- home
- Advanced Search
Filters
Clear All- European University of Technology
- Open Access
- Research data
- NL
- European University of Technology
- Open Access
- Research data
- NL
Loading
Research data keyboard_double_arrow_right Dataset 2020 Netherlands EnglishPublisher:Cambridge Crystallographic Data Centre Más-Montoya, Miriam; Gómez, Paula; Curiel, David; da Silva, Ivan; Wang, Junke; Janssen, René A.J.;Related Article: Paula Gómez, Stamatis Georgakopoulos, Miriam Más-Montoya, Jesús Cerdá, José Pérez, Enrique Ortí, Juan Aragó, David Curiel|2021|ACS Applied Materials and Interfaces|13|8620|doi:10.1021/acsami.0c18928 Related Article: Miriam Más‐Montoya, Paula Gómez, David Curiel, Ivan Silva, Junke Wang, René A. J. Janssen|2020|Chem.-Eur.J.|26|10276 |doi:10.1002/chem.202000005
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5517/ccdc.csd.cc23psxj&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5517/ccdc.csd.cc23psxj&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Image 2019Publisher:figshare Funded by:SNSF | Natural history, phenotyp..., EC | BESTCILIA, MESTD | Rare Diseases:Molecular P... +2 projectsSNSF| Natural history, phenotypes and disease classification in primary ciliary dyskinesia ,EC| BESTCILIA ,MESTD| Rare Diseases:Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects ,NWO| OptiClips for Delayed Sterilization ,ANR| RADICOKouis, Panayiotis; Myrofora Goutaki; Halbeisen, Florian; Gioti, Ifigeneia; Nicos Middleton; Amirav, Israel; Barbato, Angelo; Behan, Laura; Boon, Mieke; Emiralioglu, Nagehan; Haarman, Eric; Bulent Karadag; Koerner-Rettberg, Cordula; Lazor, Romain; Loebinger, Michael; Maitre, Bernard; Mazurek, Henryk; Morgan, Lucy; Nielsen, Kim; Heymut Omran; Ugur Özçelik; Price, Mareike; Pogorzelski, Andrzej; Snijders, Deborah; Thouvenin, Guillaume; Werner, Claudius; Zivkovic, Zorica; Kuehni, Claudia; Yiallouros, Panayiotis;Additional file 2: Figure S1. Frequency of Pseudomonas positive cultures in PCD lobectomised patients (n = 24) and controls (n = 43). Frequency of Pseudomonas positive cultures among lobectomised patients (displayed in black) and among controls (displayed in grey). The proportion of positive sputum cultures for Pseudomonas aeruginosa in each group was calculated as the sum of individual patients’ proportions of positive cultures weighted by the ratio of the number of cultures taken from the individual patient versus the total number of cultures in the specific age group.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.9876815&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.9876815&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Collection 2019Publisher:figshare Funded by:EC | BESTCILIA, NWO | OptiClips for Delayed Ste..., MESTD | Rare Diseases:Molecular P... +2 projectsEC| BESTCILIA ,NWO| OptiClips for Delayed Sterilization ,MESTD| Rare Diseases:Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects ,SNSF| Natural history, phenotypes and disease classification in primary ciliary dyskinesia ,ANR| RADICOKouis, Panayiotis; Myrofora Goutaki; Halbeisen, Florian; Gioti, Ifigeneia; Nicos Middleton; Amirav, Israel; Barbato, Angelo; Behan, Laura; Boon, Mieke; Emiralioglu, Nagehan; Haarman, Eric; Bulent Karadag; Koerner-Rettberg, Cordula; Lazor, Romain; Loebinger, Michael; Maitre, Bernard; Mazurek, Henryk; Morgan, Lucy; Nielsen, Kim; Heymut Omran; Ugur Özçelik; Price, Mareike; Pogorzelski, Andrzej; Snijders, Deborah; Thouvenin, Guillaume; Werner, Claudius; Zivkovic, Zorica; Kuehni, Claudia; Yiallouros, Panayiotis;Abstract Background Lung resection is a controversial and understudied therapeutic modality in Primary Ciliary Dyskinesia (PCD). We assessed the prevalence of lung resection in PCD across countries and compared disease course in lobectomised and non-lobectomised patients. Methods In the international iPCD cohort, we identified lobectomised and non-lobectomised age and sex-matched PCD patients and compared their characteristics, lung function and BMI cross-sectionally and longitudinally. Results Among 2896 patients in the iPCD cohort, 163 from 20 centers (15 countries) underwent lung resection (5.6%). Among adult patients, prevalence of lung resection was 8.9%, demonstrating wide variation among countries. Compared to the rest of the iPCD cohort, lobectomised patients were more often females, older at diagnosis, and more often had situs solitus. In about half of the cases (45.6%) lung resection was performed before presentation to specialized PCD centers for diagnostic work-up. Compared to controls (n = 197), lobectomised patients had lower FVC z-scores (− 2.41 vs − 1.35, p = 0.0001) and FEV1 z-scores (− 2.79 vs − 1.99, p = 0.003) at their first post-lung resection assessment. After surgery, lung function continued to decline at a faster rate in lobectomised patients compared to controls (FVC z-score slope: − 0.037/year Vs − 0.009/year, p = 0.047 and FEV1 z-score slope: − 0.052/year Vs − 0.033/year, p = 0.235), although difference did not reach statistical significance for FEV1. Within cases, females and patients with multiple lobe resections had lower lung function. Conclusions Prevalence of lung resection in PCD varies widely between countries, is often performed before PCD diagnosis and overall is more frequent in patients with delayed diagnosis. After lung resection, compared to controls most lobectomised patients have poorer and continuing decline of lung function despite lung resection. Further studies benefiting from prospective data collection are needed to confirm these findings.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.c.4670786.v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.c.4670786.v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
Loading
Research data keyboard_double_arrow_right Dataset 2020 Netherlands EnglishPublisher:Cambridge Crystallographic Data Centre Más-Montoya, Miriam; Gómez, Paula; Curiel, David; da Silva, Ivan; Wang, Junke; Janssen, René A.J.;Related Article: Paula Gómez, Stamatis Georgakopoulos, Miriam Más-Montoya, Jesús Cerdá, José Pérez, Enrique Ortí, Juan Aragó, David Curiel|2021|ACS Applied Materials and Interfaces|13|8620|doi:10.1021/acsami.0c18928 Related Article: Miriam Más‐Montoya, Paula Gómez, David Curiel, Ivan Silva, Junke Wang, René A. J. Janssen|2020|Chem.-Eur.J.|26|10276 |doi:10.1002/chem.202000005
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5517/ccdc.csd.cc23psxj&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5517/ccdc.csd.cc23psxj&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Image 2019Publisher:figshare Funded by:SNSF | Natural history, phenotyp..., EC | BESTCILIA, MESTD | Rare Diseases:Molecular P... +2 projectsSNSF| Natural history, phenotypes and disease classification in primary ciliary dyskinesia ,EC| BESTCILIA ,MESTD| Rare Diseases:Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects ,NWO| OptiClips for Delayed Sterilization ,ANR| RADICOKouis, Panayiotis; Myrofora Goutaki; Halbeisen, Florian; Gioti, Ifigeneia; Nicos Middleton; Amirav, Israel; Barbato, Angelo; Behan, Laura; Boon, Mieke; Emiralioglu, Nagehan; Haarman, Eric; Bulent Karadag; Koerner-Rettberg, Cordula; Lazor, Romain; Loebinger, Michael; Maitre, Bernard; Mazurek, Henryk; Morgan, Lucy; Nielsen, Kim; Heymut Omran; Ugur Özçelik; Price, Mareike; Pogorzelski, Andrzej; Snijders, Deborah; Thouvenin, Guillaume; Werner, Claudius; Zivkovic, Zorica; Kuehni, Claudia; Yiallouros, Panayiotis;Additional file 2: Figure S1. Frequency of Pseudomonas positive cultures in PCD lobectomised patients (n = 24) and controls (n = 43). Frequency of Pseudomonas positive cultures among lobectomised patients (displayed in black) and among controls (displayed in grey). The proportion of positive sputum cultures for Pseudomonas aeruginosa in each group was calculated as the sum of individual patients’ proportions of positive cultures weighted by the ratio of the number of cultures taken from the individual patient versus the total number of cultures in the specific age group.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.9876815&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.9876815&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Collection 2019Publisher:figshare Funded by:EC | BESTCILIA, NWO | OptiClips for Delayed Ste..., MESTD | Rare Diseases:Molecular P... +2 projectsEC| BESTCILIA ,NWO| OptiClips for Delayed Sterilization ,MESTD| Rare Diseases:Molecular Pathophysiology, Diagnostic and Therapeutic Modalities and Social, Ethical and Legal Aspects ,SNSF| Natural history, phenotypes and disease classification in primary ciliary dyskinesia ,ANR| RADICOKouis, Panayiotis; Myrofora Goutaki; Halbeisen, Florian; Gioti, Ifigeneia; Nicos Middleton; Amirav, Israel; Barbato, Angelo; Behan, Laura; Boon, Mieke; Emiralioglu, Nagehan; Haarman, Eric; Bulent Karadag; Koerner-Rettberg, Cordula; Lazor, Romain; Loebinger, Michael; Maitre, Bernard; Mazurek, Henryk; Morgan, Lucy; Nielsen, Kim; Heymut Omran; Ugur Özçelik; Price, Mareike; Pogorzelski, Andrzej; Snijders, Deborah; Thouvenin, Guillaume; Werner, Claudius; Zivkovic, Zorica; Kuehni, Claudia; Yiallouros, Panayiotis;Abstract Background Lung resection is a controversial and understudied therapeutic modality in Primary Ciliary Dyskinesia (PCD). We assessed the prevalence of lung resection in PCD across countries and compared disease course in lobectomised and non-lobectomised patients. Methods In the international iPCD cohort, we identified lobectomised and non-lobectomised age and sex-matched PCD patients and compared their characteristics, lung function and BMI cross-sectionally and longitudinally. Results Among 2896 patients in the iPCD cohort, 163 from 20 centers (15 countries) underwent lung resection (5.6%). Among adult patients, prevalence of lung resection was 8.9%, demonstrating wide variation among countries. Compared to the rest of the iPCD cohort, lobectomised patients were more often females, older at diagnosis, and more often had situs solitus. In about half of the cases (45.6%) lung resection was performed before presentation to specialized PCD centers for diagnostic work-up. Compared to controls (n = 197), lobectomised patients had lower FVC z-scores (− 2.41 vs − 1.35, p = 0.0001) and FEV1 z-scores (− 2.79 vs − 1.99, p = 0.003) at their first post-lung resection assessment. After surgery, lung function continued to decline at a faster rate in lobectomised patients compared to controls (FVC z-score slope: − 0.037/year Vs − 0.009/year, p = 0.047 and FEV1 z-score slope: − 0.052/year Vs − 0.033/year, p = 0.235), although difference did not reach statistical significance for FEV1. Within cases, females and patients with multiple lobe resections had lower lung function. Conclusions Prevalence of lung resection in PCD varies widely between countries, is often performed before PCD diagnosis and overall is more frequent in patients with delayed diagnosis. After lung resection, compared to controls most lobectomised patients have poorer and continuing decline of lung function despite lung resection. Further studies benefiting from prospective data collection are needed to confirm these findings.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.c.4670786.v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.c.4670786.v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu