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description Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2017 Germany, United Kingdom, United Kingdom, Netherlands, United States, France, United Kingdom, United Kingdom, Spain, Switzerland, AustraliaPublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:NHMRC | Quantifying the neurocogn..., NIH | Longitudinal brain develo..., NHMRC | Unravelling genetic influ... +49 projectsNHMRC| Quantifying the neurocognitive impact of cannabis across the life span: The evolution of memory deficits. ,NIH| Longitudinal brain development and clinical outcomes in ADHD from 7-17 years ,NHMRC| Unravelling genetic influences on the human brain ,NHMRC| The Older Australian Twins Study (OATS) of healthy brain ageing and age-related neurocognitive disorders ,NIH| Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASD ,NIH| INHIBITORY CONTROL AND MA SELF-ADMINISTRATION: MODAFINIL EFFECTS ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,NIH| Multi-group semi-blind ICA of fMRI ,EC| MiND ,NIH| Functional Connectivity in Schizophrenia ,NIH| Brain trajectories in ADHD ,EC| IMAGEMEND ,NIH| Mining the Genomewide Scan: Genetic Profiles of Structural Loss in Schizophrenia ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,EC| AGGRESSOTYPE ,NIH| FUNCTION BIRN ,UKRI| Anatomical connectivity in early onset schizophrenia ,NIH| Multivariate methods for identifying multitask/multimodal brain imaging biomarkers ,NIH| Genetic markers of white matter integrity in schizophrenia: Relationship to clini ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NIH| Neural Systems, Inhibitory Control, and Methamphetamine Dependence ,NIH| A clinical trial of DOT for HAART in jailed drug users ,NHMRC| Australian Twin Registry ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,NIH| International Multi-Center ADHD Genetics Project ,NIH| Oregon Clinical and Translational Research Institute ,NIH| Informed Data-Driven Fusion of Behavior, Brain Function, and Genes ,NWO| Networking through ADHD biology ,NWO| How does the neural architecture of cognition map on its genetic architecture? ,ARC| Examining the relationship between error processing, cognitive control and emotion: a cognitive neuroscience approach ,NHMRC| Enhancing and integrating addiction neuroscience knowledge with clinical practice, by transforming the approach to assessment and classification protocols, and improving outcomes by using neurocognitive phenotypes for tailored treatments ,NHMRC| Genetics of brain structure and function ,NIH| ADHD biotypes using genetic and imaging approaches ,NWO| Language in Interaction ,EC| TACTICS ,NHMRC| Cognitive control dysfunction in drug dependence ,NIH| Early Methamphetamine Abstinence: fMRI and Cognition ,NIH| SPATIOTEMPORAL FORWARD MODEL FOR DIFFUSE OPTICAL TOMOGRAPHY ,NIH| GENERAL CLINICAL RESEARCH CENTER ,NIH| Cortical Basic of Schizophrenia Sensory Gaiting Deficit ,NIH| Functional Circuits as an Endophenotype for ADHD in Children ,NSF| IGERT: Emergent Functions of Neural Systems ,NHMRC| Trajectories in brain structure and function for children with and without ADHD: Associations with academic, cognitive, social, and mental health outcomes ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NSF| Graduate Research Fellowship Program ,NIH| SCOR Application on Sex, Stress, and Cocaine Addiction ,NIH| INFORMATION PROCESSING BIASES IN DEPRESSION ,NIH| A Cross-Sectional and Longitudinal Functional MRI Study of Adolescent Depression ,SFI| The application of MRI to identify endophenotypes in focal epilepsy ,CIHR ,NIH| BIOSTATISTICS &NEUROINFORMATICS (STATNI) CORE ,NIH| Genetic influences on the brain: A twin imaging studyKong, Xiang-Zhen; Mathias, Samuel R; Francks, Clyde; Grabe, Hans; Groenewold, Nynke A; Grotegerd, Dominik; Gruber, Oliver; Gurholt, Tiril; Haavik, Jan; Hahn, Tim; Hansell, Narelle K; Harris, Mathew A; Hartman, Catharina A; Kong, Xiang-Zhen; Hernández, Maria Del Carmen Valdés; Heslenfeld, Dirk; Hester, Robert; Hibar, Derrek Paul; Ho, Beng-Choon; Ho, Tiffany C; Hoekstra, Pieter J; van Holst, Ruth J; Hoogman, Martine; Høvik, Marie F; Mathias, Samuel R; Howells, Fleur M; Hugdahl, Kenneth; Huyser, Chaim; Ingvar, Martin; Irwin, Lourdes; Ishikawa, Akari; James, Anthony; Jahanshad, Neda; Jernigan, Terry L; Jönsson, Erik G; Guadalupe, Tulio; Kähler, Claas; Kaleda, Vasily; Kelly, Clare; Kerich, Michael; Keshavan, Matcheri S; Khadka, Sabin; Kircher, Tilo; Kohls, Gregor; Konrad, Kerstin; Korucuoglu, Ozlem; Abé, Christoph; Krämer, Bernd; Krug, Axel; Kwon, Jun Soo; Lambregts-Rommelse, Nanda; Landén, Mikael; Lázaro, Luisa; Lebedeva, Irina; Lenroot, Rhoshel; Lesch, Klaus-Peter; Li, Qinqin; Agartz, Ingrid; Lim, Kelvin O; Liu, Jia; Lochner, Christine; London, Edythe D; Lonning, Vera; Lorenzetti, Valentina; Luciano, Michelle; Luijten, Maartje; Lundervold, Astri J; Mackey, Scott; Akudjedu, Theophilus N; MacMaster, Frank P; Maingault, Sophie; Malpas, Charles B; Malt, Ulrik F; Mataix-Cols, David; Martin-Santos, Rocio; Mayer, Andrew R; McCarthy, Hazel; Mitchell, Philip B; Mueller, Bryon A; Aleman, Andre; Maniega, Susana Muñoz; Mazoyer, Bernard; McDonald, Colm; McLellan, Quinn; McMahon, Katie L; McPhilemy, Genevieve; Momenan, Reza; Morales, Angelica M; Narayanaswamy, Janardhanan C; Moreira, José Carlos Vasques; Alhusaini, Saud; Nerland, Stener; Nestor, Liam; Newman, Erik; Nigg, Joel T; Nordvik, Jan Egil; Novotny, Stephanie; Weiss, Eileen Oberwelland; O'Gorman, Ruth L; Oosterlaan, Jaap; Oranje, Bob; Allen, Nicholas B; Orr, Catherine; Overs, Bronwyn; Pauli, Paul; Paulus, Martin; Plessen, Kerstin Jessica; von Polier, Georg G; Pomarol-Clotet, Edith; Portella, Maria J; Qiu, Jiang; Radua, Joaquim; Guadalupe, Tulio; Ames, David; Ramos-Quiroga, Josep Antoni; Reddy, Y C Janardhan; Reif, Andreas; Roberts, Gloria; Rosa, Pedro; Rubia, Katya; Sacchet, Matthew D; Sachdev, Perminder S; Salvador, Raymond; Schmaal, Lianne; Andreassen, Ole A; Schulte-Rüther, Martin; Schweren, Lizanne; Seidman, Larry; Seitz, Jochen; Serpa, Mauricio Henriques; Shaw, Philip; Shumskaya, Elena; Silk, Timothy J; Simmons, Alan N; Simulionyte, Egle; Vasquez, Alejandro Arias; Sinha, Rajita; Sjoerds, Zsuzsika; Smelror, Runar Elle; Soliva, Joan Carlos; Solowij, Nadia; Souza-Duran, Fabio Luisde; Sponheim, Scott R; Stein, Dan J; Stein, Elliot A; Stevens, Michael; Armstrong, Nicola J; Strike, Lachlan T; Sudre, Gustavo; Sui, Jing; Tamm, Leanne; Temmingh, Hendrik S; Thoma, Robert J; Tomyshev, Alexander; Tronchin, Giulia; Turner, Jessica; Uhlmann, Anne; Bergo, Felipe; van Erp, Theo G M; van den Heuvel, Odile A; van der Meer, Dennis; van Eijk, Liza; Vance, Alasdair; Veer, Ilya M; Veltman, Dick J; Venkatasubramanian, Ganesan; Vilarroya, Oscar; Vives-Gilabert, Yolanda; Bastin, Mark E; Voineskos, Aristotle N; Völzke, Henry; Vuletic, Daniella; Walitza, Susanne; Walter, Henrik; Walton, Esther; Wardlaw, Joanna M; Wen, Wei; Westlye, Lars T; Whelan, Christopher D; Batalla, Albert; White, Tonya; Wiers, Reinout W; Wright, Margaret J; Wittfeld, Katharina; Yang, Tony T; Yasuda, Clarissa L; Yoncheva, Yuliya; Yücel, Murat; Yun, Je-Yeon; Zanetti, Marcus Vinicius; Bauer, Jochen; Zhen, Zonglei; Zhu, Xing-Xing; Ziegler, Georg C; Zierhut, Kathrin; de Zubicaray, Greig I; Zwiers, Marcel; Glahn, David C; Franke, Barbara; Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Fisher, Simon E; Fatouros-Bergman, Helena; Bose, Anushree; Brooks, Samantha J; Calhoun, Vince; Canales-Rodríguez, Erick Jorge; Cannon, Dara M; Cavalleri, Gianpiero L; Cendes, Fernando; Christakou, Anastasia; Connolly, Colm G; Cousijn, Janna; Cubillo, Ana; Deary, Ian J; Demeter, Damion V; Dickie, Erin W; Doherty, Colin P; Earl, Eric; Ehrlich, Stefan; Ekman, Carl Johan; Förster, Katharina; Fuentes-Claramonte, Paola; Fullerton, Janice;handle: 2066/191921 , 20.500.11820/7fb463bc-b796-46f5-8a23-6c44e9518b1c , https://repository.ubn.ru.nl/handle/2066/191921 , 21.11116/0000-0003-BC00-9 , 21.11116/0000-0001-4B8C-E , 21.11116/0000-0001-4B86-4 , 1871.1/5dd1afee-c756-40e5-ab51-8659295095c3 , 1983/8a0226fd-3f3e-4031-8fbe-6856b0131ac2 , 1874/372468 , 2445/131251 , 21.11116/0000-0004-ACB6-D , 21.11116/0000-000D-1715-2 , 1765/128353 , 11245.1/0c2822db-db0c-422a-953c-e89c814fcda8
pmc: PMC5984496
pmid: 29764998
handle: 2066/191921 , 20.500.11820/7fb463bc-b796-46f5-8a23-6c44e9518b1c , https://repository.ubn.ru.nl/handle/2066/191921 , 21.11116/0000-0003-BC00-9 , 21.11116/0000-0001-4B8C-E , 21.11116/0000-0001-4B86-4 , 1871.1/5dd1afee-c756-40e5-ab51-8659295095c3 , 1983/8a0226fd-3f3e-4031-8fbe-6856b0131ac2 , 1874/372468 , 2445/131251 , 21.11116/0000-0004-ACB6-D , 21.11116/0000-000D-1715-2 , 1765/128353 , 11245.1/0c2822db-db0c-422a-953c-e89c814fcda8
pmc: PMC5984496
pmid: 29764998
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders. Contains fulltext : 191921pub.pdf (Publisher’s version ) (Open Access) 10 p.
CORE (RIOXX-UK Aggre... arrow_drop_down bioRxivPreprint . 2017NARCIS; Radboud RepositoryArticle . 2018Recolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAMETIS Research Information System; Proceedings of the National Academy of SciencesOther literature type . Article . 2018 . Peer-reviewedeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveNARCIS; Proceedings of the National Academy of SciencesArticle . 2018Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationshttps://doi.org/https://doi.or...Other literature typeData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 286 citations 286 popularity Top 0.1% influence Top 10% impulse Top 1% Powered by BIP!visibility 72visibility views 72 download downloads 162 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down bioRxivPreprint . 2017NARCIS; Radboud RepositoryArticle . 2018Recolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAMETIS Research Information System; Proceedings of the National Academy of SciencesOther literature type . Article . 2018 . Peer-reviewedeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveNARCIS; Proceedings of the National Academy of SciencesArticle . 2018Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationshttps://doi.org/https://doi.or...Other literature typeData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Italy, United States, United Kingdom, Italy, Italy, Italy, NetherlandsPublisher:Wiley Publicly fundedFunded by:NIH | Probing the Role of Polyc..., EC | EPITARGET, EC | EPISTOP +2 projectsNIH| Probing the Role of Polycomb in the Epigenetics of Epilepsy ,EC| EPITARGET ,EC| EPISTOP ,SFI| MicroRNA biofluid profiles as molecular diagnostics for epilepsy ,NIH| Inflammatory control of blood-brain barrier integrity and epileptogenesis after seizuresEleonora Aronica; Sebastian Bauer; Yuri Bozzi; Matteo Caleo; Raymond Dingledine; Jan A. Gorter; David C. Henshall; Daniela Kaufer; Sookyong Koh; Wolfgang Löscher; Jean-Pierre Louboutin; Michele Mishto; Braxton A. Norwood; Eleonora Palma; Michael O. Poulter; Gaetano Terrone; Annamaria Vezzani; Rafal M. Kaminski;SummaryA large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory molecules and pathways have been identified that influence various pathologic outcomes in different experimental models of epilepsy. Most importantly, the same inflammatory pathways have also been found in surgically resected brain tissue from patients with treatment‐resistant epilepsy. New antiseizure therapies may be derived from these novel potential targets. An essential and crucial question is whether targeting these molecules and pathways may result in anti‐ictogenesis, antiepileptogenesis, and/or disease‐modification effects. Therefore, preclinical testing in models mimicking relevant aspects of epileptogenesis is needed to guide integrated experimental and clinical trial designs. We discuss the most recent preclinical proof‐of‐concept studies validating a number of therapeutic approaches against inflammatory mechanisms in animal models that could represent novel avenues for drug development in epilepsy. Finally, we suggest future directions to accelerate preclinical to clinical translation of these recent discoveries.
IRIS - Institutional... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2017Data sources: Archivio della ricerca- Università di Roma La SapienzaeScholarship - University of CaliforniaArticle . 2017Data sources: eScholarship - University of CaliforniaEpilepsiaArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 137 citations 137 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!download 14download downloads 14 Powered bymore_vert IRIS - Institutional... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2017Data sources: Archivio della ricerca- Università di Roma La SapienzaeScholarship - University of CaliforniaArticle . 2017Data sources: eScholarship - University of CaliforniaEpilepsiaArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/epi.13783&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Germany, Ireland, United Kingdom, Netherlands, Italy, Spain, United Kingdom, France, France, France, United Kingdom, France, France, France, United Kingdom, United Kingdom, France, IrelandPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | NEUROSCHEMA, NIH | The ARIC and Neurocogniti..., NIH | Functional genomics of bi... +110 projectsEC| NEUROSCHEMA ,NIH| The ARIC and Neurocognitive Longitudinal Study ,NIH| Functional genomics of bipolar disorder ,NIH| OBESITY, DIABETES &AGING ANIMAL RESOURCE ,NIH| Genotypic Determinants of Aspirin Response in High-Risk ,NHMRC| Cerebrovascular diseases and Brain Ageing – a program of research into novel mechanisms, risk prevention and innovative health care delivery ,NHMRC| The Older Australian Twins Study (OATS) of healthy brain ageing and age-related neurocognitive disorders ,NIH| National Cell Repository for Alzheimer's Disease (NCRAD) ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,NIH| UCLA Clinical and Translational Science Institute ,NIH| HARDI Mapping of Disease Effects on the Brain ,NIH| Predicting Brain Changes in HIV/AIDS ,NSF| MRI: Acquisition of a Data Analytics Cluster for Computational Social Science ,NIH| CHS-Transition Phase -268055222 ,NIH| Searching for Endophenotypes of Bipolar Disorder ,NIH| Alzheimer's Disease Genetics Consortium ,EC| ORACLE ,NWO| Twin-family database for behavior genetics and genomics studies ,NWO| Networking through ADHD biology ,NIH| Alzheimer's Disease Genetics Consortium ,NIH| Empowering Personalized Medicine: Integrating Imaging, Genetics, and Biomarkers ,FWF| Mechanisms of Small Vessel Related Brain Damage and Cognitive Impairment ,WT| Genome-wide association studies in partial epilepsies. ,EC| MiND ,EC| TACTICS ,WT| Stratifying Resilience and Depression Longitudinally (STRADL) ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| Genetic Epidemiology of Cognitive Decline in an Aging Population Sample ,NIH| An Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel Disease ,NIH| Occult Small Vessel Cerebrovascular Disease in High Risk Families ,NHMRC| Type 2 Diabetes Mellitus and Cognitive Decline - a longitudinal study of effects and mechanisms ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,EC| EU-AIMS ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,EC| MATRICS ,NIH| CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NHMRC| Prevention, early detection and effective management of neurocognitive disorders in the elderly ,NIH| GCRC-RENOVATION ,NIH| Epidemiologic Study of Neural Reserve and Neurobiology of Aging ,NIH| International Multi-Center ADHD Genetics Project ,NHMRC| A population-based study of cerebrovascular mechanisms underyling gait, balance and cognition in older people ,NIH| Exceptional aging: 12 year trajectories to function ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NHMRC| Advancing our understanding of the genetics of Psychiatric and Neurological Disease ,EC| PHASE ,NIH| Hormonal trajectories in aging ,NIH| Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and Depression ,NIH| Major Depression: Stage 1 Genomewide Association in Population-Based Samples ,NIH| Role of Mitochondrial Health in Acute and Chronic Kidney Disease in Older Adults ,CIHR ,NHMRC| Genetics of brain structure and function ,NIH| Epidemiology of Biomarkers of Risk and Progression in LOAD ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| Laboratory of Neuro Imaging Resource (LONIR) ,NHMRC| Australian Twin Registry ,NWO| NCHA Subsidiebesluit 2008-2012 ,ARC| The articulate brain ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| Genomic Studies of Bipolar Disorder in a Large Cohort from The Netherlands ,NWO| Neuro-imaging study in twins concordant or discordant for obsessive-compulsive symptoms. ,NIH| ALZHEIMERS DISEASE DATA COORDINATING CENTER ,NHMRC| Genetics of melanoma risk factors ,NIH| Structural Brain Abnormalities In Depression ,NIH| COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA ,NIH| CYCLINS AND CHEMICAL CARCINOGENESIS ,EC| IMAGEMEND ,NIH| Alzheimer's disease risk analyzed using population imaging genomics ,NHMRC| Prevention and management of mental disorders in older Australians ,NIH| Functional Neuroimaging In Unipolar And Bipolar Depresse ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,NIH| MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATION ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness ,NHMRC| Development and Evaluation of Statistical Methods and Software for Analysis of Complex Genetic Disease Data ,NIH| CHS research resources for the cardiovascular health of older adults ,WT| A Powerful, Genome-Wide Association Scan for Susceptibility Genes for late-onset Alzheimer's disease ,NHMRC| Genetic Repositories Australia ,NIH| Genetic Influences on Human Cortical Development ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,NIH| SHORT-TERM STABILITY OF CLINICAL TESTS ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,ARC| Elucidating the genetics of attention deficit hyperactivity disorder by integrating pathway and prediction analyses ,SFI| The application of MRI to identify endophenotypes in focal epilepsy ,NWO| Functional neural network plasticity in adolescent twins and sibs ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| Vascular Cognitive and Motor Decline: Impact of aPL ,NIH| Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience ,EC| ENGAGE ,NIH| Genetic influences on the brain: A twin imaging study ,NIH| Rare variants and NHLBI traits in deeply phenotyped cohorts ,NIH| Genomics of Developmental Trajectories in Twins ,NIH| Neuroimaging genetics to study social cognitive deficits in ASD and schizophrenia ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NIH| Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes ,EC| AGGRESSOTYPE ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION ,NIH| Genetic Influences on Human Neuroanatomical Shapes ,NIH| Neurodevelopment and Imaging among HIV-infected Children from the PREDICT study ,NIH| RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITY ,NIH| Alzheimers Disease in Mild Cognitive Impairment ,EC| GMI ,NIH| Alzheimers Disease Neuroimaging Initiative ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NIH| CORONARY HEART DISEASE AND STROKEHieab H.H. Adams; Vincent Chouraki; Jason L. Stein; Miguel E. Rentería; Stella Trompet; Alejandro Arias-Vasquez; Sudha Seshadri; Sylvane Desrivières; Sven J. van der Lee; Najaf Amin; Micael Andersson; Konstantinos Arfanakis; Benjamin S. Aribisala; Nicola J. Armstrong; Alexa S. Beiser; Manon Bernard; Susan H. Blanton; Marco P. Boks; Janita Bralten; Owen Carmichael; Ganesh Chauhan; Qiang Chen; Gabriel Cuellar-Partida; Anouk den Braber; Stefan Ehrlich; Irina Filippi; Tian Ge; Rebecca F. Gottesman; Corina U. Greven; Tulio Guadalupe; Unn K. Haukvik; Saima Hilal; D. Hoehn; Tianye Jia; Marieke Klein; Phil H. Lee; David C. Liewald; Lorna M. Lopez; Michelle Luciano; Christine Macare; Andre F. Marquand; Karen A. Mather; Manuel Mattheisen; Bernard Mazoyer; Rebekah McWhirter; Yuri Milaneschi; Nazanin Mirza-Schreiber; Ryan L. Muetzel; Susana Muñoz Maniega; Kwangsik Nho; Loes M. Olde Loohuis; Jaap Oosterlaan; Irene Pappa; Lukas Pirpamer; Sara Pudas; Adaikalavan Ramasamy; Jennifer S. Richards; Shannon L. Risacher; Roberto Roiz-Santiañez; Nanda Rommelse; Emma J. Rose; Claudia L. Satizabal; Lianne Schmaal; Li Shen; Jean Shin; Albert V. Smith; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Russell Thomson; Diana Tordesillas-Gutiérrez; Roberto Toro; Daniah Trabzuni; Dhananjay Vaidya; Jeroen van der Grond; Dennis van der Meer; Marjolein M. J. Van Donkelaar; Kristel R. van Eijk; Theo G.M. van Erp; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G Windham; Anderson M. Winkler; Girma Woldehawariat; Christiane Wolf; Thomas Wolfers; Bing Xu; Ingrid Agartz; David Ames; Philippe Amouyel; Ole A. Andreassen; Sampath Arepalli; Mark E. Bastin; Diane M. Becker; James T. Becker; John Blangero; Hans van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Randy L. Buckner; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Christopher Chen; Ching-Yu Cheng; Sven Cichon; Mark R. Cookson; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Gareth E. Davies; Eco J. C. de Geus; Greig I. Zubicaray; Anita L. DeStefano; Srdjan Djurovic; Gary Donohoe; Wayne C. Drevets; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Denis A. Evans; Iryna O. Fedko; Simon E. Fisher; Debra A. Fleischman; Clyde Francks; Masaki Fukunaga; J. Raphael Gibbs; Randy L. Gollub; Harald H H Göring; Hans J. Grabe; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Narelle K. Hansell; John Hardy; Ryota Hashimoto; Andreas Heinz; Stephanie Le Hellard; Dirk J. Heslenfeld; Beng-Choon Ho; Wolfgang Hoffmann; Albert Hofman; Florian Holsboer; Georg Homuth; Hilleke E. Hulshoff Pol; M. Kamran Ikram; Clifford R. Jack; Mark Jenkinson; Robert Johnson; Erik G. Jönsson; J. Wouter Jukema; David S. Knopman; Peter Kochunov; Stephen M. Lawrie; Herve Lemaitre; Dan L. Longo; W.T. Longstreth; Oscar L. Lopez; Simon Lovestone; Jean-Luc Martinot; Colm McDonald; Andrew M. McIntosh; Katie L. McMahon; Francis J. McMahon; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Sebastian Mohnke; Derek W. Morris; Thomas H. Mosley; Thomas W. Mühleisen; Thomas E. Nichols; Wiro J. Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Roel A. Ophoff; Massimo Pandolfo; G. Bruce Pike; Bruce M. Psaty; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Peter R. Schofield; Andrew Singleton; Hilkka Soininen; Velandai Srikanth; Jessika E. Sussmann; Anbupalam Thalamuthu; Henning Tiemeier; Arthur W. Toga; Bryan J. Traynor; Juan C. Troncoso; Jessica A. Turner; Christophe Tzourio; André G. Uitterlinden; Aad van der Lugt; Nic J A van der Wee; Cornelia M. van Duijn; Dennis van 't Ent; Marie-José van Tol; Badri N. Vardarajan; Dick J. Veltman; Meike W. Vernooij; Henry Völzke; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Daniel R. Weinberger; Wei Wen; Eric Westman; Tonya White; Tien Yin Wong; H. Ronald Zielke; Alan B. Zonderman; Ian J. Deary; Nicholas G. Martin; Anton J. M. de Craen; Margaret J. Wright; Lenore J. Launer; Gunter Schumann; Barbara Franke; Stéphanie Debette; Sarah E. Medland; Paul M. Thompson;pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (rhogenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits. Contains fulltext : 165723pub.pdf (Publisher’s version ) (Closed access)
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2016Full-Text: http://livrepository.liverpool.ac.uk/3004351/1/ICV-GWAS-NN-acceptedAug31-2016embargoed.pdfData sources: CORE (RIOXX-UK Aggregator)Maynooth University ePrints & eTheses ArchiveArticle . 2016 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016 . Peer-reviewedLicense: Springer TDMFull-Text: http://www.nature.com/articles/nn.4398.pdfNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 198 citations 198 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 141visibility views 141 download downloads 458 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2016Full-Text: http://livrepository.liverpool.ac.uk/3004351/1/ICV-GWAS-NN-acceptedAug31-2016embargoed.pdfData sources: CORE (RIOXX-UK Aggregator)Maynooth University ePrints & eTheses ArchiveArticle . 2016 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016 . Peer-reviewedLicense: Springer TDMFull-Text: http://www.nature.com/articles/nn.4398.pdfNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2018 Netherlands, Norway, United Kingdom, Norway, United Kingdom, United Kingdom, Spain, France, France, Italy, Germany, GermanyPublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:NIH | National Cell Repository ..., NIH | UCLA Clinical and Transla..., NIH | CHS-Transition Phase -268... +192 projectsNIH| National Cell Repository for Alzheimer's Disease (NCRAD) ,NIH| UCLA Clinical and Translational Science Institute ,NIH| CHS-Transition Phase -268055222 ,NHMRC| Blood protein biomarkers for frontotemporal lobar degeneration ,NIH| Functional Connectivity in Schizophrenia ,NIH| CYCLINS AND CHEMICAL CARCINOGENESIS ,EC| IMAGEMEND ,EC| EU-AIMS ,NIH| Multivariate methods for identifying multitask/multimodal brain imaging biomarkers ,NHMRC| Australian Schizophrenia Research Bank (ASRB) ,NIH| Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness ,WT| Genome-wide association studies in partial epilepsies. ,EC| MiND ,NIH| DATA MANAGEMENT AND BIOSTATISTICS ,NIH| FUNCTION BIRN ,NHMRC| Improving diagnosis of early frontotemporal dementia syndromes ,NIH| SILICON GRAPHICS PRISM EXTREME 128P/1TB ,NIH| Informed Data-Driven Fusion of Behavior, Brain Function, and Genes ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,NIH| Laboratory of Neuro Imaging Resource (LONIR) ,EC| SEGWAY ,NWO| Individual development: Why some children thrive, and others don't. ,NIH| A Longitudinal Twin Study of Cognition and Personality ,NIH| Mining the Genomewide Scan: Genetic Profiles of Structural Loss in Schizophrenia ,NHMRC| Prevention, early detection and effective management of neurocognitive disorders in the elderly ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,FWF| Genetics of Cerebral Small Vessel Disease ,NIH| Institute for Clinical and Translational Research (UL1) ,EC| GMI ,NWO| Longitudinal data collection from teachers of Dutch twins and their siblings ,NHMRC| Unravelling genetic influences on the human brain ,FWF| MRI white matter abnormalities in the elderly: Genetic risk factors, rate of progression and neuropsychologic consequences ,NIH| Rare variants and NHLBI traits in deeply phenotyped cohorts ,NIH| Testosterone-Androgen Receptor Genetics: Role in Cognitive and Biological Aging ,NIH| Genomics of Developmental Trajectories in Twins ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NHMRC| Uncoupled Research Fellowship ,NIH| Genetic &environmental pathways to drug use, abuse &dependence ,NIH| Exceptional aging: 12 year trajectories to function ,NIH| FRONTOTEMPORAL DEMENTIA: GENES, IMAGES, AND EMOTIONS ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NHMRC| Advancing our understanding of the genetics of Psychiatric and Neurological Disease ,NHMRC| Research fellowship ,NIH| CORONARY HEART DISEASE AND STROKE ,NHMRC| Genetics of brain structure and function ,NIH| Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders ,EC| AGGRESSOTYPE ,NIH| Antecedent Neuroimaging Biomarkers ,UKRI| UKCRC Brain Bank Strategy: Renewal of Newcastle Brain Tissue Resource ,EC| ENGAGE ,NIH| SOLAR-Eclipse Computational Tools for Imaging Genetics ,NIH| Algorithm and Data Analysis (ADA) Core ,NIH| Mapping Individual Cognitive Differences to Neural Variance and School Readiness ,NWO| BBMRI-NL2.0: The NL-Biobank Research Facility ,NHMRC| Complete genomics for mechanistic insight and precision treatments of schizophrenia ,NIH| PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS ,NIH| ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMA ,NHMRC| Feeding disturbance and hypothalamus integrity in early frontotemporal dementia ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,SFI| The Neurobiology of Voluntary Nicotine Abstinence: Genetics, Environment and Neurocognitive Endophenotypes ,NIH| Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and Depression ,NIH| Genetic Influences on Human Cortical Development ,NIH| Amish Connectome Project on Mental Illness ,NIH| The Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia Spectrum ,NWO| Twin-family database for behavior genetics and genomics studies ,NHMRC| Epistatic genetic effects on neuroanatomical subtypes of schizophrenia ,NHMRC| Frontotemporal dementia and motor neurodegenerative syndromes ,NIH| The VETSA Longitudinal MRI Twin Study of Aging ,NIH| Circuitry-Guided Smoking Cessation in Schizophrenia ,NWO| Networking through ADHD biology ,NIH| UC Davis Alzheimer's Core Center ,NIH| Genetic markers of white matter integrity in schizophrenia: Relationship to clini ,NIH| A global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA Consortium ,EC| PRISM ,NIH| DEVELOPMENTAL TWIN STUDY: ATTENTION, AGGRESSION, AFFECT ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| Developmental Genetic Epidemiology of Smoking ,EC| HBP SGA1 ,EC| HBP SGA2 ,EC| Eat2beNICE ,NHMRC| Genome-wide combined linkage-association scan of multiply phenotyped twin sibships ,NIH| Neurogenesis in Adult Brain: Gene Networks and Alzheimer?s Disease ,EC| TACTICS ,UKRI| Consortium on Vulnerability to Externalizing Disorders and Addictions [c-VEDA] ,NIH| Characterization of Normal Genomic Variability ,NWO| Cognitive, MRI and genetic markers of persistent versus remittent ADHD ,NIH| Rescuing the ruminating brain: Identifying biomarkers of rumination and mindfulness through concurrent EEG and fMRI studies of schizophrenia and depression ,UKRI| Neurobiological underpinning of eating disorders: integrative biopsychosocial longitudinal analyses in adolescents ,NIH| A Storage Area Network for Structural and Functional Image Analysis ,EC| JPco-fuND ,EC| CoCA ,NIH| HEALTHY AGING AND SENILE DEMENTIA ,NIH| CHS research resources for the cardiovascular health of older adults ,NHMRC| Personalised genomics in precision medicine of psychotic illness ,NIH| Shared Neural Circuitry in Comorbid Schizophrenia and Nicotine Addiction ,NIH| Perimenopause in Brain Aging and Alzheimer's Disease ,NIH| Progranulin: Mutation and Regulation in Neurodegenerative disease ,NHMRC| Genetic Repositories Australia ,NHMRC| Neurobiological ‘risk’ and ‘resilience’ biomarkers of severe mental illness ,NIH| A Longitudinal Twin Study of Cognition and Aging ,UKRI| Characterization of ubiquitin inclusions in FTD-MND and MND ,UKRI| Lifelong health and wellbeing of the Scotland in Miniature : the 6-day sample of the Scottish Mental Survey 1947 ,NHMRC| Biological Characterisation of the Opiod Receptor Sigma 1 Gene in the Frontotemporal Dementia and Motor Neuron Disease ,NIH| Kynurenic Acid and Cognitive Abnormalities in Schizophrenia ,NIH| Archiving the Vietnam Era Twin Studies of Aging (VETSA): New Uses for Old Data ,NIH| Integrating Neuroimaging, Multi-omics, and Clinical Data in Complex Disease ,NIH| BIO-INFORMATICS RESEARCH NETWORK COORDINATING CENTER (BIRN-CC) ,NHMRC| Investigation of dysfunction of SIGMAR1 in transgenic mouse models, a novel gene implicated in neurodegeneration ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,EC| MATRICS ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,NSF| MRI: Acquisition of PI2, a CAVE2-Inspired Display for Discovery Science, Creativity, and Education ,UKRI| JPND BRain Imaging, cognition, Dementia and next generation GEnomics ,NIH| CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NIH| ENIGMA World Aging Center ,NSF| GV: Small: Collaborative Research: Supporting Knowledge Discovery through a Scientific Visualization Language ,NIH| COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA ,EC| ADDICTION ,NIH| Growth factors, neuroinflammation, exercise, and brain integrity ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,UKRI| Mapping the genetic architecture of global gene and exon expression in the human brain to understand common diseases ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,NIH| Psychometric and Genetic Assessments of Substance Use ,UKRI| Genetic risk factors for neurodegenerative diseases and their role in the regulation of regional gene expression in the ,NIH| Towards Multisystem-Brain Successful Aging in Schizophrenia Spectrum ,NWO| Genetische en omgevingsinvloeden op psychopathologie en geluk tijdens de adolescentie ,NIH| Limited Competition:Continuation of the Center for Genomic Studies on Mental Disorders (U24) ,NIH| An Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel Disease ,NWO| How does the neural architecture of cognition map on its genetic architecture? ,NIH| The ARIC and Neurocognitive Longitudinal Study ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| Psychometric and Genetic Assessments of Substance Use ,NIH| Multi-group semi-blind ICA of fMRI ,NIH| Multi-Source Sparse Learning to Identify MCI and Predict Decline ,NWO| Netherlands Twin Registry Repository: researching the interplay between genome and environment ,NIH| Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NWO| BBMRI-NL ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NHMRC| Depressive and bipolar disorders: Pathophysiology, phenotypes and treatment innovations ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| Role of LRP &its ligand tPA in LTP &aging ,EC| EUROHEADPAIN ,WT| Optimisation of cognitive and behavioural control in Parkinson s disease and Frontotemporal degeneration. ,NIH| GGGGCC hexanucleotide repeat expansions in neurodegenerative disease ,NIH| Neurogenetic Pathways to Drug Use in Young Adults ,EC| STRATIFY ,NIH| High resolution mapping of the genetic risk for disease in the aging brain ,NIH| Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham Cohorts ,NIH| Self-Regulation Failure: Identifying and Modifying a Risk Phenotype ,NIH| Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis ,ANR| ADODEP ,NIH| Creating a Pediatric Imaging-Genomics Data Resource ,NWO| Twin-family study of individual differences in school achievement ,NWO| Did I do that? The experience of self-agency in health and schizophrenia. ,NIH| Determinants of Adolescent Exercise Behavior; towards Evidence-Based Intervention ,FWF| Hepatocellular Epithelial to Fibroblastoid Conversion ,NIH| Identification of novel Parkinsonian genes by wholegenome ,EC| ACTION ,NIH| Genetic influences on the brain: A twin imaging study ,CIHR ,NWO| NCHA Subsidiebesluit 2008-2012 ,EC| CoSTREAM ,NIH| Axon, Testosterone and Mental Health during Adolescence ,NIH| MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults ,NIH| Understanding the role of TDP-43 in Alzheimers disease and FTLD ,NIH| Institute for Clinical and Translational Science ,NIH| CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS ,NHMRC| Investigation of dysfunction of OPRS1, a novel gene implicated in neurodegeneration ,NIH| Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults ,NIH| pathQTL: Integrative Multi-Omics Causal Inference of Molecular Mechanisms Leading to Neuropsychiatric Illness ,NIH| Major Depression: Stage 1 Genomewide Association in Population-Based Samples ,NIH| SPATIOTEMPORAL FORWARD MODEL FOR DIFFUSE OPTICAL TOMOGRAPHY ,NIH| Neural Oscillatory Biomarkers for Genetics and Animal Models of Schizophrenia ,NIH| Translational Neuroscientist and the Hope Center ,NWO| Functional neural network plasticity in adolescent twins and sibs ,NIH| Mayo Alzheimers Disease Research Center ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| GENERAL CLINICAL RESEARCH CENTER ,NIH| Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience ,NHMRC| Characterisation and modelling of schizophrenia-associated dysregulation of miR-137 expression ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| Multidisciplinary Schizophrenia Research Training ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NWO| A Twin-sibling Study of Adolescent Wellness ,NIH| The VETSA Longitudinal Twin Study of Cortisol and Aging ,NIH| Alzheimers Disease Neuroimaging Initiative ,NIH| Kynurenic Acid and Cognitive Abnormalities in Schizophrenia ,NWO| tweeling onderzoek, met een focus op gedrag en depressie ,NIH| International Multi-Center ADHD Genetics Project ,UKRI| A genome-wide association study of non-pathological cognitive ageing ,SNSF| Comprehensive genetic analysis of a series of large families affected with bipolar disorderAuthors: Grasby, Katrina L; Jahanshad, Neda; Shatokhina, Natalia; Mirza-Schreiber, Nazanin; +331 AuthorsGrasby, Katrina L; Jahanshad, Neda; Shatokhina, Natalia; Mirza-Schreiber, Nazanin; Moreira, Jose C V; Mühleisen, Thomas W; Müller-Myhsok, Bertram; Najt, Pablo; Nakahara, Soichiro; Nho, Kwangsik; Olde Loohuis, Loes M; Orfanos, Dimitri Papadopoulos; Pearson, John F; Zsembik, Leo C P; Pitcher, Toni L; Pütz, Benno; Quidé, Yann; Ragothaman, Anjanibhargavi; Rashid, Faisal M; Reay, William R; Redlich, Ronny; Reinbold, Céline S; Repple, Jonathan; Richard, Geneviève; Thomopoulos, Sophia I; Riedel, Brandalyn C; Risacher, Shannon L; Rocha, Cristiane S; Mota, Nina Roth; Salminen, Lauren; Saremi, Arvin; Saykin, Andrew J; Schlag, Fenja; Schmaal, Lianne; Schofield, Peter R; Zhu, Alyssa H; Secolin, Rodrigo; Shapland, Chin Yang; Shen, Li; Shin, Jean; Shumskaya, Elena; Sønderby, Ida E; Sprooten, Emma; Tansey, Katherine E; Teumer, Alexander; Thalamuthu, Anbupalam; Strike, Lachlan T; Tordesillas-Gutiérrez, Diana; Turner, Jessica A; Uhlmann, Anne; Vallerga, Costanza Ludovica; van der Meer, Dennis; van Donkelaar, Marjolein M J; van Eijk, Liza; van Erp, Theo G M; van Haren, Neeltje E M; van Rooij, Daan; Agartz, Ingrid; van Tol, Marie-José; Veldink, Jan H; Verhoef, Ellen; Walton, Esther; Wang, Mingyuan; Wang, Yunpeng; Wardlaw, Joanna M; Wen, Wei; Westlye, Lars T; Whelan, Christopher D; Alhusaini, Saud; Witt, Stephanie H; Wittfeld, Katharina; Wolf, Christiane; Wolfers, Thomas; Wu, Jing Qin; Yasuda, Clarissa L; Zaremba, Dario; Zhang, Zuo; Zwiers, Marcel P; Artiges, Eric; Almeida, Marcio A A; Assareh, Amelia A; Ayesa-Arriola, Rosa; Belger, Aysenil; Brandt, Christine L; Brown, Gregory G; Cichon, Sven; Curran, Joanne E; Davies, Gareth E; Degenhardt, Franziska; Dennis, Michelle F; Alnæs, Dag; Dietsche, Bruno; Djurovic, Srdjan; Doherty, Colin P; Espiritu, Ryan; Garijo, Daniel; Gil, Yolanda; Gowland, Penny A; Green, Robert C; Häusler, Alexander N; Heindel, Walter; Amlien, Inge K; Ho, Beng-Choon; Hoffmann, Wolfgang U; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Jack, Clifford R; Jang, MiHyun; Jansen, Andreas; Kimbrel, Nathan A; Kolskår, Knut; Painter, Jodie N; Andersson, Micael; Koops, Sanne; Krug, Axel; Lim, Kelvin O; Luykx, Jurjen J; Mathalon, Daniel H; Mather, Karen A; Mattay, Venkata S; Matthews, Sarah; Mayoral Van Son, Jaqueline; McEwen, Sarah C; Ard, Tyler; Melle, Ingrid; Morris, Derek W; Mueller, Bryon A; Nauck, Matthias; Nordvik, Jan E; Nöthen, Markus M; O'Leary, Daniel S; Opel, Nils; Martinot, Marie-Laure Paillère; Pike, G Bruce; Armstrong, Nicola J; Preda, Adrian; Quinlan, Erin B; Rasser, Paul E; Ratnakar, Varun; Reppermund, Simone; Steen, Vidar M; Tooney, Paul A; Torres, Fábio R; Veltman, Dick J; Voyvodic, James T; Ashley-Koch, Allison; Whelan, Robert; White, Tonya; Yamamori, Hidenaga; Adams, Hieab H H; Bis, Joshua C; Debette, Stephanie; Decarli, Charles; Fornage, Myriam; Gudnason, Vilmundur; Hofer, Edith; Atkins, Joshua R; Ikram, M Arfan; Launer, Lenore; Longstreth, W. T.; Lopez, Oscar L; Mazoyer, Bernard; Mosley, Thomas H; Roshchupkin, Gennady V; Satizabal, Claudia L; Schmidt, Reinhold; Seshadri, Sudha; Bernard, Manon; Yang, Qiong; Initiative, Alzheimer’s Disease Neuroimaging; Consortium, CHARGE; Consortium, EPIGEN; Consortium, IMAGEN; Consortium, SYS; Initiative, Parkinson’s Progression Markers; Alvim, Marina K M; Ames, David; Anderson, Tim J; Brouwer, Rachel M; Andreassen, Ole A; Arias-Vasquez, Alejandro; Bastin, Mark E; Baune, Bernhard T; Beckham, Jean C; Blangero, John; Boomsma, Dorret I; Brodaty, Henry; Brunner, Han G; Buckner, Randy L; Buimer, Elizabeth E L; Buitelaar, Jan K; Bustillo, Juan R; Cahn, Wiepke; Cairns, Murray J; Calhoun, Vince; Carr, Vaughan J; Caseras, Xavier; Caspers, Svenja; Cavalleri, Gianpiero L; Cendes, Fernando; Corvin, Aiden; Crespo-Facorro, Benedicto; Dalrymple-Alford, John C; Dannlowski, Udo; de Geus, Eco J C; Depondt, Chantal; Desrivières, Sylvane; Donohoe, Gary; Espeseth, Thomas; Fisher, Simon E; Flor, Herta; Francks, Clyde; Franke, Barbara; Gollub, Randy L; Colodro-Conde, Lucía; Cannon, Dara M; Håberg, Asta K; Hartman, Catharina A; Heinz, Andreas; Henskens, Frans A; Hillegers, Manon H J; Hoekstra, Pieter J; Holmes, Avram J; Hulshoff Pol, Hilleke E; Jönsson, Erik G; Kennedy, Martin A; Kircher, Tilo T J; Kwok, John B J; Chen, Qiang; Le Hellard, Stephanie; Martin, Nicholas G; McMahon, Katie L; Meyer-Lindenberg, Andreas; Michie, Patricia T; Morey, Rajendra A; Mowry, Bryan; Cheung, Joshua W; Nyberg, Lars; Oosterlaan, Jaap; Ophoff, Roel A; Pantelis, Christos; Pausova, Zdenka; Penninx, Brenda W J H; Polderman, Tinca J C; Posthuma, Danielle; Rietschel, Marcella; Couvy-Duchesne, Baptiste; Roffman, Joshua L; Sachdev, Perminder S; Schall, Ulrich; Schumann, Gunter; Scott, Rodney J; Sim, Kang; Dale, Anders M; Sommer, Iris E; St Pourcain, Beate; Stein, Dan J; Toga, Arthur W; Trollor, Julian N; Van der Wee, Nic J A; van 't Ent, Dennis; Walter, Henrik; Weber, Bernd; Dalvie, Shareefa; Weinberger, Daniel R; Wright, Margaret J; Zhou, Juan; Stein, Jason L; Thompson, Paul M; Medland, Sarah E; Witte, A Veronica; de Araujo, Tânia K; de Zubicaray, Greig I; Bralten, Janita; Mishra, Aniket; Dohm, Katharina; Ehrlich, Stefan; Engelbrecht, Hannah-Ruth; Erk, Susanne; Fedko, Iryna O; van Duijn, Cornelia M; Foley, Sonya F; Ford, Judith M; Fukunaga, Masaki; Garrett, Melanie E; Ge, Tian; Nees, Frauke; Green, Melissa J; Groenewold, Nynke A; Grotegerd, Dominik; Gurholt, Tiril P; Gutman, Boris A; Lind, Penelope A; Hansell, Narelle K; Harris, Mathew A; Harrison, Marc B; Haswell, Courtney C; Hauser, Michael; Herms, Stefan; Ho, New Fei; Hoehn, David; Seppi, Klaus; Hoffmann, Per; Pizzagalli, Fabrizio; Holleran, Laurena; Hoogman, Martine; Hottenga, Jouke-Jan; Knol, Maria J; Ikeda, Masashi; Janowitz, Deborah; Jansen, Iris E; Vernooij, Meike W; Jia, Tianye; Luciano, Michelle; Jockwitz, Christiane; Ghanbari, Mohsen; Kanai, Ryota; Karama, Sherif; Kaufmann, Tobias; Kikuchi, Masataka; Klein, Marieke; Knodt, Annchen R; Krämer, Bernd; Kremen, Sarah; Lancaster, Thomas M; McMahon, Mary Agnes B; Lee, Phil H; Lewis, Lindsay B; Lopes-Cendes, Iscia; Banaschewski, Tobias; Macciardi, Fabio; Saba, Yasaman; Marquand, Andre F; Melzer, Tracy R;pmc: PMC7295264
handle: 11370/b56e82d8-e68c-43de-888f-59b0b085874b , 21.11116/0000-0005-E8FE-8 , 21.11116/0000-0005-F5A0-1 , 21.11116/0000-0005-E90D-7 , 2066/218611 , 1887/3184500 , 10261/235393 , 11250/3033616 , 21.11116/0000-000D-7752-1 , 2128/25415 , 1871.1/24e85212-901f-4109-a8bc-9246e70bb73d , 11250/2760637 , 2318/1766232 , 20.500.11820/2ad2fee5-a1cb-432b-81a0-283158c2db79
pmc: PMC7295264
handle: 11370/b56e82d8-e68c-43de-888f-59b0b085874b , 21.11116/0000-0005-E8FE-8 , 21.11116/0000-0005-F5A0-1 , 21.11116/0000-0005-E90D-7 , 2066/218611 , 1887/3184500 , 10261/235393 , 11250/3033616 , 21.11116/0000-000D-7752-1 , 2128/25415 , 1871.1/24e85212-901f-4109-a8bc-9246e70bb73d , 11250/2760637 , 2318/1766232 , 20.500.11820/2ad2fee5-a1cb-432b-81a0-283158c2db79
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder. Contains fulltext : 218611.pdf (Publisher’s version ) (Open Access)
NARCIS; Science arrow_drop_down NARCIS; Archivio Istituzionale; ScienceOther literature type . Article . 2020 . Peer-reviewedbioRxivPreprint . 2018University of Bath's research portalArticle . 2020Data sources: University of Bath's research portalBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2020 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2020LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2020NARCIS; ScienceArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 485 citations 485 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 22visibility views 22 download downloads 82 Powered bymore_vert NARCIS; Science arrow_drop_down NARCIS; Archivio Istituzionale; ScienceOther literature type . Article . 2020 . Peer-reviewedbioRxivPreprint . 2018University of Bath's research portalArticle . 2020Data sources: University of Bath's research portalBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2020 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2020LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2020NARCIS; ScienceArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 IrelandPublisher:Public Library of Science (PLoS) Publicly fundedFunded by:NIH | Impact of Clot Histologic..., SFI | CÚRAM - Centre for Resear...NIH| Impact of Clot Histological and Physical Properties on Revascularization Strategies in Acute Ischaemic Stroke ,SFI| CÚRAM - Centre for Research in Medical DevicesSeán Fitzgerald; Shunli Wang; Daying Dai; Dennis H. Murphree; Abhay Pandit; Andrew Douglas; Asim Rizvi; Ramanathan Kadirvel; Michael Gilvarry; Ray McCarthy; Manuel Stritt; Matthew J. Gounis; Waleed Brinjikji; David F. Kallmes; Karen M. Doyle;Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical thrombectomy procedures. Following H&E staining, quantification of clot components was performed by two different methods: a pathologist using a reference standard method (Adobe Photoshop CC) and an experienced researcher using Orbit Image Analysis. Following quantification, the clots were categorized into 3 types: RBC dominant (≥60% RBCs), Mixed and Fibrin dominant (≥60% Fibrin). Correlations between clot composition and Hounsfield Units density on Computed Tomography (CT) were assessed. There was a significant correlation between the components of clots as quantified by the Orbit Image Analysis algorithm and the reference standard approach (ρ = 0.944**, p < 0.001, n = 150). A significant relationship was found between clot composition (RBC-Rich, Mixed, Fibrin-Rich) and the presence of a Hyperdense artery sign using the algorithmic method (X2(2) = 6.712, p = 0.035*) but not using the reference standard method (X2(2) = 3.924, p = 0.141). Orbit Image Analysis machine learning software can be used for the histological quantification of AIS clots, reproducibly generating composition analyses similar to current reference standard methods. This work was supported by the National Institutes of Health (R01 NS105853), the European Regional Development Fund and Science Foundation Ireland under Ireland’s European Structural and Investment Fund (Grant Number 13/RC/2073) and Industrial partners Cerenovus. peer-reviewed
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6894878Data sources: PubMed CentralAccess to Research at National University of Ireland, GalwayArticle . 2019 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 53 citations 53 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6894878Data sources: PubMed CentralAccess to Research at National University of Ireland, GalwayArticle . 2019 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 United States, United Kingdom, IrelandPublisher:American Psychiatric Association Publishing Publicly fundedFunded by:NIH | ENIGMA Center for Worldwi..., EC | iRELaTE, SFI | SFI ERC Support Programme...NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,EC| iRELaTE ,SFI| SFI ERC Support Programme- Gary Donohoe, NUI GalwayLaurena Holleran; Sinead Kelly; Clara Alloza; Ingrid Agartz; Ole A. Andreassen; Celso Arango; Nerisa Banaj; Vince D. Calhoun; Dara M. Cannon; Vaughan J. Carr; Aiden Corvin; David C. Glahn; Ruben C. Gur; Elliot Hong; Cyril Höschl; Fleur M. Howells; Anthony A. James; Joost Janssen; Peter Kochunov; Stephen M. Lawrie; Jingyu Liu; Covadonga Martinez; Colm McDonald; Derek W. Morris; David Mothersill; Christos Pantelis; Fabrizio Piras; Steven G. Potkin; Paul E. Rasser; David R. Roalf; Laura Rowland; Theodore D. Satterthwaite; Ulrich Schall; Gianfranco Spalletta; Filip Spaniel; Dan J. Stein; Anne Uhlmann; Aristotle N. Voineskos; Andrew Zalesky; Theo G.M. van Erp; Jessica A. Turner; Ian J. Deary; Paul M. Thompson; Neda Jahanshad; Gary Donohoe;pmc: PMC7938666
pmid: 32212855
OBJECTIVESchizophrenia has recently been associated with widespread white matter microstructural abnormalities, but the functional effects of these abnormalities remain unclear. Widespread heterogeneity of results from studies published to date preclude any definitive characterization of the relationship between white matter and cognitive performance in schizophrenia. Given the relevance of deficits in cognitive function to predicting social and functional outcomes in schizophrenia, the authors carried out a meta-analysis of available data through the ENIGMA Consortium, using a common analysis pipeline, to elucidate the relationship between white matter microstructure and a measure of general cognitive performance, IQ, in patients with schizophrenia and healthy participants.METHODSThe meta-analysis included 760 patients with schizophrenia and 957 healthy participants from 11 participating ENIGMA Consortium sites. For each site, principal component analysis was used to calculate both a global fractional anisotropy component (gFA) and a fractional anisotropy component for six long association tracts (LA-gFA) previously associated with cognition.RESULTSMeta-analyses of regression results indicated that gFA accounted for a significant amount of variation in cognition in the full sample (effect size [Hedges' g]=0.27, CI=0.17-0.36), with similar effects sizes observed for both the patient (effect size=0.20, CI=0.05-0.35) and healthy participant groups (effect size=0.32, CI=0.18-0.45). Comparable patterns of association were also observed between LA-gFA and cognition for the full sample (effect size=0.28, CI=0.18-0.37), the patient group (effect size=0.23, CI=0.09-0.38), and the healthy participant group (effect size=0.31, CI=0.18-0.44).CONCLUSIONSThis study provides robust evidence that cognitive ability is associated with global structural connectivity, with higher fractional anisotropy associated with higher IQ. This association was independent of diagnosis; while schizophrenia patients tended to have lower fractional anisotropy and lower IQ than healthy participants, the comparable size of effect in each group suggested a more general, rather than disease-specific, pattern of association.
American Journal of ... arrow_drop_down eScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 47 citations 47 popularity Top 1% influence Average impulse Top 1% Powered by BIP!more_vert American Journal of ... arrow_drop_down eScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2017 Germany, United Kingdom, United Kingdom, Netherlands, United States, France, United Kingdom, United Kingdom, Spain, Switzerland, AustraliaPublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:NHMRC | Quantifying the neurocogn..., NIH | Longitudinal brain develo..., NHMRC | Unravelling genetic influ... +49 projectsNHMRC| Quantifying the neurocognitive impact of cannabis across the life span: The evolution of memory deficits. ,NIH| Longitudinal brain development and clinical outcomes in ADHD from 7-17 years ,NHMRC| Unravelling genetic influences on the human brain ,NHMRC| The Older Australian Twins Study (OATS) of healthy brain ageing and age-related neurocognitive disorders ,NIH| Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASD ,NIH| INHIBITORY CONTROL AND MA SELF-ADMINISTRATION: MODAFINIL EFFECTS ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,NIH| Multi-group semi-blind ICA of fMRI ,EC| MiND ,NIH| Functional Connectivity in Schizophrenia ,NIH| Brain trajectories in ADHD ,EC| IMAGEMEND ,NIH| Mining the Genomewide Scan: Genetic Profiles of Structural Loss in Schizophrenia ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,EC| AGGRESSOTYPE ,NIH| FUNCTION BIRN ,UKRI| Anatomical connectivity in early onset schizophrenia ,NIH| Multivariate methods for identifying multitask/multimodal brain imaging biomarkers ,NIH| Genetic markers of white matter integrity in schizophrenia: Relationship to clini ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NIH| Neural Systems, Inhibitory Control, and Methamphetamine Dependence ,NIH| A clinical trial of DOT for HAART in jailed drug users ,NHMRC| Australian Twin Registry ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,NIH| International Multi-Center ADHD Genetics Project ,NIH| Oregon Clinical and Translational Research Institute ,NIH| Informed Data-Driven Fusion of Behavior, Brain Function, and Genes ,NWO| Networking through ADHD biology ,NWO| How does the neural architecture of cognition map on its genetic architecture? ,ARC| Examining the relationship between error processing, cognitive control and emotion: a cognitive neuroscience approach ,NHMRC| Enhancing and integrating addiction neuroscience knowledge with clinical practice, by transforming the approach to assessment and classification protocols, and improving outcomes by using neurocognitive phenotypes for tailored treatments ,NHMRC| Genetics of brain structure and function ,NIH| ADHD biotypes using genetic and imaging approaches ,NWO| Language in Interaction ,EC| TACTICS ,NHMRC| Cognitive control dysfunction in drug dependence ,NIH| Early Methamphetamine Abstinence: fMRI and Cognition ,NIH| SPATIOTEMPORAL FORWARD MODEL FOR DIFFUSE OPTICAL TOMOGRAPHY ,NIH| GENERAL CLINICAL RESEARCH CENTER ,NIH| Cortical Basic of Schizophrenia Sensory Gaiting Deficit ,NIH| Functional Circuits as an Endophenotype for ADHD in Children ,NSF| IGERT: Emergent Functions of Neural Systems ,NHMRC| Trajectories in brain structure and function for children with and without ADHD: Associations with academic, cognitive, social, and mental health outcomes ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NSF| Graduate Research Fellowship Program ,NIH| SCOR Application on Sex, Stress, and Cocaine Addiction ,NIH| INFORMATION PROCESSING BIASES IN DEPRESSION ,NIH| A Cross-Sectional and Longitudinal Functional MRI Study of Adolescent Depression ,SFI| The application of MRI to identify endophenotypes in focal epilepsy ,CIHR ,NIH| BIOSTATISTICS &NEUROINFORMATICS (STATNI) CORE ,NIH| Genetic influences on the brain: A twin imaging studyKong, Xiang-Zhen; Mathias, Samuel R; Francks, Clyde; Grabe, Hans; Groenewold, Nynke A; Grotegerd, Dominik; Gruber, Oliver; Gurholt, Tiril; Haavik, Jan; Hahn, Tim; Hansell, Narelle K; Harris, Mathew A; Hartman, Catharina A; Kong, Xiang-Zhen; Hernández, Maria Del Carmen Valdés; Heslenfeld, Dirk; Hester, Robert; Hibar, Derrek Paul; Ho, Beng-Choon; Ho, Tiffany C; Hoekstra, Pieter J; van Holst, Ruth J; Hoogman, Martine; Høvik, Marie F; Mathias, Samuel R; Howells, Fleur M; Hugdahl, Kenneth; Huyser, Chaim; Ingvar, Martin; Irwin, Lourdes; Ishikawa, Akari; James, Anthony; Jahanshad, Neda; Jernigan, Terry L; Jönsson, Erik G; Guadalupe, Tulio; Kähler, Claas; Kaleda, Vasily; Kelly, Clare; Kerich, Michael; Keshavan, Matcheri S; Khadka, Sabin; Kircher, Tilo; Kohls, Gregor; Konrad, Kerstin; Korucuoglu, Ozlem; Abé, Christoph; Krämer, Bernd; Krug, Axel; Kwon, Jun Soo; Lambregts-Rommelse, Nanda; Landén, Mikael; Lázaro, Luisa; Lebedeva, Irina; Lenroot, Rhoshel; Lesch, Klaus-Peter; Li, Qinqin; Agartz, Ingrid; Lim, Kelvin O; Liu, Jia; Lochner, Christine; London, Edythe D; Lonning, Vera; Lorenzetti, Valentina; Luciano, Michelle; Luijten, Maartje; Lundervold, Astri J; Mackey, Scott; Akudjedu, Theophilus N; MacMaster, Frank P; Maingault, Sophie; Malpas, Charles B; Malt, Ulrik F; Mataix-Cols, David; Martin-Santos, Rocio; Mayer, Andrew R; McCarthy, Hazel; Mitchell, Philip B; Mueller, Bryon A; Aleman, Andre; Maniega, Susana Muñoz; Mazoyer, Bernard; McDonald, Colm; McLellan, Quinn; McMahon, Katie L; McPhilemy, Genevieve; Momenan, Reza; Morales, Angelica M; Narayanaswamy, Janardhanan C; Moreira, José Carlos Vasques; Alhusaini, Saud; Nerland, Stener; Nestor, Liam; Newman, Erik; Nigg, Joel T; Nordvik, Jan Egil; Novotny, Stephanie; Weiss, Eileen Oberwelland; O'Gorman, Ruth L; Oosterlaan, Jaap; Oranje, Bob; Allen, Nicholas B; Orr, Catherine; Overs, Bronwyn; Pauli, Paul; Paulus, Martin; Plessen, Kerstin Jessica; von Polier, Georg G; Pomarol-Clotet, Edith; Portella, Maria J; Qiu, Jiang; Radua, Joaquim; Guadalupe, Tulio; Ames, David; Ramos-Quiroga, Josep Antoni; Reddy, Y C Janardhan; Reif, Andreas; Roberts, Gloria; Rosa, Pedro; Rubia, Katya; Sacchet, Matthew D; Sachdev, Perminder S; Salvador, Raymond; Schmaal, Lianne; Andreassen, Ole A; Schulte-Rüther, Martin; Schweren, Lizanne; Seidman, Larry; Seitz, Jochen; Serpa, Mauricio Henriques; Shaw, Philip; Shumskaya, Elena; Silk, Timothy J; Simmons, Alan N; Simulionyte, Egle; Vasquez, Alejandro Arias; Sinha, Rajita; Sjoerds, Zsuzsika; Smelror, Runar Elle; Soliva, Joan Carlos; Solowij, Nadia; Souza-Duran, Fabio Luisde; Sponheim, Scott R; Stein, Dan J; Stein, Elliot A; Stevens, Michael; Armstrong, Nicola J; Strike, Lachlan T; Sudre, Gustavo; Sui, Jing; Tamm, Leanne; Temmingh, Hendrik S; Thoma, Robert J; Tomyshev, Alexander; Tronchin, Giulia; Turner, Jessica; Uhlmann, Anne; Bergo, Felipe; van Erp, Theo G M; van den Heuvel, Odile A; van der Meer, Dennis; van Eijk, Liza; Vance, Alasdair; Veer, Ilya M; Veltman, Dick J; Venkatasubramanian, Ganesan; Vilarroya, Oscar; Vives-Gilabert, Yolanda; Bastin, Mark E; Voineskos, Aristotle N; Völzke, Henry; Vuletic, Daniella; Walitza, Susanne; Walter, Henrik; Walton, Esther; Wardlaw, Joanna M; Wen, Wei; Westlye, Lars T; Whelan, Christopher D; Batalla, Albert; White, Tonya; Wiers, Reinout W; Wright, Margaret J; Wittfeld, Katharina; Yang, Tony T; Yasuda, Clarissa L; Yoncheva, Yuliya; Yücel, Murat; Yun, Je-Yeon; Zanetti, Marcus Vinicius; Bauer, Jochen; Zhen, Zonglei; Zhu, Xing-Xing; Ziegler, Georg C; Zierhut, Kathrin; de Zubicaray, Greig I; Zwiers, Marcel; Glahn, David C; Franke, Barbara; Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Fisher, Simon E; Fatouros-Bergman, Helena; Bose, Anushree; Brooks, Samantha J; Calhoun, Vince; Canales-Rodríguez, Erick Jorge; Cannon, Dara M; Cavalleri, Gianpiero L; Cendes, Fernando; Christakou, Anastasia; Connolly, Colm G; Cousijn, Janna; Cubillo, Ana; Deary, Ian J; Demeter, Damion V; Dickie, Erin W; Doherty, Colin P; Earl, Eric; Ehrlich, Stefan; Ekman, Carl Johan; Förster, Katharina; Fuentes-Claramonte, Paola; Fullerton, Janice;handle: 2066/191921 , 20.500.11820/7fb463bc-b796-46f5-8a23-6c44e9518b1c , https://repository.ubn.ru.nl/handle/2066/191921 , 21.11116/0000-0003-BC00-9 , 21.11116/0000-0001-4B8C-E , 21.11116/0000-0001-4B86-4 , 1871.1/5dd1afee-c756-40e5-ab51-8659295095c3 , 1983/8a0226fd-3f3e-4031-8fbe-6856b0131ac2 , 1874/372468 , 2445/131251 , 21.11116/0000-0004-ACB6-D , 21.11116/0000-000D-1715-2 , 1765/128353 , 11245.1/0c2822db-db0c-422a-953c-e89c814fcda8
pmc: PMC5984496
pmid: 29764998
handle: 2066/191921 , 20.500.11820/7fb463bc-b796-46f5-8a23-6c44e9518b1c , https://repository.ubn.ru.nl/handle/2066/191921 , 21.11116/0000-0003-BC00-9 , 21.11116/0000-0001-4B8C-E , 21.11116/0000-0001-4B86-4 , 1871.1/5dd1afee-c756-40e5-ab51-8659295095c3 , 1983/8a0226fd-3f3e-4031-8fbe-6856b0131ac2 , 1874/372468 , 2445/131251 , 21.11116/0000-0004-ACB6-D , 21.11116/0000-000D-1715-2 , 1765/128353 , 11245.1/0c2822db-db0c-422a-953c-e89c814fcda8
pmc: PMC5984496
pmid: 29764998
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders. Contains fulltext : 191921pub.pdf (Publisher’s version ) (Open Access) 10 p.
CORE (RIOXX-UK Aggre... arrow_drop_down bioRxivPreprint . 2017NARCIS; Radboud RepositoryArticle . 2018Recolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAMETIS Research Information System; Proceedings of the National Academy of SciencesOther literature type . Article . 2018 . Peer-reviewedeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveNARCIS; Proceedings of the National Academy of SciencesArticle . 2018Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationshttps://doi.org/https://doi.or...Other literature typeData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 286 citations 286 popularity Top 0.1% influence Top 10% impulse Top 1% Powered by BIP!visibility 72visibility views 72 download downloads 162 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down bioRxivPreprint . 2017NARCIS; Radboud RepositoryArticle . 2018Recolector de Ciencia Abierta, RECOLECTAArticle . 2018Data sources: Recolector de Ciencia Abierta, RECOLECTAMETIS Research Information System; Proceedings of the National Academy of SciencesOther literature type . Article . 2018 . Peer-reviewedeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveNARCIS; Proceedings of the National Academy of SciencesArticle . 2018Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationshttps://doi.org/https://doi.or...Other literature typeData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Italy, United States, United Kingdom, Italy, Italy, Italy, NetherlandsPublisher:Wiley Publicly fundedFunded by:NIH | Probing the Role of Polyc..., EC | EPITARGET, EC | EPISTOP +2 projectsNIH| Probing the Role of Polycomb in the Epigenetics of Epilepsy ,EC| EPITARGET ,EC| EPISTOP ,SFI| MicroRNA biofluid profiles as molecular diagnostics for epilepsy ,NIH| Inflammatory control of blood-brain barrier integrity and epileptogenesis after seizuresEleonora Aronica; Sebastian Bauer; Yuri Bozzi; Matteo Caleo; Raymond Dingledine; Jan A. Gorter; David C. Henshall; Daniela Kaufer; Sookyong Koh; Wolfgang Löscher; Jean-Pierre Louboutin; Michele Mishto; Braxton A. Norwood; Eleonora Palma; Michael O. Poulter; Gaetano Terrone; Annamaria Vezzani; Rafal M. Kaminski;SummaryA large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory molecules and pathways have been identified that influence various pathologic outcomes in different experimental models of epilepsy. Most importantly, the same inflammatory pathways have also been found in surgically resected brain tissue from patients with treatment‐resistant epilepsy. New antiseizure therapies may be derived from these novel potential targets. An essential and crucial question is whether targeting these molecules and pathways may result in anti‐ictogenesis, antiepileptogenesis, and/or disease‐modification effects. Therefore, preclinical testing in models mimicking relevant aspects of epileptogenesis is needed to guide integrated experimental and clinical trial designs. We discuss the most recent preclinical proof‐of‐concept studies validating a number of therapeutic approaches against inflammatory mechanisms in animal models that could represent novel avenues for drug development in epilepsy. Finally, we suggest future directions to accelerate preclinical to clinical translation of these recent discoveries.
IRIS - Institutional... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2017Data sources: Archivio della ricerca- Università di Roma La SapienzaeScholarship - University of CaliforniaArticle . 2017Data sources: eScholarship - University of CaliforniaEpilepsiaArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 137 citations 137 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!download 14download downloads 14 Powered bymore_vert IRIS - Institutional... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2017Data sources: Archivio della ricerca- Università di Roma La SapienzaeScholarship - University of CaliforniaArticle . 2017Data sources: eScholarship - University of CaliforniaEpilepsiaArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Germany, Ireland, United Kingdom, Netherlands, Italy, Spain, United Kingdom, France, France, France, United Kingdom, France, France, France, United Kingdom, United Kingdom, France, IrelandPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | NEUROSCHEMA, NIH | The ARIC and Neurocogniti..., NIH | Functional genomics of bi... +110 projectsEC| NEUROSCHEMA ,NIH| The ARIC and Neurocognitive Longitudinal Study ,NIH| Functional genomics of bipolar disorder ,NIH| OBESITY, DIABETES &AGING ANIMAL RESOURCE ,NIH| Genotypic Determinants of Aspirin Response in High-Risk ,NHMRC| Cerebrovascular diseases and Brain Ageing – a program of research into novel mechanisms, risk prevention and innovative health care delivery ,NHMRC| The Older Australian Twins Study (OATS) of healthy brain ageing and age-related neurocognitive disorders ,NIH| National Cell Repository for Alzheimer's Disease (NCRAD) ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,NIH| UCLA Clinical and Translational Science Institute ,NIH| HARDI Mapping of Disease Effects on the Brain ,NIH| Predicting Brain Changes in HIV/AIDS ,NSF| MRI: Acquisition of a Data Analytics Cluster for Computational Social Science ,NIH| CHS-Transition Phase -268055222 ,NIH| Searching for Endophenotypes of Bipolar Disorder ,NIH| Alzheimer's Disease Genetics Consortium ,EC| ORACLE ,NWO| Twin-family database for behavior genetics and genomics studies ,NWO| Networking through ADHD biology ,NIH| Alzheimer's Disease Genetics Consortium ,NIH| Empowering Personalized Medicine: Integrating Imaging, Genetics, and Biomarkers ,FWF| Mechanisms of Small Vessel Related Brain Damage and Cognitive Impairment ,WT| Genome-wide association studies in partial epilepsies. ,EC| MiND ,EC| TACTICS ,WT| Stratifying Resilience and Depression Longitudinally (STRADL) ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| Genetic Epidemiology of Cognitive Decline in an Aging Population Sample ,NIH| An Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel Disease ,NIH| Occult Small Vessel Cerebrovascular Disease in High Risk Families ,NHMRC| Type 2 Diabetes Mellitus and Cognitive Decline - a longitudinal study of effects and mechanisms ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,EC| EU-AIMS ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,EC| MATRICS ,NIH| CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NHMRC| Prevention, early detection and effective management of neurocognitive disorders in the elderly ,NIH| GCRC-RENOVATION ,NIH| Epidemiologic Study of Neural Reserve and Neurobiology of Aging ,NIH| International Multi-Center ADHD Genetics Project ,NHMRC| A population-based study of cerebrovascular mechanisms underyling gait, balance and cognition in older people ,NIH| Exceptional aging: 12 year trajectories to function ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NHMRC| Advancing our understanding of the genetics of Psychiatric and Neurological Disease ,EC| PHASE ,NIH| Hormonal trajectories in aging ,NIH| Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and Depression ,NIH| Major Depression: Stage 1 Genomewide Association in Population-Based Samples ,NIH| Role of Mitochondrial Health in Acute and Chronic Kidney Disease in Older Adults ,CIHR ,NHMRC| Genetics of brain structure and function ,NIH| Epidemiology of Biomarkers of Risk and Progression in LOAD ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| Laboratory of Neuro Imaging Resource (LONIR) ,NHMRC| Australian Twin Registry ,NWO| NCHA Subsidiebesluit 2008-2012 ,ARC| The articulate brain ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| Genomic Studies of Bipolar Disorder in a Large Cohort from The Netherlands ,NWO| Neuro-imaging study in twins concordant or discordant for obsessive-compulsive symptoms. ,NIH| ALZHEIMERS DISEASE DATA COORDINATING CENTER ,NHMRC| Genetics of melanoma risk factors ,NIH| Structural Brain Abnormalities In Depression ,NIH| COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA ,NIH| CYCLINS AND CHEMICAL CARCINOGENESIS ,EC| IMAGEMEND ,NIH| Alzheimer's disease risk analyzed using population imaging genomics ,NHMRC| Prevention and management of mental disorders in older Australians ,NIH| Functional Neuroimaging In Unipolar And Bipolar Depresse ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,NIH| MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATION ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness ,NHMRC| Development and Evaluation of Statistical Methods and Software for Analysis of Complex Genetic Disease Data ,NIH| CHS research resources for the cardiovascular health of older adults ,WT| A Powerful, Genome-Wide Association Scan for Susceptibility Genes for late-onset Alzheimer's disease ,NHMRC| Genetic Repositories Australia ,NIH| Genetic Influences on Human Cortical Development ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,NIH| SHORT-TERM STABILITY OF CLINICAL TESTS ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,ARC| Elucidating the genetics of attention deficit hyperactivity disorder by integrating pathway and prediction analyses ,SFI| The application of MRI to identify endophenotypes in focal epilepsy ,NWO| Functional neural network plasticity in adolescent twins and sibs ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| Vascular Cognitive and Motor Decline: Impact of aPL ,NIH| Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience ,EC| ENGAGE ,NIH| Genetic influences on the brain: A twin imaging study ,NIH| Rare variants and NHLBI traits in deeply phenotyped cohorts ,NIH| Genomics of Developmental Trajectories in Twins ,NIH| Neuroimaging genetics to study social cognitive deficits in ASD and schizophrenia ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NIH| Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes ,EC| AGGRESSOTYPE ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION ,NIH| Genetic Influences on Human Neuroanatomical Shapes ,NIH| Neurodevelopment and Imaging among HIV-infected Children from the PREDICT study ,NIH| RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITY ,NIH| Alzheimers Disease in Mild Cognitive Impairment ,EC| GMI ,NIH| Alzheimers Disease Neuroimaging Initiative ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NIH| CORONARY HEART DISEASE AND STROKEHieab H.H. Adams; Vincent Chouraki; Jason L. Stein; Miguel E. Rentería; Stella Trompet; Alejandro Arias-Vasquez; Sudha Seshadri; Sylvane Desrivières; Sven J. van der Lee; Najaf Amin; Micael Andersson; Konstantinos Arfanakis; Benjamin S. Aribisala; Nicola J. Armstrong; Alexa S. Beiser; Manon Bernard; Susan H. Blanton; Marco P. Boks; Janita Bralten; Owen Carmichael; Ganesh Chauhan; Qiang Chen; Gabriel Cuellar-Partida; Anouk den Braber; Stefan Ehrlich; Irina Filippi; Tian Ge; Rebecca F. Gottesman; Corina U. Greven; Tulio Guadalupe; Unn K. Haukvik; Saima Hilal; D. Hoehn; Tianye Jia; Marieke Klein; Phil H. Lee; David C. Liewald; Lorna M. Lopez; Michelle Luciano; Christine Macare; Andre F. Marquand; Karen A. Mather; Manuel Mattheisen; Bernard Mazoyer; Rebekah McWhirter; Yuri Milaneschi; Nazanin Mirza-Schreiber; Ryan L. Muetzel; Susana Muñoz Maniega; Kwangsik Nho; Loes M. Olde Loohuis; Jaap Oosterlaan; Irene Pappa; Lukas Pirpamer; Sara Pudas; Adaikalavan Ramasamy; Jennifer S. Richards; Shannon L. Risacher; Roberto Roiz-Santiañez; Nanda Rommelse; Emma J. Rose; Claudia L. Satizabal; Lianne Schmaal; Li Shen; Jean Shin; Albert V. Smith; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Russell Thomson; Diana Tordesillas-Gutiérrez; Roberto Toro; Daniah Trabzuni; Dhananjay Vaidya; Jeroen van der Grond; Dennis van der Meer; Marjolein M. J. Van Donkelaar; Kristel R. van Eijk; Theo G.M. van Erp; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G Windham; Anderson M. Winkler; Girma Woldehawariat; Christiane Wolf; Thomas Wolfers; Bing Xu; Ingrid Agartz; David Ames; Philippe Amouyel; Ole A. Andreassen; Sampath Arepalli; Mark E. Bastin; Diane M. Becker; James T. Becker; John Blangero; Hans van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Randy L. Buckner; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Christopher Chen; Ching-Yu Cheng; Sven Cichon; Mark R. Cookson; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Gareth E. Davies; Eco J. C. de Geus; Greig I. Zubicaray; Anita L. DeStefano; Srdjan Djurovic; Gary Donohoe; Wayne C. Drevets; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Denis A. Evans; Iryna O. Fedko; Simon E. Fisher; Debra A. Fleischman; Clyde Francks; Masaki Fukunaga; J. Raphael Gibbs; Randy L. Gollub; Harald H H Göring; Hans J. Grabe; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Narelle K. Hansell; John Hardy; Ryota Hashimoto; Andreas Heinz; Stephanie Le Hellard; Dirk J. Heslenfeld; Beng-Choon Ho; Wolfgang Hoffmann; Albert Hofman; Florian Holsboer; Georg Homuth; Hilleke E. Hulshoff Pol; M. Kamran Ikram; Clifford R. Jack; Mark Jenkinson; Robert Johnson; Erik G. Jönsson; J. Wouter Jukema; David S. Knopman; Peter Kochunov; Stephen M. Lawrie; Herve Lemaitre; Dan L. Longo; W.T. Longstreth; Oscar L. Lopez; Simon Lovestone; Jean-Luc Martinot; Colm McDonald; Andrew M. McIntosh; Katie L. McMahon; Francis J. McMahon; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Sebastian Mohnke; Derek W. Morris; Thomas H. Mosley; Thomas W. Mühleisen; Thomas E. Nichols; Wiro J. Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Roel A. Ophoff; Massimo Pandolfo; G. Bruce Pike; Bruce M. Psaty; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Peter R. Schofield; Andrew Singleton; Hilkka Soininen; Velandai Srikanth; Jessika E. Sussmann; Anbupalam Thalamuthu; Henning Tiemeier; Arthur W. Toga; Bryan J. Traynor; Juan C. Troncoso; Jessica A. Turner; Christophe Tzourio; André G. Uitterlinden; Aad van der Lugt; Nic J A van der Wee; Cornelia M. van Duijn; Dennis van 't Ent; Marie-José van Tol; Badri N. Vardarajan; Dick J. Veltman; Meike W. Vernooij; Henry Völzke; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Daniel R. Weinberger; Wei Wen; Eric Westman; Tonya White; Tien Yin Wong; H. Ronald Zielke; Alan B. Zonderman; Ian J. Deary; Nicholas G. Martin; Anton J. M. de Craen; Margaret J. Wright; Lenore J. Launer; Gunter Schumann; Barbara Franke; Stéphanie Debette; Sarah E. Medland; Paul M. Thompson;pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (rhogenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits. Contains fulltext : 165723pub.pdf (Publisher’s version ) (Closed access)
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2016Full-Text: http://livrepository.liverpool.ac.uk/3004351/1/ICV-GWAS-NN-acceptedAug31-2016embargoed.pdfData sources: CORE (RIOXX-UK Aggregator)Maynooth University ePrints & eTheses ArchiveArticle . 2016 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016 . Peer-reviewedLicense: Springer TDMFull-Text: http://www.nature.com/articles/nn.4398.pdfNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 198 citations 198 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 141visibility views 141 download downloads 458 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2016Full-Text: http://livrepository.liverpool.ac.uk/3004351/1/ICV-GWAS-NN-acceptedAug31-2016embargoed.pdfData sources: CORE (RIOXX-UK Aggregator)Maynooth University ePrints & eTheses ArchiveArticle . 2016 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016 . Peer-reviewedLicense: Springer TDMFull-Text: http://www.nature.com/articles/nn.4398.pdfNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2018 Netherlands, Norway, United Kingdom, Norway, United Kingdom, United Kingdom, Spain, France, France, Italy, Germany, GermanyPublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:NIH | National Cell Repository ..., NIH | UCLA Clinical and Transla..., NIH | CHS-Transition Phase -268... +192 projectsNIH| National Cell Repository for Alzheimer's Disease (NCRAD) ,NIH| UCLA Clinical and Translational Science Institute ,NIH| CHS-Transition Phase -268055222 ,NHMRC| Blood protein biomarkers for frontotemporal lobar degeneration ,NIH| Functional Connectivity in Schizophrenia ,NIH| CYCLINS AND CHEMICAL CARCINOGENESIS ,EC| IMAGEMEND ,EC| EU-AIMS ,NIH| Multivariate methods for identifying multitask/multimodal brain imaging biomarkers ,NHMRC| Australian Schizophrenia Research Bank (ASRB) ,NIH| Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness ,WT| Genome-wide association studies in partial epilepsies. ,EC| MiND ,NIH| DATA MANAGEMENT AND BIOSTATISTICS ,NIH| FUNCTION BIRN ,NHMRC| Improving diagnosis of early frontotemporal dementia syndromes ,NIH| SILICON GRAPHICS PRISM EXTREME 128P/1TB ,NIH| Informed Data-Driven Fusion of Behavior, Brain Function, and Genes ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,NIH| Laboratory of Neuro Imaging Resource (LONIR) ,EC| SEGWAY ,NWO| Individual development: Why some children thrive, and others don't. ,NIH| A Longitudinal Twin Study of Cognition and Personality ,NIH| Mining the Genomewide Scan: Genetic Profiles of Structural Loss in Schizophrenia ,NHMRC| Prevention, early detection and effective management of neurocognitive disorders in the elderly ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,FWF| Genetics of Cerebral Small Vessel Disease ,NIH| Institute for Clinical and Translational Research (UL1) ,EC| GMI ,NWO| Longitudinal data collection from teachers of Dutch twins and their siblings ,NHMRC| Unravelling genetic influences on the human brain ,FWF| MRI white matter abnormalities in the elderly: Genetic risk factors, rate of progression and neuropsychologic consequences ,NIH| Rare variants and NHLBI traits in deeply phenotyped cohorts ,NIH| Testosterone-Androgen Receptor Genetics: Role in Cognitive and Biological Aging ,NIH| Genomics of Developmental Trajectories in Twins ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NHMRC| Uncoupled Research Fellowship ,NIH| Genetic &environmental pathways to drug use, abuse &dependence ,NIH| Exceptional aging: 12 year trajectories to function ,NIH| FRONTOTEMPORAL DEMENTIA: GENES, IMAGES, AND EMOTIONS ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NHMRC| Advancing our understanding of the genetics of Psychiatric and Neurological Disease ,NHMRC| Research fellowship ,NIH| CORONARY HEART DISEASE AND STROKE ,NHMRC| Genetics of brain structure and function ,NIH| Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders ,EC| AGGRESSOTYPE ,NIH| Antecedent Neuroimaging Biomarkers ,UKRI| UKCRC Brain Bank Strategy: Renewal of Newcastle Brain Tissue Resource ,EC| ENGAGE ,NIH| SOLAR-Eclipse Computational Tools for Imaging Genetics ,NIH| Algorithm and Data Analysis (ADA) Core ,NIH| Mapping Individual Cognitive Differences to Neural Variance and School Readiness ,NWO| BBMRI-NL2.0: The NL-Biobank Research Facility ,NHMRC| Complete genomics for mechanistic insight and precision treatments of schizophrenia ,NIH| PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS ,NIH| ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMA ,NHMRC| Feeding disturbance and hypothalamus integrity in early frontotemporal dementia ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,SFI| The Neurobiology of Voluntary Nicotine Abstinence: Genetics, Environment and Neurocognitive Endophenotypes ,NIH| Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and Depression ,NIH| Genetic Influences on Human Cortical Development ,NIH| Amish Connectome Project on Mental Illness ,NIH| The Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia Spectrum ,NWO| Twin-family database for behavior genetics and genomics studies ,NHMRC| Epistatic genetic effects on neuroanatomical subtypes of schizophrenia ,NHMRC| Frontotemporal dementia and motor neurodegenerative syndromes ,NIH| The VETSA Longitudinal MRI Twin Study of Aging ,NIH| Circuitry-Guided Smoking Cessation in Schizophrenia ,NWO| Networking through ADHD biology ,NIH| UC Davis Alzheimer's Core Center ,NIH| Genetic markers of white matter integrity in schizophrenia: Relationship to clini ,NIH| A global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA Consortium ,EC| PRISM ,NIH| DEVELOPMENTAL TWIN STUDY: ATTENTION, AGGRESSION, AFFECT ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| Developmental Genetic Epidemiology of Smoking ,EC| HBP SGA1 ,EC| HBP SGA2 ,EC| Eat2beNICE ,NHMRC| Genome-wide combined linkage-association scan of multiply phenotyped twin sibships ,NIH| Neurogenesis in Adult Brain: Gene Networks and Alzheimer?s Disease ,EC| TACTICS ,UKRI| Consortium on Vulnerability to Externalizing Disorders and Addictions [c-VEDA] ,NIH| Characterization of Normal Genomic Variability ,NWO| Cognitive, MRI and genetic markers of persistent versus remittent ADHD ,NIH| Rescuing the ruminating brain: Identifying biomarkers of rumination and mindfulness through concurrent EEG and fMRI studies of schizophrenia and depression ,UKRI| Neurobiological underpinning of eating disorders: integrative biopsychosocial longitudinal analyses in adolescents ,NIH| A Storage Area Network for Structural and Functional Image Analysis ,EC| JPco-fuND ,EC| CoCA ,NIH| HEALTHY AGING AND SENILE DEMENTIA ,NIH| CHS research resources for the cardiovascular health of older adults ,NHMRC| Personalised genomics in precision medicine of psychotic illness ,NIH| Shared Neural Circuitry in Comorbid Schizophrenia and Nicotine Addiction ,NIH| Perimenopause in Brain Aging and Alzheimer's Disease ,NIH| Progranulin: Mutation and Regulation in Neurodegenerative disease ,NHMRC| Genetic Repositories Australia ,NHMRC| Neurobiological ‘risk’ and ‘resilience’ biomarkers of severe mental illness ,NIH| A Longitudinal Twin Study of Cognition and Aging ,UKRI| Characterization of ubiquitin inclusions in FTD-MND and MND ,UKRI| Lifelong health and wellbeing of the Scotland in Miniature : the 6-day sample of the Scottish Mental Survey 1947 ,NHMRC| Biological Characterisation of the Opiod Receptor Sigma 1 Gene in the Frontotemporal Dementia and Motor Neuron Disease ,NIH| Kynurenic Acid and Cognitive Abnormalities in Schizophrenia ,NIH| Archiving the Vietnam Era Twin Studies of Aging (VETSA): New Uses for Old Data ,NIH| Integrating Neuroimaging, Multi-omics, and Clinical Data in Complex Disease ,NIH| BIO-INFORMATICS RESEARCH NETWORK COORDINATING CENTER (BIRN-CC) ,NHMRC| Investigation of dysfunction of SIGMAR1 in transgenic mouse models, a novel gene implicated in neurodegeneration ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,EC| MATRICS ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,NSF| MRI: Acquisition of PI2, a CAVE2-Inspired Display for Discovery Science, Creativity, and Education ,UKRI| JPND BRain Imaging, cognition, Dementia and next generation GEnomics ,NIH| CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NIH| ENIGMA World Aging Center ,NSF| GV: Small: Collaborative Research: Supporting Knowledge Discovery through a Scientific Visualization Language ,NIH| COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA ,EC| ADDICTION ,NIH| Growth factors, neuroinflammation, exercise, and brain integrity ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,UKRI| Mapping the genetic architecture of global gene and exon expression in the human brain to understand common diseases ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,NIH| Psychometric and Genetic Assessments of Substance Use ,UKRI| Genetic risk factors for neurodegenerative diseases and their role in the regulation of regional gene expression in the ,NIH| Towards Multisystem-Brain Successful Aging in Schizophrenia Spectrum ,NWO| Genetische en omgevingsinvloeden op psychopathologie en geluk tijdens de adolescentie ,NIH| Limited Competition:Continuation of the Center for Genomic Studies on Mental Disorders (U24) ,NIH| An Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel Disease ,NWO| How does the neural architecture of cognition map on its genetic architecture? ,NIH| The ARIC and Neurocognitive Longitudinal Study ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| Psychometric and Genetic Assessments of Substance Use ,NIH| Multi-group semi-blind ICA of fMRI ,NIH| Multi-Source Sparse Learning to Identify MCI and Predict Decline ,NWO| Netherlands Twin Registry Repository: researching the interplay between genome and environment ,NIH| Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NWO| BBMRI-NL ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NHMRC| Depressive and bipolar disorders: Pathophysiology, phenotypes and treatment innovations ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| Role of LRP &its ligand tPA in LTP &aging ,EC| EUROHEADPAIN ,WT| Optimisation of cognitive and behavioural control in Parkinson s disease and Frontotemporal degeneration. ,NIH| GGGGCC hexanucleotide repeat expansions in neurodegenerative disease ,NIH| Neurogenetic Pathways to Drug Use in Young Adults ,EC| STRATIFY ,NIH| High resolution mapping of the genetic risk for disease in the aging brain ,NIH| Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham Cohorts ,NIH| Self-Regulation Failure: Identifying and Modifying a Risk Phenotype ,NIH| Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis ,ANR| ADODEP ,NIH| Creating a Pediatric Imaging-Genomics Data Resource ,NWO| Twin-family study of individual differences in school achievement ,NWO| Did I do that? The experience of self-agency in health and schizophrenia. ,NIH| Determinants of Adolescent Exercise Behavior; towards Evidence-Based Intervention ,FWF| Hepatocellular Epithelial to Fibroblastoid Conversion ,NIH| Identification of novel Parkinsonian genes by wholegenome ,EC| ACTION ,NIH| Genetic influences on the brain: A twin imaging study ,CIHR ,NWO| NCHA Subsidiebesluit 2008-2012 ,EC| CoSTREAM ,NIH| Axon, Testosterone and Mental Health during Adolescence ,NIH| MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults ,NIH| Understanding the role of TDP-43 in Alzheimers disease and FTLD ,NIH| Institute for Clinical and Translational Science ,NIH| CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS ,NHMRC| Investigation of dysfunction of OPRS1, a novel gene implicated in neurodegeneration ,NIH| Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults ,NIH| pathQTL: Integrative Multi-Omics Causal Inference of Molecular Mechanisms Leading to Neuropsychiatric Illness ,NIH| Major Depression: Stage 1 Genomewide Association in Population-Based Samples ,NIH| SPATIOTEMPORAL FORWARD MODEL FOR DIFFUSE OPTICAL TOMOGRAPHY ,NIH| Neural Oscillatory Biomarkers for Genetics and Animal Models of Schizophrenia ,NIH| Translational Neuroscientist and the Hope Center ,NWO| Functional neural network plasticity in adolescent twins and sibs ,NIH| Mayo Alzheimers Disease Research Center ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| GENERAL CLINICAL RESEARCH CENTER ,NIH| Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience ,NHMRC| Characterisation and modelling of schizophrenia-associated dysregulation of miR-137 expression ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| Multidisciplinary Schizophrenia Research Training ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NWO| A Twin-sibling Study of Adolescent Wellness ,NIH| The VETSA Longitudinal Twin Study of Cortisol and Aging ,NIH| Alzheimers Disease Neuroimaging Initiative ,NIH| Kynurenic Acid and Cognitive Abnormalities in Schizophrenia ,NWO| tweeling onderzoek, met een focus op gedrag en depressie ,NIH| International Multi-Center ADHD Genetics Project ,UKRI| A genome-wide association study of non-pathological cognitive ageing ,SNSF| Comprehensive genetic analysis of a series of large families affected with bipolar disorderAuthors: Grasby, Katrina L; Jahanshad, Neda; Shatokhina, Natalia; Mirza-Schreiber, Nazanin; +331 AuthorsGrasby, Katrina L; Jahanshad, Neda; Shatokhina, Natalia; Mirza-Schreiber, Nazanin; Moreira, Jose C V; Mühleisen, Thomas W; Müller-Myhsok, Bertram; Najt, Pablo; Nakahara, Soichiro; Nho, Kwangsik; Olde Loohuis, Loes M; Orfanos, Dimitri Papadopoulos; Pearson, John F; Zsembik, Leo C P; Pitcher, Toni L; Pütz, Benno; Quidé, Yann; Ragothaman, Anjanibhargavi; Rashid, Faisal M; Reay, William R; Redlich, Ronny; Reinbold, Céline S; Repple, Jonathan; Richard, Geneviève; Thomopoulos, Sophia I; Riedel, Brandalyn C; Risacher, Shannon L; Rocha, Cristiane S; Mota, Nina Roth; Salminen, Lauren; Saremi, Arvin; Saykin, Andrew J; Schlag, Fenja; Schmaal, Lianne; Schofield, Peter R; Zhu, Alyssa H; Secolin, Rodrigo; Shapland, Chin Yang; Shen, Li; Shin, Jean; Shumskaya, Elena; Sønderby, Ida E; Sprooten, Emma; Tansey, Katherine E; Teumer, Alexander; Thalamuthu, Anbupalam; Strike, Lachlan T; Tordesillas-Gutiérrez, Diana; Turner, Jessica A; Uhlmann, Anne; Vallerga, Costanza Ludovica; van der Meer, Dennis; van Donkelaar, Marjolein M J; van Eijk, Liza; van Erp, Theo G M; van Haren, Neeltje E M; van Rooij, Daan; Agartz, Ingrid; van Tol, Marie-José; Veldink, Jan H; Verhoef, Ellen; Walton, Esther; Wang, Mingyuan; Wang, Yunpeng; Wardlaw, Joanna M; Wen, Wei; Westlye, Lars T; Whelan, Christopher D; Alhusaini, Saud; Witt, Stephanie H; Wittfeld, Katharina; Wolf, Christiane; Wolfers, Thomas; Wu, Jing Qin; Yasuda, Clarissa L; Zaremba, Dario; Zhang, Zuo; Zwiers, Marcel P; Artiges, Eric; Almeida, Marcio A A; Assareh, Amelia A; Ayesa-Arriola, Rosa; Belger, Aysenil; Brandt, Christine L; Brown, Gregory G; Cichon, Sven; Curran, Joanne E; Davies, Gareth E; Degenhardt, Franziska; Dennis, Michelle F; Alnæs, Dag; Dietsche, Bruno; Djurovic, Srdjan; Doherty, Colin P; Espiritu, Ryan; Garijo, Daniel; Gil, Yolanda; Gowland, Penny A; Green, Robert C; Häusler, Alexander N; Heindel, Walter; Amlien, Inge K; Ho, Beng-Choon; Hoffmann, Wolfgang U; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Jack, Clifford R; Jang, MiHyun; Jansen, Andreas; Kimbrel, Nathan A; Kolskår, Knut; Painter, Jodie N; Andersson, Micael; Koops, Sanne; Krug, Axel; Lim, Kelvin O; Luykx, Jurjen J; Mathalon, Daniel H; Mather, Karen A; Mattay, Venkata S; Matthews, Sarah; Mayoral Van Son, Jaqueline; McEwen, Sarah C; Ard, Tyler; Melle, Ingrid; Morris, Derek W; Mueller, Bryon A; Nauck, Matthias; Nordvik, Jan E; Nöthen, Markus M; O'Leary, Daniel S; Opel, Nils; Martinot, Marie-Laure Paillère; Pike, G Bruce; Armstrong, Nicola J; Preda, Adrian; Quinlan, Erin B; Rasser, Paul E; Ratnakar, Varun; Reppermund, Simone; Steen, Vidar M; Tooney, Paul A; Torres, Fábio R; Veltman, Dick J; Voyvodic, James T; Ashley-Koch, Allison; Whelan, Robert; White, Tonya; Yamamori, Hidenaga; Adams, Hieab H H; Bis, Joshua C; Debette, Stephanie; Decarli, Charles; Fornage, Myriam; Gudnason, Vilmundur; Hofer, Edith; Atkins, Joshua R; Ikram, M Arfan; Launer, Lenore; Longstreth, W. T.; Lopez, Oscar L; Mazoyer, Bernard; Mosley, Thomas H; Roshchupkin, Gennady V; Satizabal, Claudia L; Schmidt, Reinhold; Seshadri, Sudha; Bernard, Manon; Yang, Qiong; Initiative, Alzheimer’s Disease Neuroimaging; Consortium, CHARGE; Consortium, EPIGEN; Consortium, IMAGEN; Consortium, SYS; Initiative, Parkinson’s Progression Markers; Alvim, Marina K M; Ames, David; Anderson, Tim J; Brouwer, Rachel M; Andreassen, Ole A; Arias-Vasquez, Alejandro; Bastin, Mark E; Baune, Bernhard T; Beckham, Jean C; Blangero, John; Boomsma, Dorret I; Brodaty, Henry; Brunner, Han G; Buckner, Randy L; Buimer, Elizabeth E L; Buitelaar, Jan K; Bustillo, Juan R; Cahn, Wiepke; Cairns, Murray J; Calhoun, Vince; Carr, Vaughan J; Caseras, Xavier; Caspers, Svenja; Cavalleri, Gianpiero L; Cendes, Fernando; Corvin, Aiden; Crespo-Facorro, Benedicto; Dalrymple-Alford, John C; Dannlowski, Udo; de Geus, Eco J C; Depondt, Chantal; Desrivières, Sylvane; Donohoe, Gary; Espeseth, Thomas; Fisher, Simon E; Flor, Herta; Francks, Clyde; Franke, Barbara; Gollub, Randy L; Colodro-Conde, Lucía; Cannon, Dara M; Håberg, Asta K; Hartman, Catharina A; Heinz, Andreas; Henskens, Frans A; Hillegers, Manon H J; Hoekstra, Pieter J; Holmes, Avram J; Hulshoff Pol, Hilleke E; Jönsson, Erik G; Kennedy, Martin A; Kircher, Tilo T J; Kwok, John B J; Chen, Qiang; Le Hellard, Stephanie; Martin, Nicholas G; McMahon, Katie L; Meyer-Lindenberg, Andreas; Michie, Patricia T; Morey, Rajendra A; Mowry, Bryan; Cheung, Joshua W; Nyberg, Lars; Oosterlaan, Jaap; Ophoff, Roel A; Pantelis, Christos; Pausova, Zdenka; Penninx, Brenda W J H; Polderman, Tinca J C; Posthuma, Danielle; Rietschel, Marcella; Couvy-Duchesne, Baptiste; Roffman, Joshua L; Sachdev, Perminder S; Schall, Ulrich; Schumann, Gunter; Scott, Rodney J; Sim, Kang; Dale, Anders M; Sommer, Iris E; St Pourcain, Beate; Stein, Dan J; Toga, Arthur W; Trollor, Julian N; Van der Wee, Nic J A; van 't Ent, Dennis; Walter, Henrik; Weber, Bernd; Dalvie, Shareefa; Weinberger, Daniel R; Wright, Margaret J; Zhou, Juan; Stein, Jason L; Thompson, Paul M; Medland, Sarah E; Witte, A Veronica; de Araujo, Tânia K; de Zubicaray, Greig I; Bralten, Janita; Mishra, Aniket; Dohm, Katharina; Ehrlich, Stefan; Engelbrecht, Hannah-Ruth; Erk, Susanne; Fedko, Iryna O; van Duijn, Cornelia M; Foley, Sonya F; Ford, Judith M; Fukunaga, Masaki; Garrett, Melanie E; Ge, Tian; Nees, Frauke; Green, Melissa J; Groenewold, Nynke A; Grotegerd, Dominik; Gurholt, Tiril P; Gutman, Boris A; Lind, Penelope A; Hansell, Narelle K; Harris, Mathew A; Harrison, Marc B; Haswell, Courtney C; Hauser, Michael; Herms, Stefan; Ho, New Fei; Hoehn, David; Seppi, Klaus; Hoffmann, Per; Pizzagalli, Fabrizio; Holleran, Laurena; Hoogman, Martine; Hottenga, Jouke-Jan; Knol, Maria J; Ikeda, Masashi; Janowitz, Deborah; Jansen, Iris E; Vernooij, Meike W; Jia, Tianye; Luciano, Michelle; Jockwitz, Christiane; Ghanbari, Mohsen; Kanai, Ryota; Karama, Sherif; Kaufmann, Tobias; Kikuchi, Masataka; Klein, Marieke; Knodt, Annchen R; Krämer, Bernd; Kremen, Sarah; Lancaster, Thomas M; McMahon, Mary Agnes B; Lee, Phil H; Lewis, Lindsay B; Lopes-Cendes, Iscia; Banaschewski, Tobias; Macciardi, Fabio; Saba, Yasaman; Marquand, Andre F; Melzer, Tracy R;pmc: PMC7295264
handle: 11370/b56e82d8-e68c-43de-888f-59b0b085874b , 21.11116/0000-0005-E8FE-8 , 21.11116/0000-0005-F5A0-1 , 21.11116/0000-0005-E90D-7 , 2066/218611 , 1887/3184500 , 10261/235393 , 11250/3033616 , 21.11116/0000-000D-7752-1 , 2128/25415 , 1871.1/24e85212-901f-4109-a8bc-9246e70bb73d , 11250/2760637 , 2318/1766232 , 20.500.11820/2ad2fee5-a1cb-432b-81a0-283158c2db79
pmc: PMC7295264
handle: 11370/b56e82d8-e68c-43de-888f-59b0b085874b , 21.11116/0000-0005-E8FE-8 , 21.11116/0000-0005-F5A0-1 , 21.11116/0000-0005-E90D-7 , 2066/218611 , 1887/3184500 , 10261/235393 , 11250/3033616 , 21.11116/0000-000D-7752-1 , 2128/25415 , 1871.1/24e85212-901f-4109-a8bc-9246e70bb73d , 11250/2760637 , 2318/1766232 , 20.500.11820/2ad2fee5-a1cb-432b-81a0-283158c2db79
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder. Contains fulltext : 218611.pdf (Publisher’s version ) (Open Access)
NARCIS; Science arrow_drop_down NARCIS; Archivio Istituzionale; ScienceOther literature type . Article . 2020 . Peer-reviewedbioRxivPreprint . 2018University of Bath's research portalArticle . 2020Data sources: University of Bath's research portalBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2020 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2020LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2020NARCIS; ScienceArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 485 citations 485 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 22visibility views 22 download downloads 82 Powered bymore_vert NARCIS; Science arrow_drop_down NARCIS; Archivio Istituzionale; ScienceOther literature type . Article . 2020 . Peer-reviewedbioRxivPreprint . 2018University of Bath's research portalArticle . 2020Data sources: University of Bath's research portalBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2020 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2020LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2020NARCIS; ScienceArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 IrelandPublisher:Public Library of Science (PLoS) Publicly fundedFunded by:NIH | Impact of Clot Histologic..., SFI | CÚRAM - Centre for Resear...NIH| Impact of Clot Histological and Physical Properties on Revascularization Strategies in Acute Ischaemic Stroke ,SFI| CÚRAM - Centre for Research in Medical DevicesSeán Fitzgerald; Shunli Wang; Daying Dai; Dennis H. Murphree; Abhay Pandit; Andrew Douglas; Asim Rizvi; Ramanathan Kadirvel; Michael Gilvarry; Ray McCarthy; Manuel Stritt; Matthew J. Gounis; Waleed Brinjikji; David F. Kallmes; Karen M. Doyle;Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical thrombectomy procedures. Following H&E staining, quantification of clot components was performed by two different methods: a pathologist using a reference standard method (Adobe Photoshop CC) and an experienced researcher using Orbit Image Analysis. Following quantification, the clots were categorized into 3 types: RBC dominant (≥60% RBCs), Mixed and Fibrin dominant (≥60% Fibrin). Correlations between clot composition and Hounsfield Units density on Computed Tomography (CT) were assessed. There was a significant correlation between the components of clots as quantified by the Orbit Image Analysis algorithm and the reference standard approach (ρ = 0.944**, p < 0.001, n = 150). A significant relationship was found between clot composition (RBC-Rich, Mixed, Fibrin-Rich) and the presence of a Hyperdense artery sign using the algorithmic method (X2(2) = 6.712, p = 0.035*) but not using the reference standard method (X2(2) = 3.924, p = 0.141). Orbit Image Analysis machine learning software can be used for the histological quantification of AIS clots, reproducibly generating composition analyses similar to current reference standard methods. This work was supported by the National Institutes of Health (R01 NS105853), the European Regional Development Fund and Science Foundation Ireland under Ireland’s European Structural and Investment Fund (Grant Number 13/RC/2073) and Industrial partners Cerenovus. peer-reviewed
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6894878Data sources: PubMed CentralAccess to Research at National University of Ireland, GalwayArticle . 2019 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0225841&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 53 citations 53 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6894878Data sources: PubMed CentralAccess to Research at National University of Ireland, GalwayArticle . 2019 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0225841&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 United States, United Kingdom, IrelandPublisher:American Psychiatric Association Publishing Publicly fundedFunded by:NIH | ENIGMA Center for Worldwi..., EC | iRELaTE, SFI | SFI ERC Support Programme...NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,EC| iRELaTE ,SFI| SFI ERC Support Programme- Gary Donohoe, NUI GalwayLaurena Holleran; Sinead Kelly; Clara Alloza; Ingrid Agartz; Ole A. Andreassen; Celso Arango; Nerisa Banaj; Vince D. Calhoun; Dara M. Cannon; Vaughan J. Carr; Aiden Corvin; David C. Glahn; Ruben C. Gur; Elliot Hong; Cyril Höschl; Fleur M. Howells; Anthony A. James; Joost Janssen; Peter Kochunov; Stephen M. Lawrie; Jingyu Liu; Covadonga Martinez; Colm McDonald; Derek W. Morris; David Mothersill; Christos Pantelis; Fabrizio Piras; Steven G. Potkin; Paul E. Rasser; David R. Roalf; Laura Rowland; Theodore D. Satterthwaite; Ulrich Schall; Gianfranco Spalletta; Filip Spaniel; Dan J. Stein; Anne Uhlmann; Aristotle N. Voineskos; Andrew Zalesky; Theo G.M. van Erp; Jessica A. Turner; Ian J. Deary; Paul M. Thompson; Neda Jahanshad; Gary Donohoe;pmc: PMC7938666
pmid: 32212855
OBJECTIVESchizophrenia has recently been associated with widespread white matter microstructural abnormalities, but the functional effects of these abnormalities remain unclear. Widespread heterogeneity of results from studies published to date preclude any definitive characterization of the relationship between white matter and cognitive performance in schizophrenia. Given the relevance of deficits in cognitive function to predicting social and functional outcomes in schizophrenia, the authors carried out a meta-analysis of available data through the ENIGMA Consortium, using a common analysis pipeline, to elucidate the relationship between white matter microstructure and a measure of general cognitive performance, IQ, in patients with schizophrenia and healthy participants.METHODSThe meta-analysis included 760 patients with schizophrenia and 957 healthy participants from 11 participating ENIGMA Consortium sites. For each site, principal component analysis was used to calculate both a global fractional anisotropy component (gFA) and a fractional anisotropy component for six long association tracts (LA-gFA) previously associated with cognition.RESULTSMeta-analyses of regression results indicated that gFA accounted for a significant amount of variation in cognition in the full sample (effect size [Hedges' g]=0.27, CI=0.17-0.36), with similar effects sizes observed for both the patient (effect size=0.20, CI=0.05-0.35) and healthy participant groups (effect size=0.32, CI=0.18-0.45). Comparable patterns of association were also observed between LA-gFA and cognition for the full sample (effect size=0.28, CI=0.18-0.37), the patient group (effect size=0.23, CI=0.09-0.38), and the healthy participant group (effect size=0.31, CI=0.18-0.44).CONCLUSIONSThis study provides robust evidence that cognitive ability is associated with global structural connectivity, with higher fractional anisotropy associated with higher IQ. This association was independent of diagnosis; while schizophrenia patients tended to have lower fractional anisotropy and lower IQ than healthy participants, the comparable size of effect in each group suggested a more general, rather than disease-specific, pattern of association.
American Journal of ... arrow_drop_down eScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1176/appi.ajp.2019.19030225&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 47 citations 47 popularity Top 1% influence Average impulse Top 1% Powered by BIP!more_vert American Journal of ... arrow_drop_down eScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1176/appi.ajp.2019.19030225&type=result"></script>'); --> </script>
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