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apps Other research productkeyboard_double_arrow_right Other ORP type , InteractiveResource 2022 Netherlands EnglishZenodo Authors: Philip Verhagen; Bjørn P. Bartholdy;Philip Verhagen; Bjørn P. Bartholdy;This is part 4 of the Rchon statistics course. It continues the basics of statistical testing in R. In this tutorial, we will treat the following statistical testing methods: Mann-Whitney test Kruskal-Wallis test Kolmogorov-Smirnov test Follow the instructions in Instructions Tutorial 4.pdf to start the tutorial. This course was originally created for Archon Research School of Archaeology by Philip Verhagen (Vrije Universiteit Amsterdam) and Bjørn P. Bartholdy (University of Leiden), and consists of an instruction, a tutorial, a test and two datafiles. All content is CC BY-NC-SA: it can be freely distributed and modified under the condition of proper attribution and non-commercial use. How to cite: Verhagen, P. & B.P. Bartholdy, 2022. "Rchon statistics course, part 3". Amsterdam, ARCHON Research School of Archaeology. https://doi.org/10.5281/zenodo.7458108
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7458108&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type , InteractiveResource 2022 Netherlands EnglishZenodo Authors: Philip Verhagen; Bjørn P. Bartholdy;Philip Verhagen; Bjørn P. Bartholdy;This is part 3 of the Rchon statistics course. It continues the basics of statistical testing in R. In this tutorial, we will treat the following statistical testing methods: chi square test Fisher's exact test Follow the instructions in Instructions Tutorial 3.pdf to start the tutorial. This course was originally created for Archon Research School of Archaeology by Philip Verhagen (Vrije Universiteit Amsterdam) and Bjørn P. Bartholdy (University of Leiden), and consists of an instruction, a tutorial, a test and two datafiles. All content is CC BY-NC-SA: it can be freely distributed and modified under the condition of proper attribution and non-commercial use. How to cite: Verhagen, P. & B.P. Bartholdy, 2022. "Rchon statistics course, part 3". Amsterdam, ARCHON Research School of Archaeology. https://doi.org/10.5281/zenodo.7457698
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7457698&type=result"></script>'); --> </script>
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visibility 16visibility views 16 download downloads 22 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7457698&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishARIADNEplus Hollander, Hella; Wright, Holly; Ronzino, Paola; Massara, Flavia; Doorn, P.K.; Flohr, Pascal;This final ARIADNEplus project report on Policies and Good Practices for FAIR Archaeological Data Management describes how focused and dedicated support has established structured policies and strategies for the creation of archaeological data of high quality. A standardised and online tool offers a Data Management Plan for archaeologists which helps researchers to conduct their research following standard quality criteria. Researchers can save a lot of time when preparing a Data Management Plan, since a motivation is only required when deviating from the standard reply, which the Domain Protocol for Archaeological Data Management offers as pre-formulated statements. A related Guide for Archaeological Data Management Planning helps users in their work to find good practices in archaeological data management.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::4d319abdaa9280d263f35afa7dcf55f7&type=result"></script>'); --> </script>
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more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::4d319abdaa9280d263f35afa7dcf55f7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishAuthors: Lerchi, A.; Krap, T.; Eppenberger, P.; Pedergnana, A.;Lerchi, A.; Krap, T.; Eppenberger, P.; Pedergnana, A.;Residue analysis is an established area of expertise focused on detecting traces of substances found on the surface of objects. It is routinely employed in forensic casework and increasingly incorporated into archaeological investigations.In archaeology, sampling and data interpretation sometimes lacked strict standards, resulting in incorrect residue classifications. In particular, molecular signals of salts of fatty acids identified by FTIR have been, at times, interpreted as evidence for adipocere, a substance formed as a consequence of adipose tissues' degradation.This article reviews and discusses the possibilities and limitations of the analytical protocols used in residue analysis in archaeology. The focus is on three main points: (1) reviewing the decomposition processes and the chemical components of adipocere; (2) highlighting potential misidentifications of adipocere while, at the same time, addressing issues related to residue preservation and contamination; and (3) proposing new research avenues to identify adipocere on archaeological objects.(c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::3bf558339f590054ecfa85f6229f803e&type=result"></script>'); --> </script>
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For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishCenter for Open Sciences Rulkens, C.C.S.; Van Eyghen, Hans; Pear, Rachel; Peels, R.; Bouter, Lex; Stols-Witlox, Maartje; van den Brink, Gijsbert; Meloni, Sabrina; Buijsen, Edwin; van Woudenberg, René;At the Vrije Universiteit Amsterdam, we have set out to explore the strengths and limitations of replication studies in the humanities in practice. We are doing so by replicating two original studies: one in the field of art history, the other in the field of history of science and religion. In this blog, we outline the design, purposes, and aims of these projects and explore some of the challenges.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::3d5818cf0a240ee1cd12ad093c384546&type=result"></script>'); --> </script>
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more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::3d5818cf0a240ee1cd12ad093c384546&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishSpyrou, A.; Nobles, G.; Hadjikoumis, A.; Evin, A.; Hulme-Beaman, A.; Çakirlar, C.; Ameen, C.; Loucas, N.; Nikita, E.; Hanot, P.; de Boer, N. M.; Avgousti, A.; Zohar, I.; May, H.; Rehren, Th;Digital technologies are an increasingly pervasive medium for zooarchaeological scholarship, providing a means to document and preserve fragile zooarchaeological specimens, share primary data, address methodological questions, and spread the information to the wider public. During the last decade, a broad array of digital technologies has been widely applied for the creation of three-dimensional images of animal bones, with a number of freely accessible collections being developed and published online. To be beneficial for academic and non-academic audiences, the creation of these collections requires careful planning, and more attention is needed in order to ensure their longevity in the web as well as their future usability. Drawing on an online workshop, organised by the Science and Technology in Archaeology and Culture Research Center of The Cyprus Institute, titled “Zooarchaeology in the Digital Era”, this article aims to provide a snapshot of the current state of art, and the methods and digital tools being employed in the digitisation of animal remains. The article also raises some of the challenges that the international zooarchaeological community is facing in the era of Linked Open Data, including management, archiving, curation, storage, dissemination and communication of digital data to the scientific world and the wider public. In addition, the paper highlights the need for a stronger collaboration between archaeologists and researchers from the Digital Humanities’ sector in order to stimulate an innovative discourse and create fertile ground for the production of new scientific knowledge.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::cb2376dbb243013caf245dfa1a4fd9d5&type=result"></script>'); --> </script>
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more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::cb2376dbb243013caf245dfa1a4fd9d5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishParrini, I.; Luca, F.; Rao, C.M.; Parise, G.; Micali, L.R.; Musumeci, G.; La Meir, M.; Colivicchi, F.; Gulizia, M.M.; Gelsomino, S.;Background and aim. Cancer and atrial fibrillation (AF) may be associated, and anticoagulation, either with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs), is necessary to prevent thromboembolic events by reducing the risk of bleeding. The log incidence rate ratio (IRR) and 95% confidence interval were used as index statistics. Higgin's I-2 test was adopted to assess statistical inconsistencies by considering interstudy variations, defined by values ranging from 0 to 100%. I-2 values of less than 40% are associated with very low heterogeneity among the studies; values between 40% and 75% indicate moderate heterogeneity, and those greater than 75% suggest severe heterogeneity. The aim of this meta-analysis was to compare the safety and efficacy of VKAs and DOACs in oncologic patients with AF. Methods. A meta-analysis was conducted comparing VKAs to DOACs in terms of thromboembolic events and bleeding. A meta-regression was conducted to investigate the differences in efficacy and safety between four different DOACs. Moreover, a sub-analysis on active-cancer-only patients was conducted. Results. A total of eight papers were included. The log incidence rate ratio (IRR) for thromboembolic events between the two groups was -0.69 (p 0.9). The Log IRR was -0.38 (p = 0.008) for ischemic stroke, -0.43 (p = 0.02) for myocardial infarction, -0.39 (p = 0.45) for arterial embolism, and -1.04 (p = 0.003) for venous thromboembolism. The log IRR for bleeding events was -0.43 (p < 0.005), and the meta-regression revealed no statistical difference (p = 0.7). The log IRR of hemorrhagic stroke, major bleeding, and clinically relevant non-major bleeding between the VKA and DOAC groups was -0.51 (p < 0.0001), -0.45 (p = 0.03), and 0.0045 (p = 0.97), respectively. Similar results were found in active-cancer patients for all the endpoints except for clinically-relevant non-major bleedings. Conclusions. DOACs showed better efficacy and safety outcomes than VKAs. No difference was found between types of DOACs.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::163c8b7cfb4c70f9f1387db11cedc466&type=result"></script>'); --> </script>
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For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishAuthors: van Zundert, Joris J.;van Zundert, Joris J.;Increasingly code and algorithms are techniques also applied in textual scholarship, giving rise to new interactions between software engineers and textual scholars. This book argues that much of that process and its effects on textual scholarship are still poorly understood and go unchecked by otherwise normal processes of quality control in scholarship such as peer review. The text provides case studies in which some of these interactions become more apparent, as well as the academic challenges and problems that they introduce. The book demonstrates that the space between code creation and conventional scholarship is one that offers many affordances to textual scholarship that until now remain unexplored. The author argues that it is an intellectual obligation of programmers and textual scholars to examine the properties of digital text and how its existence changes and challenges textual scholarship.
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For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishDiggit Magazine Authors: Swanenberg, Jos;Swanenberg, Jos;Regional language, ranging from local dialects to an iconic accent, is an important part of cultural heritage and identity. Consequently, dialects and accents are also of significance for many online communities. This article deals with one of these communities: Brabantians who are involved online with their regional language
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For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishAuthors: Kelder, J.M.;Kelder, J.M.;handle: 1887/3448269
From an Ancient Egyptian plague to the Black Death and Spanish flu, epidemics have often spurred societal transformations. Understanding why can help us create a better world after covid-19
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more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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apps Other research productkeyboard_double_arrow_right Other ORP type , InteractiveResource 2022 Netherlands EnglishZenodo Authors: Philip Verhagen; Bjørn P. Bartholdy;Philip Verhagen; Bjørn P. Bartholdy;This is part 4 of the Rchon statistics course. It continues the basics of statistical testing in R. In this tutorial, we will treat the following statistical testing methods: Mann-Whitney test Kruskal-Wallis test Kolmogorov-Smirnov test Follow the instructions in Instructions Tutorial 4.pdf to start the tutorial. This course was originally created for Archon Research School of Archaeology by Philip Verhagen (Vrije Universiteit Amsterdam) and Bjørn P. Bartholdy (University of Leiden), and consists of an instruction, a tutorial, a test and two datafiles. All content is CC BY-NC-SA: it can be freely distributed and modified under the condition of proper attribution and non-commercial use. How to cite: Verhagen, P. & B.P. Bartholdy, 2022. "Rchon statistics course, part 3". Amsterdam, ARCHON Research School of Archaeology. https://doi.org/10.5281/zenodo.7458108
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7458108&type=result"></script>'); --> </script>
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visibility 16visibility views 16 download downloads 26 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7458108&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type , InteractiveResource 2022 Netherlands EnglishZenodo Authors: Philip Verhagen; Bjørn P. Bartholdy;Philip Verhagen; Bjørn P. Bartholdy;This is part 3 of the Rchon statistics course. It continues the basics of statistical testing in R. In this tutorial, we will treat the following statistical testing methods: chi square test Fisher's exact test Follow the instructions in Instructions Tutorial 3.pdf to start the tutorial. This course was originally created for Archon Research School of Archaeology by Philip Verhagen (Vrije Universiteit Amsterdam) and Bjørn P. Bartholdy (University of Leiden), and consists of an instruction, a tutorial, a test and two datafiles. All content is CC BY-NC-SA: it can be freely distributed and modified under the condition of proper attribution and non-commercial use. How to cite: Verhagen, P. & B.P. Bartholdy, 2022. "Rchon statistics course, part 3". Amsterdam, ARCHON Research School of Archaeology. https://doi.org/10.5281/zenodo.7457698
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7457698&type=result"></script>'); --> </script>
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visibility 16visibility views 16 download downloads 22 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7457698&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishARIADNEplus Hollander, Hella; Wright, Holly; Ronzino, Paola; Massara, Flavia; Doorn, P.K.; Flohr, Pascal;This final ARIADNEplus project report on Policies and Good Practices for FAIR Archaeological Data Management describes how focused and dedicated support has established structured policies and strategies for the creation of archaeological data of high quality. A standardised and online tool offers a Data Management Plan for archaeologists which helps researchers to conduct their research following standard quality criteria. Researchers can save a lot of time when preparing a Data Management Plan, since a motivation is only required when deviating from the standard reply, which the Domain Protocol for Archaeological Data Management offers as pre-formulated statements. A related Guide for Archaeological Data Management Planning helps users in their work to find good practices in archaeological data management.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::4d319abdaa9280d263f35afa7dcf55f7&type=result"></script>'); --> </script>
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more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::4d319abdaa9280d263f35afa7dcf55f7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishAuthors: Lerchi, A.; Krap, T.; Eppenberger, P.; Pedergnana, A.;Lerchi, A.; Krap, T.; Eppenberger, P.; Pedergnana, A.;Residue analysis is an established area of expertise focused on detecting traces of substances found on the surface of objects. It is routinely employed in forensic casework and increasingly incorporated into archaeological investigations.In archaeology, sampling and data interpretation sometimes lacked strict standards, resulting in incorrect residue classifications. In particular, molecular signals of salts of fatty acids identified by FTIR have been, at times, interpreted as evidence for adipocere, a substance formed as a consequence of adipose tissues' degradation.This article reviews and discusses the possibilities and limitations of the analytical protocols used in residue analysis in archaeology. The focus is on three main points: (1) reviewing the decomposition processes and the chemical components of adipocere; (2) highlighting potential misidentifications of adipocere while, at the same time, addressing issues related to residue preservation and contamination; and (3) proposing new research avenues to identify adipocere on archaeological objects.(c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishCenter for Open Sciences Rulkens, C.C.S.; Van Eyghen, Hans; Pear, Rachel; Peels, R.; Bouter, Lex; Stols-Witlox, Maartje; van den Brink, Gijsbert; Meloni, Sabrina; Buijsen, Edwin; van Woudenberg, René;At the Vrije Universiteit Amsterdam, we have set out to explore the strengths and limitations of replication studies in the humanities in practice. We are doing so by replicating two original studies: one in the field of art history, the other in the field of history of science and religion. In this blog, we outline the design, purposes, and aims of these projects and explore some of the challenges.
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For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishSpyrou, A.; Nobles, G.; Hadjikoumis, A.; Evin, A.; Hulme-Beaman, A.; Çakirlar, C.; Ameen, C.; Loucas, N.; Nikita, E.; Hanot, P.; de Boer, N. M.; Avgousti, A.; Zohar, I.; May, H.; Rehren, Th;Digital technologies are an increasingly pervasive medium for zooarchaeological scholarship, providing a means to document and preserve fragile zooarchaeological specimens, share primary data, address methodological questions, and spread the information to the wider public. During the last decade, a broad array of digital technologies has been widely applied for the creation of three-dimensional images of animal bones, with a number of freely accessible collections being developed and published online. To be beneficial for academic and non-academic audiences, the creation of these collections requires careful planning, and more attention is needed in order to ensure their longevity in the web as well as their future usability. Drawing on an online workshop, organised by the Science and Technology in Archaeology and Culture Research Center of The Cyprus Institute, titled “Zooarchaeology in the Digital Era”, this article aims to provide a snapshot of the current state of art, and the methods and digital tools being employed in the digitisation of animal remains. The article also raises some of the challenges that the international zooarchaeological community is facing in the era of Linked Open Data, including management, archiving, curation, storage, dissemination and communication of digital data to the scientific world and the wider public. In addition, the paper highlights the need for a stronger collaboration between archaeologists and researchers from the Digital Humanities’ sector in order to stimulate an innovative discourse and create fertile ground for the production of new scientific knowledge.
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For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishParrini, I.; Luca, F.; Rao, C.M.; Parise, G.; Micali, L.R.; Musumeci, G.; La Meir, M.; Colivicchi, F.; Gulizia, M.M.; Gelsomino, S.;Background and aim. Cancer and atrial fibrillation (AF) may be associated, and anticoagulation, either with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs), is necessary to prevent thromboembolic events by reducing the risk of bleeding. The log incidence rate ratio (IRR) and 95% confidence interval were used as index statistics. Higgin's I-2 test was adopted to assess statistical inconsistencies by considering interstudy variations, defined by values ranging from 0 to 100%. I-2 values of less than 40% are associated with very low heterogeneity among the studies; values between 40% and 75% indicate moderate heterogeneity, and those greater than 75% suggest severe heterogeneity. The aim of this meta-analysis was to compare the safety and efficacy of VKAs and DOACs in oncologic patients with AF. Methods. A meta-analysis was conducted comparing VKAs to DOACs in terms of thromboembolic events and bleeding. A meta-regression was conducted to investigate the differences in efficacy and safety between four different DOACs. Moreover, a sub-analysis on active-cancer-only patients was conducted. Results. A total of eight papers were included. The log incidence rate ratio (IRR) for thromboembolic events between the two groups was -0.69 (p 0.9). The Log IRR was -0.38 (p = 0.008) for ischemic stroke, -0.43 (p = 0.02) for myocardial infarction, -0.39 (p = 0.45) for arterial embolism, and -1.04 (p = 0.003) for venous thromboembolism. The log IRR for bleeding events was -0.43 (p < 0.005), and the meta-regression revealed no statistical difference (p = 0.7). The log IRR of hemorrhagic stroke, major bleeding, and clinically relevant non-major bleeding between the VKA and DOAC groups was -0.51 (p < 0.0001), -0.45 (p = 0.03), and 0.0045 (p = 0.97), respectively. Similar results were found in active-cancer patients for all the endpoints except for clinically-relevant non-major bleedings. Conclusions. DOACs showed better efficacy and safety outcomes than VKAs. No difference was found between types of DOACs.
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For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishAuthors: van Zundert, Joris J.;van Zundert, Joris J.;Increasingly code and algorithms are techniques also applied in textual scholarship, giving rise to new interactions between software engineers and textual scholars. This book argues that much of that process and its effects on textual scholarship are still poorly understood and go unchecked by otherwise normal processes of quality control in scholarship such as peer review. The text provides case studies in which some of these interactions become more apparent, as well as the academic challenges and problems that they introduce. The book demonstrates that the space between code creation and conventional scholarship is one that offers many affordances to textual scholarship that until now remain unexplored. The author argues that it is an intellectual obligation of programmers and textual scholars to examine the properties of digital text and how its existence changes and challenges textual scholarship.
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For further information contact us at helpdesk@openaire.euapps Other research productkeyboard_double_arrow_right Other ORP type 2022 Netherlands EnglishDiggit Magazine Authors: Swanenberg, Jos;Swanenberg, Jos;