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Abstract. The Last Interglacial period (LIG) is a period with increased summer insolation at high northern latitudes, which results in strong changes in the terrestrial and marine cryosphere. Understanding the mechanisms for this response via climate modelling and comparing the models' representation of climate reconstructions is one of the objectives set up by the Paleoclimate Modelling Intercomparison Project for its contribution to the sixth phase of the Coupled Model Intercomparison Project. Here we analyse the results from 16 climate models in terms of Arctic sea ice. The multi-model mean reduction in minimum sea ice area from the pre industrial period (PI) to the LIG reaches 50 % (multi-model mean LIG area is 3.20×106 km2, compared to 6.46×106 km2 for the PI). On the other hand, there is little change for the maximum sea ice area (which is 15–16×106 km2 for both the PI and the LIG. To evaluate the model results we synthesise LIG sea ice data from marine cores collected in the Arctic Ocean, Nordic Seas and northern North Atlantic. The reconstructions for the northern North Atlantic show year-round ice-free conditions, and most models yield results in agreement with these reconstructions. Model–data disagreement appear for the sites in the Nordic Seas close to Greenland and at the edge of the Arctic Ocean. The northernmost site with good chronology, for which a sea ice concentration larger than 75 % is reconstructed even in summer, discriminates those models which simulate too little sea ice. However, the remaining models appear to simulate too much sea ice over the two sites south of the northernmost one, for which the reconstructed sea ice cover is seasonal. Hence models either underestimate or overestimate sea ice cover for the LIG, and their bias does not appear to be related to their bias for the pre-industrial period. Drivers for the inter-model differences are different phasing of the up and down short-wave anomalies over the Arctic Ocean, which are associated with differences in model albedo; possible cloud property differences, in terms of optical depth; and LIG ocean circulation changes which occur for some, but not all, LIG simulations. Finally, we note that inter-comparisons between the LIG simulations and simulations for future climate with moderate (1 % yr−1) CO2 increase show a relationship between LIG sea ice and sea ice simulated under CO2 increase around the years of doubling CO2. The LIG may therefore yield insight into likely 21st century Arctic sea ice changes using these LIG simulations. International audience

Abstract The two branches of the East African Rift System (EARS) are believed to have initiated diachronously. However, a growing body of work continues to suggest the onset of rifting in the Western Branch occurred in the Paleogene, coeval to the Eastern Branch. Due to a lack of pre-Miocene stratigraphy, attempts to resolve the geological history of the Western Branch must study the uplift and erosional histories of the modern rift topography. In this study, the rock uplift history of the Rwenzori Mountains, Western Uganda, is resolved to better our understanding of the tectonic history of the Western Branch of the EAR. Through the application of low-temperature thermochronology, χ-mapping and the modelling of river profiles, we show that rock uplift of the Rwenzori dates back to the Oligocene, with thermal history models suggesting uplift induced exhumation may date back as far as the Eocene. This provides tangible evidence that extension began in the region in the Paleogene, coeval with the Eastern Branch, and not the late Neogene. These results have broad implications for the tectonic evolution of the entire East African Rift System and suggest our current understanding of the region's rift history remains incomplete.

Strontium isotopes (⁸⁷Sr/⁸⁶Sr) are used as geochemical tracers for paleomobility studies because they display predictable and stable patterns in ecosystems primarily controlled by the underlying geological regimes. While bedrock geology is stable over thousands of years, geomorphological processes can influence the ⁸⁷Sr/⁸⁶Sr in ecosystems over archeologically relevant timescales. Among these geomorphological processes, the deposition and reworking of volcanic sediments over Quaternary timescales are little studied but could be an important control of ⁸⁷Sr/⁸⁶Sr variations in many archeological regions. North Patagonia is a key archeological region to address animal and human movements, and an ideal location to test the influence of Quaternary volcanism on ⁸⁷Sr/⁸⁶Sr variation as it is located downwind of major volcanic centers. In this study, we aim to assess the main environmental and geological controls of bioavailable ⁸⁷Sr/⁸⁶Sr and to build a high-resolution isoscape using a machine learning regression framework for forthcoming paleomobility studies. We sampled several locations and analyzed different types of samples (N = 94). The ratios show a limited range of variation, which is not related to the bedrock geology. Rather, bioavailable ⁸⁷Sr/⁸⁶Sr variations display a progressive increase going eastward (away from the Andes), following dust aerosol deposition and elevation variations (R² = 0.71, RMSE = 0.00041). We argue that this trend relates to the deposition and reworking of unradiogenic volcanic sediments by aeolian, fluvial and glacial erosion during the Quaternary. As most of this sediment reworking occurred during glacial periods, the current bioavailable ⁸⁷Sr/⁸⁶Sr variations across the study area likely represent a long-term average that varied little during the Holocene. Consequently, our isoscape provides a solid base for Holocene paleomobility studies in North Patagonia and underlines the importance of Quaternary volcanism processes for interpreting ⁸⁷Sr/⁸⁶Sr data in paleomobility studies in volcanic regions. Facultad de Ciencias Naturales y Museo

Magnetoencephalography (MEG) records weak magnetic fields outside the human head and thereby provides millisecond-accurate information about neuronal currents supporting human brain function. MEG and electroencephalography (EEG) are closely related complementary methods and should be interpreted together whenever possible. This manuscript covers the basic physical and physiological principles of MEG and discusses the main aspects of state-of-the-art MEG data analysis. We provide guidelines for best practices of patient preparation, stimulus presentation, MEG data collection and analysis, as well as for MEG interpretation in routine clinical examinations. In 2017, about 200 whole-scalp MEG devices were in operation worldwide, many of them located in clinical environments. Yet, the established clinical indications for MEG examinations remain few, mainly restricted to the diagnostics of epilepsy and to preoperative functional evaluation of neurosurgical patients. We are confident that the extensive ongoing basic MEG research indicates potential for the evaluation of neurological and psychiatric syndromes, developmental disorders, and the integrity of cortical brain networks after stroke. Basic and clinical research is, thus, paving way for new clinical applications to be identified by an increasing number of practitioners of MEG. Highlights • The main principles of magnetoencephalography (MEG) and the value of combined MEG and EEG are discussed. • Established and some potential future clinical applications of MEG are reviewed. • Practical guidelines for clinical MEG examinations are presented.

S.J.O., T.W.J.G., L.Br., A.Lo., A.A.C., D.S.S., E.A.C., C.M., J.B., D.M.A., F.C., and M.C.F. were supported through NERC (standard grant NE/K014455/1). S.J.O. acknowledges a Microsoft Azure for Research Sponsorship (subscription ID: ab7cd695-49cf-4a83-910a-ef71603e708b). T.W.J.G., A.Lo., A.A.C., D.S.S., E.A.C., C.M., J.B., D.M.A., F.C., and M.C.F. were also supported by the EU BiodivERsA scheme (RACE, funded through NERC directed grant NE/G002193/1 and ANR08-Biodiversa-002-03) and NERC (standard grant NE/K012509/1). M.C.F., E.A.C., and C.M. acknowledge the Nouragues Travel Grant Program 2014. R.A.F. was supported by an MIT/Wellcome Trust Fellowship. T.W.J.G. was supported by the People’s Trust for Endangered Species and the Morris Animal Foundation (D12ZO002). J.M.G.S. and M.C.F. were supported by the Leverhulme Trust (RPG-2014-273) and the Morris Animal Foundation (D16ZO-022). F.B. was supported by the ERC (grant ERC 260801–Big_Idea). D.M.A. was funded by Wellcome Trust grant 099202. J.V. was supported by the Hungarian Scientific Research Fund (OTKA K77841) and Bolyai János Research Scholarship, Hungarian Academy of Sciences (BO/00579/14/8). D.J.G. was supported by the Conservation Leadership Programme (grant 0134010) with additional assistance from F. Gebresenbet, R. Kassahun, and S. P. Loader. C.S.-A. was supported by Fondecyt Nº11140902 and 1181758. T.M.D.-B. was supported by the Royal Geographical Society and the Royal Zoological Society of Scotland with assistance from M. Hirschfeld and the Budongo Conservation Field Station. B.W. was supported by the National Research Foundation of Korea (2015R1D1A1A01057282). L.F.T. was supported by FAPESP (#2016/25358-3) and CNPq (#300896/2016-6). L.Be., L.F.S., and R.J.W. were supported by the Australian Research Council (FT100100375, DP120100811). A.A.C. was supported by a Royal Society Wolfson Research Merit award. J.H., A.La., and S.M. were funded by the Swedish Research Council Formas (grant no. 2013- 1389-26445-20). C.W. was funded by the National Research Foundation, South Africa. T.Y.J. and T.S.J. acknowledge NSF grant DEB-1601259. W.E.H. was funded by the NSERC Strategic and Discovery grant programs Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis, a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, BdASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity and the original source of these lineages that now parasitize amphibians worldwide.