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Milestone 34, Expose ESS’ interoperable services to external consumers, was achieved on 17 December 2021. The new system gives users access to the data catalogue of the European Social Survey (ESS) from the new data and metadata repositories via https://ess-search.nsd.no/en/all/query/.

Abstract. The detection and attribution (D&A) of paleoclimatic change to external radiative forcing relies on regression of statistical reconstructions on simulations. However, this procedure may be biased by assumptions of stationarity and univariate linear response of the underlying paleoclimatic observations. Here we perform a D&A study, modeling paleoclimate data observations as a function of paleoclimatic data simulations. Specifically, we detect and attribute tree-ring width (TRW) observations as a linear function of TRW simulations, which are themselves a nonlinear and multivariate TRW simulation driven with singly forced and cumulatively forced climate simulations for the period 1401–2000 CE. Temperature- and moisture-sensitive TRW simulations detect distinct patterns in time and space. Temperature-sensitive TRW observations and simulations are significantly correlated for Northern Hemisphere averages, and their variation is attributed to volcanic forcing. In decadally smoothed temporal fingerprints, we find the observed responses to be significantly larger and/or more persistent than the simulated responses. The pattern of simulated TRW of moisture-limited trees is consistent with the observed anomalies in the 2 years following major volcanic eruptions. We can for the first time attribute this spatiotemporal fingerprint in moisture-limited tree-ring records to volcanic forcing. These results suggest that the use of nonlinear and multivariate proxy system models in paleoclimatic detection and attribution studies may permit more realistic, spatially resolved and multivariate fingerprint detection studies and evaluation of the climate sensitivity to external radiative forcing than has previously been possible.

This article presents an overview that systematically maps the historical development, thematic foci and temporal trends of research in Balkan – Southeast European studies. It uses bibliographic and content analysis as well as other tools to synthesize around 8000 scholarly publications on the Balkans – Southeast Europe that are indexed in the Web of Science databases (SSCI, A&HCI, ESCI, BKCI-SSH). We provide a visual representation of the intellectual historiography and the conceptual content and dynamics of Balkan – Southeast European studies, identifying the most prominent works, the active research themes and the emerging trajectories in the field.

Studies of childbearing across partnerships-having children with more than one partner-have generally focused on countries with relatively high separation rates. We complement this previous research with analyses for Italy using nationally representative, retrospective data and event-history techniques. This study offers three key findings. First, we detected a non-negligible share of childbearing across partnerships, although at substantially lower levels relative to other wealthy countries (5 per cent of parents aged 25-54 with at least two children). Second, multivariate analyses revealed an impressive similarity to the demographic correlates found elsewhere. Finally, we showed that childbearing across partnerships was initiated by the 'social vanguard' of new family behaviours but then diffused among the least well-off. Overall, this paper adds to the growing literature on childbearing across partnerships by showing the phenomenon to be demographically and sociologically relevant, even in countries with strong family ties and a limited diffusion of union dissolution.

AbstractTwo Greek gospel manuscripts with an exegetical commentary in catena form present a text of Mark which ends in the middle of Mark 16.8. One is GA 304, a twelfth-century codex which is often adduced as a witness to the Short Ending. The other is the eleventh-century GA 239, which has not previously featured in discussions of the conclusion of Mark. In each case, it is shown that considerations of scribal practice, codicology and the broader traditions of text and catena mean that neither witness should be treated as evidence for the Short Ending as found in Codices Sinaiticus and Vaticanus.

BackgroundPrior research has solely focused on the association between handgrip strength and risk of depression in single countries or general populations, but more knowledge is required from wider-spread cohorts and target populations.AimsThis study aimed to investigate the association between handgrip strength and risk of depression using repeated measures in adults aged 50 years and over.MethodData on handgrip strength and risk of depression were retrieved from the Survey of Health, Ageing and Retirement in Europe (SHARE) waves 1, 2, 4, 5, 6 and 7, using a hand dynamometer (Smedley, S Dynamometer, TTM) and the EURO-D 12-item scale, respectively. Time-varying exposure and covariates were modelled using both Cox regression and restricted cubic splines.ResultsA total of 115 601 participants (mean age 64.3 years (s.d. = 9.9), 54.3% women) were followed-up for a median of 7.3 years (interquartile range: 3.9–11.8) and 792 459 person-years. During this period, 30 208 (26.1%) participants experienced a risk of depression. When modelled as a continuous variable, we observed an inverse significant association for each kg increase of handgrip strength and depression up to 40 kg in men and up to 27 kg in women.ConclusionsBeing physically strong may serve as a preventive factor for depression in older adults, but this is limited up to a maximum specific threshold for men and women.

This article aims to diversify STS perspectives on populism by addressing a sequence of episodes of Mexican science policy in terms of clashes between populism and scientific communities. The article describes a reorientation of Mexican science policy that has destabilized the academic system during the present administration. Specifically, it looks at the legislative project initiated by Mexico’s National Science and Technology Council (Conacyt) to overhaul the national regulatory framework on science, technology and innovation, and controversial political actions taken by Conacyt against the scientific community. Contextualizing these grievances, the article concludes that at stake is a form of ‘trickle-down populism’ that, through systematic authoritarianism, seeks to impose on the academic community a model of ‘populist science governance’.

CRISPR-Cas are prokaryotic adaptive immune systems. Cas nucleases generally use CRISPR-derived RNA guides to specifically bind and cleave DNA or RNA targets. Here, we describe the experimental characterization of a bacterial CRISPR effector protein Cas12m representing subtype V-M. Despite being less than half the size of Cas12a, Cas12m catalyzes auto-processing of a crRNA guide, recognizes a 5′-TTN′ protospacer-adjacent motif (PAM), and stably binds a guide-complementary double-stranded DNA (dsDNA). Cas12m has a RuvC domain with a non-canonical catalytic site and accordingly is incapable of guide-dependent cleavage of target nucleic acids. Despite lacking target cleavage activity, the high binding affinity of Cas12m to dsDNA targets allows for interference as demonstrated by its ability to protect bacteria against invading plasmids through silencing invader transcription and/or replication. Based on these molecular features, we repurposed Cas12m by fusing it to a cytidine deaminase that resulted in base editing within a distinct window.

This article challenges the observation that historians and the discipline of History have not been helpful in addressing some of the important challenges in the Study of Religion by concentrating on “the local” and on deconstruction rather than on construction and “the global.” By undertaking a cross-cultural case study — Medieval and Early Modern prophecies in the Muslim world and Europe — and focusing on the role and significance of the Granadan Sacromonte Lead Books (1588–1606) and the work of the radical Antitrinitarian Jacobus Paleologus (1520–1585), this paper argues that global and connected microhistorical approaches have been of great value to developing the promising trend of a relational approach in the Study of Religion.