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description Publicationkeyboard_double_arrow_right Article 2022 United KingdomPublisher:Elsevier BV Funded by:WT | Health Priorities in Reso...WT| Health Priorities in Resource-Limited SettingsStolbrink, M; Chinouya, MJ; Jayasooriya, S; Nightingale, R; Evans-Hill, L; Allan, K; Allen, H; Balen, J; Beacon, T; Bissell, K; Chakaya, J; Chiang, C-Y; Cohen, M; Devereux, G; El Sony, A; Halpin, DMG; Hurst,; Kiprop, C; Lawson, A; Macé, C; Makhanu, A; Makokha, P; Masekela, R; Meme, H; Khoo, EM; Nantanda, R; Pasternak, S; Perrin, C; Reddel, H; Rylance, S; Schweikert, P; Were, C; Williams, S; Winders, T; Yorgancioglu, A; Marks, GB; Mortimer, K;pmid: 36447314
pmc: PMC9621306
BACKGROUND: Access to affordable inhaled medicines for chronic respiratory diseases (CRDs) is severely limited in low- and middle-income countries (LMICs), causing avoidable morbidity and mortality. The International Union Against Tuberculosis and Lung Disease convened a stakeholder meeting on this topic in February 2022.METHODS: Focused group discussions were informed by literature and presentations summarising experiences of obtaining inhaled medicines in LMICs. The virtual meeting was moderated using a topic guide around barriers and solutions to improve access. The thematic framework approach was used for analysis.RESULTS: A total of 58 key stakeholders, including patients, healthcare practitioners, members of national and international organisations, industry and WHO representatives attended the meeting. There were 20 pre-meeting material submissions. The main barriers identified were 1) low awareness of CRDs; 2) limited data on CRD burden and treatments in LMICs; 3) ineffective procurement and distribution networks; and 4) poor communication of the needs of people with CRDs. Solutions discussed were 1) generation of data to inform policy and practice; 2) capacity building; 3) improved procurement mechanisms; 4) strengthened advocacy practices; and 5) a World Health Assembly Resolution.CONCLUSION: There are opportunities to achieve improved access to affordable, quality-assured inhaled medicines in LMICs through coordinated, multi-stakeholder, collaborative efforts. Funder: Medical Research Council
Apollo arrow_drop_down The International Journal of Tuberculosis and Lung DiseaseArticle . 2022 . Peer-reviewedData sources: CrossrefThe International Journal of Tuberculosis and Lung DiseaseArticle . 2022Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4107776&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 9 citations 9 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 10visibility views 10 download downloads 2 Powered bymore_vert Apollo arrow_drop_down The International Journal of Tuberculosis and Lung DiseaseArticle . 2022 . Peer-reviewedData sources: CrossrefThe International Journal of Tuberculosis and Lung DiseaseArticle . 2022Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4107776&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, SwedenPublisher:Wiley Funded by:EC | DDMORE, WTEC| DDMORE ,WTSmith, MK; Moodie, SL; Bizzotto, R; E, Blaudez.; Borella, E; Carrara, L; Chan, P; Chenel, M; Comets, E; Gieschke, R; Harling, K; Harnisch, L; Hartung, N; Hooker, AC; Karlsson, MO; Kaye, R; Kloft, C; Kokash, N; Lavielle, M; Lestini, G; Magni, P; Mari, A; Mentré, F; Muselle, C; Nordgren, R; Nyberg, HB; Parra-Guillén, ZP; Pasotti, L; Rode-Kristensen, N; Sardu, ML; Smith, GR; Swat, MJ; Terranova, N; Yngman, G; Yvon, F; Holford, N; consortium, DDMoRe;Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics. 1-3 Currently, models are encoded in a variety of computer languages and are shared through publications that rarely include original code and generally lack reproducibility. The DDMoRe Model Description Language (MDL) has been developed primarily as a language standard to facilitate sharing knowledge and understanding of models.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5658286Data sources: PubMed CentralCPT: Pharmacometrics & Systems PharmacologyArticle . 2017 . Peer-reviewedLicense: CC BY NCData sources: CrossrefPublikationer från Uppsala UniversitetArticle . 2017 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/psp4.12222&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 14 citations 14 popularity Average influence Average impulse Top 10% Powered by BIP!visibility 9visibility views 9 download downloads 2 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5658286Data sources: PubMed CentralCPT: Pharmacometrics & Systems PharmacologyArticle . 2017 . Peer-reviewedLicense: CC BY NCData sources: CrossrefPublikationer från Uppsala UniversitetArticle . 2017 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/psp4.12222&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1997Publisher:Oxford University Press (OUP) Funded by:WTWTAuthors: Katharina Judith Rowold;Katharina Judith Rowold;doi: 10.1093/gh/15.3.392
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/gh/15.3.392&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/gh/15.3.392&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 NetherlandsPublisher:F1000 Research Ltd Funded by:WTWTFrancien G. Bossema; Peter Burger; Luke Bratton; Aimee Challenger; Rachel Adams; Petroc Sumner; Joop Schat; Mattijs E Numans; Ionica Smeets;Background This research is an investigation into the role of expert quotes in health news, specifically whether news articles containing a quote from an independent expert are less often exaggerated than articles without such a quote. Methods Retrospective quantitative content analysis of journal articles, press releases, and associated news articles was performed. The investigated sample are press releases on peer-reviewed health research and the associated research articles and news stories. Our sample consisted of 462 press releases and 668 news articles from the UK (2011) and 129 press releases and 185 news articles from The Netherlands (2015). We hand-coded all journal articles, press releases and news articles for correlational claims, using a well-tested codebook. The main outcome measures are types of sources that were quoted and exaggeration of correlational claims. We used counts, 2x2 tables and odds ratios to assess the relationship between presence of quotes and exaggeration of the causal claim. Results Overall, 99.1% of the UK press releases and 84.5% of the Dutch press releases contain at least one quote. For the associated news articles these percentages are: 88.6% in the UK and 69.7% in the Netherlands. Authors of the study are most often quoted and only 7.5% of UK and 7.0% of Dutch news articles contained a new quote by an expert source, i.e. one not provided by the press release. The relative odds that an article without an external expert quote contains an exaggeration of causality is 2.6. Conclusions The number of articles containing a quote from an independent expert is low, but articles that cite an external expert do contain less exaggeration.
NARCIS arrow_drop_down Europe PubMed CentralArticle . 2019 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC6619368Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/wellcomeopenres.15147.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!download 18download downloads 18 Powered bymore_vert NARCIS arrow_drop_down Europe PubMed CentralArticle . 2019 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC6619368Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/wellcomeopenres.15147.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United KingdomPublisher:Springer Science and Business Media LLC Funded by:WTWTAuthors: Devolder, Katrien;Devolder, Katrien;AbstractGenome editing in livestock could potentially be used in ways that help resolve some of the most urgent and serious global problems pertaining to livestock, including animal suffering, pollution, antimicrobial resistance, and the spread of infectious disease. But despite this potential, some may object to pursuing it, not because genome editing is wrong in and of itself, but because it is the wrong kind of solution to the problems it addresses: it is merely a ‘technological fix’ to a complex societal problem. Yet though this objection might have wide intuitive appeal, it is often not clear what, exactly, the moral problem is supposed to be. The aim of this paper is to formulate and shed some light on the ‘technological fix objection’ to genome editing in livestock. I suggest that three concerns may underlie it, make implicit assumptions underlying the concerns explicit, and cast some doubt on several of these assumptions, at least as they apply to the use of genome editing to produce pigs resistant to the Porcine Reproductive and Respiratory Syndrome and hornless dairy cattle. I then suggest that the third, and most important, concern could be framed as a concern about complicity in factory farming. I suggest ways to evaluate this concern, and to reduce or offset any complicity in factory farming. Thinking of genome editing’s contribution to factory farming in terms of complicity, may, I suggest, tie it more explicitly and strongly to the wider obligations that come with pursuing it, including the cessation of factory farming, thereby addressing the concern that technological fixes focus only on a narrow problem.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8550048Data sources: PubMed CentralOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveJournal of Agricultural and Environmental EthicsArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10806-021-09858-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 6visibility views 6 download downloads 1 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8550048Data sources: PubMed CentralOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveJournal of Agricultural and Environmental EthicsArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10806-021-09858-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 NetherlandsPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | TRAIN-OLD, WT, EC | MetabinnateEC| TRAIN-OLD ,WT ,EC| MetabinnateAuthors: Luke A. J. O'Neill; Mihai G. Netea;Luke A. J. O'Neill; Mihai G. Netea;Bacillus Calmette–Guérin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19. Could the BCG vaccine be used to bridge the gap until a specific COVID-19 vaccine is developed? Luke O’Neill and Mihai Netea discuss the science behind this approach.
Nature Reviews Immun... arrow_drop_down Nature Reviews ImmunologyOther literature type . Article . 2020 . Peer-reviewedLicense: Springer TDMEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7212510Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41577-020-0337-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 387 citations 387 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!more_vert Nature Reviews Immun... arrow_drop_down Nature Reviews ImmunologyOther literature type . Article . 2020 . Peer-reviewedLicense: Springer TDMEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7212510Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41577-020-0337-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 Italy, Italy, United KingdomPublisher:Springer Science and Business Media LLC Funded by:WTWTClaudio Ottoni; Hannah E.C. Koon; Matthew J. Collins; Kirsty Penkman; Olga Rickards; Oliver E. Craig;Evolutionary biologists are increasingly relying on ancient DNA from archaeological animal bones to study processes such as domestication and population dispersals. As many animal bones found on archaeological sites are likely to have been cooked, the potential for DNA preservation must be carefully considered to maximise the chance of amplification success. Here, we assess the preservation of mitochondrial DNA in a medieval cattle bone assemblage from Coppergate, York, UK. These bones have variable degrees of thermal alterations to bone collagen fibrils, indicative of cooking. Our results show that DNA preservation is not reliant on the presence of intact collagen fibrils. In fact, a greater number of template molecules could be extracted from bones with damaged collagen. We conclude that moderate heating of bone may enhance the retention of DNA fragments. Our results also indicate that ancient DNA preservation is highly variable, even within a relatively recent assemblage from contexts conducive to organic preservation, and that diagenetic parameters based on protein diagenesis are not always useful for predicting ancient DNA survival.
Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2009Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di Roma Tor vergataArticle . 2009Data sources: Archivio della Ricerca - Università di Roma Tor vergataArchivio della Ricerca - Università di Roma Tor vergataArticle . 2009Data sources: Archivio della Ricerca - Università di Roma Tor vergataArchivio della ricerca- Università di Roma La SapienzaArticle . 2009Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00114-008-0478-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 60 citations 60 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 3visibility views 3 Powered bymore_vert Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2009Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di Roma Tor vergataArticle . 2009Data sources: Archivio della Ricerca - Università di Roma Tor vergataArchivio della Ricerca - Università di Roma Tor vergataArticle . 2009Data sources: Archivio della Ricerca - Università di Roma Tor vergataArchivio della ricerca- Università di Roma La SapienzaArticle . 2009Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00114-008-0478-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United KingdomPublisher:Elsevier BV Funded by:WTWTAuthors: Thomas Searle; Zina M. Ibrahim; James T. Teo; Richard Dobson;Thomas Searle; Zina M. Ibrahim; James T. Teo; Richard Dobson;pmid: 34695581
Abstract The current mode of use of Electronic Health Records (EHR) elicits text redundancy. Clinicians often populate new documents by duplicating existing notes, then updating accordingly. Data duplication can lead to propagation of errors, inconsistencies and misreporting of care. Therefore, measures to quantify information redundancy play an essential role in evaluating innovations that operate on clinical narratives. This work is a quantitative examination of information redundancy in EHR notes. We present and evaluate two methods to measure redundancy: an information-theoretic approach and a lexicosyntactic and semantic model. Our first measure trains large Transformer-based language models using clinical text from a large openly available US-based ICU dataset and a large multi-site UK based Hospital. By comparing the information-theoretic efficient encoding of clinical text against open-domain corpora, we find that clinical text is ∼ 1.5 × to ∼ 3 × less efficient than open-domain corpora at conveying information. Our second measure, evaluates automated summarisation metrics Rouge and BERTScore to evaluate successive note pairs demonstrating lexicosyntactic and semantic redundancy, with averages from ∼ 43 to ∼ 65%.
UCL Discovery arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2021Data sources: arXiv.org e-Print ArchiveJournal of Biomedical InformaticsArticle . 2021 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jbi.2021.103938&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert UCL Discovery arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2021Data sources: arXiv.org e-Print ArchiveJournal of Biomedical InformaticsArticle . 2021 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jbi.2021.103938&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Publisher:Informa UK Limited Funded by:WTWTAuthors: Kristin Hay;Kristin Hay;In 1967, the Abortion Act was passed which legalised terminations conducted by a doctor between the first and twenty-fourth week of pregnancy in Britain. Despite having abortion legalised in law, the cultural shift from the prejudiced to permissive took far longer to arrive, and women continued to face barriers to their reproductive autonomy in the 1970s and 1980s. The inequalities in abortion healthcare were most pronounced in Scotland, prompting the emergence of the Scottish Abortion Campaign in 1980. This article explores the role of the Scottish Abortion Campaign and their efforts to defend and extend the Abortion Act of 1967 in post-legalisation Scotland. Through archival research and oral testimony, this article demonstrates that the SAC operated semi-autonomously from the broader National Abortion Campaign, demonstrating a distinctive, Scottish feminist identity that influenced their activities during this period.
CORE (RIOXX-UK Aggre... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/09612025.2020.1791405&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!visibility 7visibility views 7 download downloads 20 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/09612025.2020.1791405&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015Publisher:Elsevier BV Funded by:WTWTAuthors: Abecasis, Gonçalo R.;Abecasis, Gonçalo R.;Thank you very much. I would first like to thank the Awards Committee, The Society, and all of you who are here this morning. For the past 15 years, I have treasured coming to this meeting, which is always full of energy, ideas, and brilliant scientists. To be honest, I find it hard to see myself in Aravinda Chakravarti’s and Michael Boehnke’s kind description of me, and in the next few minutes, I will probably disprove their claim that I am a good communicator. I stand before you trembling.
The American Journal... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ajhg.2015.02.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert The American Journal... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2022 United KingdomPublisher:Elsevier BV Funded by:WT | Health Priorities in Reso...WT| Health Priorities in Resource-Limited SettingsStolbrink, M; Chinouya, MJ; Jayasooriya, S; Nightingale, R; Evans-Hill, L; Allan, K; Allen, H; Balen, J; Beacon, T; Bissell, K; Chakaya, J; Chiang, C-Y; Cohen, M; Devereux, G; El Sony, A; Halpin, DMG; Hurst,; Kiprop, C; Lawson, A; Macé, C; Makhanu, A; Makokha, P; Masekela, R; Meme, H; Khoo, EM; Nantanda, R; Pasternak, S; Perrin, C; Reddel, H; Rylance, S; Schweikert, P; Were, C; Williams, S; Winders, T; Yorgancioglu, A; Marks, GB; Mortimer, K;pmid: 36447314
pmc: PMC9621306
BACKGROUND: Access to affordable inhaled medicines for chronic respiratory diseases (CRDs) is severely limited in low- and middle-income countries (LMICs), causing avoidable morbidity and mortality. The International Union Against Tuberculosis and Lung Disease convened a stakeholder meeting on this topic in February 2022.METHODS: Focused group discussions were informed by literature and presentations summarising experiences of obtaining inhaled medicines in LMICs. The virtual meeting was moderated using a topic guide around barriers and solutions to improve access. The thematic framework approach was used for analysis.RESULTS: A total of 58 key stakeholders, including patients, healthcare practitioners, members of national and international organisations, industry and WHO representatives attended the meeting. There were 20 pre-meeting material submissions. The main barriers identified were 1) low awareness of CRDs; 2) limited data on CRD burden and treatments in LMICs; 3) ineffective procurement and distribution networks; and 4) poor communication of the needs of people with CRDs. Solutions discussed were 1) generation of data to inform policy and practice; 2) capacity building; 3) improved procurement mechanisms; 4) strengthened advocacy practices; and 5) a World Health Assembly Resolution.CONCLUSION: There are opportunities to achieve improved access to affordable, quality-assured inhaled medicines in LMICs through coordinated, multi-stakeholder, collaborative efforts. Funder: Medical Research Council
Apollo arrow_drop_down The International Journal of Tuberculosis and Lung DiseaseArticle . 2022 . Peer-reviewedData sources: CrossrefThe International Journal of Tuberculosis and Lung DiseaseArticle . 2022Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4107776&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 9 citations 9 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 10visibility views 10 download downloads 2 Powered bymore_vert Apollo arrow_drop_down The International Journal of Tuberculosis and Lung DiseaseArticle . 2022 . Peer-reviewedData sources: CrossrefThe International Journal of Tuberculosis and Lung DiseaseArticle . 2022Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4107776&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, SwedenPublisher:Wiley Funded by:EC | DDMORE, WTEC| DDMORE ,WTSmith, MK; Moodie, SL; Bizzotto, R; E, Blaudez.; Borella, E; Carrara, L; Chan, P; Chenel, M; Comets, E; Gieschke, R; Harling, K; Harnisch, L; Hartung, N; Hooker, AC; Karlsson, MO; Kaye, R; Kloft, C; Kokash, N; Lavielle, M; Lestini, G; Magni, P; Mari, A; Mentré, F; Muselle, C; Nordgren, R; Nyberg, HB; Parra-Guillén, ZP; Pasotti, L; Rode-Kristensen, N; Sardu, ML; Smith, GR; Swat, MJ; Terranova, N; Yngman, G; Yvon, F; Holford, N; consortium, DDMoRe;Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics. 1-3 Currently, models are encoded in a variety of computer languages and are shared through publications that rarely include original code and generally lack reproducibility. The DDMoRe Model Description Language (MDL) has been developed primarily as a language standard to facilitate sharing knowledge and understanding of models.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5658286Data sources: PubMed CentralCPT: Pharmacometrics & Systems PharmacologyArticle . 2017 . Peer-reviewedLicense: CC BY NCData sources: CrossrefPublikationer från Uppsala UniversitetArticle . 2017 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/psp4.12222&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 14 citations 14 popularity Average influence Average impulse Top 10% Powered by BIP!visibility 9visibility views 9 download downloads 2 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5658286Data sources: PubMed CentralCPT: Pharmacometrics & Systems PharmacologyArticle . 2017 . Peer-reviewedLicense: CC BY NCData sources: CrossrefPublikationer från Uppsala UniversitetArticle . 2017 . Peer-reviewedData sources: Publikationer från Uppsala Universitetadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/psp4.12222&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1997Publisher:Oxford University Press (OUP) Funded by:WTWTAuthors: Katharina Judith Rowold;Katharina Judith Rowold;doi: 10.1093/gh/15.3.392
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/gh/15.3.392&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/gh/15.3.392&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 NetherlandsPublisher:F1000 Research Ltd Funded by:WTWTFrancien G. Bossema; Peter Burger; Luke Bratton; Aimee Challenger; Rachel Adams; Petroc Sumner; Joop Schat; Mattijs E Numans; Ionica Smeets;Background This research is an investigation into the role of expert quotes in health news, specifically whether news articles containing a quote from an independent expert are less often exaggerated than articles without such a quote. Methods Retrospective quantitative content analysis of journal articles, press releases, and associated news articles was performed. The investigated sample are press releases on peer-reviewed health research and the associated research articles and news stories. Our sample consisted of 462 press releases and 668 news articles from the UK (2011) and 129 press releases and 185 news articles from The Netherlands (2015). We hand-coded all journal articles, press releases and news articles for correlational claims, using a well-tested codebook. The main outcome measures are types of sources that were quoted and exaggeration of correlational claims. We used counts, 2x2 tables and odds ratios to assess the relationship between presence of quotes and exaggeration of the causal claim. Results Overall, 99.1% of the UK press releases and 84.5% of the Dutch press releases contain at least one quote. For the associated news articles these percentages are: 88.6% in the UK and 69.7% in the Netherlands. Authors of the study are most often quoted and only 7.5% of UK and 7.0% of Dutch news articles contained a new quote by an expert source, i.e. one not provided by the press release. The relative odds that an article without an external expert quote contains an exaggeration of causality is 2.6. Conclusions The number of articles containing a quote from an independent expert is low, but articles that cite an external expert do contain less exaggeration.
NARCIS arrow_drop_down Europe PubMed CentralArticle . 2019 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC6619368Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/wellcomeopenres.15147.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!download 18download downloads 18 Powered bymore_vert NARCIS arrow_drop_down Europe PubMed CentralArticle . 2019 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC6619368Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/wellcomeopenres.15147.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United KingdomPublisher:Springer Science and Business Media LLC Funded by:WTWTAuthors: Devolder, Katrien;Devolder, Katrien;AbstractGenome editing in livestock could potentially be used in ways that help resolve some of the most urgent and serious global problems pertaining to livestock, including animal suffering, pollution, antimicrobial resistance, and the spread of infectious disease. But despite this potential, some may object to pursuing it, not because genome editing is wrong in and of itself, but because it is the wrong kind of solution to the problems it addresses: it is merely a ‘technological fix’ to a complex societal problem. Yet though this objection might have wide intuitive appeal, it is often not clear what, exactly, the moral problem is supposed to be. The aim of this paper is to formulate and shed some light on the ‘technological fix objection’ to genome editing in livestock. I suggest that three concerns may underlie it, make implicit assumptions underlying the concerns explicit, and cast some doubt on several of these assumptions, at least as they apply to the use of genome editing to produce pigs resistant to the Porcine Reproductive and Respiratory Syndrome and hornless dairy cattle. I then suggest that the third, and most important, concern could be framed as a concern about complicity in factory farming. I suggest ways to evaluate this concern, and to reduce or offset any complicity in factory farming. Thinking of genome editing’s contribution to factory farming in terms of complicity, may, I suggest, tie it more explicitly and strongly to the wider obligations that come with pursuing it, including the cessation of factory farming, thereby addressing the concern that technological fixes focus only on a narrow problem.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8550048Data sources: PubMed CentralOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveJournal of Agricultural and Environmental EthicsArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10806-021-09858-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 6visibility views 6 download downloads 1 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8550048Data sources: PubMed CentralOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveJournal of Agricultural and Environmental EthicsArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10806-021-09858-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 NetherlandsPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | TRAIN-OLD, WT, EC | MetabinnateEC| TRAIN-OLD ,WT ,EC| MetabinnateAuthors: Luke A. J. O'Neill; Mihai G. Netea;Luke A. J. O'Neill; Mihai G. Netea;Bacillus Calmette–Guérin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19. Could the BCG vaccine be used to bridge the gap until a specific COVID-19 vaccine is developed? Luke O’Neill and Mihai Netea discuss the science behind this approach.
Nature Reviews Immun... arrow_drop_down Nature Reviews ImmunologyOther literature type . Article . 2020 . Peer-reviewedLicense: Springer TDMEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7212510Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41577-020-0337-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 387 citations 387 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!more_vert Nature Reviews Immun... arrow_drop_down Nature Reviews ImmunologyOther literature type . Article . 2020 . Peer-reviewedLicense: Springer TDMEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7212510Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41577-020-0337-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 Italy, Italy, United KingdomPublisher:Springer Science and Business Media LLC Funded by:WTWTClaudio Ottoni; Hannah E.C. Koon; Matthew J. Collins; Kirsty Penkman; Olga Rickards; Oliver E. Craig;Evolutionary biologists are increasingly relying on ancient DNA from archaeological animal bones to study processes such as domestication and population dispersals. As many animal bones found on archaeological sites are likely to have been cooked, the potential for DNA preservation must be carefully considered to maximise the chance of amplification success. Here, we assess the preservation of mitochondrial DNA in a medieval cattle bone assemblage from Coppergate, York, UK. These bones have variable degrees of thermal alterations to bone collagen fibrils, indicative of cooking. Our results show that DNA preservation is not reliant on the presence of intact collagen fibrils. In fact, a greater number of template molecules could be extracted from bones with damaged collagen. We conclude that moderate heating of bone may enhance the retention of DNA fragments. Our results also indicate that ancient DNA preservation is highly variable, even within a relatively recent assemblage from contexts conducive to organic preservation, and that diagenetic parameters based on protein diagenesis are not always useful for predicting ancient DNA survival.
Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2009Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di Roma Tor vergataArticle . 2009Data sources: Archivio della Ricerca - Università di Roma Tor vergataArchivio della Ricerca - Università di Roma Tor vergataArticle . 2009Data sources: Archivio della Ricerca - Università di Roma Tor vergataArchivio della ricerca- Università di Roma La SapienzaArticle . 2009Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00114-008-0478-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 60 citations 60 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 3visibility views 3 Powered bymore_vert Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2009Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di Roma Tor vergataArticle . 2009Data sources: Archivio della Ricerca - Università di Roma Tor vergataArchivio della Ricerca - Università di Roma Tor vergataArticle . 2009Data sources: Archivio della Ricerca - Università di Roma Tor vergataArchivio della ricerca- Università di Roma La SapienzaArticle . 2009Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00114-008-0478-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United KingdomPublisher:Elsevier BV Funded by:WTWTAuthors: Thomas Searle; Zina M. Ibrahim; James T. Teo; Richard Dobson;Thomas Searle; Zina M. Ibrahim; James T. Teo; Richard Dobson;pmid: 34695581
Abstract The current mode of use of Electronic Health Records (EHR) elicits text redundancy. Clinicians often populate new documents by duplicating existing notes, then updating accordingly. Data duplication can lead to propagation of errors, inconsistencies and misreporting of care. Therefore, measures to quantify information redundancy play an essential role in evaluating innovations that operate on clinical narratives. This work is a quantitative examination of information redundancy in EHR notes. We present and evaluate two methods to measure redundancy: an information-theoretic approach and a lexicosyntactic and semantic model. Our first measure trains large Transformer-based language models using clinical text from a large openly available US-based ICU dataset and a large multi-site UK based Hospital. By comparing the information-theoretic efficient encoding of clinical text against open-domain corpora, we find that clinical text is ∼ 1.5 × to ∼ 3 × less efficient than open-domain corpora at conveying information. Our second measure, evaluates automated summarisation metrics Rouge and BERTScore to evaluate successive note pairs demonstrating lexicosyntactic and semantic redundancy, with averages from ∼ 43 to ∼ 65%.
UCL Discovery arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2021Data sources: arXiv.org e-Print ArchiveJournal of Biomedical InformaticsArticle . 2021 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jbi.2021.103938&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert UCL Discovery arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2021Data sources: arXiv.org e-Print ArchiveJournal of Biomedical InformaticsArticle . 2021 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jbi.2021.103938&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Publisher:Informa UK Limited Funded by:WTWTAuthors: Kristin Hay;Kristin Hay;In 1967, the Abortion Act was passed which legalised terminations conducted by a doctor between the first and twenty-fourth week of pregnancy in Britain. Despite having abortion legalised in law, the cultural shift from the prejudiced to permissive took far longer to arrive, and women continued to face barriers to their reproductive autonomy in the 1970s and 1980s. The inequalities in abortion healthcare were most pronounced in Scotland, prompting the emergence of the Scottish Abortion Campaign in 1980. This article explores the role of the Scottish Abortion Campaign and their efforts to defend and extend the Abortion Act of 1967 in post-legalisation Scotland. Through archival research and oral testimony, this article demonstrates that the SAC operated semi-autonomously from the broader National Abortion Campaign, demonstrating a distinctive, Scottish feminist identity that influenced their activities during this period.
CORE (RIOXX-UK Aggre... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/09612025.2020.1791405&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!visibility 7visibility views 7 download downloads 20 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015Publisher:Elsevier BV Funded by:WTWTAuthors: Abecasis, Gonçalo R.;Abecasis, Gonçalo R.;Thank you very much. I would first like to thank the Awards Committee, The Society, and all of you who are here this morning. For the past 15 years, I have treasured coming to this meeting, which is always full of energy, ideas, and brilliant scientists. To be honest, I find it hard to see myself in Aravinda Chakravarti’s and Michael Boehnke’s kind description of me, and in the next few minutes, I will probably disprove their claim that I am a good communicator. I stand before you trembling.
The American Journal... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert The American Journal... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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