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description Publicationkeyboard_double_arrow_right Article , Other literature type 2021Publisher:Informa UK Limited Funded by:EC | iPLACENTAEC| iPLACENTAAuthors: José Morales-Roselló; Gabriela Loscalzo; Eva María García-Lopez; José Santiago Ibañez Cabellos; +3 AuthorsJosé Morales-Roselló; Gabriela Loscalzo; Eva María García-Lopez; José Santiago Ibañez Cabellos; José Luis García-Gimenez; Antonio José Cañada Martínez; Alfredo Perales Marín;To compare the expression of microRNA-185-5p (miR-185-5p) in normal foetuses and in foetuses with late-onset growth restriction (FGR) and to determine the factors influencing this expression. In a prospective study, 40 foetuses (22 of them with late-onset FGR and 18 with normal growth) were scanned with Doppler ultrasound after week 35 and followed until birth. Subsequently, blood samples from umbilical cords were collected after delivery to evaluate the expression of miR-185-5p using real-time qPCR. Finally, multivariable regression analysis was applied to determine the clinical and ultrasonographic factors influencing miR-185-5p expression in both normal and late-onset FGR foetuses. In comparison with normal foetuses, late-onset FGR foetuses expressed upregulation of miR-185-5p (2.26 ± 1.30 versus 1.27 ± 1.03 2^-ddCt, P = 0.011). Multivariable regression analysis confirmed that cerebroplacental ratio (P < 0.05) was the only determinant of this overexpression. FGR foetuses overexpress miR-185-5p in relation to brain-sparing. Future studies will be needed to investigate the role of miR-185 in the management of late-onset FGR.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/15592294.2021.2023271&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/15592294.2021.2023271&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Wiley Funded by:FCT | ICVS/3B’s - LA, FCT | ICVS/3B’s - LA, EC | VALENCEFCT| ICVS/3B’s - LA ,FCT| ICVS/3B’s - LA ,EC| VALENCEAuthors: Silveira‐Rosa, Tiago; Mateus‐Pinheiro, António; Correia, Joana Sofia; Silva, Joana Margarida; +12 AuthorsSilveira‐Rosa, Tiago; Mateus‐Pinheiro, António; Correia, Joana Sofia; Silva, Joana Margarida; Martins‐Macedo, Joana; Araújo, Bruna; Machado‐Santos, Ana Rita; Alves, Nuno Dinis; Silva, Mariana; Loureiro‐Campos, Eduardo; Sotiropoulos, Ioannis; Bessa, João Miguel; Rodrigues, Ana João; Sousa, Nuno; Patrício, Patrícia; Pinto, Luísa;AbstractObjectivesThe action of stress hormones, mainly glucocorticoids, starts and coordinates the systemic response to stressful events. The HPA axis activity is predicated on information processing and modulation by upstream centres, such as the hippocampus where adult‐born neurons (hABN) have been reported to be an important component in the processing and integration of new information. Still, it remains unclear whether and how hABN regulates HPA axis activity and CORT production, particularly when considering sex differences.Materials and MethodsUsing both sexes of a transgenic rat model of cytogenesis ablation (GFAP‐Tk rat model), we examined the endocrinological and behavioural effects of disrupting the generation of new astrocytes and neurons within the hippocampal dentate gyrus (DG).ResultsOur results show that GFAP‐Tk male rats present a heightened acute stress response. In contrast, GFAP‐Tk female rats have increased corticosterone secretion at nadir, a heightened, yet delayed, response to an acute stress stimulus, accompanied by neuronal hypertrophy in the basal lateral amygdala and increased expression of the glucocorticoid receptors in the ventral DG.ConclusionsOur results reveal that hABN regulation of the HPA axis response is sex‐differentiated.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/cpr.13165&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Spain, Netherlands, Spain, Spain, GermanyPublisher:MDPI AG Funded by:EC | Eat2beNICE, EC | MiND, EC | CoCAEC| Eat2beNICE ,EC| MiND ,EC| CoCAAuthors: Fernàndez-Castillo, Noèlia; Cabana-Domínguez, Judit; Kappel, Djenifer B.; Torrico, Bàrbara; +6 AuthorsFernàndez-Castillo, Noèlia; Cabana-Domínguez, Judit; Kappel, Djenifer B.; Torrico, Bàrbara; Weber, Heike; Lesch, Klaus-Peter; Lao, Oscar; Reif, Andreas; Cormand, Bru; Universitat Autònoma de Barcelona;Attention-deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder characterized by hyperactivity, impulsivity, and/or inattention, which are symptoms also observed in many rare genetic disorders. We searched for genes involved in Mendelian disorders presenting with ADHD symptoms in the Online Mendelian Inheritance in Man (OMIM) database, to curate a list of new candidate risk genes for ADHD. We explored the enrichment of functions and pathways in this gene list, and tested whether rare or common variants in these genes are associated with ADHD or with its comorbidities. We identified 139 genes, causal for 137 rare disorders, mainly related to neurodevelopmental and brain function. Most of these Mendelian disorders also present with other psychiatric traits that are often comorbid with ADHD. Using whole exome sequencing (WES) data from 668 ADHD cases, we found rare variants associated with the dimension of the severity of inattention symptoms in three genes: KIF11, WAC, and CRBN. Then, we focused on common variants and identified six genes associated with ADHD (in 19,099 cases and 34,194 controls): MANBA, UQCC2, HIVEP2, FOPX1, KANSL1, and AUH. Furthermore, HIVEP2, FOXP1, and KANSL1 were nominally associated with autism spectrum disorder (ASD) (18,382 cases and 27,969 controls), as well as HIVEP2 with anxiety (7016 cases and 14,475 controls), and FOXP1 with aggression (18,988 individuals), which is in line with the symptomatology of the rare disorders they are responsible for. In conclusion, inspecting Mendelian disorders and the genes responsible for them constitutes a valuable approach for identifying new risk genes and the mechanisms of complex disorders. This work was supported mainly by funding from the European Union H2020 Program [H2020/2014–2020, grant agreements n° 667302, 643051 and 728018, corresponding to projects CoCA, coca-project.eu/; Eat2BeNice: newbrainnutrition.com/ (accessed on 16 December 2021); and MiND; www.mind-project.eu (accessed on 16 December 2021), respectively], and from the ‘ECNP network on ADHD across the lifespan’. NC-F received funding from ‘Plan Nacional Sobre Drogas of the Spanish Ministry of Health‘ [PNSD-2020I042] and was supported by a contract of the ‘Centro de Investigación Biomédica en Red de Enfermedades Raras' (CIBERER). BC received funding from the Spanish ‘Ministerio de Economía y Competitividad’ [SAF2015-68341-R, RTI2018-100968-B-100 and PID2021-1277760B-I100], ‘Plan Nacional sobre Drogas of the Spanish Ministry of Health’ [PNSD-2017I050] and AGAUR, ‘Generalitat de Catalunya’ [2017-SGR-738]. JC-D and BT were supported by the H2020 CoCA (n° 667302) and Eat2beNICE (n° 728018) projects. DBK was supported by the European Union H2020 Program [H2020/2014-2020] under grant agreements n° 643051 (MiND) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-148273/2016-5). OL acknowledges the support from Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa, CERCA Program/Generalitat de Catalunya, Spanish Ministry of Science and Innovation through the Instituto de Salud Carlos III, Generalitat de Catalunya through Departament de Salut and Departament d’Empresa i Coneixement, Co-financing with funds from the European Regional Development Fund by the Spanish Ministry of Science and Innovation corresponding to the Programa Operativo FEDER Plurirregional de España (POPE) 2014–2020 and by the Secretaria d’Universitats i Recerca, Departament d’Empresa i Coneixement of the Generalitat de Catalunya corresponding to the Programa Operatiu FEDER de Catalunya 2014–2020, Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness)—RYC-2013-14797, BFU2015-68759-P and PGC2018-098574-B-I00 and Generalitat de Catalunya (Government of Catalonia)—GRC 2017 SGR 937.
Online-Publikations-... arrow_drop_down Online-Publikations-Server der Universität WürzburgArticle . 2021License: CC BYData sources: Online-Publikations-Server der Universität WürzburgGenesOther literature type . Article . 2021 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/2073-4425/13/1/93/pdfEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8775234Data sources: PubMed CentralNARCIS; GenesArticle . 2022Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 42visibility views 42 download downloads 104 Powered bymore_vert Online-Publikations-... arrow_drop_down Online-Publikations-Server der Universität WürzburgArticle . 2021License: CC BYData sources: Online-Publikations-Server der Universität WürzburgGenesOther literature type . Article . 2021 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/2073-4425/13/1/93/pdfEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8775234Data sources: PubMed CentralNARCIS; GenesArticle . 2022Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/genes13010093&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Netherlands English Funded by:EC | TUBEEC| TUBEAuthors: Martikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; +23 AuthorsMartikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; Carare, Roxana O; Chew, Sweelin; Dinnyes, Andras; Giugno, Rosalba; Kanninen, Katja M; Malm, Tarja; Muala, Ala; Nedergaard, Maiken; Oudin, Anna; Oyola, Pedro; Pfeiffer, Tobias V; Rönkkö, Topi; Saarikoski, Sanna; Sandström, Thomas; Schins, Roel P F; Topinka, Jan; Yang, Mo; Zeng, Xiaowen; Westerink, Remco H S; Jalava, Pasi I; IRAS OH Toxicology; dIRAS RA-1; LS Voortplanting Inwendige Ziekten;The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer's disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.
NARCIS arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::1b8d173d9adce03bdf3ca89b029d8fd9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert NARCIS arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::1b8d173d9adce03bdf3ca89b029d8fd9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 PolandPublisher:MDPI AG Funded by:EC | PMCOSTEC| PMCOSTIana Markevych; Natasza Orlov; James Grellier; Katarzyna Kaczmarek-Majer; Małgorzata Lipowska; Katarzyna Sitnik-Warchulska; Yarema Mysak; Clemens Baumbach; Maja Wierzba-Łukaszyk; Munawar Hussain Soomro; Mikołaj Compa; Bernadetta Izydorczyk; Krzysztof Skotak; Anna Degórska; Jakub Bratkowski; Bartosz Kossowski; Aleksandra Domagalik; Marcin Szwed;Exposure to airborne particulate matter (PM) may affect neurodevelopmental outcomes in children. The mechanisms underlying these relationships are not currently known. We aim to assess whether PM affects the developing brains of schoolchildren in Poland, a country characterized by high levels of PM pollution. Children aged from 10 to 13 years (n = 800) are recruited to participate in this case–control study. Cases (children with attention deficit hyperactivity disorder (ADHD)) are being recruited by field psychologists. Population-based controls are being sampled from schools. The study area comprises 18 towns in southern Poland characterized by wide-ranging levels of PM. Comprehensive psychological assessments are conducted to assess cognitive and social functioning. Participants undergo structural, diffusion-weighted, task, and resting-state magnetic resonance imaging (MRI). PM concentrations are estimated using land use regression models, incorporating information from air monitoring networks, dispersion models, and characteristics of roads and other land cover types. The estimated concentrations will be assigned to the prenatal and postnatal residential and preschool/school addresses of the study participants. We will assess whether long-term exposure to PM affects brain function, structure, and connectivity in healthy children and in those diagnosed with ADHD. This study will provide novel, in-depth understanding of the neurodevelopmental effects of PM pollution. PM2.5, PM10, children, neuroimaging, cognitive functioning, social functioning, epidemiology, Poland, air pollution, case–control study 1-21 140 1
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2021 . Peer-reviewedLicense: CC BYFull-Text: https://www.mdpi.com/1660-4601/19/1/310/pdfEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8744611Data sources: PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2022Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph19010310&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2021 . Peer-reviewedLicense: CC BYFull-Text: https://www.mdpi.com/1660-4601/19/1/310/pdfEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8744611Data sources: PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2022Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph19010310&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 FrancePublisher:The Royal Society Funded by:WT | Explaining Language Outco..., EC | ThinkAhead, EC | HBP SGA2 +1 projectsWT| Explaining Language Outcome and Recovery After Stroke (ELORAS) ,EC| ThinkAhead ,EC| HBP SGA2 ,EC| HBP SGA3Authors: Giovanni Pezzulo; Thomas Parr; Karl Friston;Giovanni Pezzulo; Thomas Parr; Karl Friston;This article considers the evolution of brain architectures for predictive processing. We argue that brain mechanisms for predictive perception and action are not late evolutionary additions of advanced creatures like us. Rather, they emerged gradually from simpler predictive loops (e.g. autonomic and motor reflexes) that were a legacy from our earlier evolutionary ancestors—and were key to solving their fundamental problems of adaptive regulation. We characterize simpler-to-more-complex brains formally, in terms ofgenerative modelsthat include predictive loops of increasing hierarchical breadth and depth. These may start from a simple homeostatic motif and be elaborated during evolution in four main ways: these include themultimodal expansionof predictive control into an allostatic loop; itsduplicationto form multiple sensorimotor loops that expand an animal's behavioural repertoire; and the gradual endowment of generative models withhierarchical depth(to deal with aspects of the world that unfold at different spatial scales) andtemporal depth(to select plans in a future-oriented manner). In turn, these elaborations underwrite the solution to biological regulation problems faced by increasingly sophisticated animals. Our proposal aligns neuroscientific theorising—about predictive processing—with evolutionary and comparative data on brain architectures in different animal species.This article is part of the theme issue ‘Systems neuroscience through the lens of evolutionary theory’.
Europe PubMed Centra... arrow_drop_down Philosophical Transactions of the Royal Society B Biological SciencesArticleData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesOther literature type . Article . 2022 . 2021 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0531&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 21 citations 21 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Philosophical Transactions of the Royal Society B Biological SciencesArticleData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesOther literature type . Article . 2022 . 2021 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0531&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 SpainPublisher:Frontiers Media SA Funded by:EC | HBP SGA3, EC | HBP SGA2EC| HBP SGA3 ,EC| HBP SGA2Sergio E. Galindo; Pablo Toharia; Pablo Toharia; Oscar D. Robles; Oscar D. Robles; Luis Pastor; Luis Pastor;Brain complexity has traditionally fomented the division of neuroscience into somehow separated compartments; the coexistence of the anatomical, physiological, and connectomics points of view is just a paradigmatic example of this situation. However, there are times when it is important to combine some of these standpoints for getting a global picture, like for fully analyzing the morphological and topological features of a specific neuronal circuit. Within this framework, this article presents SynCoPa, a tool designed for bridging gaps among representations by providing techniques that allow combining detailed morphological neuron representations with the visualization of neuron interconnections at the synapse level. SynCoPa has been conceived for the interactive exploration and analysis of the connectivity elements and paths of simple to medium complexity neuronal circuits at the connectome level. This has been done by providing visual metaphors for synapses and interconnection paths, in combination with the representation of detailed neuron morphologies. SynCoPa could be helpful, for example, for establishing or confirming a hypothesis about the spatial distributions of synapses, or for answering questions about the way neurons establish connections or the relationships between connectivity and morphological features. Last, SynCoPa is easily extendable to include functional data provided, for example, by any of the morphologically-detailed simulators available nowadays, such as Neuron and Arbor, for providing a deep insight into the circuits features prior to simulating it, in particular any analysis where it is important to combine morphology, network topology, and physiology. The research leading to these results has received funding from the Spanish Ministry of Economy and Competitiveness under grants C080020-09 (Cajal Blue Brain Project, Spanish partner of the Blue Brain Project initiative from EPFL) and TIN2017-83132, and the Spanish Ministry of Science and Innovation under grants PID2020-113013RB-C21 and PID2020-113013RB-C22, as well as from the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreements No. 785907 (Human Brain Project SGA2) and 945539 (Human Brain Project SGA3).
Frontiers in Neuroin... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8751653Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fninf.2021.753997&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Frontiers in Neuroin... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8751653Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fninf.2021.753997&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:The Royal Society Funded by:EC | HBP SGA3EC| HBP SGA3Authors: Stuart P. Wilson; Tony J. Prescott;Stuart P. Wilson; Tony J. Prescott;The functional organization of the mammalian brain can be considered to form a layered control architecture, but how this complex system has emerged through evolution and is constructed during development remains a puzzle. Here we consider brain organization through the framework of constraint closure, viewed as a general characteristic of living systems, that they are composed of multiple sub-systems that constrain each other at different timescales. We do so by developing a new formalism for constraint closure, inspired by a previous model showing how within-lifetime dynamics can constrain between-lifetime dynamics, and we demonstrate how this interaction can be generalized to multi-layered systems. Through this model, we consider brain organization in the context of two major examples of constraint closure—physiological regulation and visual orienting. Our analysis draws attention to the capacity of layered brain architectures to scaffold themselves across multiple timescales, including the ability of cortical processes to constrain the evolution of sub-cortical processes, and of the latter to constrain the space in which cortical systems self-organize and refine themselves.This article is part of the theme issue ‘Systems neuroscience through the lens of evolutionary theory’.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8710877Data sources: PubMed CentralPhilosophical Transactions of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesOther literature type . Article . 2021 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0519&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8710877Data sources: PubMed CentralPhilosophical Transactions of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesOther literature type . Article . 2021 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0519&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Dataset 2021 EnglishPublisher:Zenodo Funded by:EC | IMAGING-INTHE-MAGNETEC| IMAGING-INTHE-MAGNETAuthors: Aydin, Ali-Kemal; Verdier, Camille; Charpak, Serge;Aydin, Ali-Kemal; Verdier, Camille; Charpak, Serge;Datasets containing the data used to generate the figures and results from The oxygen initial dip in the brain of anesthetized and awake mice, Aydin et al. (PNAS, 2022), along with the corresponding MATLAB code on GitHub. Download the file, and unzip it in the same folder as the scripts from the GitHub repository.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.5804932&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 116visibility views 116 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.5804932&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Oxford University Press (OUP) Funded by:EC | NEUROSEMANTICSEC| NEUROSEMANTICSAuthors: Gunnar Norrman; Emanuel Bylund; Guillaume Thierry;Gunnar Norrman; Emanuel Bylund; Guillaume Thierry;AbstractIn early childhood, the human brain goes through a period of tuning to native speech sounds but retains remarkable flexibility, allowing the learning of new languages throughout life. However, little is known about the stability over time of early neural specialization for speech and its influence on the formation of novel language representations. Here, we provide evidence that early international adoptees, who lose contact with their native language environment after adoption, retain enhanced sensitivity to a native lexical tone contrast more than 15 years after being adopted to Sweden from China, in the absence of any pretest familiarization with the stimuli. Changes in oscillatory brain activity showed how adoptees resort to inhibiting the processing of defunct phonological representations, rather than forgetting or replacing them with new ones. Furthermore, neurophysiological responses to native and nonnative contrasts were not negatively correlated, suggesting that native language retention does not interfere with the acquisition of adoptive phonology acquisition. These results suggest that early language experience provides strikingly resilient specialization for speech which is compensated for through inhibitory control mechanisms as learning conditions change later in life.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/cercor/bhab447&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/cercor/bhab447&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2021Publisher:Informa UK Limited Funded by:EC | iPLACENTAEC| iPLACENTAAuthors: José Morales-Roselló; Gabriela Loscalzo; Eva María García-Lopez; José Santiago Ibañez Cabellos; +3 AuthorsJosé Morales-Roselló; Gabriela Loscalzo; Eva María García-Lopez; José Santiago Ibañez Cabellos; José Luis García-Gimenez; Antonio José Cañada Martínez; Alfredo Perales Marín;To compare the expression of microRNA-185-5p (miR-185-5p) in normal foetuses and in foetuses with late-onset growth restriction (FGR) and to determine the factors influencing this expression. In a prospective study, 40 foetuses (22 of them with late-onset FGR and 18 with normal growth) were scanned with Doppler ultrasound after week 35 and followed until birth. Subsequently, blood samples from umbilical cords were collected after delivery to evaluate the expression of miR-185-5p using real-time qPCR. Finally, multivariable regression analysis was applied to determine the clinical and ultrasonographic factors influencing miR-185-5p expression in both normal and late-onset FGR foetuses. In comparison with normal foetuses, late-onset FGR foetuses expressed upregulation of miR-185-5p (2.26 ± 1.30 versus 1.27 ± 1.03 2^-ddCt, P = 0.011). Multivariable regression analysis confirmed that cerebroplacental ratio (P < 0.05) was the only determinant of this overexpression. FGR foetuses overexpress miR-185-5p in relation to brain-sparing. Future studies will be needed to investigate the role of miR-185 in the management of late-onset FGR.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/15592294.2021.2023271&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/15592294.2021.2023271&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Wiley Funded by:FCT | ICVS/3B’s - LA, FCT | ICVS/3B’s - LA, EC | VALENCEFCT| ICVS/3B’s - LA ,FCT| ICVS/3B’s - LA ,EC| VALENCEAuthors: Silveira‐Rosa, Tiago; Mateus‐Pinheiro, António; Correia, Joana Sofia; Silva, Joana Margarida; +12 AuthorsSilveira‐Rosa, Tiago; Mateus‐Pinheiro, António; Correia, Joana Sofia; Silva, Joana Margarida; Martins‐Macedo, Joana; Araújo, Bruna; Machado‐Santos, Ana Rita; Alves, Nuno Dinis; Silva, Mariana; Loureiro‐Campos, Eduardo; Sotiropoulos, Ioannis; Bessa, João Miguel; Rodrigues, Ana João; Sousa, Nuno; Patrício, Patrícia; Pinto, Luísa;AbstractObjectivesThe action of stress hormones, mainly glucocorticoids, starts and coordinates the systemic response to stressful events. The HPA axis activity is predicated on information processing and modulation by upstream centres, such as the hippocampus where adult‐born neurons (hABN) have been reported to be an important component in the processing and integration of new information. Still, it remains unclear whether and how hABN regulates HPA axis activity and CORT production, particularly when considering sex differences.Materials and MethodsUsing both sexes of a transgenic rat model of cytogenesis ablation (GFAP‐Tk rat model), we examined the endocrinological and behavioural effects of disrupting the generation of new astrocytes and neurons within the hippocampal dentate gyrus (DG).ResultsOur results show that GFAP‐Tk male rats present a heightened acute stress response. In contrast, GFAP‐Tk female rats have increased corticosterone secretion at nadir, a heightened, yet delayed, response to an acute stress stimulus, accompanied by neuronal hypertrophy in the basal lateral amygdala and increased expression of the glucocorticoid receptors in the ventral DG.ConclusionsOur results reveal that hABN regulation of the HPA axis response is sex‐differentiated.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/cpr.13165&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/cpr.13165&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Spain, Netherlands, Spain, Spain, GermanyPublisher:MDPI AG Funded by:EC | Eat2beNICE, EC | MiND, EC | CoCAEC| Eat2beNICE ,EC| MiND ,EC| CoCAAuthors: Fernàndez-Castillo, Noèlia; Cabana-Domínguez, Judit; Kappel, Djenifer B.; Torrico, Bàrbara; +6 AuthorsFernàndez-Castillo, Noèlia; Cabana-Domínguez, Judit; Kappel, Djenifer B.; Torrico, Bàrbara; Weber, Heike; Lesch, Klaus-Peter; Lao, Oscar; Reif, Andreas; Cormand, Bru; Universitat Autònoma de Barcelona;Attention-deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder characterized by hyperactivity, impulsivity, and/or inattention, which are symptoms also observed in many rare genetic disorders. We searched for genes involved in Mendelian disorders presenting with ADHD symptoms in the Online Mendelian Inheritance in Man (OMIM) database, to curate a list of new candidate risk genes for ADHD. We explored the enrichment of functions and pathways in this gene list, and tested whether rare or common variants in these genes are associated with ADHD or with its comorbidities. We identified 139 genes, causal for 137 rare disorders, mainly related to neurodevelopmental and brain function. Most of these Mendelian disorders also present with other psychiatric traits that are often comorbid with ADHD. Using whole exome sequencing (WES) data from 668 ADHD cases, we found rare variants associated with the dimension of the severity of inattention symptoms in three genes: KIF11, WAC, and CRBN. Then, we focused on common variants and identified six genes associated with ADHD (in 19,099 cases and 34,194 controls): MANBA, UQCC2, HIVEP2, FOPX1, KANSL1, and AUH. Furthermore, HIVEP2, FOXP1, and KANSL1 were nominally associated with autism spectrum disorder (ASD) (18,382 cases and 27,969 controls), as well as HIVEP2 with anxiety (7016 cases and 14,475 controls), and FOXP1 with aggression (18,988 individuals), which is in line with the symptomatology of the rare disorders they are responsible for. In conclusion, inspecting Mendelian disorders and the genes responsible for them constitutes a valuable approach for identifying new risk genes and the mechanisms of complex disorders. This work was supported mainly by funding from the European Union H2020 Program [H2020/2014–2020, grant agreements n° 667302, 643051 and 728018, corresponding to projects CoCA, coca-project.eu/; Eat2BeNice: newbrainnutrition.com/ (accessed on 16 December 2021); and MiND; www.mind-project.eu (accessed on 16 December 2021), respectively], and from the ‘ECNP network on ADHD across the lifespan’. NC-F received funding from ‘Plan Nacional Sobre Drogas of the Spanish Ministry of Health‘ [PNSD-2020I042] and was supported by a contract of the ‘Centro de Investigación Biomédica en Red de Enfermedades Raras' (CIBERER). BC received funding from the Spanish ‘Ministerio de Economía y Competitividad’ [SAF2015-68341-R, RTI2018-100968-B-100 and PID2021-1277760B-I100], ‘Plan Nacional sobre Drogas of the Spanish Ministry of Health’ [PNSD-2017I050] and AGAUR, ‘Generalitat de Catalunya’ [2017-SGR-738]. JC-D and BT were supported by the H2020 CoCA (n° 667302) and Eat2beNICE (n° 728018) projects. DBK was supported by the European Union H2020 Program [H2020/2014-2020] under grant agreements n° 643051 (MiND) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-148273/2016-5). OL acknowledges the support from Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa, CERCA Program/Generalitat de Catalunya, Spanish Ministry of Science and Innovation through the Instituto de Salud Carlos III, Generalitat de Catalunya through Departament de Salut and Departament d’Empresa i Coneixement, Co-financing with funds from the European Regional Development Fund by the Spanish Ministry of Science and Innovation corresponding to the Programa Operativo FEDER Plurirregional de España (POPE) 2014–2020 and by the Secretaria d’Universitats i Recerca, Departament d’Empresa i Coneixement of the Generalitat de Catalunya corresponding to the Programa Operatiu FEDER de Catalunya 2014–2020, Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness)—RYC-2013-14797, BFU2015-68759-P and PGC2018-098574-B-I00 and Generalitat de Catalunya (Government of Catalonia)—GRC 2017 SGR 937.
Online-Publikations-... arrow_drop_down Online-Publikations-Server der Universität WürzburgArticle . 2021License: CC BYData sources: Online-Publikations-Server der Universität WürzburgGenesOther literature type . Article . 2021 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/2073-4425/13/1/93/pdfEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8775234Data sources: PubMed CentralNARCIS; GenesArticle . 2022Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/genes13010093&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 42visibility views 42 download downloads 104 Powered bymore_vert Online-Publikations-... arrow_drop_down Online-Publikations-Server der Universität WürzburgArticle . 2021License: CC BYData sources: Online-Publikations-Server der Universität WürzburgGenesOther literature type . Article . 2021 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/2073-4425/13/1/93/pdfEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8775234Data sources: PubMed CentralNARCIS; GenesArticle . 2022Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/genes13010093&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Netherlands English Funded by:EC | TUBEEC| TUBEAuthors: Martikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; +23 AuthorsMartikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; Carare, Roxana O; Chew, Sweelin; Dinnyes, Andras; Giugno, Rosalba; Kanninen, Katja M; Malm, Tarja; Muala, Ala; Nedergaard, Maiken; Oudin, Anna; Oyola, Pedro; Pfeiffer, Tobias V; Rönkkö, Topi; Saarikoski, Sanna; Sandström, Thomas; Schins, Roel P F; Topinka, Jan; Yang, Mo; Zeng, Xiaowen; Westerink, Remco H S; Jalava, Pasi I; IRAS OH Toxicology; dIRAS RA-1; LS Voortplanting Inwendige Ziekten;The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer's disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.
NARCIS arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::1b8d173d9adce03bdf3ca89b029d8fd9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert NARCIS arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=narcis______::1b8d173d9adce03bdf3ca89b029d8fd9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 PolandPublisher:MDPI AG Funded by:EC | PMCOSTEC| PMCOSTIana Markevych; Natasza Orlov; James Grellier; Katarzyna Kaczmarek-Majer; Małgorzata Lipowska; Katarzyna Sitnik-Warchulska; Yarema Mysak; Clemens Baumbach; Maja Wierzba-Łukaszyk; Munawar Hussain Soomro; Mikołaj Compa; Bernadetta Izydorczyk; Krzysztof Skotak; Anna Degórska; Jakub Bratkowski; Bartosz Kossowski; Aleksandra Domagalik; Marcin Szwed;Exposure to airborne particulate matter (PM) may affect neurodevelopmental outcomes in children. The mechanisms underlying these relationships are not currently known. We aim to assess whether PM affects the developing brains of schoolchildren in Poland, a country characterized by high levels of PM pollution. Children aged from 10 to 13 years (n = 800) are recruited to participate in this case–control study. Cases (children with attention deficit hyperactivity disorder (ADHD)) are being recruited by field psychologists. Population-based controls are being sampled from schools. The study area comprises 18 towns in southern Poland characterized by wide-ranging levels of PM. Comprehensive psychological assessments are conducted to assess cognitive and social functioning. Participants undergo structural, diffusion-weighted, task, and resting-state magnetic resonance imaging (MRI). PM concentrations are estimated using land use regression models, incorporating information from air monitoring networks, dispersion models, and characteristics of roads and other land cover types. The estimated concentrations will be assigned to the prenatal and postnatal residential and preschool/school addresses of the study participants. We will assess whether long-term exposure to PM affects brain function, structure, and connectivity in healthy children and in those diagnosed with ADHD. This study will provide novel, in-depth understanding of the neurodevelopmental effects of PM pollution. PM2.5, PM10, children, neuroimaging, cognitive functioning, social functioning, epidemiology, Poland, air pollution, case–control study 1-21 140 1
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2021 . Peer-reviewedLicense: CC BYFull-Text: https://www.mdpi.com/1660-4601/19/1/310/pdfEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8744611Data sources: PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2022Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph19010310&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2021 . Peer-reviewedLicense: CC BYFull-Text: https://www.mdpi.com/1660-4601/19/1/310/pdfEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8744611Data sources: PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2022Data sources: DOAJ-ArticlesInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph19010310&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 FrancePublisher:The Royal Society Funded by:WT | Explaining Language Outco..., EC | ThinkAhead, EC | HBP SGA2 +1 projectsWT| Explaining Language Outcome and Recovery After Stroke (ELORAS) ,EC| ThinkAhead ,EC| HBP SGA2 ,EC| HBP SGA3Authors: Giovanni Pezzulo; Thomas Parr; Karl Friston;Giovanni Pezzulo; Thomas Parr; Karl Friston;This article considers the evolution of brain architectures for predictive processing. We argue that brain mechanisms for predictive perception and action are not late evolutionary additions of advanced creatures like us. Rather, they emerged gradually from simpler predictive loops (e.g. autonomic and motor reflexes) that were a legacy from our earlier evolutionary ancestors—and were key to solving their fundamental problems of adaptive regulation. We characterize simpler-to-more-complex brains formally, in terms ofgenerative modelsthat include predictive loops of increasing hierarchical breadth and depth. These may start from a simple homeostatic motif and be elaborated during evolution in four main ways: these include themultimodal expansionof predictive control into an allostatic loop; itsduplicationto form multiple sensorimotor loops that expand an animal's behavioural repertoire; and the gradual endowment of generative models withhierarchical depth(to deal with aspects of the world that unfold at different spatial scales) andtemporal depth(to select plans in a future-oriented manner). In turn, these elaborations underwrite the solution to biological regulation problems faced by increasingly sophisticated animals. Our proposal aligns neuroscientific theorising—about predictive processing—with evolutionary and comparative data on brain architectures in different animal species.This article is part of the theme issue ‘Systems neuroscience through the lens of evolutionary theory’.
Europe PubMed Centra... arrow_drop_down Philosophical Transactions of the Royal Society B Biological SciencesArticleData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesOther literature type . Article . 2022 . 2021 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0531&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 21 citations 21 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Philosophical Transactions of the Royal Society B Biological SciencesArticleData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesOther literature type . Article . 2022 . 2021 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0531&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 SpainPublisher:Frontiers Media SA Funded by:EC | HBP SGA3, EC | HBP SGA2EC| HBP SGA3 ,EC| HBP SGA2Sergio E. Galindo; Pablo Toharia; Pablo Toharia; Oscar D. Robles; Oscar D. Robles; Luis Pastor; Luis Pastor;Brain complexity has traditionally fomented the division of neuroscience into somehow separated compartments; the coexistence of the anatomical, physiological, and connectomics points of view is just a paradigmatic example of this situation. However, there are times when it is important to combine some of these standpoints for getting a global picture, like for fully analyzing the morphological and topological features of a specific neuronal circuit. Within this framework, this article presents SynCoPa, a tool designed for bridging gaps among representations by providing techniques that allow combining detailed morphological neuron representations with the visualization of neuron interconnections at the synapse level. SynCoPa has been conceived for the interactive exploration and analysis of the connectivity elements and paths of simple to medium complexity neuronal circuits at the connectome level. This has been done by providing visual metaphors for synapses and interconnection paths, in combination with the representation of detailed neuron morphologies. SynCoPa could be helpful, for example, for establishing or confirming a hypothesis about the spatial distributions of synapses, or for answering questions about the way neurons establish connections or the relationships between connectivity and morphological features. Last, SynCoPa is easily extendable to include functional data provided, for example, by any of the morphologically-detailed simulators available nowadays, such as Neuron and Arbor, for providing a deep insight into the circuits features prior to simulating it, in particular any analysis where it is important to combine morphology, network topology, and physiology. The research leading to these results has received funding from the Spanish Ministry of Economy and Competitiveness under grants C080020-09 (Cajal Blue Brain Project, Spanish partner of the Blue Brain Project initiative from EPFL) and TIN2017-83132, and the Spanish Ministry of Science and Innovation under grants PID2020-113013RB-C21 and PID2020-113013RB-C22, as well as from the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreements No. 785907 (Human Brain Project SGA2) and 945539 (Human Brain Project SGA3).
Frontiers in Neuroin... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8751653Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fninf.2021.753997&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Frontiers in Neuroin... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8751653Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fninf.2021.753997&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:The Royal Society Funded by:EC | HBP SGA3EC| HBP SGA3Authors: Stuart P. Wilson; Tony J. Prescott;Stuart P. Wilson; Tony J. Prescott;The functional organization of the mammalian brain can be considered to form a layered control architecture, but how this complex system has emerged through evolution and is constructed during development remains a puzzle. Here we consider brain organization through the framework of constraint closure, viewed as a general characteristic of living systems, that they are composed of multiple sub-systems that constrain each other at different timescales. We do so by developing a new formalism for constraint closure, inspired by a previous model showing how within-lifetime dynamics can constrain between-lifetime dynamics, and we demonstrate how this interaction can be generalized to multi-layered systems. Through this model, we consider brain organization in the context of two major examples of constraint closure—physiological regulation and visual orienting. Our analysis draws attention to the capacity of layered brain architectures to scaffold themselves across multiple timescales, including the ability of cortical processes to constrain the evolution of sub-cortical processes, and of the latter to constrain the space in which cortical systems self-organize and refine themselves.This article is part of the theme issue ‘Systems neuroscience through the lens of evolutionary theory’.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8710877Data sources: PubMed CentralPhilosophical Transactions of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesOther literature type . Article . 2021 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0519&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8710877Data sources: PubMed CentralPhilosophical Transactions of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesOther literature type . Article . 2021 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0519&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Dataset 2021 EnglishPublisher:Zenodo Funded by:EC | IMAGING-INTHE-MAGNETEC| IMAGING-INTHE-MAGNETAuthors: Aydin, Ali-Kemal; Verdier, Camille; Charpak, Serge;Aydin, Ali-Kemal; Verdier, Camille; Charpak, Serge;Datasets containing the data used to generate the figures and results from The oxygen initial dip in the brain of anesthetized and awake mice, Aydin et al. (PNAS, 2022), along with the corresponding MATLAB code on GitHub. Download the file, and unzip it in the same folder as the scripts from the GitHub repository.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.5804932&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 116visibility views 116 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.5804932&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Oxford University Press (OUP) Funded by:EC | NEUROSEMANTICSEC| NEUROSEMANTICSAuthors: Gunnar Norrman; Emanuel Bylund; Guillaume Thierry;Gunnar Norrman; Emanuel Bylund; Guillaume Thierry;AbstractIn early childhood, the human brain goes through a period of tuning to native speech sounds but retains remarkable flexibility, allowing the learning of new languages throughout life. However, little is known about the stability over time of early neural specialization for speech and its influence on the formation of novel language representations. Here, we provide evidence that early international adoptees, who lose contact with their native language environment after adoption, retain enhanced sensitivity to a native lexical tone contrast more than 15 years after being adopted to Sweden from China, in the absence of any pretest familiarization with the stimuli. Changes in oscillatory brain activity showed how adoptees resort to inhibiting the processing of defunct phonological representations, rather than forgetting or replacing them with new ones. Furthermore, neurophysiological responses to native and nonnative contrasts were not negatively correlated, suggesting that native language retention does not interfere with the acquisition of adoptive phonology acquisition. These results suggest that early language experience provides strikingly resilient specialization for speech which is compensated for through inhibitory control mechanisms as learning conditions change later in life.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/cercor/bhab447&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/cercor/bhab447&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu