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  • Digital Humanities and Cultural Heritage
  • 2012-2021
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Volodymyr P. Pylypenko; Khrystyna T. Sliusarchuk; Pavlo B. Pylypyshyn; Svitlana V. Boichenko;

    This paper provides a comprehensive study of theoretical and practical issues of violation of human rights by war crimes, protection of legitimate interests of individuals in national and international law as a result of such violation. The purpose of this study is a comprehensive analysis of theoretical and applied issues related to the protection of violated rights and legitimate interests of individuals in public international law as a result of the commission of war crimes, and the formulation of scientifically sound proposals for improving the current legislation of Ukraine and the practice of its application in this area. The paper analyses the current scientific opinions and legislation on the regulation of illegal acts and liability for damage caused to victims as a result of violation of human rights and fundamental freedoms by war crimes. Furthermore, the existing forms, methods, and means of protecting the rights and legitimate interests of such persons in Ukraine and in the international arena were determined. The paper also provides a comprehensive study of the existing concept, legal nature and main features of war crimes and their legal regulation in Ukrainian legislation. Legislative amendments to the regulations governing this issue are proposed and the study justifies the position regarding the existence of an exclusively judicial procedure for resolving issues of human rights violations by war crimes, the result of which should be the adoption of a court decision. As a result of the study, the current scientific statements and achievements are clearly identified, as well as those that have emerged due to the constant development of public relations and substantial changes in international relations of various states, which causes armed conflicts and war crimes. One of the achievements of the scientific study is the proof of the importance of the problem of violated human rights in modern society and the extreme need for its research. After all, modern legislation requires substantial changes and improvement of the existing provisions with the subsequent possibility of their practical application

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ OpenAIRE; Journal of...arrow_drop_down
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ OpenAIRE; Journal of...arrow_drop_down
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yilin Chen; Xu Ji; Xu Ji; Hong Xiao; +8 Authors

    Background: Centralizing procurement for prescription drugs has the potential to reduce drug spending by creating economies of scale and by improving purchasing power. In March 2019, the Chinese government launched a volume-based purchasing (VBP) pilot program using a competitive bidding process to purchase high-quality generic drugs for which branded drug substitutes were available. We evaluated the impact of introducing the VBP pilot on drug purchase quantity and spending. Methods: We performed an interrupted time-series design to estimate the change in monthly drug purchase quantity and spending comparing fourteen months before and seven months after the VBP pilot. We obtained monthly prescription drug purchase data for all purchases from public hospitals in the three large pilot cities (Beijing, Shanghai and Xi’an) and two non-pilot cities (Changsha and Zhengzhou) between January 2018 to September 2019. We measured quantity and spending outcomes separately for the branded and generic substitutes that were selected in the VBP, and other drugs for the treatment of the same diseases. We evaluated heterogeneity of impact by pilot city, drug type, and therapeutic class (cardiovascular disease, mental disorder and cancer) separately. Findings: The VBP pilot in these three cities covered 60 million individuals. The implementation of the pilot reform was associated with a 132% (95%-CI: 104%-165%, p<0·001) increase in the purchase quantity of selected drugs in pilot cities compared to an 17% decrease (95%-CI: 9%-25%, p<0·001) in control cities. In contrast, the purchase quantity of branded and other drugs in pilot cities decreased by 38% (95%-CI: 27%-46%, p<0·001) and 77% (95%-CI: 71%-81%, p<0·001), respectively; while in control cities, these remained at similar levels. Overall, there was a 35% (95%-CI: 28%-41%, p<0·001) decrease in the purchase spending for all drugs in the first post-policy month, from 8·1 billion CNY estimated in the absence of VBP down to 5·3 billion CNY. The largest reduction in spending was in Shanghai and from drugs for the treatment of cardiovascular diseases. Interpretation: The evidence suggests positive impact of the VBP pilot in reducing the overall drug spending and increasing the use of high-quality generics in three pilot cities. This overall trend is not observed in two non-pilot cities. Assessment of long-term impact of the VBP policy is needed on various outcomes such as drug prescription and utilization patterns, patients’ health outcomes and spending. Funding: None to declare. Declaration of Interest: None to declare.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Frontiers in Pharmac...arrow_drop_down
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    OpenAIRE; SSRN Electronic Journal
    Article . 2021 . Peer-reviewed
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    Frontiers in Pharmacology
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    DOAJ
    Article . 2021
    Data sources: DOAJ
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Frontiers in Pharmac...arrow_drop_down
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      OpenAIRE; SSRN Electronic Journal
      Article . 2021 . Peer-reviewed
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Frontiers in Pharmacology
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      Article . 2021
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lisseth Dolores Rodriguez Cruz;

    Self-medication is a latent problem in our society. It is the own initiative or decision to take drugs, the consumption of drugs regardless of their origin, or medical prescription1,2. This has been increasing and has become a phenomenon that is highly studied by researchers. Thus, in pre-pandemic times, self-medication was a considerable problem in several countries, although with differences between countries in Europe and Latin America. So we have, in Spain3; The National Health System announced that in 2017 15.3% of people self-medicate. Also, in Mexico4; 86% consume medications without a doctor's prescription. La automedicación es un problema latente en nuestra sociedad. Es la iniciativa propia o decisión de tomar medicamentos el consumo de fármacos sin importar su origen, ni prescripción médica1,2. Esta ha ido en aumento y se ha vuelto un fenómeno muy estudiado por investigadores. Así, en épocas pre-pandemia la automedicación era un problema considerable en varios países, aunque con diferencias entre países de Europa y Latinoamérica. Así tenemos, en España3; el Sistema Nacional de Salud dio a conocer que en el año 2017 el 15,3 % de personas se automedica. Asimismo, en México4; el 86 % consume medicamentos sin la prescripción de un médico. Sin embargo, el miedo, la saturación de hospitales y la afectación económica por la pandemia COVID-195 ha incentivado a realizar con más frecuencia esta práctica e inclusive aumentó la prevalencia en la población joven6. Puesto que, justificaban la práctica por diversos factores entre ellos; el 33,49 % de los jóvenes relacionan la similitud de los síntomas con enfermedades pasadas, el 19,17 % percibían la enfermedad como algo leve, el 18,24 % desde el aspecto económico les resultaba más barato la automedicación7. Además, en Perú, al inicio de la pandemia se distribuyó kits para tratar la enfermedad leve por coronavirus; por lo que algunos cuando eran hospitalizados por la enfermedad, referían haberse automedicado con ivermectina que les habían entregado a sus familiares8. Además, la pandemia ha incrementado el consumo de tranquilizantes para tratar la ansiedad y el insomnio, trastornos que han aumentado a consecuencia de la pandemia9. En tal sentido, algunos por el miedo y la ansiedad, han optado por el automedicarse sustancias tales como el dióxido de cloro, vitaminas, hierbas, cloroquina10. En tanto, se usaron también medicamentos que permitan mejorar el sistema inmunológico como vitaminas C, D, A y B y suplementos de zinc11. Finalmente, la población, debido al SARS-CoV-2 como una acción preventiva y tranquilizadora, recurrió al acopio de fármacos y su eventual autoconsumo sin consultar con una prescripción. Sin embargo, fue una medida errónea debido a que existen fármacos como los antibióticos que debilitan el sistema inmune12. Frente a lo expuesto, es necesario reflexionar que una consecuencia de la automedicación es la resistencia a los antibióticos, esta aumenta la letalidad de la enfermedad porque el tratamiento se vuelve más difícil debido a la pérdida de eficacia de los mismos. Por lo que es importante implementar en todas las farmacias la vigilancia del expendio de antibióticos, ansiolíticos, etc. con receta. Además, se debe concientizar a la población sobre los riesgos de la automedicación para la salud, puesto que puede causar resistencia a los antibióticos y la dependencia de ansiolíticos y analgésicos.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ LAReferencia - Red F...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    ACC CIETNA Revista de la Escuela de Enfermería
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ LAReferencia - Red F...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • Authors: Maxi Nieto;

    Abstract Since the 1980s, authors of the Austrian School have argued that the problem of rational allocation in a planned economy is not computational or technical in nature (static optimisation, with given information) but a question of dynamic efficiency (innovation and the creation of new information), and that this would be impossible without market processes and free entrepreneurship. In this article, we argue to the contrary that a planned economy can effectively drive dynamic efficiency. We first reveal that the Austrian thesis on the impossibility of dynamic efficiency in socialist planning is based on tautological arguments, or on problems already solved by technological development. Secondly, we present an institutional formula for promoting innovative activities and entrepreneurship within a framework of social ownership of the means of production and social control of investment.

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    Authors: Nikolay Pavlov;

    The paper analyses the Concept Development and Experimentation (CD&E) approach which has been developed and implemented in NATO over the last 20 years. NATO’s CD&E approach is explained as an organisational innovation and institutional response to external and internal pressures. Within the theoretical framing of institutional isomorphism, the paper analyses the adoption of CD&E in the European Union’s (EU) Common Security and Defence Policy (CSDP). The research hypothesis is that the EU will adopt and apply NATO’s CD&E approach in the EU’s defence planning and capability development process. The empirical findings from the analysis of the EU policy practice, however, show that CD&E has actually been adopted from NATO and applied by the EU to a very limited extent. The low degree of isomorphism between NATO and the EU with regard to applying CD&E is explained by a complex set of factors. The research results have broader implications, suggesting that under the current institutional settings it is highly unlikely CD&E to be adopted by other international organisations in the field of international security.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODO; Defence Stud...arrow_drop_down
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    Defence Studies
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Geoff M. Boucher;

    In this article, I investigate the literary representation of the religious convictions and political strategy of neo-Nazi ideologues who are influential in rightwing authoritarian movements in the USA today. The reason that I do this is because in contemporary fascism, the novel has replaced the political manifesto, the military manual and proselytizing testimony, since fiction can evade censorship and avoid prosecution. I read William Luther Pierce’s Turner Diaries and Hunter together with his text on speculative metaphysics and religious belief, Cosmotheism. Then, I turn to Harold Covington’s Northwestern Quintet with The Brigade, reading this with Christian Identity and his own conception of Nazi religious tolerance. Finally, I look at OT Gunnarsson’s Hear the Cradle Song, reading this together with discussions of racism in Californian Odinism. I propose that what this literature shows is that the doctrinal differences between the three main strands of neo-Nazi religion—Cosmotheism, Christian Identity and Odinism—are less significant than their common ideological functions. These are twofold: (1) the sacralization of violence and (2) the sanctification of elites. The dystopian fictions of fascist literature present civil war scenarios whose white nationalist and genocidal outcome is the result of what are, strictly speaking, supremacist death cults.

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    Other literature type . Article . 2021 . Peer-reviewed
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    Authors: Anna Trono; Luigi Oliva;

    Religious routes and itineraries can be seen as promoting not only the sharing of ethical and religious values and sentiments of peace and brotherhood but also the awareness and personal growth of the traveller. Those who walk remote pilgrimage paths today wish to experience the fascination of the past, to feel something of the dread and the passion of ancient travellers, but they also seek to fulfil an emotional and intellectual need for authenticity, spirituality and culture. The Puglia region has numerous religious paths that arose in past centuries and continue to be practised by modern pilgrims, who treat the journey as an emotional, educational, social and participatory experience. Appropriate exploitation of this type of journey would enable the promotion of a “gentle” but no less successful tourism, above all in a period of social distancing and global suffering. The present study starts with a presentation of some of the precursors of the many routes that led from the Orient towards Rome, such as those of the Apostle Peter, St Francis of Assisi and the anonymous Pilgrim of Bordeaux. It then examines the new values that prompt people to follow the Via Francigena del Sud that runs along the Italian peninsula linking Europe north of the Alps to the ports of Puglia, and it is just an exemplary case aimed at fulfilling the potential of eastern Mediterranean coastal regions by offering cultural routes and itineraries for sustainable and quality tourism.

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    Other literature type . Article . 2021 . Peer-reviewed
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      Other literature type . Article . 2021 . Peer-reviewed
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    Authors: Antonio Moreno-Almárcegui; Germán Scalzo;

    This article analyzes Marian art in Spain from the tenth to nineteenth centuries in order to show how popular piety represented Mary’s motherhood. Through art, including architecture, painting, sculpture, and oral preaching, a popular image of Mary emerged and, in turn, became key for understanding the history of the family in western Catholic countries. Studying the evolution of Marian iconography during this thousand-year period reveals a kind of grandeur, and then a certain crisis, surrounding Mary’s motherhood. This crisis specifically involves the meaning of the body as an effective sign of the personal gift-of-self. We argue that this process ran parallel to growing problems in theological culture related to reconciling the natural and supernatural realms, and we further sustain that it contains a true cultural revolution, a shift that is at the origin of many later transformations. This interpretation helps better understand the dilemmas surrounding the history of the family in the West, and specifically of motherhood, from the point of view of the Christian tradition.

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    Other literature type . Article . 2021 . Peer-reviewed
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    Authors: Bing Huang;

    The discovery of the Northern Zhou (557–581AD) tomb of Shi Jun (494–579 CE) presents us with spectacular visual information about the Sogdians in medieval China, which was previously available to us only through written sources. The iconography-heavy sarcophagus in the tomb is an important vehicle for understanding the practices of religious (and everyday) life in the Sino-Sogdian community. The imagery on the Shi Jun sarcophagus reveals a mix of religious beliefs that existed among migrants in the premodern Eurasian world. Due to the absence of a dominant religion associated with Sino-Sogdian funerals, the iconography of the sarcophagus cannot be interpreted within an orthodox theological framework. Instead, it is possible that more syncretistic, indigenous, and regionally based folklore, tales, and hymns, in combination with a diversity of religious beliefs, might explain the sarcophagus’s enigmatic imagery, since the social order and religious order are often mutually reinforcing.

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    Other literature type . Article . 2021 . Peer-reviewed
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    Authors: Simone Zimmermann Kuoni;

    The Minoan peak sanctuaries call for systematic comparative research as an island-bound phenomenon whose significance to the (pre)history of medicine far transcends the Cretan context: they yield clay anatomical offerings attesting to the earliest known healing cult in the Aegean. The peak sanctuary of Petsophas produced figurines of weasels, which are usually interpreted as pests, ignoring their association with votives that express concerns about childbirth, traditionally the first single cause of death for women. The paper draws from primary sources to examine the weasel’s puzzling bond with birth and midwives, concluding that it stems from the animal’s pharmacological role in ancient obstetrics. This novel interpretation then steers the analysis of archaeological evidence for rituals involving mustelids beyond and within Bronze Age Crete, revealing the existence of a midwifery koine across the Near East and the Mediterranean; a net of interconnections relevant to female therapeutics which brings to light a package of animals and plants bespeaking of a Minoan healing tradition likely linked to the cult of the midwife goddess Eileithyia. Challenging mainstream accounts of the beginnings of Western medicine as a male accomplishment, this overlooked midwifery tradition characterises Minoan Crete as a unique crucible of healing knowledge, ideas, and practices.

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    Other literature type . Article . 2021 . Peer-reviewed
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    Article . 2021
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      Religions
      Other literature type . Article . 2021 . Peer-reviewed
      License: CC BY
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Volodymyr P. Pylypenko; Khrystyna T. Sliusarchuk; Pavlo B. Pylypyshyn; Svitlana V. Boichenko;

    This paper provides a comprehensive study of theoretical and practical issues of violation of human rights by war crimes, protection of legitimate interests of individuals in national and international law as a result of such violation. The purpose of this study is a comprehensive analysis of theoretical and applied issues related to the protection of violated rights and legitimate interests of individuals in public international law as a result of the commission of war crimes, and the formulation of scientifically sound proposals for improving the current legislation of Ukraine and the practice of its application in this area. The paper analyses the current scientific opinions and legislation on the regulation of illegal acts and liability for damage caused to victims as a result of violation of human rights and fundamental freedoms by war crimes. Furthermore, the existing forms, methods, and means of protecting the rights and legitimate interests of such persons in Ukraine and in the international arena were determined. The paper also provides a comprehensive study of the existing concept, legal nature and main features of war crimes and their legal regulation in Ukrainian legislation. Legislative amendments to the regulations governing this issue are proposed and the study justifies the position regarding the existence of an exclusively judicial procedure for resolving issues of human rights violations by war crimes, the result of which should be the adoption of a court decision. As a result of the study, the current scientific statements and achievements are clearly identified, as well as those that have emerged due to the constant development of public relations and substantial changes in international relations of various states, which causes armed conflicts and war crimes. One of the achievements of the scientific study is the proof of the importance of the problem of violated human rights in modern society and the extreme need for its research. After all, modern legislation requires substantial changes and improvement of the existing provisions with the subsequent possibility of their practical application

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yilin Chen; Xu Ji; Xu Ji; Hong Xiao; +8 Authors

    Background: Centralizing procurement for prescription drugs has the potential to reduce drug spending by creating economies of scale and by improving purchasing power. In March 2019, the Chinese government launched a volume-based purchasing (VBP) pilot program using a competitive bidding process to purchase high-quality generic drugs for which branded drug substitutes were available. We evaluated the impact of introducing the VBP pilot on drug purchase quantity and spending. Methods: We performed an interrupted time-series design to estimate the change in monthly drug purchase quantity and spending comparing fourteen months before and seven months after the VBP pilot. We obtained monthly prescription drug purchase data for all purchases from public hospitals in the three large pilot cities (Beijing, Shanghai and Xi’an) and two non-pilot cities (Changsha and Zhengzhou) between January 2018 to September 2019. We measured quantity and spending outcomes separately for the branded and generic substitutes that were selected in the VBP, and other drugs for the treatment of the same diseases. We evaluated heterogeneity of impact by pilot city, drug type, and therapeutic class (cardiovascular disease, mental disorder and cancer) separately. Findings: The VBP pilot in these three cities covered 60 million individuals. The implementation of the pilot reform was associated with a 132% (95%-CI: 104%-165%, p<0·001) increase in the purchase quantity of selected drugs in pilot cities compared to an 17% decrease (95%-CI: 9%-25%, p<0·001) in control cities. In contrast, the purchase quantity of branded and other drugs in pilot cities decreased by 38% (95%-CI: 27%-46%, p<0·001) and 77% (95%-CI: 71%-81%, p<0·001), respectively; while in control cities, these remained at similar levels. Overall, there was a 35% (95%-CI: 28%-41%, p<0·001) decrease in the purchase spending for all drugs in the first post-policy month, from 8·1 billion CNY estimated in the absence of VBP down to 5·3 billion CNY. The largest reduction in spending was in Shanghai and from drugs for the treatment of cardiovascular diseases. Interpretation: The evidence suggests positive impact of the VBP pilot in reducing the overall drug spending and increasing the use of high-quality generics in three pilot cities. This overall trend is not observed in two non-pilot cities. Assessment of long-term impact of the VBP policy is needed on various outcomes such as drug prescription and utilization patterns, patients’ health outcomes and spending. Funding: None to declare. Declaration of Interest: None to declare.

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    OpenAIRE; SSRN Electronic Journal
    Article . 2021 . Peer-reviewed
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    Frontiers in Pharmacology
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      OpenAIRE; SSRN Electronic Journal
      Article . 2021 . Peer-reviewed
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      Frontiers in Pharmacology
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lisseth Dolores Rodriguez Cruz;

    Self-medication is a latent problem in our society. It is the own initiative or decision to take drugs, the consumption of drugs regardless of their origin, or medical prescription1,2. This has been increasing and has become a phenomenon that is highly studied by researchers. Thus, in pre-pandemic times, self-medication was a considerable problem in several countries, although with differences between countries in Europe and Latin America. So we have, in Spain3; The National Health System announced that in 2017 15.3% of people self-medicate. Also, in Mexico4; 86% consume medications without a doctor's prescription. La automedicación es un problema latente en nuestra sociedad. Es la iniciativa propia o decisión de tomar medicamentos el consumo de fármacos sin importar su origen, ni prescripción médica1,2. Esta ha ido en aumento y se ha vuelto un fenómeno muy estudiado por investigadores. Así, en épocas pre-pandemia la automedicación era un problema considerable en varios países, aunque con diferencias entre países de Europa y Latinoamérica. Así tenemos, en España3; el Sistema Nacional de Salud dio a conocer que en el año 2017 el 15,3 % de personas se automedica. Asimismo, en México4; el 86 % consume medicamentos sin la prescripción de un médico. Sin embargo, el miedo, la saturación de hospitales y la afectación económica por la pandemia COVID-195 ha incentivado a realizar con más frecuencia esta práctica e inclusive aumentó la prevalencia en la población joven6. Puesto que, justificaban la práctica por diversos factores entre ellos; el 33,49 % de los jóvenes relacionan la similitud de los síntomas con enfermedades pasadas, el 19,17 % percibían la enfermedad como algo leve, el 18,24 % desde el aspecto económico les resultaba más barato la automedicación7. Además, en Perú, al inicio de la pandemia se distribuyó kits para tratar la enfermedad leve por coronavirus; por lo que algunos cuando eran hospitalizados por la enfermedad, referían haberse automedicado con ivermectina que les habían entregado a sus familiares8. Además, la pandemia ha incrementado el consumo de tranquilizantes para tratar la ansiedad y el insomnio, trastornos que han aumentado a consecuencia de la pandemia9. En tal sentido, algunos por el miedo y la ansiedad, han optado por el automedicarse sustancias tales como el dióxido de cloro, vitaminas, hierbas, cloroquina10. En tanto, se usaron también medicamentos que permitan mejorar el sistema inmunológico como vitaminas C, D, A y B y suplementos de zinc11. Finalmente, la población, debido al SARS-CoV-2 como una acción preventiva y tranquilizadora, recurrió al acopio de fármacos y su eventual autoconsumo sin consultar con una prescripción. Sin embargo, fue una medida errónea debido a que existen fármacos como los antibióticos que debilitan el sistema inmune12. Frente a lo expuesto, es necesario reflexionar que una consecuencia de la automedicación es la resistencia a los antibióticos, esta aumenta la letalidad de la enfermedad porque el tratamiento se vuelve más difícil debido a la pérdida de eficacia de los mismos. Por lo que es importante implementar en todas las farmacias la vigilancia del expendio de antibióticos, ansiolíticos, etc. con receta. Además, se debe concientizar a la población sobre los riesgos de la automedicación para la salud, puesto que puede causar resistencia a los antibióticos y la dependencia de ansiolíticos y analgésicos.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ LAReferencia - Red F...arrow_drop_down
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    ACC CIETNA Revista de la Escuela de Enfermería
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  • Authors: Maxi Nieto;

    Abstract Since the 1980s, authors of the Austrian School have argued that the problem of rational allocation in a planned economy is not computational or technical in nature (static optimisation, with given information) but a question of dynamic efficiency (innovation and the creation of new information), and that this would be impossible without market processes and free entrepreneurship. In this article, we argue to the contrary that a planned economy can effectively drive dynamic efficiency. We first reveal that the Austrian thesis on the impossibility of dynamic efficiency in socialist planning is based on tautological arguments, or on problems already solved by technological development. Secondly, we present an institutional formula for promoting innovative activities and entrepreneurship within a framework of social ownership of the means of production and social control of investment.

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    Authors: Nikolay Pavlov;

    The paper analyses the Concept Development and Experimentation (CD&E) approach which has been developed and implemented in NATO over the last 20 years. NATO’s CD&E approach is explained as an organisational innovation and institutional response to external and internal pressures. Within the theoretical framing of institutional isomorphism, the paper analyses the adoption of CD&E in the European Union’s (EU) Common Security and Defence Policy (CSDP). The research hypothesis is that the EU will adopt and apply NATO’s CD&E approach in the EU’s defence planning and capability development process. The empirical findings from the analysis of the EU policy practice, however, show that CD&E has actually been adopted from NATO and applied by the EU to a very limited extent. The low degree of isomorphism between NATO and the EU with regard to applying CD&E is explained by a complex set of factors. The research results have broader implications, suggesting that under the current institutional settings it is highly unlikely CD&E to be adopted by other international organisations in the field of international security.

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    Authors: Geoff M. Boucher;

    In this article, I investigate the literary representation of the religious convictions and political strategy of neo-Nazi ideologues who are influential in rightwing authoritarian movements in the USA today. The reason that I do this is because in contemporary fascism, the novel has replaced the political manifesto, the military manual and proselytizing testimony, since fiction can evade censorship and avoid prosecution. I read William Luther Pierce’s Turner Diaries and Hunter together with his text on speculative metaphysics and religious belief, Cosmotheism. Then, I turn to Harold Covington’s Northwestern Quintet with The Brigade, reading this with Christian Identity and his own conception of Nazi religious tolerance. Finally, I look at OT Gunnarsson’s Hear the Cradle Song, reading this together with discussions of racism in Californian Odinism. I propose that what this literature shows is that the doctrinal differences between the three main strands of neo-Nazi religion—Cosmotheism, Christian Identity and Odinism—are less significant than their common ideological functions. These are twofold: (1) the sacralization of violence and (2) the sanctification of elites. The dystopian fictions of fascist literature present civil war scenarios whose white nationalist and genocidal outcome is the result of what are, strictly speaking, supremacist death cults.

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    Other literature type . Article . 2021 . Peer-reviewed
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    Article . 2021
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    Authors: Anna Trono; Luigi Oliva;

    Religious routes and itineraries can be seen as promoting not only the sharing of ethical and religious values and sentiments of peace and brotherhood but also the awareness and personal growth of the traveller. Those who walk remote pilgrimage paths today wish to experience the fascination of the past, to feel something of the dread and the passion of ancient travellers, but they also seek to fulfil an emotional and intellectual need for authenticity, spirituality and culture. The Puglia region has numerous religious paths that arose in past centuries and continue to be practised by modern pilgrims, who treat the journey as an emotional, educational, social and participatory experience. Appropriate exploitation of this type of journey would enable the promotion of a “gentle” but no less successful tourism, above all in a period of social distancing and global suffering. The present study starts with a presentation of some of the precursors of the many routes that led from the Orient towards Rome, such as those of the Apostle Peter, St Francis of Assisi and the anonymous Pilgrim of Bordeaux. It then examines the new values that prompt people to follow the Via Francigena del Sud that runs along the Italian peninsula linking Europe north of the Alps to the ports of Puglia, and it is just an exemplary case aimed at fulfilling the potential of eastern Mediterranean coastal regions by offering cultural routes and itineraries for sustainable and quality tourism.

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    Other literature type . Article . 2021 . Peer-reviewed
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      Other literature type . Article . 2021 . Peer-reviewed
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    Authors: Antonio Moreno-Almárcegui; Germán Scalzo;

    This article analyzes Marian art in Spain from the tenth to nineteenth centuries in order to show how popular piety represented Mary’s motherhood. Through art, including architecture, painting, sculpture, and oral preaching, a popular image of Mary emerged and, in turn, became key for understanding the history of the family in western Catholic countries. Studying the evolution of Marian iconography during this thousand-year period reveals a kind of grandeur, and then a certain crisis, surrounding Mary’s motherhood. This crisis specifically involves the meaning of the body as an effective sign of the personal gift-of-self. We argue that this process ran parallel to growing problems in theological culture related to reconciling the natural and supernatural realms, and we further sustain that it contains a true cultural revolution, a shift that is at the origin of many later transformations. This interpretation helps better understand the dilemmas surrounding the history of the family in the West, and specifically of motherhood, from the point of view of the Christian tradition.

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    Other literature type . Article . 2021 . Peer-reviewed
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    Article . 2021
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    Article . 2021
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    Authors: Bing Huang;

    The discovery of the Northern Zhou (557–581AD) tomb of Shi Jun (494–579 CE) presents us with spectacular visual information about the Sogdians in medieval China, which was previously available to us only through written sources. The iconography-heavy sarcophagus in the tomb is an important vehicle for understanding the practices of religious (and everyday) life in the Sino-Sogdian community. The imagery on the Shi Jun sarcophagus reveals a mix of religious beliefs that existed among migrants in the premodern Eurasian world. Due to the absence of a dominant religion associated with Sino-Sogdian funerals, the iconography of the sarcophagus cannot be interpreted within an orthodox theological framework. Instead, it is possible that more syncretistic, indigenous, and regionally based folklore, tales, and hymns, in combination with a diversity of religious beliefs, might explain the sarcophagus’s enigmatic imagery, since the social order and religious order are often mutually reinforcing.

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    Other literature type . Article . 2021 . Peer-reviewed
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    Authors: Simone Zimmermann Kuoni;

    The Minoan peak sanctuaries call for systematic comparative research as an island-bound phenomenon whose significance to the (pre)history of medicine far transcends the Cretan context: they yield clay anatomical offerings attesting to the earliest known healing cult in the Aegean. The peak sanctuary of Petsophas produced figurines of weasels, which are usually interpreted as pests, ignoring their association with votives that express concerns about childbirth, traditionally the first single cause of death for women. The paper draws from primary sources to examine the weasel’s puzzling bond with birth and midwives, concluding that it stems from the animal’s pharmacological role in ancient obstetrics. This novel interpretation then steers the analysis of archaeological evidence for rituals involving mustelids beyond and within Bronze Age Crete, revealing the existence of a midwifery koine across the Near East and the Mediterranean; a net of interconnections relevant to female therapeutics which brings to light a package of animals and plants bespeaking of a Minoan healing tradition likely linked to the cult of the midwife goddess Eileithyia. Challenging mainstream accounts of the beginnings of Western medicine as a male accomplishment, this overlooked midwifery tradition characterises Minoan Crete as a unique crucible of healing knowledge, ideas, and practices.

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Religionsarrow_drop_down
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