03018-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Richard, Van Noorden;Richard, Van Noorden;pmid: 37532856
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02470-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02470-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Karan Singhal; Shekoofeh Azizi; Tao Tu; S. Sara Mahdavi; Jason Wei; Hyung Won Chung; Nathan Scales; Ajay Tanwani; Heather Cole-Lewis; Stephen Pfohl; Perry Payne; Martin Seneviratne; Paul Gamble; Chris Kelly; Abubakr Babiker; Nathanael Schärli; Aakanksha Chowdhery; Philip Mansfield; Dina Demner-Fushman; Blaise Agüera y Arcas; Dale Webster; Greg S. Corrado; Yossi Matias; Katherine Chou; Juraj Gottweis; Nenad Tomasev; Yun Liu; Alvin Rajkomar; Joelle Barral; Christopher Semturs; Alan Karthikesalingam; Vivek Natarajan;AbstractLarge language models (LLMs) have demonstrated impressive capabilities, but the bar for clinical applications is high. Attempts to assess the clinical knowledge of models typically rely on automated evaluations based on limited benchmarks. Here, to address these limitations, we present MultiMedQA, a benchmark combining six existing medical question answering datasets spanning professional medicine, research and consumer queries and a new dataset of medical questions searched online, HealthSearchQA. We propose a human evaluation framework for model answers along multiple axes including factuality, comprehension, reasoning, possible harm and bias. In addition, we evaluate Pathways Language Model1 (PaLM, a 540-billion parameter LLM) and its instruction-tuned variant, Flan-PaLM2 on MultiMedQA. Using a combination of prompting strategies, Flan-PaLM achieves state-of-the-art accuracy on every MultiMedQA multiple-choice dataset (MedQA3, MedMCQA4, PubMedQA5 and Measuring Massive Multitask Language Understanding (MMLU) clinical topics6), including 67.6% accuracy on MedQA (US Medical Licensing Exam-style questions), surpassing the prior state of the art by more than 17%. However, human evaluation reveals key gaps. To resolve this, we introduce instruction prompt tuning, a parameter-efficient approach for aligning LLMs to new domains using a few exemplars. The resulting model, Med-PaLM, performs encouragingly, but remains inferior to clinicians. We show that comprehension, knowledge recall and reasoning improve with model scale and instruction prompt tuning, suggesting the potential utility of LLMs in medicine. Our human evaluations reveal limitations of today’s models, reinforcing the importance of both evaluation frameworks and method development in creating safe, helpful LLMs for clinical applications.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06291-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 170 citations 170 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-023-06291-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Shotaro Kinoshita; Hiromi Yokoyama;Shotaro Kinoshita; Hiromi Yokoyama;pmid: 37433929
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02230-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02230-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Authors: Gemma, Conroy;Gemma, Conroy;pmid: 37419951
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02218-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 17 citations 17 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/d41586-023-02218-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu