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Research data keyboard_double_arrow_right Dataset 2018Embargo end date: 13 Mar 2018 Spain EnglishPublisher:Dryad Funded by:EC | 100 Archaic Genomes, ARC | Australian Laureate Fello..., ARC | ARC Future Fellowships - ... +1 projectsEC| 100 Archaic Genomes ,ARC| Australian Laureate Fellowships - Grant ID: FL130100116 ,ARC| ARC Future Fellowships - Grant ID: FT140100384 ,ARC| ARC Future Fellowships - Grant ID: FT150100138Slon, Viviane; Hopfe, Charlotte; Weiss, Clemens L.; Mafessoni, Fabrizio; de la Rasilla, Marco; Lalueza-Fox, Carles;doi: 10.5061/dryad.m2dk7
handle: 10261/278288
Although a rich record of Pleistocene human-associated archaeological assemblages exists, the scarcity of hominin fossils often impedes the understanding of which hominins occupied a site. Using targeted enrichment of mitochondrial DNA we show that cave sediments represent a rich source of ancient mammalian DNA that often includes traces of hominin DNA, even at sites and in layers where no hominin remains have been discovered. By automation-assisted screening of numerous sediment samples we detect Neandertal DNA in eight archaeological layers from four caves in Eurasia. In Denisova Cave we retrieved Denisovan DNA in a Middle Pleistocene layer near the bottom of the stratigraphy. Our work opens the possibility to detect the presence of hominin groups at sites and in areas where no skeletal remains are found. Multiple sequence alignment files This submission contains multiple sequence alignment files used for phylogenetic reconstructions. Sequences reconstructed from sediments are denominated by the site and layer of origin. The comparative data (identical in all files) is identified by the name of the individual and the accession code of its mtDNA sequence. MSA_sedimentDNA.zip Peer reviewed
DRYAD; ZENODO; NARCI... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICDataset . 2022 . 2018 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5061/dryad.m2dk7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 33visibility views 33 download downloads 4 Powered bymore_vert DRYAD; ZENODO; NARCI... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICDataset . 2022 . 2018 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5061/dryad.m2dk7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Dataset 2017Embargo end date: 14 Feb 2017 EnglishPublisher:Dryad Funded by:ARC | Mapping the connectome th..., EC | HBP, NHMRC | Reduced baroreceptor refl... +1 projectsARC| Mapping the connectome that controls blood pressure ,EC| HBP ,NHMRC| Reduced baroreceptor reflex control of heart rate in chronic renal failure ,EC| HBP SGA1Dempsey, Bowen; Le, Sheng; Turner, Anita; Bokiniec, Phill; Ramadas, Radhika; Bjaalie, Jan G.; Menuet, Clement; Neve, Rachael; Allen, Andrew; Goodchild, Ann; McMullan, Simon; Bokiniec, Phil; Goodchild, Ann K.; Allen, Andrew M.;doi: 10.5061/dryad.q5t5s
Spinally projecting neurons in the rostral ventrolateral medulla (RVLM) play a critical role in the generation of vasomotor sympathetic tone and are thought to receive convergent input from neurons at every level of the neuraxis; the factors that determine their ongoing activity remain unresolved. In this study we use a genetically restricted viral tracing strategy to definitively map their spatially diffuse connectome. We infected bulbospinal RVLM neurons with recombinant rabies variant that drives reporter expression in monosynaptically connected input neurons and mapped their distribution using a MRI-based volumetric atlas and a novel image alignment and visualization tool that efficiently translates the positions of neurons captured in conventional photomicrographs to Cartesian coordinates. We identified prominent inputs from well-established neurohumoral and viscero-sympathetic sensory actuators, medullary autonomic and respiratory subnuclei, and supramedullary autonomic nuclei. The majority of inputs lay within the brainstem (88 – 94%), and included putative respiratory neurons in the pre-Bötzinger Complex and post-inspiratory complex that are therefore likely to underlie respiratory-sympathetic coupling. We also discovered a substantial and previously unrecognized input from the region immediately ventral to nucleus prepositus hypoglossi. In contrast, RVLM sympathetic premotor neurons were only sparsely innervated by suprapontine structures including the paraventricular nucleus, lateral hypothalamus, periaqueductal grey and superior colliculus, and we found almost no evidence of direct inputs from the cortex or amygdala. Our approach can be used to quantify, standardize and share complete neuroanatomical datasets, and therefore provides researchers with a platform for presentation, analysis and independent analysis of connectomic data. Waxholm Rat Calculation TemplateThis template will help you to translate pixel co-ordinates of cells identified from microscopy images to Waxholm co-ordinates. In needs to be used in conjunction with the AlignNii image anchoring tool, which aligns 2d histological images in the 3d MRI Waxholm rat brain. Access to this tool can be requested from Jan Bjaalie (j.g.bjaalie@medisin.uio.no).Waxholm volumetric atlasThis is the zipped Imaris file that contains the Waxholm MRI dataset, the corresponding segmented dataset, the volumetric segmentation model and all of connectomic data from this paper.Dempsey 2016 RVLM Connectome Resource.zip
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5061/dryad.q5t5s&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 94visibility views 94 download downloads 20 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5061/dryad.q5t5s&type=result"></script>'); --> </script>
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Research data keyboard_double_arrow_right Dataset 2018Embargo end date: 13 Mar 2018 Spain EnglishPublisher:Dryad Funded by:EC | 100 Archaic Genomes, ARC | Australian Laureate Fello..., ARC | ARC Future Fellowships - ... +1 projectsEC| 100 Archaic Genomes ,ARC| Australian Laureate Fellowships - Grant ID: FL130100116 ,ARC| ARC Future Fellowships - Grant ID: FT140100384 ,ARC| ARC Future Fellowships - Grant ID: FT150100138Slon, Viviane; Hopfe, Charlotte; Weiss, Clemens L.; Mafessoni, Fabrizio; de la Rasilla, Marco; Lalueza-Fox, Carles;doi: 10.5061/dryad.m2dk7
handle: 10261/278288
Although a rich record of Pleistocene human-associated archaeological assemblages exists, the scarcity of hominin fossils often impedes the understanding of which hominins occupied a site. Using targeted enrichment of mitochondrial DNA we show that cave sediments represent a rich source of ancient mammalian DNA that often includes traces of hominin DNA, even at sites and in layers where no hominin remains have been discovered. By automation-assisted screening of numerous sediment samples we detect Neandertal DNA in eight archaeological layers from four caves in Eurasia. In Denisova Cave we retrieved Denisovan DNA in a Middle Pleistocene layer near the bottom of the stratigraphy. Our work opens the possibility to detect the presence of hominin groups at sites and in areas where no skeletal remains are found. Multiple sequence alignment files This submission contains multiple sequence alignment files used for phylogenetic reconstructions. Sequences reconstructed from sediments are denominated by the site and layer of origin. The comparative data (identical in all files) is identified by the name of the individual and the accession code of its mtDNA sequence. MSA_sedimentDNA.zip Peer reviewed
DRYAD; ZENODO; NARCI... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICDataset . 2022 . 2018 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5061/dryad.m2dk7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 33visibility views 33 download downloads 4 Powered bymore_vert DRYAD; ZENODO; NARCI... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICDataset . 2022 . 2018 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5061/dryad.m2dk7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Dataset 2017Embargo end date: 14 Feb 2017 EnglishPublisher:Dryad Funded by:ARC | Mapping the connectome th..., EC | HBP, NHMRC | Reduced baroreceptor refl... +1 projectsARC| Mapping the connectome that controls blood pressure ,EC| HBP ,NHMRC| Reduced baroreceptor reflex control of heart rate in chronic renal failure ,EC| HBP SGA1Dempsey, Bowen; Le, Sheng; Turner, Anita; Bokiniec, Phill; Ramadas, Radhika; Bjaalie, Jan G.; Menuet, Clement; Neve, Rachael; Allen, Andrew; Goodchild, Ann; McMullan, Simon; Bokiniec, Phil; Goodchild, Ann K.; Allen, Andrew M.;doi: 10.5061/dryad.q5t5s
Spinally projecting neurons in the rostral ventrolateral medulla (RVLM) play a critical role in the generation of vasomotor sympathetic tone and are thought to receive convergent input from neurons at every level of the neuraxis; the factors that determine their ongoing activity remain unresolved. In this study we use a genetically restricted viral tracing strategy to definitively map their spatially diffuse connectome. We infected bulbospinal RVLM neurons with recombinant rabies variant that drives reporter expression in monosynaptically connected input neurons and mapped their distribution using a MRI-based volumetric atlas and a novel image alignment and visualization tool that efficiently translates the positions of neurons captured in conventional photomicrographs to Cartesian coordinates. We identified prominent inputs from well-established neurohumoral and viscero-sympathetic sensory actuators, medullary autonomic and respiratory subnuclei, and supramedullary autonomic nuclei. The majority of inputs lay within the brainstem (88 – 94%), and included putative respiratory neurons in the pre-Bötzinger Complex and post-inspiratory complex that are therefore likely to underlie respiratory-sympathetic coupling. We also discovered a substantial and previously unrecognized input from the region immediately ventral to nucleus prepositus hypoglossi. In contrast, RVLM sympathetic premotor neurons were only sparsely innervated by suprapontine structures including the paraventricular nucleus, lateral hypothalamus, periaqueductal grey and superior colliculus, and we found almost no evidence of direct inputs from the cortex or amygdala. Our approach can be used to quantify, standardize and share complete neuroanatomical datasets, and therefore provides researchers with a platform for presentation, analysis and independent analysis of connectomic data. Waxholm Rat Calculation TemplateThis template will help you to translate pixel co-ordinates of cells identified from microscopy images to Waxholm co-ordinates. In needs to be used in conjunction with the AlignNii image anchoring tool, which aligns 2d histological images in the 3d MRI Waxholm rat brain. Access to this tool can be requested from Jan Bjaalie (j.g.bjaalie@medisin.uio.no).Waxholm volumetric atlasThis is the zipped Imaris file that contains the Waxholm MRI dataset, the corresponding segmented dataset, the volumetric segmentation model and all of connectomic data from this paper.Dempsey 2016 RVLM Connectome Resource.zip
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5061/dryad.q5t5s&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 94visibility views 94 download downloads 20 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5061/dryad.q5t5s&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu