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description Publicationkeyboard_double_arrow_right Article 2020Publisher:MDPI AG Publicly fundedFunded by:IRC, EC | INMARE, SFI | Pre-clinical testing of n...IRC ,EC| INMARE ,SFI| Pre-clinical testing of novel fungal biofilm blockers for the medical device sector.Stephanie Flynn; F. Jerry Reen; J. Caparros-Martin; David Woods; Jörg Peplies; Sarath Ranganathan; Stephen M. Stick; Fergal O'Gara;lung axis connection, which may modulate the progression of lung disease. Molecular signals governing the interplay between these two organs are therefore candidate molecules requiring further clinical evaluation as potential biomarkers. We demonstrate a temporal association between bile acid (BA) metabolites and inflammatory markers in bronchoalveolar lavage fluid (BALF) from clinically stable children with CF. By modelling the BALF-associated microbial communities, we demonstrate that profiles enriched in operational taxonomic units assigned to supraglottic taxa and opportunistic pathogens are closely associated with inflammatory biomarkers. Applying regression analyses, we also confirmed a linear link between BA concentration and pathogen abundance in BALF. Analysis of the time series data suggests that the continuous detection of BAs in BALF is linked to differential ecological succession trajectories of the lung microbiota. Our data provide further evidence supporting a role for BAs in the early pathogenesis and progression of CF lung disease. Cystic fibrosis (CF) is a congenital disorder resulting in a multisystemic impairment in ion homeostasis. The subsequent alteration of electrochemical gradients severely compromises the function of the airway epithelia. These functional changes are accompanied by recurrent cycles of inflammation&ndash infection that progressively lead to pulmonary insufficiency. Recent developments have pointed to the existence of a gut&ndash
Microorganisms arrow_drop_down MicroorganismsOther literature type . Article . 2020 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/2076-2607/8/11/1741/pdfEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7694639Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/microorganisms8111741&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Microorganisms arrow_drop_down MicroorganismsOther literature type . Article . 2020 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/2076-2607/8/11/1741/pdfEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7694639Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/microorganisms8111741&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2020Publisher:MDPI AG Publicly fundedFunded by:IRC, EC | INMARE, SFI | Pre-clinical testing of n...IRC ,EC| INMARE ,SFI| Pre-clinical testing of novel fungal biofilm blockers for the medical device sector.Stephanie Flynn; F. Jerry Reen; J. Caparros-Martin; David Woods; Jörg Peplies; Sarath Ranganathan; Stephen M. Stick; Fergal O'Gara;lung axis connection, which may modulate the progression of lung disease. Molecular signals governing the interplay between these two organs are therefore candidate molecules requiring further clinical evaluation as potential biomarkers. We demonstrate a temporal association between bile acid (BA) metabolites and inflammatory markers in bronchoalveolar lavage fluid (BALF) from clinically stable children with CF. By modelling the BALF-associated microbial communities, we demonstrate that profiles enriched in operational taxonomic units assigned to supraglottic taxa and opportunistic pathogens are closely associated with inflammatory biomarkers. Applying regression analyses, we also confirmed a linear link between BA concentration and pathogen abundance in BALF. Analysis of the time series data suggests that the continuous detection of BAs in BALF is linked to differential ecological succession trajectories of the lung microbiota. Our data provide further evidence supporting a role for BAs in the early pathogenesis and progression of CF lung disease. Cystic fibrosis (CF) is a congenital disorder resulting in a multisystemic impairment in ion homeostasis. The subsequent alteration of electrochemical gradients severely compromises the function of the airway epithelia. These functional changes are accompanied by recurrent cycles of inflammation&ndash infection that progressively lead to pulmonary insufficiency. Recent developments have pointed to the existence of a gut&ndash
Microorganisms arrow_drop_down MicroorganismsOther literature type . Article . 2020 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/2076-2607/8/11/1741/pdfEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7694639Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/microorganisms8111741&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Microorganisms arrow_drop_down MicroorganismsOther literature type . Article . 2020 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/2076-2607/8/11/1741/pdfEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7694639Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/microorganisms8111741&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu