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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Wartacz, D.; Riesch, J. ; https://orcid.org/0000-0001-6896-6352; Pantleon, K.; Pantleon, W.;

    Abstract High heat fluxes in future fusion reactors pose big challenges on the materials of plasma-facing components due to restoration processes occurring at high temperatures. Tungsten is considered most suitable as plasma-facing material. To overcome its inherent brittleness at low temperatures, tungsten fiber-reinforced tungsten composites are developed which contain ductile, potassium-doped, drawn tungsten wires in an undeformed tungsten matrix. Such composites show pseudo-ductile behavior, an improved toughness and a more controlled fracture compared to undeformed tungsten. Model systems containing a single fiber either without any interlayer or with an yttria interlayer between fiber and matrix are annealed and characterized by electron backscatter diffraction (EBSD) in order to investigate their thermal stability. The restoration process in wire and matrix differ from each other: Recrystallization followed by grain growth occurs in the deformation structure of the wire. Grain growth is the sole mechanism affecting the undeformed matrix. An yttria interlayer between fiber and matrix is supposed to separate the differently restoring microstructures from each other and thereby preserve the improved mechanical properties of the composite. The investigation focuses on characterizing the as-processed condition and the microstructural changes after annealing at 1450 °C for either four days or two weeks. After two weeks of annealing, grains in the region or the vicinity of the wire have coarsened so much that former fiber and matrix cannot be distinguished any longer; not even in a model composite with a 1 μm thick yttria interlayer.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ MPG.PuRearrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    MPG.PuRe
    Article . 2023
    Data sources: MPG.PuRe
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Journal of Physics : Conference Series
    Article . 2023 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
    MPG.PuRe
    Article . 2023
    Data sources: MPG.PuRe
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ MPG.PuRearrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      MPG.PuRe
      Article . 2023
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Journal of Physics : Conference Series
      Article . 2023 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
      MPG.PuRe
      Article . 2023
      Data sources: MPG.PuRe
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Naihui Wang; Yang Xu; Zhuowei Tang; Cunding He; +3 Authors

    The application of Zooarchaeology by Mass Spectrometry (ZooMS) on Pleistocene sites in Europe and northern Asia has resulted in the discovery of important new hominin fossils and has expanded the range of identified fauna. However, no systematic, large-scale application of ZooMS on Palaeolithic sites in East Asia has been attempted thus far. Here, we analyse 866 morphologically non-diagnostic bones from Jinsitai Cave in northeast China and Yumidong Cave in South China, from archaeological horizons dating to 150–10 ka BP. Bones from both sites revealed a high degree of collagen preservation and potentially time-related deamidation patterns, despite being located in very distinct environmental settings. At Jinsitai, we identified 31 camel bones, five of which were radiocarbon dated to 37–20 ka BP. All dated specimens correspond to colder periods of Marine Isotope Stages 3 and 2. We regard the presence of camels at Jinsitai as evidence of wild camels being a megafauna taxon targeted, most likely by early modern humans, during their expansion across northeast Asia. This large-scale application of ZooMS in China highlights the potential of the method for furthering our knowledge of the palaeoanthropological and zooarchaeological records of East Asia. 1. Introduction 2. Material and methods (a) Studied sites (b) Materials (c) Sampling and data generating (d) Data processing 3. Results and discussion (a) Deamidation (b) ZooMS taxonomic results and comparison with zooarchaeological data (c) Camels in Jinsitai Cave 4. Conclusion

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    MPG.PuRe
    Article . 2023
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    MPG.PuRe
    Article . 2023
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Proceedings of the Royal Society B Biological Sciences
    Article . 2023 . Peer-reviewed
    License: Royal Society Data Sharing and Accessibility
    Data sources: Crossref
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ MPG.PuRearrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      MPG.PuRe
      Article . 2023
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      MPG.PuRe
      Article . 2023
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Proceedings of the Royal Society B Biological Sciences
      Article . 2023 . Peer-reviewed
      License: Royal Society Data Sharing and Accessibility
      Data sources: Crossref
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Fradkin, Isaac; Nour, Matthew M.; Dolan, Raymond J.;

    BACKGROUND: Natural language processing (NLP) holds promise to transform psychiatric research and practice. A pertinent example is the success of NLP in the automatic detection of speech disorganization in formal thought disorder (FTD). However, we lack an understanding of precisely what common NLP metrics measure and how they relate to theoretical accounts of FTD. We propose tackling these questions by using deep generative language models to simulate FTD-like narratives by perturbing computational parameters instantiating theory-based mechanisms of FTD. METHODS: We simulated FTD-like narratives using Generative-Pretrained-Transformer-2 by either increasing word selection stochasticity or limiting the model's memory span. We then examined the sensitivity of common NLP measures of derailment (semantic distance between consecutive words or sentences) and tangentiality (how quickly meaning drifts away from the topic) in detecting and dissociating the 2 underlying impairments. RESULTS: Both parameters led to narratives characterized by greater semantic distance between consecutive sentences. Conversely, semantic distance between words was increased by increasing stochasticity, but decreased by limiting memory span. An NLP measure of tangentiality was uniquely predicted by limited memory span. The effects of limited memory span were nonmonotonic in that forgetting the global context resulted in sentences that were semantically closer to their local, intermediate context. Finally, different methods for encoding the meaning of sentences varied dramatically in performance. CONCLUSIONS: This work validates a simulation-based approach as a valuable tool for hypothesis generation and mechanistic analysis of NLP markers in psychiatry. To facilitate dissemination of this approach, we accompany the paper with a hands-on Python tutorial.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ MPG.PuRearrow_drop_down
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    MPG.PuRe
    Article . 2023
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Biological Psychiatry Cognitive Neuroscience and Neuroimaging
    Article . 2023 . Peer-reviewed
    License: Elsevier TDM
    Data sources: Sygma; Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    UCL Discovery
    Article . 2023
    Data sources: UCL Discovery
    MPG.PuRe
    Article . 2023
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ MPG.PuRearrow_drop_down
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      MPG.PuRe
      Article . 2023
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      Biological Psychiatry Cognitive Neuroscience and Neuroimaging
      Article . 2023 . Peer-reviewed
      License: Elsevier TDM
      Data sources: Sygma; Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      UCL Discovery
      Article . 2023
      Data sources: UCL Discovery
      MPG.PuRe
      Article . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Claudia Chang; Sergei S. Ivanov; Robert N. Spengler; Basira Mir-Makhamad; +1 Authors

    In this paper, we use preliminary archaeological data spanning the Iron Age through Medieval periods (ca. 800 BCE to 1200 CE) in the Juuku Valley in Kyrgyzstan on the south side of Lake Issyk-Kul to model land use across vertical mountain zones. We have (1) established a radiometric chronology; (2) conducted test excavations of an Iron Age settlement at 2100 m asl and a Turkic period burial at 1934 m asl; (3) undertaken preliminary archaeobotanical research; and (4) performed pedestrian surveys. Archaeobotanical remains of wheat (Triticum aestivum), barley (Hordeum vulgare), broomcorn millet (Panicum milaceum), foxtail millet (Setaria italica), and legumes were recovered in very small quantities from both sites. We compare these preliminary archaeobotanical results with previously published data from Talgar Iron Age settlements on the north side of the Tian Shan Mountain range in Kazakhstan. A small assemblage of faunal remains found at the Turkic period kurgan and from a profile at the upland Iron Age settlement demonstrates the practice of herding sheep/goats, cattle, and horses in the Juuku Valley. The goal of this study was to test the hypothesis that pastoral transhumance and agropastoralism were interchangeable economic strategies used by peoples in the Iron Age through Medieval periods in mountain-river valleys between 600 m to 2100 m asl. These economic strategies combined the pasturing of sheep, goats, cattle, and horses with the cultivation of cereals in a system that was adapted to different vegetational zones along a vertical gradient. This paper is based on preliminary research using survey data and test excavations and initiates a long-term research study of four millennia of settlements that appear to have ranged from pastoral transhumance and combined mountain agriculture. 1. Introduction 1.1. Theoretical Perspectives 1.2. Our Model 2. Materials and Methods 2.1. Study Areas 2.1.1. The Talgar Alluvial Fan 2.1.2. The Juuku Valley 2.2. Chronological Framework for the Juuku Valley 2.3. Test Excavations and Kurgan Excavations 2.3.1. Lower Juuku Kurgan 1 2.3.2. Block Excavations at Eastern Juuku Settlement 1 2.3.3. Profiles 4 and 6 2.4. Radiometric Dating 2.5. Archaeobotanical Sampling 3. Results 3.1. The Radiometric Sequence for Juuku Valley 3.1.1. Kurgan Excavation 3.1.2. Excavations at EJS1 3.1.3. Archaeobotanical Results 4. Discussion 5. Conclusions

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Landarrow_drop_down
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    Other literature type . Article . 2023 . Peer-reviewed
    License: CC BY
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Land
    Article . 2023
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    MPG.PuRe
    Article . 2023
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    MPG.PuRe
    Article . 2023
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      Other literature type . Article . 2023 . Peer-reviewed
      License: CC BY
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      Article . 2023
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      MPG.PuRe
      Article . 2023
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      Article . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Hermine Xhauflair; Sheldon Jago-on; Timothy James Vitales; Dante Manipon; +6 Authors

    A large part of our material culture is made of organic materials, and this was likely the case also during prehistory. Amongst this prehistoric organic material culture are textiles and cordages, taking advantage of the flexibility and resistance of plant fibres. While in very exceptional cases and under very favourable circumstances, fragments of baskets and cords have survived and were discovered in late Pleistocene and Holocene archaeological sites, these objects are generally not preserved, especially in tropical regions. We report here indirect evidence of basket/tying material making found on stone tools dating to 39–33,000 BP from Tabon Cave, Palawan Philippines. The distribution of use-wear on these artefacts is the same as the distribution observed on experimental tools used to thin fibres, following a technique that is widespread in the region currently. The goal of this activity is to turn hard plant segments into supple strips suitable as tying material or to weave baskets, traps, and even boats. This study shows early evidence of this practice in Southeast Asia and adds to the growing set of discoveries showing that fibre technology was an integral part of late Pleistocene skillset. This paper also provides a new way to identify supple strips of fibres made of tropical plants in the archaeological record, an organic technology that is otherwise most of the time invisible. 1. Introduction 2. Material and methods 2.1. Tabon Cave, Palawan, Philippines 2.2. Use-wear analysis of the artefacts 2.3. Reference collection: Experiments and ethnoarchaeology 3. Results 3.1. Use-wear and residues found on 3 stone tools from Tabon Cave 3.2. Similar use-wear pattern observed on experimental tools used for thinning plant fibres 3.3. Ethnoarchaeological basis of the experiments: Fibre processing among Pala’wan communities from Brooke’s Point, Philippines 3.4. Developing an understanding of the function of Tabon Cave artefacts based on experimental and ethnographic data 4. Discussion 5. Conclusion

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    PLoS ONE
    Article . 2023
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    PLoS ONE
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    This essay provides an overview of recent histories of medicine and global health from a socialist perspective, and maps out possible new directions of research. It focuses on key themes in the history of medicine in Eastern Europe, its global connections and Latin American, East Asian and African contexts. Through a discussion of international professional and diplomatic networks, health systems, medical technologies and aid and technical assistance, the essay argues that integrating missing actors, ideas and practices is crucial for a complete understanding of global health history. Peer Reviewed

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    https://doi.org/10.18452/27776...
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      https://doi.org/10.18452/27776...
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    Authors: Alexandra A. de Sousa; Amélie Beaudet; Tanya Calvey; Ameline Bardo; +17 Authors

    Fossil endocasts record features of brains from the past: size, shape, vasculature, and gyrification. These data, alongside experimental and comparative evidence, are needed to resolve questions about brain energetics, cognitive specializations, and developmental plasticity. Through the application of interdisciplinary techniques to the fossil record, paleoneurology has been leading major innovations. Neuroimaging is shedding light on fossil brain organization and behaviors. Inferences about the development and physiology of the brains of extinct species can be experimentally investigated through brain organoids and transgenic models based on ancient DNA. Phylogenetic comparative methods integrate data across species and associate genotypes to phenotypes, and brains to behaviors. Meanwhile, fossil and archeological discoveries continuously contribute new knowledge. Through cooperation, the scientific community can accelerate knowledge acquisition. Sharing digitized museum collections improves the availability of rare fossils and artifacts. Comparative neuroanatomical data are available through online databases, along with tools for their measurement and analysis. In the context of these advances, the paleoneurological record provides ample opportunity for future research. Biomedical and ecological sciences can benefit from paleoneurology’s approach to understanding the mind as well as its novel research pipelines that establish connections between neuroanatomy, genes and behavior. International audience

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    Apollo
    Article . 2023
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    Communications Biology
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    Communications Biology
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      Communications Biology
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    Authors: Rigaud, S.; Rybin, E.; Khatsenovich, A.; Queffelec, A.; +13 Authors

    AbstractFigurative depictions in art first occur ca. 50,000 years ago in Europe, Africa, and Southeast Asia. Considered by most as an advanced form of symbolic behavior, they are restricted to our species. Here, we report a piece of ornament interpreted as a phallus-like representation. It was found in a 42,000 ca.-year-old Upper Paleolithic archaeological layer at the open-air archaeological site of Tolbor-21, in Mongolia. Mineralogical, microscopic, and rugosimetric analyses points toward the allochthonous origin of the pendant and a complex functional history. Three-dimensional phallic pendants are unknown in the Paleolithic record, and this discovery predates the earliest known sexed anthropomorphic representation. It attests that hunter-gatherer communities used sex anatomical attributes as symbols at a very early stage of their dispersal in the region. The pendant was produced during a period that overlaps with age estimates for early introgression events between Homo sapiens and Denisovans, and in a region where such encounters are plausible.

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    Scientific Reports
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    Scientific Reports
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    Authors: Pooja Swali; Rick Schulting; Alexandre Gilardet; Monica Kelly; +20 Authors

    AbstractExtinct lineages of Yersinia pestis, the causative agent of the plague, have been identified in several individuals from Eurasia between 5000 and 2500 years before present (BP). One of these, termed the ‘LNBA lineage’ (Late Neolithic and Bronze Age), has been suggested to have spread into Europe with human groups expanding from the Eurasian steppe. Here, we show that the LNBA plague was spread to Europe’s northwestern periphery by sequencing three Yersinia pestis genomes from Britain, all dating to ~4000 cal BP. Two individuals were from an unusual mass burial context in Charterhouse Warren, Somerset, and one individual was from a single burial under a ring cairn monument in Levens, Cumbria. To our knowledge, this represents the earliest evidence of LNBA plague in Britain documented to date. All three British Yersinia pestis genomes belong to a sublineage previously observed in Bronze Age individuals from Central Europe that had lost the putative virulence factor yapC. This sublineage is later found in Eastern Asia ~3200 cal BP. While the severity of the disease is currently unclear, the wide geographic distribution within a few centuries suggests substantial transmissibility.

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    https://doi.org/10.25418/crick...
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    Authors: Künzi, M.; Sieber, S.; Joly-Burra, E.; Cullati, S.; +5 Authors

    AbstractThis study set out to examine the role of different adversities experienced at different life course stages on cognitive aging (i.e., level and change). Data from the longitudinal study: Survey of Health, Ageing, and Retirement in Europe (SHARE) with the selection of participants over 60 years were used (N = 2662, Mdnage = 68, SDage = 5.39) in a Structural Equation Modeling. In early life, the experience of hunger predicted lower delayed recall (β = − 0.10, p < 0.001) and verbal fluency (β = − 0.06, p = 0.001) performance in older age, whereas financial hardship predicted lower verbal fluency (β = − 0.06, p = 0.005) performance and steeper decline in delayed recall (β = − 0.11, p < 0.001). In early adulthood, financial hardship and stress predicted better delayed recall (financial hardship: β = 0.08, p = 0.001; stress: β = 0.07, p = 0.003) and verbal fluency performance (financial hardship: β = 0.08, p = 0.001; stress β = 0.10, p < 0.001), but no adversities were associated with a change in cognitive performance. In middle adulthood, no adversities were associated with the level of cognitive performance, but financial hardship predicted lower decline in delayed recall (β = 0.07, p = 0.048). This study highlights the importance of disentangling the period effect from the specific effect of the adversity experienced in the association between adversity and cognition in older age. Moreover, differential results for delayed recall and verbal fluency measures suggest that it is also important to consider the cognitive outcome domains examined.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Wartacz, D.; Riesch, J. ; https://orcid.org/0000-0001-6896-6352; Pantleon, K.; Pantleon, W.;

    Abstract High heat fluxes in future fusion reactors pose big challenges on the materials of plasma-facing components due to restoration processes occurring at high temperatures. Tungsten is considered most suitable as plasma-facing material. To overcome its inherent brittleness at low temperatures, tungsten fiber-reinforced tungsten composites are developed which contain ductile, potassium-doped, drawn tungsten wires in an undeformed tungsten matrix. Such composites show pseudo-ductile behavior, an improved toughness and a more controlled fracture compared to undeformed tungsten. Model systems containing a single fiber either without any interlayer or with an yttria interlayer between fiber and matrix are annealed and characterized by electron backscatter diffraction (EBSD) in order to investigate their thermal stability. The restoration process in wire and matrix differ from each other: Recrystallization followed by grain growth occurs in the deformation structure of the wire. Grain growth is the sole mechanism affecting the undeformed matrix. An yttria interlayer between fiber and matrix is supposed to separate the differently restoring microstructures from each other and thereby preserve the improved mechanical properties of the composite. The investigation focuses on characterizing the as-processed condition and the microstructural changes after annealing at 1450 °C for either four days or two weeks. After two weeks of annealing, grains in the region or the vicinity of the wire have coarsened so much that former fiber and matrix cannot be distinguished any longer; not even in a model composite with a 1 μm thick yttria interlayer.

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    Journal of Physics : Conference Series
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    Authors: Naihui Wang; Yang Xu; Zhuowei Tang; Cunding He; +3 Authors

    The application of Zooarchaeology by Mass Spectrometry (ZooMS) on Pleistocene sites in Europe and northern Asia has resulted in the discovery of important new hominin fossils and has expanded the range of identified fauna. However, no systematic, large-scale application of ZooMS on Palaeolithic sites in East Asia has been attempted thus far. Here, we analyse 866 morphologically non-diagnostic bones from Jinsitai Cave in northeast China and Yumidong Cave in South China, from archaeological horizons dating to 150–10 ka BP. Bones from both sites revealed a high degree of collagen preservation and potentially time-related deamidation patterns, despite being located in very distinct environmental settings. At Jinsitai, we identified 31 camel bones, five of which were radiocarbon dated to 37–20 ka BP. All dated specimens correspond to colder periods of Marine Isotope Stages 3 and 2. We regard the presence of camels at Jinsitai as evidence of wild camels being a megafauna taxon targeted, most likely by early modern humans, during their expansion across northeast Asia. This large-scale application of ZooMS in China highlights the potential of the method for furthering our knowledge of the palaeoanthropological and zooarchaeological records of East Asia. 1. Introduction 2. Material and methods (a) Studied sites (b) Materials (c) Sampling and data generating (d) Data processing 3. Results and discussion (a) Deamidation (b) ZooMS taxonomic results and comparison with zooarchaeological data (c) Camels in Jinsitai Cave 4. Conclusion

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    Article . 2023
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    Proceedings of the Royal Society B Biological Sciences
    Article . 2023 . Peer-reviewed
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      Proceedings of the Royal Society B Biological Sciences
      Article . 2023 . Peer-reviewed
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    Authors: Fradkin, Isaac; Nour, Matthew M.; Dolan, Raymond J.;

    BACKGROUND: Natural language processing (NLP) holds promise to transform psychiatric research and practice. A pertinent example is the success of NLP in the automatic detection of speech disorganization in formal thought disorder (FTD). However, we lack an understanding of precisely what common NLP metrics measure and how they relate to theoretical accounts of FTD. We propose tackling these questions by using deep generative language models to simulate FTD-like narratives by perturbing computational parameters instantiating theory-based mechanisms of FTD. METHODS: We simulated FTD-like narratives using Generative-Pretrained-Transformer-2 by either increasing word selection stochasticity or limiting the model's memory span. We then examined the sensitivity of common NLP measures of derailment (semantic distance between consecutive words or sentences) and tangentiality (how quickly meaning drifts away from the topic) in detecting and dissociating the 2 underlying impairments. RESULTS: Both parameters led to narratives characterized by greater semantic distance between consecutive sentences. Conversely, semantic distance between words was increased by increasing stochasticity, but decreased by limiting memory span. An NLP measure of tangentiality was uniquely predicted by limited memory span. The effects of limited memory span were nonmonotonic in that forgetting the global context resulted in sentences that were semantically closer to their local, intermediate context. Finally, different methods for encoding the meaning of sentences varied dramatically in performance. CONCLUSIONS: This work validates a simulation-based approach as a valuable tool for hypothesis generation and mechanistic analysis of NLP markers in psychiatry. To facilitate dissemination of this approach, we accompany the paper with a hands-on Python tutorial.

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    Biological Psychiatry Cognitive Neuroscience and Neuroimaging
    Article . 2023 . Peer-reviewed
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    UCL Discovery
    Article . 2023
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      Biological Psychiatry Cognitive Neuroscience and Neuroimaging
      Article . 2023 . Peer-reviewed
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      UCL Discovery
      Article . 2023
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    Authors: Claudia Chang; Sergei S. Ivanov; Robert N. Spengler; Basira Mir-Makhamad; +1 Authors

    In this paper, we use preliminary archaeological data spanning the Iron Age through Medieval periods (ca. 800 BCE to 1200 CE) in the Juuku Valley in Kyrgyzstan on the south side of Lake Issyk-Kul to model land use across vertical mountain zones. We have (1) established a radiometric chronology; (2) conducted test excavations of an Iron Age settlement at 2100 m asl and a Turkic period burial at 1934 m asl; (3) undertaken preliminary archaeobotanical research; and (4) performed pedestrian surveys. Archaeobotanical remains of wheat (Triticum aestivum), barley (Hordeum vulgare), broomcorn millet (Panicum milaceum), foxtail millet (Setaria italica), and legumes were recovered in very small quantities from both sites. We compare these preliminary archaeobotanical results with previously published data from Talgar Iron Age settlements on the north side of the Tian Shan Mountain range in Kazakhstan. A small assemblage of faunal remains found at the Turkic period kurgan and from a profile at the upland Iron Age settlement demonstrates the practice of herding sheep/goats, cattle, and horses in the Juuku Valley. The goal of this study was to test the hypothesis that pastoral transhumance and agropastoralism were interchangeable economic strategies used by peoples in the Iron Age through Medieval periods in mountain-river valleys between 600 m to 2100 m asl. These economic strategies combined the pasturing of sheep, goats, cattle, and horses with the cultivation of cereals in a system that was adapted to different vegetational zones along a vertical gradient. This paper is based on preliminary research using survey data and test excavations and initiates a long-term research study of four millennia of settlements that appear to have ranged from pastoral transhumance and combined mountain agriculture. 1. Introduction 1.1. Theoretical Perspectives 1.2. Our Model 2. Materials and Methods 2.1. Study Areas 2.1.1. The Talgar Alluvial Fan 2.1.2. The Juuku Valley 2.2. Chronological Framework for the Juuku Valley 2.3. Test Excavations and Kurgan Excavations 2.3.1. Lower Juuku Kurgan 1 2.3.2. Block Excavations at Eastern Juuku Settlement 1 2.3.3. Profiles 4 and 6 2.4. Radiometric Dating 2.5. Archaeobotanical Sampling 3. Results 3.1. The Radiometric Sequence for Juuku Valley 3.1.1. Kurgan Excavation 3.1.2. Excavations at EJS1 3.1.3. Archaeobotanical Results 4. Discussion 5. Conclusions

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    Other literature type . Article . 2023 . Peer-reviewed
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    Article . 2023
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      Other literature type . Article . 2023 . Peer-reviewed
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    Authors: Hermine Xhauflair; Sheldon Jago-on; Timothy James Vitales; Dante Manipon; +6 Authors

    A large part of our material culture is made of organic materials, and this was likely the case also during prehistory. Amongst this prehistoric organic material culture are textiles and cordages, taking advantage of the flexibility and resistance of plant fibres. While in very exceptional cases and under very favourable circumstances, fragments of baskets and cords have survived and were discovered in late Pleistocene and Holocene archaeological sites, these objects are generally not preserved, especially in tropical regions. We report here indirect evidence of basket/tying material making found on stone tools dating to 39–33,000 BP from Tabon Cave, Palawan Philippines. The distribution of use-wear on these artefacts is the same as the distribution observed on experimental tools used to thin fibres, following a technique that is widespread in the region currently. The goal of this activity is to turn hard plant segments into supple strips suitable as tying material or to weave baskets, traps, and even boats. This study shows early evidence of this practice in Southeast Asia and adds to the growing set of discoveries showing that fibre technology was an integral part of late Pleistocene skillset. This paper also provides a new way to identify supple strips of fibres made of tropical plants in the archaeological record, an organic technology that is otherwise most of the time invisible. 1. Introduction 2. Material and methods 2.1. Tabon Cave, Palawan, Philippines 2.2. Use-wear analysis of the artefacts 2.3. Reference collection: Experiments and ethnoarchaeology 3. Results 3.1. Use-wear and residues found on 3 stone tools from Tabon Cave 3.2. Similar use-wear pattern observed on experimental tools used for thinning plant fibres 3.3. Ethnoarchaeological basis of the experiments: Fibre processing among Pala’wan communities from Brooke’s Point, Philippines 3.4. Developing an understanding of the function of Tabon Cave artefacts based on experimental and ethnographic data 4. Discussion 5. Conclusion

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    Article . 2023
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    PLoS ONE
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    This essay provides an overview of recent histories of medicine and global health from a socialist perspective, and maps out possible new directions of research. It focuses on key themes in the history of medicine in Eastern Europe, its global connections and Latin American, East Asian and African contexts. Through a discussion of international professional and diplomatic networks, health systems, medical technologies and aid and technical assistance, the essay argues that integrating missing actors, ideas and practices is crucial for a complete understanding of global health history. Peer Reviewed

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    MPG.PuRe
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    https://doi.org/10.18452/27776...
    Article . 2023
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      https://doi.org/10.18452/27776...
      Article . 2023
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    Authors: Alexandra A. de Sousa; Amélie Beaudet; Tanya Calvey; Ameline Bardo; +17 Authors

    Fossil endocasts record features of brains from the past: size, shape, vasculature, and gyrification. These data, alongside experimental and comparative evidence, are needed to resolve questions about brain energetics, cognitive specializations, and developmental plasticity. Through the application of interdisciplinary techniques to the fossil record, paleoneurology has been leading major innovations. Neuroimaging is shedding light on fossil brain organization and behaviors. Inferences about the development and physiology of the brains of extinct species can be experimentally investigated through brain organoids and transgenic models based on ancient DNA. Phylogenetic comparative methods integrate data across species and associate genotypes to phenotypes, and brains to behaviors. Meanwhile, fossil and archeological discoveries continuously contribute new knowledge. Through cooperation, the scientific community can accelerate knowledge acquisition. Sharing digitized museum collections improves the availability of rare fossils and artifacts. Comparative neuroanatomical data are available through online databases, along with tools for their measurement and analysis. In the context of these advances, the paleoneurological record provides ample opportunity for future research. Biomedical and ecological sciences can benefit from paleoneurology’s approach to understanding the mind as well as its novel research pipelines that establish connections between neuroanatomy, genes and behavior. International audience

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    Apollo
    Article . 2023
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    Apollo
    Article . 2023
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    UCL Discovery
    Article . 2023
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    Communications Biology
    Article . 2023
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    Communications Biology
    Article . 2023 . Peer-reviewed
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    Article . 2023
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      Article . 2023
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      Communications Biology
      Article . 2023 . Peer-reviewed
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      Article . 2023
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    Authors: Rigaud, S.; Rybin, E.; Khatsenovich, A.; Queffelec, A.; +13 Authors

    AbstractFigurative depictions in art first occur ca. 50,000 years ago in Europe, Africa, and Southeast Asia. Considered by most as an advanced form of symbolic behavior, they are restricted to our species. Here, we report a piece of ornament interpreted as a phallus-like representation. It was found in a 42,000 ca.-year-old Upper Paleolithic archaeological layer at the open-air archaeological site of Tolbor-21, in Mongolia. Mineralogical, microscopic, and rugosimetric analyses points toward the allochthonous origin of the pendant and a complex functional history. Three-dimensional phallic pendants are unknown in the Paleolithic record, and this discovery predates the earliest known sexed anthropomorphic representation. It attests that hunter-gatherer communities used sex anatomical attributes as symbols at a very early stage of their dispersal in the region. The pendant was produced during a period that overlaps with age estimates for early introgression events between Homo sapiens and Denisovans, and in a region where such encounters are plausible.

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    Scientific Reports
    Article . 2023
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    Scientific Reports
    Article . 2023 . Peer-reviewed
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      Scientific Reports
      Article . 2023 . Peer-reviewed
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    Authors: Pooja Swali; Rick Schulting; Alexandre Gilardet; Monica Kelly; +20 Authors

    AbstractExtinct lineages of Yersinia pestis, the causative agent of the plague, have been identified in several individuals from Eurasia between 5000 and 2500 years before present (BP). One of these, termed the ‘LNBA lineage’ (Late Neolithic and Bronze Age), has been suggested to have spread into Europe with human groups expanding from the Eurasian steppe. Here, we show that the LNBA plague was spread to Europe’s northwestern periphery by sequencing three Yersinia pestis genomes from Britain, all dating to ~4000 cal BP. Two individuals were from an unusual mass burial context in Charterhouse Warren, Somerset, and one individual was from a single burial under a ring cairn monument in Levens, Cumbria. To our knowledge, this represents the earliest evidence of LNBA plague in Britain documented to date. All three British Yersinia pestis genomes belong to a sublineage previously observed in Bronze Age individuals from Central Europe that had lost the putative virulence factor yapC. This sublineage is later found in Eastern Asia ~3200 cal BP. While the severity of the disease is currently unclear, the wide geographic distribution within a few centuries suggests substantial transmissibility.

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    Authors: Künzi, M.; Sieber, S.; Joly-Burra, E.; Cullati, S.; +5 Authors

    AbstractThis study set out to examine the role of different adversities experienced at different life course stages on cognitive aging (i.e., level and change). Data from the longitudinal study: Survey of Health, Ageing, and Retirement in Europe (SHARE) with the selection of participants over 60 years were used (N = 2662, Mdnage = 68, SDage = 5.39) in a Structural Equation Modeling. In early life, the experience of hunger predicted lower delayed recall (β = − 0.10, p < 0.001) and verbal fluency (β = − 0.06, p = 0.001) performance in older age, whereas financial hardship predicted lower verbal fluency (β = − 0.06, p = 0.005) performance and steeper decline in delayed recall (β = − 0.11, p < 0.001). In early adulthood, financial hardship and stress predicted better delayed recall (financial hardship: β = 0.08, p = 0.001; stress: β = 0.07, p = 0.003) and verbal fluency performance (financial hardship: β = 0.08, p = 0.001; stress β = 0.10, p < 0.001), but no adversities were associated with a change in cognitive performance. In middle adulthood, no adversities were associated with the level of cognitive performance, but financial hardship predicted lower decline in delayed recall (β = 0.07, p = 0.048). This study highlights the importance of disentangling the period effect from the specific effect of the adversity experienced in the association between adversity and cognition in older age. Moreover, differential results for delayed recall and verbal fluency measures suggest that it is also important to consider the cognitive outcome domains examined.

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    Scientific Reports
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    Scientific Reports
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