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description Publicationkeyboard_double_arrow_right Article 2022 United Kingdom, United Kingdom, Denmark, NetherlandsPublisher:Springer Science and Business Media LLC Funded by:EC | COREX, WT | Human Adaptation to Chang..., EC | MICROSCOPE +1 projectsEC| COREX ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,EC| MICROSCOPE ,NIH| Population mixture in evolutionary and medical geneticsJoscha Gretzinger; Duncan Sayer; Pierre Justeau; Eveline Altena; Maria Pala; Katharina Dulias; Ceiridwen J. Edwards; Susanne Jodoin; Laura Lacher; Susanna Sabin; Åshild J. Vågene; Wolfgang Haak; S. Sunna Ebenesersdóttir; Kristjan H. S. Moore; Rita Radzeviciute; Kara Schmidt; Selina Brace; Martina Abenhus Bager; Nick Patterson; Luka Papac; Nasreen Broomandkhoshbacht; Kimberly Callan; Éadaoin Harney; Lora Iliev; Ann Marie Lawson; Megan Michel; Kristin Stewardson; Fatma Zalzala; Nadin Rohland; Stefanie Kappelhoff-Beckmann; Frank Both; Daniel Winger; Daniel Neumann; Lars Saalow; Stefan Krabath; Sophie Beckett; Melanie Van Twest; Neil Faulkner; Chris Read; Tabatha Barton; Joanna Caruth; John Hines; Ben Krause-Kyora; Ursula Warnke; Verena J. Schuenemann; Ian Barnes; Hanna Dahlström; Jane Jark Clausen; Andrew Richardson; Elizabeth Popescu; Natasha Dodwell; Stuart Ladd; Tom Phillips; Richard Mortimer; Faye Sayer; Diana Swales; Allison Stewart; Dominic Powlesland; Robert Kenyon; Lilian Ladle; Christina Peek; Silke Grefen-Peters; Paola Ponce; Robin Daniels; Cecily Spall; Jennifer Woolcock; Andy M. Jones; Amy V. Roberts; Robert Symmons; Anooshka C. Rawden; Alan Cooper; Kirsten I. Bos; Tom Booth; Hannes Schroeder; Mark G. Thomas; Agnar Helgason; Martin B. Richards; David Reich; Johannes Krause; Stephan Schiffels;pmid: 36253469
pmc: PMC9534755
The history of the British Isles and Ireland is characterized by multiple periods of major cultural change, including the influential transformation after the end of Roman rule, which precipitated shifts in language, settlement patterns and material culture1. The extent to which migration from continental Europe mediated these transitions is a matter of long-standing debate2–4. Here we study genome-wide ancient DNA from 460 medieval northwestern Europeans—including 278 individuals from England—alongside archaeological data, to infer contemporary population dynamics. We identify a substantial increase of continental northern European ancestry in early medieval England, which is closely related to the early medieval and present-day inhabitants of Germany and Denmark, implying large-scale substantial migration across the North Sea into Britain during the Early Middle Ages. As a result, the individuals who we analysed from eastern England derived up to 76% of their ancestry from the continental North Sea zone, albeit with substantial regional variation and heterogeneity within sites. We show that women with immigrant ancestry were more often furnished with grave goods than women with local ancestry, whereas men with weapons were as likely not to be of immigrant ancestry. A comparison with present-day Britain indicates that subsequent demographic events reduced the fraction of continental northern European ancestry while introducing further ancestry components into the English gene pool, including substantial southwestern European ancestry most closely related to that seen in Iron Age France
CORE (RIOXX-UK Aggre... arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 28 citations 28 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 19visibility views 19 download downloads 18 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Netherlands, Croatia, United Kingdom, United Kingdom, SpainPublisher:Springer Science and Business Media LLC Funded by:NIH | Advanced tools for using ..., WT | Human Adaptation to Chang..., FCT | LA 14 +4 projectsNIH| Advanced tools for using ancient DNA to study biology and history ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,FCT| LA 14 ,UKRI| Urban-Air Port | "Air-One" [Rapidly Deployable Vertiport For Drone-Delivery, Air-Taxi, Disaster Management] ,EC| COREX ,EC| COMMIOS ,NIH| Population mixture in evolutionary and medical geneticsNick Patterson; Michael Isakov; Thomas Booth; Lindsey Büster; Claire-Elise Fischer; Iñigo Olalde; Harald Ringbauer; Ali Akbari; Olivia Cheronet; Madeleine Bleasdale; Nicole Adamski; Eveline Altena; Rebecca Bernardos; Selina Brace; Nasreen Broomandkhoshbacht; Kimberly Callan; Francesca Candilio; Brendan Culleton; Elizabeth Curtis; Lea Demetz; Kellie Sara Duffett Carlson; Ceiridwen J. Edwards; Daniel M. Fernandes; M. George B. Foody; Suzanne Freilich; Helen Goodchild; Aisling Kearns; Ann Marie Lawson; Iosif Lazaridis; Matthew Mah; Swapan Mallick; Kirsten Mandl; Adam Micco; Megan Michel; Guillermo Bravo Morante; Jonas Oppenheimer; Kadir Toykan Özdoğan; Lijun Qiu; Constanze Schattke; Kristin Stewardson; J. Noah Workman; Fatma Zalzala; Zhao Zhang; Bibiana Agustí; Tim Allen; Katalin Almássy; Luc Amkreutz; Abigail Ash; Christèle Baillif-Ducros; Alistair Barclay; László Bartosiewicz; Katherine Baxter; Zsolt Bernert; Jan Blažek; Mario Bodružić; Philippe Boissinot; Clive Bonsall; Pippa Bradley; Marcus Brittain; Alison Brookes; Fraser Brown; Lisa Brown; Richard Brunning; Chelsea Budd; Josip Burmaz; Sylvain Canet; Silvia Carnicero-Cáceres; Morana Čaušević-Bully; Andrew Chamberlain; Sébastien Chauvin; Sharon Clough; Natalija Čondić; Alfredo Coppa; Oliver Craig; Matija Črešnar; Vicki Cummings; Szabolcs Czifra; Alžběta Danielisová; Robin Daniels; Alex Davies; Philip de Jersey; Jody Deacon; Csilla Deminger; Peter W. Ditchfield; Marko Dizdar; Miroslav Dobeš; Miluše Dobisíková; László Domboróczki; Gail Drinkall; Ana Đukić; Michal Ernée; Christopher Evans; Jane Evans; Manuel Fernández-Götz; Slavica Filipović; Andrew Fitzpatrick; Harry Fokkens; Chris Fowler; Allison Fox; Zsolt Gallina; Michelle Gamble; Manuel R. González Morales; Borja González-Rabanal; Adrian Green; Katalin Gyenesei; Diederick Habermehl; Tamás Hajdu; Derek Hamilton; James Harris; Chris Hayden; Joep Hendriks; Bénédicte Hernu; Gill Hey; Milan Horňák; Gábor Ilon; Eszter Istvánovits; Andy M. Jones; Martina Blečić Kavur; Kevin Kazek; Robert A. Kenyon; Amal Khreisheh; Viktória Kiss; Jos Kleijne; Mark Knight; Lisette M. Kootker; Péter F. Kovács; Anita Kozubová; Gabriella Kulcsár; Valéria Kulcsár; Christophe Le Pennec; Michael Legge; Matt Leivers; Louise Loe; Olalla López-Costas; Tom Lord; Dženi Los; James Lyall; Ana B. Marín-Arroyo; Philip Mason; Damir Matošević; Andy Maxted; Lauren McIntyre; Jacqueline McKinley; Kathleen McSweeney; Bernard Meijlink; Balázs G. Mende; Marko Menđušić; Milan Metlička; Sophie Meyer; Kristina Mihovilić; Lidija Milasinovic; Steve Minnitt; Joanna Moore; Geoff Morley; Graham Mullan; Margaréta Musilová; Benjamin Neil; Rebecca Nicholls; Mario Novak; Maria Pala; Martin Papworth; Cécile Paresys; Ricky Patten; Domagoj Perkić; Krisztina Pesti; Alba Petit; Katarína Petriščáková; Coline Pichon; Catriona Pickard; Zoltán Pilling; T. Douglas Price; Siniša Radović; Rebecca Redfern; Branislav Resutík; Daniel T. Rhodes; Martin B. Richards; Amy Roberts; Jean Roefstra; Pavel Sankot; Alena Šefčáková; Alison Sheridan; Sabine Skae; Miroslava Šmolíková; Krisztina Somogyi; Ágnes Somogyvári; Mark Stephens; Géza Szabó; Anna Szécsényi-Nagy; Tamás Szeniczey; Jonathan Tabor; Károly Tankó; Clenis Tavarez Maria; Rachel Terry; Biba Teržan; Maria Teschler-Nicola; Jesús F. Torres-Martínez; Julien Trapp; Ross Turle; Ferenc Ujvári; Menno van der Heiden; Petr Veleminsky; Barbara Veselka; Carles Lalueza-Fox; Peter de Knijff; Ian Barnes; Mark G. Thomas; Douglas J. Kennett; Malcolm Lillie; Ron Pinhasi; David Reich;pmc: PMC8889665
This work was funded in part by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 834087; the COMMIOS Project to I.A.). M.N. was supported by the Croatian Science Fund grant (HRZZ IP-2016-06-1450). P.V., M.Dobeš and Z.V. were supported by the Ministry of Culture of the Czech Republic (DKRVO 2019-2023/7.I.c, 00023272). M.E. was supported by Czech Academy of Sciences award Praemium Academiae. M.Dobisíková and A.Danielisová were supported by the grant RVO 67985912 of the Institute of Archaeology of the Czech Academy of Sciences. M.G.B.F. was funded by The Leverhulme Trust via a Doctoral Scholarship scheme awarded to M.Pala and M.B.R. Support to M.Legge came from the South, West & Wales Doctoral Training Partnership. M.G.’s osteological analyses were funded by Culture Vannin. A.S.-N. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. T.H., T.S. and K.K.’s work was supported by a grant from the Hungarian Research, Development and Innovation Office (project number: FK128013). We acknowledge support for radiocarbon dating and stable isotope analyses as well as access to skeletal material from Manx National Heritage and A. Fox. Dating analysis was funded by Leverhulme Trust grant RPG-388. M.G.T. and I.B. were supported by a Wellcome Trust Investigator Award (project 100713/Z/12/Z). I.O. was supported by a Ramón y Cajal grant from Ministerio de Ciencia e Innovación, Spanish Government (RYC2019-027909-I). The research directed at Harvard was funded by NIH grants GM100233 and HG012287, by John Templeton Foundation grant 61220, by a gift from Jean-François Clin, and by the Allen Discovery Center program, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. D.R. is also an Investigator of the Howard Hughes Medical Institute. Present-day people from England and Wales have more ancestry derived from early European farmers (EEF) than did people of the Early Bronze Age1. To understand this, here we generated genome-wide data from 793 individuals, increasing data from the Middle to the Late Bronze Age and Iron Age in Britain by 12-fold, and western and central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of people of England and Wales from the Iron Age, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to the Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and the independent genetic trajectory in Britain is also reflected in the rise of the allele conferring lactase persistence to approximately 50% by this time compared to approximately 7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period. Peer reviewed
CORE (RIOXX-UK Aggre... arrow_drop_down NARCIS; Nature; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional RepositoryArticle . 2021 . 2022NARCIS; NatureArticle . 2021 . 2022Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Springer TDMLeiden University Scholarly Publications RepositoryArticle . 2021Data sources: Leiden University Scholarly Publications Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 72 citations 72 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 216visibility views 216 download downloads 1,655 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down NARCIS; Nature; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional RepositoryArticle . 2021 . 2022NARCIS; NatureArticle . 2021 . 2022Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Springer TDMLeiden University Scholarly Publications RepositoryArticle . 2021Data sources: Leiden University Scholarly Publications Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, Spain, Belgium, United KingdomPublisher:Springer Science and Business Media LLC Funded by:NIH | Population mixture in evo..., WT | Inferring human colonizat..., NSF | Investigating The Relatio... +1 projectsNIH| Population mixture in evolutionary and medical genetics ,WT| Inferring human colonization history using genetic data. ,NSF| Investigating The Relationship Between Climate Change And Social Organization In A Small Scale Society ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present.Mark Lipson; Isabelle Ribot; Swapan Mallick; Nadin Rohland; Iñigo Olalde; Nicole Adamski; Nasreen Broomandkhoshbacht; Ann Marie Lawson; Saioa López; Jonas Oppenheimer; Kristin Stewardson; R. Asombang; Hervé Bocherens; Neil Bradman; Brendan J. Culleton; Els Cornelissen; Isabelle Crevecoeur; Pierre de Maret; Forka Leypey Mathew Fomine; P. Lavachery; Christophe Mbida Mindzie; Rosine Orban; Elizabeth A. Sawchuk; Patrick Semal; Mark G. Thomas; Wim Van Neer; Krishna R. Veeramah; Douglas J. Kennett; Nick Patterson; Garrett Hellenthal; Carles Lalueza-Fox; Scott MacEachern; Mary E. Prendergast; David Reich;The Shum Laka excavations were supported by the Belgian Fund for Scientific Research (FNRS), the Université Libre de Bruxelles, the Royal Museum for Central Africa and the Leakey Foundation. The collection of samples from present-day individuals in Cameroon was supported by N. Bradman and the Melford Charitable Trust. The genotyping of the present-day individuals sampled from Cameroon was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/L009382/1). I.R. was supported by a Université de Montréal exploration grant (2018-2020). M.G.T. was supported by Wellcome Trust Senior Investigator Award Grant 100719/Z/12/Z. G.H. was supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant number 098386/Z/12/Z). C.L-F. was supported by Obra Social La Caixa 328, Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880), and a FEDER-MINECO grant (PGC2018-095931-B-100). Radiocarbon work was supported by the NSF Archaeometry program (grant BCS-1460369) to D.J.K. and B.J.C. M.E.P. was supported by a fellowship from the Radcliffe Institute for Advanced Study at Harvard University during the development of this project. D.R. was supported by the National Institutes of Health (NIGMS GM100233), by an Allen Discovery Center grant and by grant 61220 from the John Templeton Foundation, and is an Investigator of the Howard Hughes Medical Institute. Our knowledge of ancient human population structure in sub-Saharan Africa, particularly prior to the advent of food production, remains limited. Here we report genome-wide DNA data from four children—two of whom were buried approximately 8,000 years ago and two 3,000 years ago—from Shum Laka (Cameroon), one of the earliest known archaeological sites within the probable homeland of the Bantu language group1,2,3,4,5,6,7,8,9,10,11. One individual carried the deeply divergent Y chromosome haplogroup A00, which today is found almost exclusively in the same region12,13. However, the genome-wide ancestry profiles of all four individuals are most similar to those of present-day hunter-gatherers from western Central Africa, which implies that populations in western Cameroon today—as well as speakers of Bantu languages from across the continent—are not descended substantially from the population represented by these four people. We infer an Africa-wide phylogeny that features widespread admixture and three prominent radiations, including one that gave rise to at least four major lineages deep in the history of modern humans. Peer reviewed
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8386425Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2020 . Peer-reviewedMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02990305/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 88 citations 88 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 18visibility views 18 download downloads 61 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8386425Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2020 . Peer-reviewedMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02990305/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2018 United States, Finland, DenmarkPublisher:Cold Spring Harbor Laboratory Funded by:NIH | Powering whole genome seq..., NIH | Genome-wide approaches to..., NIH | Leveraging functional dat... +10 projectsNIH| Powering whole genome sequence-based genetic discovery for common human diseases- Extended 2021-2022. ,NIH| Genome-wide approaches to polygenic adaptation ,NIH| Leveraging functional data to predict disease risk in multi-ethnic populations ,NIH| Population genetic modeling of the genetic architecture of complex disease ,NIH| Statistical methods for studies of rare variants ,NIH| Natural selection in recent human evolution ,WT ,NIH| Integration of functional data and GWAS to elucidate genetic basis of diseases ,NIH| The population genetics of disease risk and other quantitative traits ,NIH| Functional and population genetic architectures of complex disease ,NIH| Population mixture in evolutionary and medical genetics ,NIH| The origin, the function and the phenotypic impact of human alleles ,NIH| The population genetics of disease risk and other quantitative traitsMashaal Sohail; Robert Maier; Andrea Ganna; Alex Bloemendal; Alicia R. Martin; Michael C. Turchin; Charleston W. K. Chiang; Joel N. Hirschhorn; Mark J. Daly; Nick Patterson; Benjamin M. Neale; Iain Mathieson; David Reich; Shamil R. Sunyaev;handle: 10138/300784
pmc: PMC6428571 , PMC6428565 , PMC6428572
Genetic predictions of height differ among human populations and these differences have been interpreted as evidence of polygenic adaptation. These differences were first detected using SNPs genome-wide significantly associated with height, and shown to grow stronger when large numbers of sub-significant SNPs were included, leading to excitement about the prospect of analyzing large fractions of the genome to detect polygenic adaptation for multiple traits. Previous studies of height have been based on SNP effect size measurements in the GIANT Consortium meta-analysis. Here we repeat the analyses in the UK Biobank, a much more homogeneously designed study. We show that polygenic adaptation signals based on large numbers of SNPs below genome-wide significance are extremely sensitive to biases due to uncorrected population stratification. More generally, our results imply that typical constructions of polygenic scores are sensitive to population stratification and that population-level differences should be interpreted with caution. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter). Peer reviewed
bioRxiv arrow_drop_down bioRxivPreprint . 2018eLifeArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428572Data sources: PubMed CentralEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428571Data sources: PubMed CentralEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428565Data sources: PubMed CentralHELDA - Digital Repository of the University of HelsinkiArticle . 2019 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 318 citations 318 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert bioRxiv arrow_drop_down bioRxivPreprint . 2018eLifeArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428572Data sources: PubMed CentralEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428571Data sources: PubMed CentralEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428565Data sources: PubMed CentralHELDA - Digital Repository of the University of HelsinkiArticle . 2019 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2018 United Kingdom, France, FrancePublisher:Cold Spring Harbor Laboratory Funded by:WT, ARC | Northern Vanuatu as a Pac..., ARC | Persistence and transform... +5 projectsWT ,ARC| Northern Vanuatu as a Pacific Crossroads: The archaeology of discovery, interaction and the emergence of the ethnographic present ,ARC| Persistence and transformation in Ancestral Oceanic Society: the archaeology of the first 1500 years in the Vanuatu archipelago ,NSF| A new history and geography of human genes informed by ancient DNA ,WT| Characterisation of the Effect of Newly Identified Associated Genetic Variantson Lymphocyte Differentiation and Response to Childhood Vaccination. ,NSF| Investigating The Relationship Between Climate Change And Social Organization In A Small Scale Society ,ARC| Understanding the migrations of prehistoric populations through direct dating and isotopic tracking of their mobility patterns ,NIH| Population mixture in evolutionary and medical geneticsMark Lipson; Pontus Skoglund; Matthew Spriggs; Frédérique Valentin; Stuart Bedford; Richard Shing; Hallie R. Buckley; Iarawai Phillip; Graeme K. Ward; Swapan Mallick; Nadin Rohland; Nasreen Broomandkhoshbacht; Olivia Cheronet; Matthew Ferry; Thomas K. Harper; Megan Michel; Jonas Oppenheimer; Kendra Sirak; Kristin Stewardson; Kathryn Auckland; Adrian V. S. Hill; Kathryn Maitland; Stephen Oppenheimer; Tom Parks; Kathryn J. H. Robson; Thomas N. Williams; Douglas J. Kennett; Alexander J. Mentzer; Ron Pinhasi; David Reich;SummaryAncient DNA analysis of three individuals dated to ~3000 years before present (BP) from Vanuatu and one ~2600 BP individual from Tonga has revealed that the first inhabitants of Remote Oceania (“First Remote Oceanians”) were almost entirely of East Asian ancestry, and thus their ancestors passed New Guinea, the Bismarck Archipelago, and the Solomon Islands with minimal admixture with the Papuan groups they encountered [1]. However, all present-day populations in Near and Remote Oceania harbor 25-100% Papuan ancestry, implying that there must have been at least one later stream of migration eastward from Near Oceania. We generated genome-wide data for 14 ancient individuals from Efate and Epi Islands in Vanuatu ranging from 3,000-150 BP, along with 185 present-day Vanuatu individuals from 18 islands. We show that people of almost entirely Papuan ancestry had arrived in Vanuatu by 2400 BP, an event that coincided with the end of the Lapita cultural period, changes in skeletal morphology, and the cessation of long-distance trade between Near and Remote Oceania [2]. First Remote Oceanian ancestry subsequently increased via admixture but remains at 10-20% in most islands. Through a fine-grained comparison of ancestry profiles in Vanuatu and Polynesia with diverse groups in Near Oceania, we find that Papuan ancestry in Vanuatu is consistent with deriving from the Bismarck Archipelago instead of the geographically closer Solomon Islands. Papuan ancestry in Polynesia also shows connections to the ancestry profiles present in the Bismarck Archipelago but is more similar to Tolai from New Britain and Tutuba from Vanuatu than to the ancient Vanuatu individuals and the great majority of present-day Vanuatu populations. This suggests a third eastward stream of migration from Near to Remote Oceania bringing a different type of Papuan ancestry.
HAL Paris Nanterre; ... arrow_drop_down bioRxivPreprint . 2018Spiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryCurrent BiologyArticle . 2018 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 94 citations 94 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 7visibility views 7 download downloads 43 Powered bymore_vert HAL Paris Nanterre; ... arrow_drop_down bioRxivPreprint . 2018Spiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryCurrent BiologyArticle . 2018 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 France, United Kingdom, United Kingdom, Switzerland, France, Italy, United Kingdom, Portugal, Italy, Spain, Poland, United Kingdom, Portugal, NetherlandsPublisher:Cold Spring Harbor Laboratory Funded by:NSF | Long Term Population Resp..., IRC, WT | Human Adaptation to Chang... +4 projectsNSF| Long Term Population Response to Environmental Fluctuation ,IRC ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,NSF| Investigating The Relationship Between Climate Change And Social Organization In A Small Scale Society ,UKRI| RootDetect: Remote Detection and Precision Management of Root Health ,NSF| A new history and geography of human genes informed by ancient DNA ,NIH| Population mixture in evolutionary and medical geneticsIñigo Olalde; Selina Brace; Morten E. Allentoft; Ian Armit; Kristian Kristiansen; Thomas J. Booth; Nadin Rohland; Swapan Mallick; Anna Szécsényi-Nagy; Alissa Mittnik; Eveline Altena; Mark Lipson; Iosif Lazaridis; Thomas K. Harper; Nick Patterson; Nasreen Broomandkhoshbacht; Yoan Diekmann; Zuzana Faltyskova; Daniel Fernandes; Matthew Ferry; Eadaoin Harney; Peter de Knijff; Megan Michel; Jonas Oppenheimer; Kristin Stewardson; Alistair Barclay; Kurt W. Alt; Corina Liesau; Patricia Ríos; Concepción Blasco; Jorge Vega de Miguel; Roberto Menduiña García; Azucena Avilés Fernández; Eszter Bánffy; Maria Bernabò-Brea; David Billoin; Clive Bonsall; Laura Bonsall; Tim Allen; Lindsey Büster; Sophie Carver; Laura Castells Navarro; Oliver E. Craig; Gordon Cook; Barry Cunliffe; Anthony Denaire; Kirsten Egging Dinwiddy; Natasha Dodwell; Michal Ernée; Christopher Evans; Milan Kuchařík; Joan Francès Farré; Chris Fowler; Michiel Gazenbeek; Rafael Garrido Pena; María Haber-Uriarte; Elżbieta Haduch; Gill Hey; Nick Jowett; Timothy D J Knowles; Ken Massy; Saskia Pfrengle; Philippe Lefranc; Olivier Lemercier; Arnaud Lefebvre; César Heras Martínez; Virginia Galera Olmo; Ana Bastida Ramírez; Joaquín Lomba Maurandi; Tona Majó; Jacqueline I. McKinley; Kathleen McSweeney; Balázs Gusztáv Mende; Alessandra Modi; Gabriella Kulcsár; Viktória Kiss; András Czene; Róbert Patay; Anna Endrődi; Kitti Köhler; Tamás Hajdu; Tamás Szeniczey; János Dani; Zsolt Bernert; Maya Hoole; Olivia Cheronet; Denise Keating; Petr Velemínský; Miroslav Dobeš; Francesca Candilio; Fraser Brown; Raúl Flores Fernández; Ana-Mercedes Herrero-Corral; Sebastiano Tusa; Emiliano Carnieri; Luigi Lentini; Antonella Valenti; Alessandro Zanini; Clive Waddington; Germán Delibes; Elisa Guerra-Doce; Benjamin Neil; Marcus Brittain; Mike Luke; Richard Mortimer; Jocelyne Desideri; Marie Besse; Günter Brücken; Mirosław Furmanek; Agata Hałuszko; Maksym Mackiewicz; Artur Rapiński; Stephany Leach; Ignacio Soriano; Katina T. Lillios; João Luís Cardoso; Mike Parker Pearson; Piotr Włodarczak; T. Douglas Price; Pilar Prieto; Pierre-Jérôme Rey; Roberto Risch; Manuel Ángel Rojo Guerra; Aurore Schmitt; Joël Serralongue; Ana Maria Silva; Václav Smrčka; Luc Vergnaud; João Zilhão; David Caramelli; Thomas Higham; Mark G. Thomas; Douglas J. Kennett; Harry Fokkens; Volker M Heyd; Alison Sheridan; Karl-Göran Sjögren; Philipp W. Stockhammer; Johannes Krause; Ron Pinhasi; Wolfgang Haak; Ian Barnes; Carles Lalueza-Fox; David Reich;pmc: PMC5973796
From around 2750 to 2500 BC, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 BC. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions. However, migration had a key role in the further dissemination of the Beaker complex. We document this phenomenon most clearly in Britain, where the spread of the Beaker complex introduced high levels of steppe-related ancestry and was associated with the replacement of approximately 90% of Britain’s gene pool within a few hundred years, continuing the east-to-west expansion that had brought steppe-related ancestry into central and northern Europe over the previous centuries. info:eu-repo/semantics/publishedVersion
LAReferencia - Red F... arrow_drop_down LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Repositório Aberto da Universidade Aberta; bioRxivArticle . Preprint . 2017 . 2018License: CC BY NC NDEurope PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5973796Data sources: PubMed CentralRepositório Aberto da Universidade AbertaArticle . 2017License: CC BY NC NDData sources: Repositório Aberto da Universidade AbertaRepositório Aberto da Universidade AbertaArticle . 2018Data sources: Repositório Aberto da Universidade AbertaRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTALeiden University Scholarly Publications RepositoryArticle . 2018Data sources: Leiden University Scholarly Publications RepositoryNature; Flore (Florence Research Repository); Archivio della ricerca- Università di Roma La Sapienza; NARCISArticle . 2018 . Peer-reviewedLicense: Springer TDMArchivio della ricerca- Università di Roma La SapienzaArticle . 2018Data sources: Archivio della ricerca- Università di Roma La SapienzaUniversidade de Lisboa: Repositório.ULArticle . 2018Data sources: Universidade de Lisboa: Repositório.ULadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/135962&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 469 citations 469 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 652visibility views 652 download downloads 1,571 Powered bymore_vert LAReferencia - Red F... arrow_drop_down LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Repositório Aberto da Universidade Aberta; bioRxivArticle . Preprint . 2017 . 2018License: CC BY NC NDEurope PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5973796Data sources: PubMed CentralRepositório Aberto da Universidade AbertaArticle . 2017License: CC BY NC NDData sources: Repositório Aberto da Universidade AbertaRepositório Aberto da Universidade AbertaArticle . 2018Data sources: Repositório Aberto da Universidade AbertaRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTALeiden University Scholarly Publications RepositoryArticle . 2018Data sources: Leiden University Scholarly Publications RepositoryNature; Flore (Florence Research Repository); Archivio della ricerca- Università di Roma La Sapienza; NARCISArticle . 2018 . Peer-reviewedLicense: Springer TDMArchivio della ricerca- Università di Roma La SapienzaArticle . 2018Data sources: Archivio della ricerca- Università di Roma La SapienzaUniversidade de Lisboa: Repositório.ULArticle . 2018Data sources: Universidade de Lisboa: Repositório.ULadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/135962&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2013 Italy, Croatia, Spain, United States, United Kingdom, Argentina, ArgentinaPublisher:Cold Spring Harbor Laboratory Funded by:NSERC, WT, NSF | XSEDE: eXtreme Science an... +7 projectsNSERC ,WT ,NSF| XSEDE: eXtreme Science and Engineering Discovery Environment ,NIH| Human Genome Structural Variation ,NSF| Collaborative Research: Genetic Bases for the Evolution of Human Diet ,NIH| Population mixture in evolutionary and medical genetics ,NSF| A new history and geography of human genes informed by ancient DNA ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,EC| MALADAPTED ,NIH| Models of Complex Genetic SystemsIosif Lazaridis; Nick Patterson; Alissa Mittnik; Gabriel Renaud; Swapan Mallick; Karola Kirsanow; Peter H. Sudmant; Joshua G. Schraiber; Sergi Castellano; Mark Lipson; Bonnie Berger; Christos Economou; Ruth Bollongino; Qiaomei Fu; Kirsten I. Bos; Susanne Nordenfelt; Heng Li; Cesare de Filippo; Kay Prüfer; Susanna Sawyer; Cosimo Posth; Wolfgang Haak; Fredrik Hallgren; Elin Fornander; Nadin Rohland; Dominique Delsate; Michael Francken; Jean-Michel Guinet; Joachim Wahl; George Ayodo; Hamza A. Babiker; Graciela Bailliet; Elena Balanovska; Oleg Balanovsky; Ramiro Barrantes; Gabriel Bedoya; Haim Ben-Ami; Judit Bene; Fouad Berrada; Claudio M. Bravi; Francesca Brisighelli; George B.J. Busby; Francesco Calì; Mikhail Churnosov; David E. C. Cole; Daniel Corach; Larissa Damba; George van Driem; Stanislav Dryomov; Jean-Michel Dugoujon; Sardana A. Fedorova; Irene Gallego Romero; Marina Gubina; Michael F. Hammer; Brenna M. Henn; Tor Hervig; Ugur Hodoglugil; Aashish R. Jha; Sena Karachanak-Yankova; Rita Khusainova; Elza Khusnutdinova; Rick A. Kittles; Toomas Kivisild; William Klitz; Vaidutis Kučinskas; Alena Kushniarevich; Leila Laredj; Sergey Litvinov; Theologos Loukidis; Robert W. Mahley; Béla Melegh; Ene Metspalu; Julio Molina; Joanna L. Mountain; Klemetti Näkkäläjärvi; Desislava Nesheva; Thomas B. Nyambo; Ludmila P. Osipova; Jüri Parik; Fedor Platonov; Olga L. Posukh; Valentino Romano; Francisco Rothhammer; Igor Rudan; Ruslan Ruizbakiev; Hovhannes Sahakyan; Antti Sajantila; Antonio Salas; Elena B. Starikovskaya; Ayele Tarekegn; Draga Toncheva; Shahlo Turdikulova; Ingrida Uktveryte; Olga Utevska; René Vasquez; Mercedes Villena; Mikhail Voevoda; Cheryl A. Winkler; Levon Yepiskoposyan; Pierre Zalloua; Tatijana Zemunik; Alan Cooper; Cristian Capelli; Mark G. Thomas; Andres Ruiz-Linares; Sarah A. Tishkoff; Lalji Singh; Kumarasamy Thangaraj; Richard Villems; David Comas; Rem I. Sukernik; Mait Metspalu; Matthias Meyer; Evan E. Eichler; Joachim Burger; Montgomery Slatkin; Svante Pääbo; Janet Kelso; David Reich; Johannes Krause;J. Kr., A.M. and C.P. are grateful for support from DFG grant number KR 4015/1-1, the Carl-Zeiss Foundation and the Baden Württemberg Foundation. S. P., G. R., Q. F., C. F., K. P., S.C. and J.Ke. acknowledge support from the Presidential Innovation Fund of the Max Planck Society. G.R. was supported by an NSERC fellowship. J.G.S. acknowledges use of the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF grant number OCI-1053575. E.B. and O.B. were supported by RFBR grants 13-06-00670, 13-04-01711, 13-04-90420. B.M. was supported by grants OTKA 73430 and 103983. A.Saj. was supported by a Finnish Professor Pool (Paulo Foundation) Grant. The Lithuanian sampling was supported by the LITGEN project (VP1-3.1-ŠMM-07-K-01-013), funded by the European Social Fund under the Global Grant Measure. A.S. was supported by Spanish grants SAF2011-26983 and EM 2012/045. O.U. was supported by Ukrainian SFFS grant F53.4/071. S.A.T. was supported by NIH Pioneer Award 8DP1ES022577-04 and NSF HOMINID award BCS-0827436. K.T. was supported by an Indian CSIR Network Project (GENESIS: BSC0121). L.S. was supported by an Indian CSIR Bhatnagar Fellowship. R.V., M.M., J.P. and E.M. were supported by the European Union Regional Development Fund through the Centre of Excellence in Genomics to the Estonian Biocentre and University of Tartu and by an Estonian Basic Research grant SF0270177As08. M.M. was additionally supported by Estonian Science Foundation grant number 8973. J.G.S. and M.S. were supported by NIH grant GM40282. P.H.S. and E.E.E. were supported by NIH grants HG004120 and HG002385. D.R. and N.P. were supported by NSF HOMINID award BCS-1032255 and NIH grant GM100233. This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN26120080001E. This Research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.
bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4170574Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; NatureArticle . 2014 . Peer-reviewedLicense: Springer TDMarXiv.org e-Print ArchiveOther literature type . Preprint . 2013Data sources: arXiv.org e-Print ArchiveCroatian Scientific Bibliography - CROSBIArticle . 2014Data sources: Croatian Scientific Bibliography - CROSBIServicio de Difusión de la Creación IntelectualArticle . 2014Data sources: Servicio de Difusión de la Creación Intelectualhttps://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 1K citations 1,096 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 24visibility views 24 download downloads 297 Powered bymore_vert bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4170574Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; NatureArticle . 2014 . Peer-reviewedLicense: Springer TDMarXiv.org e-Print ArchiveOther literature type . Preprint . 2013Data sources: arXiv.org e-Print ArchiveCroatian Scientific Bibliography - CROSBIArticle . 2014Data sources: Croatian Scientific Bibliography - CROSBIServicio de Difusión de la Creación IntelectualArticle . 2014Data sources: Servicio de Difusión de la Creación Intelectualhttps://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2022 United Kingdom, United Kingdom, Denmark, NetherlandsPublisher:Springer Science and Business Media LLC Funded by:EC | COREX, WT | Human Adaptation to Chang..., EC | MICROSCOPE +1 projectsEC| COREX ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,EC| MICROSCOPE ,NIH| Population mixture in evolutionary and medical geneticsJoscha Gretzinger; Duncan Sayer; Pierre Justeau; Eveline Altena; Maria Pala; Katharina Dulias; Ceiridwen J. Edwards; Susanne Jodoin; Laura Lacher; Susanna Sabin; Åshild J. Vågene; Wolfgang Haak; S. Sunna Ebenesersdóttir; Kristjan H. S. Moore; Rita Radzeviciute; Kara Schmidt; Selina Brace; Martina Abenhus Bager; Nick Patterson; Luka Papac; Nasreen Broomandkhoshbacht; Kimberly Callan; Éadaoin Harney; Lora Iliev; Ann Marie Lawson; Megan Michel; Kristin Stewardson; Fatma Zalzala; Nadin Rohland; Stefanie Kappelhoff-Beckmann; Frank Both; Daniel Winger; Daniel Neumann; Lars Saalow; Stefan Krabath; Sophie Beckett; Melanie Van Twest; Neil Faulkner; Chris Read; Tabatha Barton; Joanna Caruth; John Hines; Ben Krause-Kyora; Ursula Warnke; Verena J. Schuenemann; Ian Barnes; Hanna Dahlström; Jane Jark Clausen; Andrew Richardson; Elizabeth Popescu; Natasha Dodwell; Stuart Ladd; Tom Phillips; Richard Mortimer; Faye Sayer; Diana Swales; Allison Stewart; Dominic Powlesland; Robert Kenyon; Lilian Ladle; Christina Peek; Silke Grefen-Peters; Paola Ponce; Robin Daniels; Cecily Spall; Jennifer Woolcock; Andy M. Jones; Amy V. Roberts; Robert Symmons; Anooshka C. Rawden; Alan Cooper; Kirsten I. Bos; Tom Booth; Hannes Schroeder; Mark G. Thomas; Agnar Helgason; Martin B. Richards; David Reich; Johannes Krause; Stephan Schiffels;pmid: 36253469
pmc: PMC9534755
The history of the British Isles and Ireland is characterized by multiple periods of major cultural change, including the influential transformation after the end of Roman rule, which precipitated shifts in language, settlement patterns and material culture1. The extent to which migration from continental Europe mediated these transitions is a matter of long-standing debate2–4. Here we study genome-wide ancient DNA from 460 medieval northwestern Europeans—including 278 individuals from England—alongside archaeological data, to infer contemporary population dynamics. We identify a substantial increase of continental northern European ancestry in early medieval England, which is closely related to the early medieval and present-day inhabitants of Germany and Denmark, implying large-scale substantial migration across the North Sea into Britain during the Early Middle Ages. As a result, the individuals who we analysed from eastern England derived up to 76% of their ancestry from the continental North Sea zone, albeit with substantial regional variation and heterogeneity within sites. We show that women with immigrant ancestry were more often furnished with grave goods than women with local ancestry, whereas men with weapons were as likely not to be of immigrant ancestry. A comparison with present-day Britain indicates that subsequent demographic events reduced the fraction of continental northern European ancestry while introducing further ancestry components into the English gene pool, including substantial southwestern European ancestry most closely related to that seen in Iron Age France
CORE (RIOXX-UK Aggre... arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 28 citations 28 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 19visibility views 19 download downloads 18 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Netherlands, Croatia, United Kingdom, United Kingdom, SpainPublisher:Springer Science and Business Media LLC Funded by:NIH | Advanced tools for using ..., WT | Human Adaptation to Chang..., FCT | LA 14 +4 projectsNIH| Advanced tools for using ancient DNA to study biology and history ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,FCT| LA 14 ,UKRI| Urban-Air Port | "Air-One" [Rapidly Deployable Vertiport For Drone-Delivery, Air-Taxi, Disaster Management] ,EC| COREX ,EC| COMMIOS ,NIH| Population mixture in evolutionary and medical geneticsNick Patterson; Michael Isakov; Thomas Booth; Lindsey Büster; Claire-Elise Fischer; Iñigo Olalde; Harald Ringbauer; Ali Akbari; Olivia Cheronet; Madeleine Bleasdale; Nicole Adamski; Eveline Altena; Rebecca Bernardos; Selina Brace; Nasreen Broomandkhoshbacht; Kimberly Callan; Francesca Candilio; Brendan Culleton; Elizabeth Curtis; Lea Demetz; Kellie Sara Duffett Carlson; Ceiridwen J. Edwards; Daniel M. Fernandes; M. George B. Foody; Suzanne Freilich; Helen Goodchild; Aisling Kearns; Ann Marie Lawson; Iosif Lazaridis; Matthew Mah; Swapan Mallick; Kirsten Mandl; Adam Micco; Megan Michel; Guillermo Bravo Morante; Jonas Oppenheimer; Kadir Toykan Özdoğan; Lijun Qiu; Constanze Schattke; Kristin Stewardson; J. Noah Workman; Fatma Zalzala; Zhao Zhang; Bibiana Agustí; Tim Allen; Katalin Almássy; Luc Amkreutz; Abigail Ash; Christèle Baillif-Ducros; Alistair Barclay; László Bartosiewicz; Katherine Baxter; Zsolt Bernert; Jan Blažek; Mario Bodružić; Philippe Boissinot; Clive Bonsall; Pippa Bradley; Marcus Brittain; Alison Brookes; Fraser Brown; Lisa Brown; Richard Brunning; Chelsea Budd; Josip Burmaz; Sylvain Canet; Silvia Carnicero-Cáceres; Morana Čaušević-Bully; Andrew Chamberlain; Sébastien Chauvin; Sharon Clough; Natalija Čondić; Alfredo Coppa; Oliver Craig; Matija Črešnar; Vicki Cummings; Szabolcs Czifra; Alžběta Danielisová; Robin Daniels; Alex Davies; Philip de Jersey; Jody Deacon; Csilla Deminger; Peter W. Ditchfield; Marko Dizdar; Miroslav Dobeš; Miluše Dobisíková; László Domboróczki; Gail Drinkall; Ana Đukić; Michal Ernée; Christopher Evans; Jane Evans; Manuel Fernández-Götz; Slavica Filipović; Andrew Fitzpatrick; Harry Fokkens; Chris Fowler; Allison Fox; Zsolt Gallina; Michelle Gamble; Manuel R. González Morales; Borja González-Rabanal; Adrian Green; Katalin Gyenesei; Diederick Habermehl; Tamás Hajdu; Derek Hamilton; James Harris; Chris Hayden; Joep Hendriks; Bénédicte Hernu; Gill Hey; Milan Horňák; Gábor Ilon; Eszter Istvánovits; Andy M. Jones; Martina Blečić Kavur; Kevin Kazek; Robert A. Kenyon; Amal Khreisheh; Viktória Kiss; Jos Kleijne; Mark Knight; Lisette M. Kootker; Péter F. Kovács; Anita Kozubová; Gabriella Kulcsár; Valéria Kulcsár; Christophe Le Pennec; Michael Legge; Matt Leivers; Louise Loe; Olalla López-Costas; Tom Lord; Dženi Los; James Lyall; Ana B. Marín-Arroyo; Philip Mason; Damir Matošević; Andy Maxted; Lauren McIntyre; Jacqueline McKinley; Kathleen McSweeney; Bernard Meijlink; Balázs G. Mende; Marko Menđušić; Milan Metlička; Sophie Meyer; Kristina Mihovilić; Lidija Milasinovic; Steve Minnitt; Joanna Moore; Geoff Morley; Graham Mullan; Margaréta Musilová; Benjamin Neil; Rebecca Nicholls; Mario Novak; Maria Pala; Martin Papworth; Cécile Paresys; Ricky Patten; Domagoj Perkić; Krisztina Pesti; Alba Petit; Katarína Petriščáková; Coline Pichon; Catriona Pickard; Zoltán Pilling; T. Douglas Price; Siniša Radović; Rebecca Redfern; Branislav Resutík; Daniel T. Rhodes; Martin B. Richards; Amy Roberts; Jean Roefstra; Pavel Sankot; Alena Šefčáková; Alison Sheridan; Sabine Skae; Miroslava Šmolíková; Krisztina Somogyi; Ágnes Somogyvári; Mark Stephens; Géza Szabó; Anna Szécsényi-Nagy; Tamás Szeniczey; Jonathan Tabor; Károly Tankó; Clenis Tavarez Maria; Rachel Terry; Biba Teržan; Maria Teschler-Nicola; Jesús F. Torres-Martínez; Julien Trapp; Ross Turle; Ferenc Ujvári; Menno van der Heiden; Petr Veleminsky; Barbara Veselka; Carles Lalueza-Fox; Peter de Knijff; Ian Barnes; Mark G. Thomas; Douglas J. Kennett; Malcolm Lillie; Ron Pinhasi; David Reich;pmc: PMC8889665
This work was funded in part by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 834087; the COMMIOS Project to I.A.). M.N. was supported by the Croatian Science Fund grant (HRZZ IP-2016-06-1450). P.V., M.Dobeš and Z.V. were supported by the Ministry of Culture of the Czech Republic (DKRVO 2019-2023/7.I.c, 00023272). M.E. was supported by Czech Academy of Sciences award Praemium Academiae. M.Dobisíková and A.Danielisová were supported by the grant RVO 67985912 of the Institute of Archaeology of the Czech Academy of Sciences. M.G.B.F. was funded by The Leverhulme Trust via a Doctoral Scholarship scheme awarded to M.Pala and M.B.R. Support to M.Legge came from the South, West & Wales Doctoral Training Partnership. M.G.’s osteological analyses were funded by Culture Vannin. A.S.-N. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. T.H., T.S. and K.K.’s work was supported by a grant from the Hungarian Research, Development and Innovation Office (project number: FK128013). We acknowledge support for radiocarbon dating and stable isotope analyses as well as access to skeletal material from Manx National Heritage and A. Fox. Dating analysis was funded by Leverhulme Trust grant RPG-388. M.G.T. and I.B. were supported by a Wellcome Trust Investigator Award (project 100713/Z/12/Z). I.O. was supported by a Ramón y Cajal grant from Ministerio de Ciencia e Innovación, Spanish Government (RYC2019-027909-I). The research directed at Harvard was funded by NIH grants GM100233 and HG012287, by John Templeton Foundation grant 61220, by a gift from Jean-François Clin, and by the Allen Discovery Center program, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. D.R. is also an Investigator of the Howard Hughes Medical Institute. Present-day people from England and Wales have more ancestry derived from early European farmers (EEF) than did people of the Early Bronze Age1. To understand this, here we generated genome-wide data from 793 individuals, increasing data from the Middle to the Late Bronze Age and Iron Age in Britain by 12-fold, and western and central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of people of England and Wales from the Iron Age, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to the Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and the independent genetic trajectory in Britain is also reflected in the rise of the allele conferring lactase persistence to approximately 50% by this time compared to approximately 7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period. Peer reviewed
CORE (RIOXX-UK Aggre... arrow_drop_down NARCIS; Nature; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional RepositoryArticle . 2021 . 2022NARCIS; NatureArticle . 2021 . 2022Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Springer TDMLeiden University Scholarly Publications RepositoryArticle . 2021Data sources: Leiden University Scholarly Publications Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 72 citations 72 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 216visibility views 216 download downloads 1,655 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down NARCIS; Nature; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional RepositoryArticle . 2021 . 2022NARCIS; NatureArticle . 2021 . 2022Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Springer TDMLeiden University Scholarly Publications RepositoryArticle . 2021Data sources: Leiden University Scholarly Publications Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, Spain, Belgium, United KingdomPublisher:Springer Science and Business Media LLC Funded by:NIH | Population mixture in evo..., WT | Inferring human colonizat..., NSF | Investigating The Relatio... +1 projectsNIH| Population mixture in evolutionary and medical genetics ,WT| Inferring human colonization history using genetic data. ,NSF| Investigating The Relationship Between Climate Change And Social Organization In A Small Scale Society ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present.Mark Lipson; Isabelle Ribot; Swapan Mallick; Nadin Rohland; Iñigo Olalde; Nicole Adamski; Nasreen Broomandkhoshbacht; Ann Marie Lawson; Saioa López; Jonas Oppenheimer; Kristin Stewardson; R. Asombang; Hervé Bocherens; Neil Bradman; Brendan J. Culleton; Els Cornelissen; Isabelle Crevecoeur; Pierre de Maret; Forka Leypey Mathew Fomine; P. Lavachery; Christophe Mbida Mindzie; Rosine Orban; Elizabeth A. Sawchuk; Patrick Semal; Mark G. Thomas; Wim Van Neer; Krishna R. Veeramah; Douglas J. Kennett; Nick Patterson; Garrett Hellenthal; Carles Lalueza-Fox; Scott MacEachern; Mary E. Prendergast; David Reich;The Shum Laka excavations were supported by the Belgian Fund for Scientific Research (FNRS), the Université Libre de Bruxelles, the Royal Museum for Central Africa and the Leakey Foundation. The collection of samples from present-day individuals in Cameroon was supported by N. Bradman and the Melford Charitable Trust. The genotyping of the present-day individuals sampled from Cameroon was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/L009382/1). I.R. was supported by a Université de Montréal exploration grant (2018-2020). M.G.T. was supported by Wellcome Trust Senior Investigator Award Grant 100719/Z/12/Z. G.H. was supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant number 098386/Z/12/Z). C.L-F. was supported by Obra Social La Caixa 328, Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880), and a FEDER-MINECO grant (PGC2018-095931-B-100). Radiocarbon work was supported by the NSF Archaeometry program (grant BCS-1460369) to D.J.K. and B.J.C. M.E.P. was supported by a fellowship from the Radcliffe Institute for Advanced Study at Harvard University during the development of this project. D.R. was supported by the National Institutes of Health (NIGMS GM100233), by an Allen Discovery Center grant and by grant 61220 from the John Templeton Foundation, and is an Investigator of the Howard Hughes Medical Institute. Our knowledge of ancient human population structure in sub-Saharan Africa, particularly prior to the advent of food production, remains limited. Here we report genome-wide DNA data from four children—two of whom were buried approximately 8,000 years ago and two 3,000 years ago—from Shum Laka (Cameroon), one of the earliest known archaeological sites within the probable homeland of the Bantu language group1,2,3,4,5,6,7,8,9,10,11. One individual carried the deeply divergent Y chromosome haplogroup A00, which today is found almost exclusively in the same region12,13. However, the genome-wide ancestry profiles of all four individuals are most similar to those of present-day hunter-gatherers from western Central Africa, which implies that populations in western Cameroon today—as well as speakers of Bantu languages from across the continent—are not descended substantially from the population represented by these four people. We infer an Africa-wide phylogeny that features widespread admixture and three prominent radiations, including one that gave rise to at least four major lineages deep in the history of modern humans. Peer reviewed
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8386425Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2020 . Peer-reviewedMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02990305/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 88 citations 88 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 18visibility views 18 download downloads 61 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8386425Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2020 . Peer-reviewedMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-02990305/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2018 United States, Finland, DenmarkPublisher:Cold Spring Harbor Laboratory Funded by:NIH | Powering whole genome seq..., NIH | Genome-wide approaches to..., NIH | Leveraging functional dat... +10 projectsNIH| Powering whole genome sequence-based genetic discovery for common human diseases- Extended 2021-2022. ,NIH| Genome-wide approaches to polygenic adaptation ,NIH| Leveraging functional data to predict disease risk in multi-ethnic populations ,NIH| Population genetic modeling of the genetic architecture of complex disease ,NIH| Statistical methods for studies of rare variants ,NIH| Natural selection in recent human evolution ,WT ,NIH| Integration of functional data and GWAS to elucidate genetic basis of diseases ,NIH| The population genetics of disease risk and other quantitative traits ,NIH| Functional and population genetic architectures of complex disease ,NIH| Population mixture in evolutionary and medical genetics ,NIH| The origin, the function and the phenotypic impact of human alleles ,NIH| The population genetics of disease risk and other quantitative traitsMashaal Sohail; Robert Maier; Andrea Ganna; Alex Bloemendal; Alicia R. Martin; Michael C. Turchin; Charleston W. K. Chiang; Joel N. Hirschhorn; Mark J. Daly; Nick Patterson; Benjamin M. Neale; Iain Mathieson; David Reich; Shamil R. Sunyaev;handle: 10138/300784
pmc: PMC6428571 , PMC6428565 , PMC6428572
Genetic predictions of height differ among human populations and these differences have been interpreted as evidence of polygenic adaptation. These differences were first detected using SNPs genome-wide significantly associated with height, and shown to grow stronger when large numbers of sub-significant SNPs were included, leading to excitement about the prospect of analyzing large fractions of the genome to detect polygenic adaptation for multiple traits. Previous studies of height have been based on SNP effect size measurements in the GIANT Consortium meta-analysis. Here we repeat the analyses in the UK Biobank, a much more homogeneously designed study. We show that polygenic adaptation signals based on large numbers of SNPs below genome-wide significance are extremely sensitive to biases due to uncorrected population stratification. More generally, our results imply that typical constructions of polygenic scores are sensitive to population stratification and that population-level differences should be interpreted with caution. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter). Peer reviewed
bioRxiv arrow_drop_down bioRxivPreprint . 2018eLifeArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428572Data sources: PubMed CentralEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428571Data sources: PubMed CentralEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428565Data sources: PubMed CentralHELDA - Digital Repository of the University of HelsinkiArticle . 2019 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 318 citations 318 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert bioRxiv arrow_drop_down bioRxivPreprint . 2018eLifeArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428572Data sources: PubMed CentralEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428571Data sources: PubMed CentralEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6428565Data sources: PubMed CentralHELDA - Digital Repository of the University of HelsinkiArticle . 2019 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2018 United Kingdom, France, FrancePublisher:Cold Spring Harbor Laboratory Funded by:WT, ARC | Northern Vanuatu as a Pac..., ARC | Persistence and transform... +5 projectsWT ,ARC| Northern Vanuatu as a Pacific Crossroads: The archaeology of discovery, interaction and the emergence of the ethnographic present ,ARC| Persistence and transformation in Ancestral Oceanic Society: the archaeology of the first 1500 years in the Vanuatu archipelago ,NSF| A new history and geography of human genes informed by ancient DNA ,WT| Characterisation of the Effect of Newly Identified Associated Genetic Variantson Lymphocyte Differentiation and Response to Childhood Vaccination. ,NSF| Investigating The Relationship Between Climate Change And Social Organization In A Small Scale Society ,ARC| Understanding the migrations of prehistoric populations through direct dating and isotopic tracking of their mobility patterns ,NIH| Population mixture in evolutionary and medical geneticsMark Lipson; Pontus Skoglund; Matthew Spriggs; Frédérique Valentin; Stuart Bedford; Richard Shing; Hallie R. Buckley; Iarawai Phillip; Graeme K. Ward; Swapan Mallick; Nadin Rohland; Nasreen Broomandkhoshbacht; Olivia Cheronet; Matthew Ferry; Thomas K. Harper; Megan Michel; Jonas Oppenheimer; Kendra Sirak; Kristin Stewardson; Kathryn Auckland; Adrian V. S. Hill; Kathryn Maitland; Stephen Oppenheimer; Tom Parks; Kathryn J. H. Robson; Thomas N. Williams; Douglas J. Kennett; Alexander J. Mentzer; Ron Pinhasi; David Reich;SummaryAncient DNA analysis of three individuals dated to ~3000 years before present (BP) from Vanuatu and one ~2600 BP individual from Tonga has revealed that the first inhabitants of Remote Oceania (“First Remote Oceanians”) were almost entirely of East Asian ancestry, and thus their ancestors passed New Guinea, the Bismarck Archipelago, and the Solomon Islands with minimal admixture with the Papuan groups they encountered [1]. However, all present-day populations in Near and Remote Oceania harbor 25-100% Papuan ancestry, implying that there must have been at least one later stream of migration eastward from Near Oceania. We generated genome-wide data for 14 ancient individuals from Efate and Epi Islands in Vanuatu ranging from 3,000-150 BP, along with 185 present-day Vanuatu individuals from 18 islands. We show that people of almost entirely Papuan ancestry had arrived in Vanuatu by 2400 BP, an event that coincided with the end of the Lapita cultural period, changes in skeletal morphology, and the cessation of long-distance trade between Near and Remote Oceania [2]. First Remote Oceanian ancestry subsequently increased via admixture but remains at 10-20% in most islands. Through a fine-grained comparison of ancestry profiles in Vanuatu and Polynesia with diverse groups in Near Oceania, we find that Papuan ancestry in Vanuatu is consistent with deriving from the Bismarck Archipelago instead of the geographically closer Solomon Islands. Papuan ancestry in Polynesia also shows connections to the ancestry profiles present in the Bismarck Archipelago but is more similar to Tolai from New Britain and Tutuba from Vanuatu than to the ancient Vanuatu individuals and the great majority of present-day Vanuatu populations. This suggests a third eastward stream of migration from Near to Remote Oceania bringing a different type of Papuan ancestry.
HAL Paris Nanterre; ... arrow_drop_down bioRxivPreprint . 2018Spiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryCurrent BiologyArticle . 2018 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 94 citations 94 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 7visibility views 7 download downloads 43 Powered bymore_vert HAL Paris Nanterre; ... arrow_drop_down bioRxivPreprint . 2018Spiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryCurrent BiologyArticle . 2018 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 France, United Kingdom, United Kingdom, Switzerland, France, Italy, United Kingdom, Portugal, Italy, Spain, Poland, United Kingdom, Portugal, NetherlandsPublisher:Cold Spring Harbor Laboratory Funded by:NSF | Long Term Population Resp..., IRC, WT | Human Adaptation to Chang... +4 projectsNSF| Long Term Population Response to Environmental Fluctuation ,IRC ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,NSF| Investigating The Relationship Between Climate Change And Social Organization In A Small Scale Society ,UKRI| RootDetect: Remote Detection and Precision Management of Root Health ,NSF| A new history and geography of human genes informed by ancient DNA ,NIH| Population mixture in evolutionary and medical geneticsIñigo Olalde; Selina Brace; Morten E. Allentoft; Ian Armit; Kristian Kristiansen; Thomas J. Booth; Nadin Rohland; Swapan Mallick; Anna Szécsényi-Nagy; Alissa Mittnik; Eveline Altena; Mark Lipson; Iosif Lazaridis; Thomas K. Harper; Nick Patterson; Nasreen Broomandkhoshbacht; Yoan Diekmann; Zuzana Faltyskova; Daniel Fernandes; Matthew Ferry; Eadaoin Harney; Peter de Knijff; Megan Michel; Jonas Oppenheimer; Kristin Stewardson; Alistair Barclay; Kurt W. Alt; Corina Liesau; Patricia Ríos; Concepción Blasco; Jorge Vega de Miguel; Roberto Menduiña García; Azucena Avilés Fernández; Eszter Bánffy; Maria Bernabò-Brea; David Billoin; Clive Bonsall; Laura Bonsall; Tim Allen; Lindsey Büster; Sophie Carver; Laura Castells Navarro; Oliver E. Craig; Gordon Cook; Barry Cunliffe; Anthony Denaire; Kirsten Egging Dinwiddy; Natasha Dodwell; Michal Ernée; Christopher Evans; Milan Kuchařík; Joan Francès Farré; Chris Fowler; Michiel Gazenbeek; Rafael Garrido Pena; María Haber-Uriarte; Elżbieta Haduch; Gill Hey; Nick Jowett; Timothy D J Knowles; Ken Massy; Saskia Pfrengle; Philippe Lefranc; Olivier Lemercier; Arnaud Lefebvre; César Heras Martínez; Virginia Galera Olmo; Ana Bastida Ramírez; Joaquín Lomba Maurandi; Tona Majó; Jacqueline I. McKinley; Kathleen McSweeney; Balázs Gusztáv Mende; Alessandra Modi; Gabriella Kulcsár; Viktória Kiss; András Czene; Róbert Patay; Anna Endrődi; Kitti Köhler; Tamás Hajdu; Tamás Szeniczey; János Dani; Zsolt Bernert; Maya Hoole; Olivia Cheronet; Denise Keating; Petr Velemínský; Miroslav Dobeš; Francesca Candilio; Fraser Brown; Raúl Flores Fernández; Ana-Mercedes Herrero-Corral; Sebastiano Tusa; Emiliano Carnieri; Luigi Lentini; Antonella Valenti; Alessandro Zanini; Clive Waddington; Germán Delibes; Elisa Guerra-Doce; Benjamin Neil; Marcus Brittain; Mike Luke; Richard Mortimer; Jocelyne Desideri; Marie Besse; Günter Brücken; Mirosław Furmanek; Agata Hałuszko; Maksym Mackiewicz; Artur Rapiński; Stephany Leach; Ignacio Soriano; Katina T. Lillios; João Luís Cardoso; Mike Parker Pearson; Piotr Włodarczak; T. Douglas Price; Pilar Prieto; Pierre-Jérôme Rey; Roberto Risch; Manuel Ángel Rojo Guerra; Aurore Schmitt; Joël Serralongue; Ana Maria Silva; Václav Smrčka; Luc Vergnaud; João Zilhão; David Caramelli; Thomas Higham; Mark G. Thomas; Douglas J. Kennett; Harry Fokkens; Volker M Heyd; Alison Sheridan; Karl-Göran Sjögren; Philipp W. Stockhammer; Johannes Krause; Ron Pinhasi; Wolfgang Haak; Ian Barnes; Carles Lalueza-Fox; David Reich;pmc: PMC5973796
From around 2750 to 2500 BC, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 BC. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions. However, migration had a key role in the further dissemination of the Beaker complex. We document this phenomenon most clearly in Britain, where the spread of the Beaker complex introduced high levels of steppe-related ancestry and was associated with the replacement of approximately 90% of Britain’s gene pool within a few hundred years, continuing the east-to-west expansion that had brought steppe-related ancestry into central and northern Europe over the previous centuries. info:eu-repo/semantics/publishedVersion
LAReferencia - Red F... arrow_drop_down LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Repositório Aberto da Universidade Aberta; bioRxivArticle . Preprint . 2017 . 2018License: CC BY NC NDEurope PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5973796Data sources: PubMed CentralRepositório Aberto da Universidade AbertaArticle . 2017License: CC BY NC NDData sources: Repositório Aberto da Universidade AbertaRepositório Aberto da Universidade AbertaArticle . 2018Data sources: Repositório Aberto da Universidade AbertaRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTALeiden University Scholarly Publications RepositoryArticle . 2018Data sources: Leiden University Scholarly Publications RepositoryNature; Flore (Florence Research Repository); Archivio della ricerca- Università di Roma La Sapienza; NARCISArticle . 2018 . Peer-reviewedLicense: Springer TDMArchivio della ricerca- Università di Roma La SapienzaArticle . 2018Data sources: Archivio della ricerca- Università di Roma La SapienzaUniversidade de Lisboa: Repositório.ULArticle . 2018Data sources: Universidade de Lisboa: Repositório.ULadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 469 citations 469 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 652visibility views 652 download downloads 1,571 Powered bymore_vert LAReferencia - Red F... arrow_drop_down LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Repositório Aberto da Universidade Aberta; bioRxivArticle . Preprint . 2017 . 2018License: CC BY NC NDEurope PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5973796Data sources: PubMed CentralRepositório Aberto da Universidade AbertaArticle . 2017License: CC BY NC NDData sources: Repositório Aberto da Universidade AbertaRepositório Aberto da Universidade AbertaArticle . 2018Data sources: Repositório Aberto da Universidade AbertaRecolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTALeiden University Scholarly Publications RepositoryArticle . 2018Data sources: Leiden University Scholarly Publications RepositoryNature; Flore (Florence Research Repository); Archivio della ricerca- Università di Roma La Sapienza; NARCISArticle . 2018 . Peer-reviewedLicense: Springer TDMArchivio della ricerca- Università di Roma La SapienzaArticle . 2018Data sources: Archivio della ricerca- Università di Roma La SapienzaUniversidade de Lisboa: Repositório.ULArticle . 2018Data sources: Universidade de Lisboa: Repositório.ULadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/135962&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2013 Italy, Croatia, Spain, United States, United Kingdom, Argentina, ArgentinaPublisher:Cold Spring Harbor Laboratory Funded by:NSERC, WT, NSF | XSEDE: eXtreme Science an... +7 projectsNSERC ,WT ,NSF| XSEDE: eXtreme Science and Engineering Discovery Environment ,NIH| Human Genome Structural Variation ,NSF| Collaborative Research: Genetic Bases for the Evolution of Human Diet ,NIH| Population mixture in evolutionary and medical genetics ,NSF| A new history and geography of human genes informed by ancient DNA ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,EC| MALADAPTED ,NIH| Models of Complex Genetic SystemsIosif Lazaridis; Nick Patterson; Alissa Mittnik; Gabriel Renaud; Swapan Mallick; Karola Kirsanow; Peter H. Sudmant; Joshua G. Schraiber; Sergi Castellano; Mark Lipson; Bonnie Berger; Christos Economou; Ruth Bollongino; Qiaomei Fu; Kirsten I. Bos; Susanne Nordenfelt; Heng Li; Cesare de Filippo; Kay Prüfer; Susanna Sawyer; Cosimo Posth; Wolfgang Haak; Fredrik Hallgren; Elin Fornander; Nadin Rohland; Dominique Delsate; Michael Francken; Jean-Michel Guinet; Joachim Wahl; George Ayodo; Hamza A. Babiker; Graciela Bailliet; Elena Balanovska; Oleg Balanovsky; Ramiro Barrantes; Gabriel Bedoya; Haim Ben-Ami; Judit Bene; Fouad Berrada; Claudio M. Bravi; Francesca Brisighelli; George B.J. Busby; Francesco Calì; Mikhail Churnosov; David E. C. Cole; Daniel Corach; Larissa Damba; George van Driem; Stanislav Dryomov; Jean-Michel Dugoujon; Sardana A. Fedorova; Irene Gallego Romero; Marina Gubina; Michael F. Hammer; Brenna M. Henn; Tor Hervig; Ugur Hodoglugil; Aashish R. Jha; Sena Karachanak-Yankova; Rita Khusainova; Elza Khusnutdinova; Rick A. Kittles; Toomas Kivisild; William Klitz; Vaidutis Kučinskas; Alena Kushniarevich; Leila Laredj; Sergey Litvinov; Theologos Loukidis; Robert W. Mahley; Béla Melegh; Ene Metspalu; Julio Molina; Joanna L. Mountain; Klemetti Näkkäläjärvi; Desislava Nesheva; Thomas B. Nyambo; Ludmila P. Osipova; Jüri Parik; Fedor Platonov; Olga L. Posukh; Valentino Romano; Francisco Rothhammer; Igor Rudan; Ruslan Ruizbakiev; Hovhannes Sahakyan; Antti Sajantila; Antonio Salas; Elena B. Starikovskaya; Ayele Tarekegn; Draga Toncheva; Shahlo Turdikulova; Ingrida Uktveryte; Olga Utevska; René Vasquez; Mercedes Villena; Mikhail Voevoda; Cheryl A. Winkler; Levon Yepiskoposyan; Pierre Zalloua; Tatijana Zemunik; Alan Cooper; Cristian Capelli; Mark G. Thomas; Andres Ruiz-Linares; Sarah A. Tishkoff; Lalji Singh; Kumarasamy Thangaraj; Richard Villems; David Comas; Rem I. Sukernik; Mait Metspalu; Matthias Meyer; Evan E. Eichler; Joachim Burger; Montgomery Slatkin; Svante Pääbo; Janet Kelso; David Reich; Johannes Krause;J. Kr., A.M. and C.P. are grateful for support from DFG grant number KR 4015/1-1, the Carl-Zeiss Foundation and the Baden Württemberg Foundation. S. P., G. R., Q. F., C. F., K. P., S.C. and J.Ke. acknowledge support from the Presidential Innovation Fund of the Max Planck Society. G.R. was supported by an NSERC fellowship. J.G.S. acknowledges use of the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF grant number OCI-1053575. E.B. and O.B. were supported by RFBR grants 13-06-00670, 13-04-01711, 13-04-90420. B.M. was supported by grants OTKA 73430 and 103983. A.Saj. was supported by a Finnish Professor Pool (Paulo Foundation) Grant. The Lithuanian sampling was supported by the LITGEN project (VP1-3.1-ŠMM-07-K-01-013), funded by the European Social Fund under the Global Grant Measure. A.S. was supported by Spanish grants SAF2011-26983 and EM 2012/045. O.U. was supported by Ukrainian SFFS grant F53.4/071. S.A.T. was supported by NIH Pioneer Award 8DP1ES022577-04 and NSF HOMINID award BCS-0827436. K.T. was supported by an Indian CSIR Network Project (GENESIS: BSC0121). L.S. was supported by an Indian CSIR Bhatnagar Fellowship. R.V., M.M., J.P. and E.M. were supported by the European Union Regional Development Fund through the Centre of Excellence in Genomics to the Estonian Biocentre and University of Tartu and by an Estonian Basic Research grant SF0270177As08. M.M. was additionally supported by Estonian Science Foundation grant number 8973. J.G.S. and M.S. were supported by NIH grant GM40282. P.H.S. and E.E.E. were supported by NIH grants HG004120 and HG002385. D.R. and N.P. were supported by NSF HOMINID award BCS-1032255 and NIH grant GM100233. This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN26120080001E. This Research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.
bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4170574Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; NatureArticle . 2014 . Peer-reviewedLicense: Springer TDMarXiv.org e-Print ArchiveOther literature type . Preprint . 2013Data sources: arXiv.org e-Print ArchiveCroatian Scientific Bibliography - CROSBIArticle . 2014Data sources: Croatian Scientific Bibliography - CROSBIServicio de Difusión de la Creación IntelectualArticle . 2014Data sources: Servicio de Difusión de la Creación Intelectualhttps://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/001552&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 1K citations 1,096 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 24visibility views 24 download downloads 297 Powered bymore_vert bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4170574Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; NatureArticle . 2014 . Peer-reviewedLicense: Springer TDMarXiv.org e-Print ArchiveOther literature type . Preprint . 2013Data sources: arXiv.org e-Print ArchiveCroatian Scientific Bibliography - CROSBIArticle . 2014Data sources: Croatian Scientific Bibliography - CROSBIServicio de Difusión de la Creación IntelectualArticle . 2014Data sources: Servicio de Difusión de la Creación Intelectualhttps://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/001552&type=result"></script>'); --> </script>
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