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description Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Kyrkohistoria Authors: Forsell, Gustaf;Forsell, Gustaf;Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::cf6be8c2999c6af415115cf2d36e1ed5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::cf6be8c2999c6af415115cf2d36e1ed5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publication2022 Sweden EnglishPublisher:Umeå universitet, Institutionen för idé- och samhällsstudier Authors: Åström Elmersjö, Henrik;Åström Elmersjö, Henrik;Review (English): Johan Samuelsson, Läroverken och progressivismen: Perspektiv på historieundervisningens praktik och policy 1920–1950, Lund: Nordic Academic Press, 2021, 290pp.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______264::5f723c663acf6568f8319928dbf01bba&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publication2022 EnglishPublisher:Uppsala universitet, Historiska institutionen Authors: Hunt, Margaret R.;Hunt, Margaret R.;Review of: The society of prisoners: Anglo-French wars and incarceration in the eighteenth century. By Renaud Morieux. Oxford: Oxford University Press, 2019Title in WoS: The society of prisoners: Anglo-French wars and incarceration in the eighteenth century
Digitala Vetenskapli... arrow_drop_down Digitala Vetenskapliga Arkivet - Academic Archive On-lineReview . Other literature type . 2022All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______681::e75ba2487bb038384895bf5c3c57370a&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Digitala Vetenskapli... arrow_drop_down Digitala Vetenskapliga Arkivet - Academic Archive On-lineReview . Other literature type . 2022All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______681::e75ba2487bb038384895bf5c3c57370a&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Antikens kultur och samhällsliv Authors: Karlsson, Lars;Karlsson, Lars;Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::5f6e4fc6908c38f988255e0f77070a35&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::5f6e4fc6908c38f988255e0f77070a35&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Avdelningen Svenska institutet för nordamerikastudier (SINAS) Authors: Hjorthén, Adam;Hjorthén, Adam;Review of Mark Jensen (book and lyrics), Gary Rue (lyrics and musical arrangements), Tyler Michaels King (director), Brian Pekol (musical direction). Runestone! A Rock Musical. St. Paul, MN: History Theater, May 7–29, 2022. 2 hours, 19 minutes. (Online stream), and Gordon Campbell. Norse America: The Story of a Founding Myth. Oxford: Ox- ford University Press, 2021. 247 pages, illustrations. ISBN: 978-0198861553.
Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::ddcd13d969b19eb5f01e7473573b36bc&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::ddcd13d969b19eb5f01e7473573b36bc&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publication2022 Sweden EnglishPublisher:Uppsala universitet, Avdelningen Svenska institutet för nordamerikastudier (SINAS) Authors: Hjorthén, Adam;Hjorthén, Adam;All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::d869795b4c3e00679d4ac9d880a0390f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::d869795b4c3e00679d4ac9d880a0390f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Institutionen för idé- och lärdomshistoria Authors: Wisselgren, Per;Wisselgren, Per;Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_002::a6f62040b504ba1938994c39121f9bfe&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_002::a6f62040b504ba1938994c39121f9bfe&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Teologiska institutionen Authors: Forsell, Gustaf;Forsell, Gustaf;Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::a7aaa16dfd57eb9b2daee64fb1c4a446&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::a7aaa16dfd57eb9b2daee64fb1c4a446&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Sweden, NetherlandsPublisher:Elsevier BV Funded by:UKRI | MICA: randomized trial of..., NIH | Diagnostics and Pharmacot..., NIH | Improving Pediatric Tb Di... +5 projectsUKRI| MICA: randomized trial of therapy shortening for minimal TB with new WHO-recommended doses and FDC drugs in African/Indian HIV+/HIV- children ,NIH| Diagnostics and Pharmacotherapy for Severe Forms of TB ,NIH| Improving Pediatric Tb Diagnosis and Management in Tanzania ,NIH| Optimal dosing of 1st line antituberculosis and antiretroviral drugs in children ,WT ,NIH| PHARMACOKINETICS OF ANTITUBERCULOSIS DRUGS ,NIH| Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children ,NIH| ROLE OF PROSTAGLANDINS IN ANTIHYPERTENSIVE DRUG RESPONSEGafar, F.; Wasmann, R.E.; McIlleron, H.M.; Aarnoutse, R.E.; Aarnoutse, R.E.; Schaaf, H.S.; Marais, B.J.; Agarwal, D.; Antwi, S.; Bang, N.D.; Bekker, A.; Bell, D.J.; Chabala, C.; Choo, L.; Davies, G.R.; Day, J.N.; Dayal, R.; Denti, P.; Donald, P.R.; Engidawork, E.; Garcia-Prats, A.J.; Gibb, D.; Graham, S.M.; Hesseling, A.C.; Heysell, S.K.; Idris, M.I.; Kabra, S.K.; Kinikar, A.; Kumar, A.K.H.; Kwara, A.; Lodha, R.; Magis-Escurra, C.; Martinez, N.; Mathew, B.S.; Mave, V.; Mduma, E.; Mlotha-Mitole, R.; Mpagama, S.G.; Mukherjee, A.; Nataprawira, H.M.; Peloquin, C.A.; Pouplin, T.; Ramachandran, G.; Ranjalkar, J.; Roy, V.; Ruslami, Rovina; Shah, I.; Singh, Y.; Sturkenboom, M.G.; Svensson, E.M.; Svensson, E.M.; Swaminathan, S.; Thatte, U.; Thee, S.; Thomas, T.A.; Tikiso, T.; Touw, D.J.; Turkova, A.; Velpandian, T.; Verhagen, L.M.; Verhagen, L.M.; Winckler, J.L.; Yang, H.; Yunivita, V.; Taxis, K.; Stevens, J.; Alffenaar, J.C.;BACKGROUND: Suboptimal exposure to antituberculosis (anti-TB) drugs has been associated with unfavourable treatment outcomes. We aimed to investigate estimates and determinants of first-line anti-TB drug pharmacokinetics in children and adolescents at a global level. METHODS: We systematically searched MEDLINE, Embase and Web of Science (1990-2021) for pharmacokinetic studies of first-line anti-TB drugs in children and adolescents. Individual patient data were obtained from authors of eligible studies. Summary estimates of total/extrapolated area under the plasma concentration-time curve from 0 to 24 h post-dose (AUC(0-24)) and peak plasma concentration (C (max)) were assessed with random-effects models, normalised with current World Health Organization-recommended paediatric doses. Determinants of AUC(0-24) and C (max) were assessed with linear mixed-effects models. RESULTS: Of 55 eligible studies, individual patient data were available for 39 (71%), including 1628 participants from 12 countries. Geometric means of steady-state AUC(0-24) were summarised for isoniazid (18.7 (95% CI 15.5-22.6) h·mg·L(-1)), rifampicin (34.4 (95% CI 29.4-40.3) h·mg·L(-1)), pyrazinamide (375.0 (95% CI 339.9-413.7) h·mg·L(-1)) and ethambutol (8.0 (95% CI 6.4-10.0) h·mg·L(-1)). Our multivariate models indicated that younger age (especially <2 years) and HIV-positive status were associated with lower AUC(0-24) for all first-line anti-TB drugs, while severe malnutrition was associated with lower AUC(0-24) for isoniazid and pyrazinamide. N-acetyltransferase 2 rapid acetylators had lower isoniazid AUC(0-24) and slow acetylators had higher isoniazid AUC(0-24) than intermediate acetylators. Determinants of C (max) were generally similar to those for AUC(0-24). CONCLUSIONS: This study provides the most comprehensive estimates of plasma exposures to first-line anti-TB drugs in children and adolescents. Key determinants of drug exposures were identified. These may be relevant for population-specific dose adjustment or individualised therapeutic drug monitoring. Contains fulltext : 290797.pdf (Publisher’s version ) (Open Access)
NARCIS arrow_drop_down European Respiratory Journal; METIS Research Information SystemReview . Other literature type . Article . 2022 . 2023 . Peer-reviewedLicense: CC BY NCPublikationer från Uppsala UniversitetArticle . 2023 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down European Respiratory Journal; METIS Research Information SystemReview . Other literature type . Article . 2022 . 2023 . Peer-reviewedLicense: CC BY NCPublikationer från Uppsala UniversitetArticle . 2023 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4161712&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Historiska institutionen Authors: Hunt, Margaret R.;Hunt, Margaret R.;Review of: The society of prisoners: Anglo-French wars and incarceration in the eighteenth century. By Renaud Morieux. Oxford: Oxford University Press, 2019Title in WoS: The society of prisoners: Anglo-French wars and incarceration in the eighteenth century
Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_002::1e58717ad4b6bff60fb376670ebc24ce&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_002::1e58717ad4b6bff60fb376670ebc24ce&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Kyrkohistoria Authors: Forsell, Gustaf;Forsell, Gustaf;Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::cf6be8c2999c6af415115cf2d36e1ed5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::cf6be8c2999c6af415115cf2d36e1ed5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publication2022 Sweden EnglishPublisher:Umeå universitet, Institutionen för idé- och samhällsstudier Authors: Åström Elmersjö, Henrik;Åström Elmersjö, Henrik;Review (English): Johan Samuelsson, Läroverken och progressivismen: Perspektiv på historieundervisningens praktik och policy 1920–1950, Lund: Nordic Academic Press, 2021, 290pp.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______264::5f723c663acf6568f8319928dbf01bba&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______264::5f723c663acf6568f8319928dbf01bba&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publication2022 EnglishPublisher:Uppsala universitet, Historiska institutionen Authors: Hunt, Margaret R.;Hunt, Margaret R.;Review of: The society of prisoners: Anglo-French wars and incarceration in the eighteenth century. By Renaud Morieux. Oxford: Oxford University Press, 2019Title in WoS: The society of prisoners: Anglo-French wars and incarceration in the eighteenth century
Digitala Vetenskapli... arrow_drop_down Digitala Vetenskapliga Arkivet - Academic Archive On-lineReview . Other literature type . 2022All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______681::e75ba2487bb038384895bf5c3c57370a&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Digitala Vetenskapli... arrow_drop_down Digitala Vetenskapliga Arkivet - Academic Archive On-lineReview . Other literature type . 2022All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______681::e75ba2487bb038384895bf5c3c57370a&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Antikens kultur och samhällsliv Authors: Karlsson, Lars;Karlsson, Lars;Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::5f6e4fc6908c38f988255e0f77070a35&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::5f6e4fc6908c38f988255e0f77070a35&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Avdelningen Svenska institutet för nordamerikastudier (SINAS) Authors: Hjorthén, Adam;Hjorthén, Adam;Review of Mark Jensen (book and lyrics), Gary Rue (lyrics and musical arrangements), Tyler Michaels King (director), Brian Pekol (musical direction). Runestone! A Rock Musical. St. Paul, MN: History Theater, May 7–29, 2022. 2 hours, 19 minutes. (Online stream), and Gordon Campbell. Norse America: The Story of a Founding Myth. Oxford: Ox- ford University Press, 2021. 247 pages, illustrations. ISBN: 978-0198861553.
Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::ddcd13d969b19eb5f01e7473573b36bc&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::ddcd13d969b19eb5f01e7473573b36bc&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publication2022 Sweden EnglishPublisher:Uppsala universitet, Avdelningen Svenska institutet för nordamerikastudier (SINAS) Authors: Hjorthén, Adam;Hjorthén, Adam;All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::d869795b4c3e00679d4ac9d880a0390f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::d869795b4c3e00679d4ac9d880a0390f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Institutionen för idé- och lärdomshistoria Authors: Wisselgren, Per;Wisselgren, Per;Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_002::a6f62040b504ba1938994c39121f9bfe&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_002::a6f62040b504ba1938994c39121f9bfe&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Teologiska institutionen Authors: Forsell, Gustaf;Forsell, Gustaf;Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::a7aaa16dfd57eb9b2daee64fb1c4a446&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______361::a7aaa16dfd57eb9b2daee64fb1c4a446&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Sweden, NetherlandsPublisher:Elsevier BV Funded by:UKRI | MICA: randomized trial of..., NIH | Diagnostics and Pharmacot..., NIH | Improving Pediatric Tb Di... +5 projectsUKRI| MICA: randomized trial of therapy shortening for minimal TB with new WHO-recommended doses and FDC drugs in African/Indian HIV+/HIV- children ,NIH| Diagnostics and Pharmacotherapy for Severe Forms of TB ,NIH| Improving Pediatric Tb Diagnosis and Management in Tanzania ,NIH| Optimal dosing of 1st line antituberculosis and antiretroviral drugs in children ,WT ,NIH| PHARMACOKINETICS OF ANTITUBERCULOSIS DRUGS ,NIH| Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in Children ,NIH| ROLE OF PROSTAGLANDINS IN ANTIHYPERTENSIVE DRUG RESPONSEGafar, F.; Wasmann, R.E.; McIlleron, H.M.; Aarnoutse, R.E.; Aarnoutse, R.E.; Schaaf, H.S.; Marais, B.J.; Agarwal, D.; Antwi, S.; Bang, N.D.; Bekker, A.; Bell, D.J.; Chabala, C.; Choo, L.; Davies, G.R.; Day, J.N.; Dayal, R.; Denti, P.; Donald, P.R.; Engidawork, E.; Garcia-Prats, A.J.; Gibb, D.; Graham, S.M.; Hesseling, A.C.; Heysell, S.K.; Idris, M.I.; Kabra, S.K.; Kinikar, A.; Kumar, A.K.H.; Kwara, A.; Lodha, R.; Magis-Escurra, C.; Martinez, N.; Mathew, B.S.; Mave, V.; Mduma, E.; Mlotha-Mitole, R.; Mpagama, S.G.; Mukherjee, A.; Nataprawira, H.M.; Peloquin, C.A.; Pouplin, T.; Ramachandran, G.; Ranjalkar, J.; Roy, V.; Ruslami, Rovina; Shah, I.; Singh, Y.; Sturkenboom, M.G.; Svensson, E.M.; Svensson, E.M.; Swaminathan, S.; Thatte, U.; Thee, S.; Thomas, T.A.; Tikiso, T.; Touw, D.J.; Turkova, A.; Velpandian, T.; Verhagen, L.M.; Verhagen, L.M.; Winckler, J.L.; Yang, H.; Yunivita, V.; Taxis, K.; Stevens, J.; Alffenaar, J.C.;BACKGROUND: Suboptimal exposure to antituberculosis (anti-TB) drugs has been associated with unfavourable treatment outcomes. We aimed to investigate estimates and determinants of first-line anti-TB drug pharmacokinetics in children and adolescents at a global level. METHODS: We systematically searched MEDLINE, Embase and Web of Science (1990-2021) for pharmacokinetic studies of first-line anti-TB drugs in children and adolescents. Individual patient data were obtained from authors of eligible studies. Summary estimates of total/extrapolated area under the plasma concentration-time curve from 0 to 24 h post-dose (AUC(0-24)) and peak plasma concentration (C (max)) were assessed with random-effects models, normalised with current World Health Organization-recommended paediatric doses. Determinants of AUC(0-24) and C (max) were assessed with linear mixed-effects models. RESULTS: Of 55 eligible studies, individual patient data were available for 39 (71%), including 1628 participants from 12 countries. Geometric means of steady-state AUC(0-24) were summarised for isoniazid (18.7 (95% CI 15.5-22.6) h·mg·L(-1)), rifampicin (34.4 (95% CI 29.4-40.3) h·mg·L(-1)), pyrazinamide (375.0 (95% CI 339.9-413.7) h·mg·L(-1)) and ethambutol (8.0 (95% CI 6.4-10.0) h·mg·L(-1)). Our multivariate models indicated that younger age (especially <2 years) and HIV-positive status were associated with lower AUC(0-24) for all first-line anti-TB drugs, while severe malnutrition was associated with lower AUC(0-24) for isoniazid and pyrazinamide. N-acetyltransferase 2 rapid acetylators had lower isoniazid AUC(0-24) and slow acetylators had higher isoniazid AUC(0-24) than intermediate acetylators. Determinants of C (max) were generally similar to those for AUC(0-24). CONCLUSIONS: This study provides the most comprehensive estimates of plasma exposures to first-line anti-TB drugs in children and adolescents. Key determinants of drug exposures were identified. These may be relevant for population-specific dose adjustment or individualised therapeutic drug monitoring. Contains fulltext : 290797.pdf (Publisher’s version ) (Open Access)
NARCIS arrow_drop_down European Respiratory Journal; METIS Research Information SystemReview . Other literature type . Article . 2022 . 2023 . Peer-reviewedLicense: CC BY NCPublikationer från Uppsala UniversitetArticle . 2023 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4161712&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down European Respiratory Journal; METIS Research Information SystemReview . Other literature type . Article . 2022 . 2023 . Peer-reviewedLicense: CC BY NCPublikationer från Uppsala UniversitetArticle . 2023 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4161712&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2022 Sweden EnglishPublisher:Uppsala universitet, Historiska institutionen Authors: Hunt, Margaret R.;Hunt, Margaret R.;Review of: The society of prisoners: Anglo-French wars and incarceration in the eighteenth century. By Renaud Morieux. Oxford: Oxford University Press, 2019Title in WoS: The society of prisoners: Anglo-French wars and incarceration in the eighteenth century
Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_002::1e58717ad4b6bff60fb376670ebc24ce&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Publikationer från U... arrow_drop_down Publikationer från Uppsala UniversitetReview . 2022Data sources: Publikationer från Uppsala UniversitetAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_002::1e58717ad4b6bff60fb376670ebc24ce&type=result"></script>'); --> </script>
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