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description Publicationkeyboard_double_arrow_right Review , Article 2014Publisher:Springer Science and Business Media LLC Funded by:WTWTAuthors: Gan, Victor C.;Gan, Victor C.;Opinion statement Treatment of dengue remains supportive in the absence of targeted antiviral therapy or approved vaccines. Responsive fluid management is key to preventing progression to shock or other severe manifestations. The dynamic natural history of dengue infection and its influence on hemodynamic homeostasis needs to be carefully considered in the planning of individualized therapy. Though largely self-limiting, the sheer burden of dengue disease on the global population will result in atypical manifestations especially in children, older adults, and comorbid patients. Management of these has not yet been systematized. The failure of recent randomized controlled trials to show utility for antiviral and immunomodulatory agents in dengue is disappointing. Vaccine candidates hold promise, but growing outbreaks require more robust, evidence-based management guidelines to inform clinicians, especially in novel epidemic situations.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4431705Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 22 citations 22 popularity Top 10% influence Top 10% impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4431705Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United Kingdom, Germany, Australia, Germany, United Kingdom, Sweden, United Kingdom, Netherlands, Australia, Italy, Poland, United Kingdom, Sweden, SwedenPublisher:Elsevier BV Publicly fundedFunded by:FCT | SFRH/BPD/92934/2013, WT | Defining the population a..., SNSF | Morbidity and cost of hel...FCT| SFRH/BPD/92934/2013 ,WT| Defining the population at risk and burden of disease of Plasmodium vivax malaria. ,SNSF| Morbidity and cost of helminth infections: fitting existing and investigating missing pieces of evidenceAuthors: Zulfiqar A Bhutta; Matthew M Coates; Khassoum Diallo; Elisabeth Barboza França; +331 AuthorsZulfiqar A Bhutta; Matthew M Coates; Khassoum Diallo; Elisabeth Barboza França; Simon I. Hay; Yohannes Kinfu; Xie Rachel Kulikoff; Heidi J. Larson; Xiaofeng Liang; Margaret Lind; Rafael Lozano; George A. Mensah; Ali H. Mokdad; Meghan D. Mooney; Grant Nguyen; Ivo Rakovac; Joshua A. Salomon; Naris Silpakit; Amber Sligar; Amanuel Alemu Abajobir; Foad Abd-Allah; Semaw Ferede Abera; Victor Aboyans; Biju Abraham; Ibrahim Abubakar; Laith J. Abu-Raddad; Gebre Yitayih Abyu; Tom Achoki; Akindele Olupelumi Adebiyi; Ademola Lukman Adelekan; Oluremi N Ajala; Khurshid Alam; Noore Alam; Deena Alasfoor; Robert W Aldridge; Miguel Angel Alegretti; Zewdie Aderaw Alemu; Ala'a Alkerwi; François Alla; Rajaa Al-Raddadi; Ubai Alsharif; Khalid A Altirkawi; Nelson Alvis-Guzman; Walid Ammar; Hjalte Holm Andersen; Carl Abelardo T. Antonio; Johan Ärnlöv; Al Artaman; Hamid Asayesh; Rana Jawad Asghar; Reza Assadi; Suleman Atique; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Kalpana Balakrishnan; Amitava Banerjee; Aleksandra Barac; Lope H Barrero; Yibeltal Tebekaw Bayou; Justin Beardsley; Neeraj Bedi; Aminu K. Bello; Derrick A Bennett; Isabela M. Benseñor; Adugnaw Berhane; Eduardo Bernabé; Balem Demtsu Betsu; Samir Bhatt; Sibhatu Biadgilign; Boris Bikbov; Sait Mentes Birlik; Rupert R A Bourne; Michael Brainin; Alexandra Brazinova; Nicholas J K Breitborde; Geoffrey Buckle; Daniel C Casey; Carlos A Castañeda-Orjuela; Jacqueline Castillo Rivas; Ruben Castro; Ferrán Catalá-López; Jung-Chen Chang; Chioma Ezinne Chibueze; Vesper Hichilombwe Chisumpa; Rajiv Chowdhury; Devasahayam J. Christopher; Liliana G Ciobanu; Samantha M. Colquhoun; Leslie Cornaby; Solomon Abrha Damtew; Rakhi Dandona; José Neves; Pieter de Jager; Diego De Leo; Louisa Degenhardt; Kebede Deribe; Amare Deribew; Preet K Dhillon; Eric L. Ding; Kerrie E. Doyle; Manisha Dubey; Hedyeh Ebrahimi; Iqbal R. F. Elyazar; Aman Yesuf Endries; Sergey Petrovich Ermakov; Alireza Esteghamati; Carla Sofia e Sa Farinha; Maryam S. Farvid; Farshad Farzadfar; Florian Fischer; Nataliya Foigt; Richard C. Franklin; Amiran Gamkrelidze; Parthasarathi Ganguly; Tsegaye Tewelde Gebrehiwot; Amanuel Tesfay Gebremedhin; Johanna M. Geleijnse; Bradford D. Gessner; Ibrahim Abdelmageem Mohamed Ginawi; Melkamu Dedefo Gishu; Philimon Gona; Amador Goodridge; Sameer Vali Gopalani; Atsushi Goto; Hebe N. Gouda; Yuming Guo; Bishal Gyawali; Juanita A. Haagsma; Gessessew Bugssa Hailu; Samer Hamidi; Graeme J. Hankey; Sivadasanpillai Harikrishnan; Ileana Heredia-Pi; Hans W. Hoek; H. Dean Hosgood; Damian G Hoy; Mohamed Hsairi; Guoqing Hu; John J Huang; Laetitia Huiart; Chantal Huynh; Kaire Innos; Kathryn H. Jacobsen; Nader Jahanmehr; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Vivekanand Jha; Zubair Kabir; Yogeshwar Kalkonde; Ritul Kamal; Haidong Kan; Gagandeep Kang; André Karch; Corine Karema; Amir Kasaeian; Norito Kawakami; Jeanne Françoise Kayibanda; Peter Njenga Keiyoro; Andrew H. Kemp; Andre Pascal Kengne; Maia Kereselidze; Yousef Khader; Ejaz Ahmad Khan; Young-Ho Khang; Jagdish Khubchandani; Daniel Kim; Yun Jin Kim; Niranjan Kissoon; Miia Kivipelto; Luke D. Knibbs; Yoshihiro Kokubo; Soewarta Kosen; Parvaiz A Koul; Ai Koyanagi; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Andreas A Kudom; Michael Kutz; Ratilal Lalloo; Van C. Lansingh; Anders Larsson; Ricky Leung; Yichong Li; Shiwei Liu; Belinda K Lloyd; Warren D. Lo; Giancarlo Logroscino; Nicola Low; Raimundas Lunevicius; Ronan A Lyons; Hassan Magdy Abd El Razek; Mahdi Mahdavi; Marek Majdan; Azeem Majeed; Jose Martinez-Raga; John J. McGrath; Man Mohan Mehndiratta; Alemayehu B. Mekonnen; Yohannes Adama Melaku; Atte Meretoja; Francis Apolinary Mhimbira; Ted R. Miller; Edward J Mills; Charles N Mock; Alireza Mohammadi; Shafiu Mohammed; Lorenzo Monasta; Julio Cesar Montañez Hernandez; Marcella Montico; Ami R. Moore; Maziar Moradi-Lakeh; Lidia Morawska; Rintaro Mori; Georgina A. V. Murphy; Srinivas Murthy; Jean B. Nachega; Aliya Naheed; Luigi Naldi; Devina Nand; Subas Neupane; John N Newton; Marie Ng; Peter Nguhiu; Quyen Nguyen; Muhammad Imran Nisar; Ole Frithjof Norheim; Rosana E. Norman; Pedro R. Olivares; Bolajoko O. Olusanya; Jacob Olusegun Olusanya; Eyal Oren; Erika Ota; Padukudru Anand Mahesh; Mahboubeh Parsaeian; João Mário Pedro; David M. Pereira; Norberto Perico; Konrad Pesudovs; Michael R. Phillips; Julian David Pillay; Farhad Pishgar; Suzanne Polinder; Mostafa Qorbani; Vafa Rahimi-Movaghar; Mahfuzar Rahman; Mohammad Hifz Ur Rahman; Sajjad Ur Rahman; Rajesh Kumar Rai; Giuseppe Remuzzi; Gholamreza Roshandel; Gregory A. Roth; Ambuj Roy; George Mugambage Ruhago; Rajesh Sagar; Muhammad Muhammad Saleh; Maria Dolores Sanchez-Niño; Itamar S. Santos; João Vasco Santos; Rodrigo Sarmiento-Suarez; Benn Sartorius; Maheswar Satpathy; Ione Jayce Ceola Schneider; Ben Schöttker; Soraya Seedat; Edson Serván-Mori; Tesfaye Setegn; Marina Shakh-Nazarova; Rajesh Sharma; Jun She; Sara Sheikhbahaei; Jiabin Shen; Kenji Shibuya; Min-Jeong Shin; Rahman Shiri; Ivy Shuie; Inga Dora Sigfusdottir; Diego Augusto Santos Silva; Jonathan I. Silverberg; Shireen Sindi; Abhishek Singh; Om Prakash Singh; Joan B. Soriano; Sergey Soshnikov; Chandrashekhar T Sreeramareddy; Nicholas Steel; Konstantinos Stroumpoulis; Lela Sturua; Bruno F. Sunguya; Soumya Swaminathan; Cassandra Szoeke; Rafael Tabarés-Seisdedos; Bineyam Taye; Bemnet Amare Tedla; Abdullah Sulieman Terkawi; Fisaha Haile Tesfay; Gizachew Assefa Tessema; Andrew L. Thorne-Lyman; Ruoyan Tobe-Gai; Marcello Tonelli; Fotis Topouzis; Bach Xuan Tran; Christopher Troeger; Zacharie Tsala Dimbuene; Stefanos Tyrovolas; Kingsley N. Ukwaja; Chigozie Jesse Uneke; Olalekan A. Uthman; Tommi Vasankari; Ana Maria Nogales Vasconcelos; Raj Kumar Verma; Vasiliy Victorovich Vlassov; Scott Weichenthal; Elisabete Weiderpass; Daniel J. Weiss; Ronny Westerman; Tissa Wijeratne; Charles Shey Wiysonge; Charles D.A. Wolfe; Ingrid Wolfe; Sungho Won; Mamo Wubshet; Gelin Xu; Bereket Yakob; Yuichiro Yano; Mehdi Yaseri; Pengpeng Ye; Henock Yebyo; Paul S. F. Yip; Seok Jun Yoon; Mustafa Z. Younis; Zoubida Zaidi; Maysaa El Sayed Zaki; Hajo Zeeb; Maigeng Zhou; Sanjay Zodpey;pmc: PMC5224696
BACKGROUND: Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time. METHODS: Drawing from analytical approaches developed and refined in previous iterations of the GBD study, we generated updated estimates of child mortality by age group (neonatal, post-neonatal, ages 1-4 years, and under 5) for 195 countries and territories and selected subnational geographies, from 1980-2015. We also estimated numbers and rates of stillbirths for these geographies and years. Gaussian process regression with data source adjustments for sampling and non-sampling bias was applied to synthesise input data for under-5 mortality for each geography. Age-specific mortality estimates were generated through a two-stage age-sex splitting process, and stillbirth estimates were produced with a mixed-effects model, which accounted for variable stillbirth definitions and data source-specific biases. For GBD 2015, we did a series of novel analyses to systematically quantify the drivers of trends in child mortality across geographies. First, we assessed observed and expected levels and annualised rates of decrease for under-5 mortality and stillbirths as they related to the Soci-demographic Index (SDI). Second, we examined the ratio of recorded and expected levels of child mortality, on the basis of SDI, across geographies, as well as differences in recorded and expected annualised rates of change for under-5 mortality. Third, we analysed levels and cause compositions of under-5 mortality, across time and geographies, as they related to rising SDI. Finally, we decomposed the changes in under-5 mortality to changes in SDI at the global level, as well as changes in leading causes of under-5 deaths for countries and territories. We documented each step of the GBD 2015 child mortality estimation process, as well as data sources, in accordance with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). FINDINGS: Globally, 5·8 million (95% uncertainty interval [UI] 5·7-6·0) children younger than 5 years died in 2015, representing a 52·0% (95% UI 50·7-53·3) decrease in the number of under-5 deaths since 1990. Neonatal deaths and stillbirths fell at a slower pace since 1990, decreasing by 42·4% (41·3-43·6) to 2·6 million (2·6-2·7) neonatal deaths and 47·0% (35·1-57·0) to 2·1 million (1·8-2·5) stillbirths in 2015. Between 1990 and 2015, global under-5 mortality decreased at an annualised rate of decrease of 3·0% (2·6-3·3), falling short of the 4·4% annualised rate of decrease required to achieve MDG4. During this time, 58 countries met or exceeded the pace of progress required to meet MDG4. Between 2000, the year MDG4 was formally enacted, and 2015, 28 additional countries that did not achieve the 4·4% rate of decrease from 1990 met the MDG4 pace of decrease. However, absolute levels of under-5 mortality remained high in many countries, with 11 countries still recording rates exceeding 100 per 1000 livebirths in 2015. Marked decreases in under-5 deaths due to a number of communicable diseases, including lower respiratory infections, diarrhoeal diseases, measles, and malaria, accounted for much of the progress in lowering overall under-5 mortality in low-income countries. Compared with gains achieved for infectious diseases and nutritional deficiencies, the persisting toll of neonatal conditions and congenital anomalies on child survival became evident, especially in low-income and low-middle-income countries. We found sizeable heterogeneities in comparing observed and expected rates of under-5 mortality, as well as differences in observed and expected rates of change for under-5 mortality. At the global level, we recorded a divergence in observed and expected levels of under-5 mortality starting in 2000, with the observed trend falling much faster than what was expected based on SDI through 2015. Between 2000 and 2015, the world recorded 10·3 million fewer under-5 deaths than expected on the basis of improving SDI alone. INTERPRETATION: Gains in child survival have been large, widespread, and in many places in the world, faster than what was anticipated based on improving levels of development. Yet some countries, particularly in sub-Saharan Africa, still had high rates of under-5 mortality in 2015. Unless these countries are able to accelerate reductions in child deaths at an extraordinary pace, their achievement of proposed SDG targets is unlikely. Improving the evidence base on drivers that might hasten the pace of progress for child survival, ranging from cost-effective intervention packages to innovative financing mechanisms, is vital to charting the pathways for ultimately ending preventable child deaths by 2030. FUNDING: Bill & Melinda Gates Foundation. Erratum: Department of Error, The Lancet,Volume 389, Issue 10064, 2017, Page e1. DOI: 10.1016/S0140-6736(16)32608-3
CORE (RIOXX-UK Aggre... arrow_drop_down Helmholtz Zentrum für Infektionsforschung RepositoryArticle . 2016License: CC BY NC SAData sources: Helmholtz Zentrum für Infektionsforschung RepositorySpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryFachrepositorium LebenswissenschaftenArticle . 2016Data sources: Fachrepositorium LebenswissenschaftenRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTAOxford University Research ArchiveArticle . 2018License: CC BYData sources: Oxford University Research ArchiveNARCIS; The LancetArticle . 2016UniSA Research Outputs RepositoryArticle . 2016 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 533 citations 533 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 24visibility views 24 download downloads 57 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Helmholtz Zentrum für Infektionsforschung RepositoryArticle . 2016License: CC BY NC SAData sources: Helmholtz Zentrum für Infektionsforschung RepositorySpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryFachrepositorium LebenswissenschaftenArticle . 2016Data sources: Fachrepositorium LebenswissenschaftenRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTAOxford University Research ArchiveArticle . 2018License: CC BYData sources: Oxford University Research ArchiveNARCIS; The LancetArticle . 2016UniSA Research Outputs RepositoryArticle . 2016 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2007 Italy, GermanyPublisher:Springer Science and Business Media LLC Funded by:NIH | A Core Database of Intera..., WTNIH| A Core Database of Interacting Proteins ,WTSamuel Kerrien; Sandra Orchard; Luisa Montecchi-Palazzi; Bruno Aranda; Antony F. Quinn; Nisha Vinod; Gary D. Bader; Ioannis Xenarios; Jérôme Wojcik; David James Sherman; Mike Tyers; John J. Salama; Susan Moore; Arnaud Ceol; Andrew Chatr-aryamontri; Matthias Oesterheld; Volker Stümpflen; Lukasz Salwinski; Jason Nerothin; Ethan Cerami; Michael E. Cusick; Marc Vidal; Michael K. Gilson; John Armstrong; Peter Woollard; Christopher W. V. Hogue; David Eisenberg; Gianni Cesareni; Rolf Apweiler; Henning Hermjakob;Abstract Background Molecular interaction Information is a key resource in modern biomedical research. Publicly available data have previously been provided in a broad array of diverse formats, making access to this very difficult. The publication and wide implementation of the Human Proteome Organisation Proteomics Standards Initiative Molecular Interactions (HUPO PSI-MI) format in 2004 was a major step towards the establishment of a single, unified format by which molecular interactions should be presented, but focused purely on protein-protein interactions. Results The HUPO-PSI has further developed the PSI-MI XML schema to enable the description of interactions between a wider range of molecular types, for example nucleic acids, chemical entities, and molecular complexes. Extensive details about each supported molecular interaction can now be captured, including the biological role of each molecule within that interaction, detailed description of interacting domains, and the kinetic parameters of the interaction. The format is supported by data management and analysis tools and has been adopted by major interaction data providers. Additionally, a simpler, tab-delimited format MITAB2.5 has been developed for the benefit of users who require only minimal information in an easy to access configuration. Conclusion The PSI-MI XML2.5 and MITAB2.5 formats have been jointly developed by interaction data producers and providers from both the academic and commercial sector, and are already widely implemented and well supported by an active development community. PSI-MI XML2.5 enables the description of highly detailed molecular interaction data and facilitates data exchange between databases and users without loss of information. MITAB2.5 is a simpler format appropriate for fast Perl parsing or loading into Microsoft Excel.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2007Full-Text: http://europepmc.org/articles/PMC2189715Data sources: PubMed CentralPublication Server of Helmholtz Zentrum München (PuSH)Article . 2007Data sources: Publication Server of Helmholtz Zentrum München (PuSH)BMC Biology; Archivio della Ricerca - Università di Roma Tor vergataArticle . 2007 . Peer-reviewedLicense: CC BYArchivio della Ricerca - Università di Roma Tor vergataArticle . 2007Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 265 citations 265 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2007Full-Text: http://europepmc.org/articles/PMC2189715Data sources: PubMed CentralPublication Server of Helmholtz Zentrum München (PuSH)Article . 2007Data sources: Publication Server of Helmholtz Zentrum München (PuSH)BMC Biology; Archivio della Ricerca - Università di Roma Tor vergataArticle . 2007 . Peer-reviewedLicense: CC BYArchivio della Ricerca - Università di Roma Tor vergataArticle . 2007Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Denmark, United Kingdom, Italy, PeruPublisher:Elsevier BV Funded by:WT | Health and economic impac..., UKRI | UK Centre for Research on..., WT | Lancet Countdown: Trackin... +5 projectsWT| Health and economic impacts of urban heat islands and greenspace ,UKRI| UK Centre for Research on Energy Demand ,WT| Lancet Countdown: Tracking Progress on Health and Climate Change ,WT| Complex Urban Systems for Sustainability and Health (London Hub) ,UKRI| Developing integrated environmental indicators for sustainable global food production and trade ,UKRI| UK Energy Research Centre Phase 4 ,UKRI| Human health in an increasingly urbanized and warming world ,WT| Sustainable and Healthy Food Systems (SHEFS)Romanello, Marina; McGushin, Alice; Di Napoli, Claudia; Drummond, Paul; Hughes, Nick; Jamart, Louis; Kennard, Harry; Lampard, Pete; Rodriguez, Baltazar Solano; Arnell, Nigel; Ayeb-Karlsson, Sonja; Belesova, Kristine; Cai, Wenjia; Campbell-Lendrum, Diarmid; Capstick, Stuart; Chambers, Jonathan; Chu, Lingzhi; Ciampi, Luisa; Dalin, Carole; Dasandi, Niheer; Dasgupta, Shoura; Davies, Michael; Dominguez-Salas, Paula; Dubrow, Robert; Ebi, Kristie; Eckelman, Matthew; Ekins, Paul; Escobar, Luis; Georgeson, Lucien; Grace, Delia; Graham, Hilary; Gunther, Samuel; Hartinger, Stella; He, Kehan; Heaviside, C.; Hess, Jeremy; Hsu, Shih-Che; Jankin, Slava; Jimenez, Marcia; Kelman, Ilan; Kiesewetter, Gregor; Kinney, Patrick; Kjellstrom, Tord; Kniveton, Dominic; Lee, J.; Lemke, Bruno; Liu, Y; Liu, Z.; Lott, Melissa; Lowe, Rachel; Martinez-Urtaza, Jaime; Maslin, Mark; McAllister, Lucy; McMichael, Celia; Mi, Zhifu; Milner, James; Minor, Kelton; Mohajeri, Nahid; Moradi-Lakeh, Maziar; Morrissey, Karyn; Munzert, Simon; Murray, Kris; Neville, Tara; Nilsson, Maria; Obradovich, Nick; Odhiambo Sewe, Maquins; Oreszczyn, Tadj; Otto, Matthias; Owfi, Fereidoon; Pearman, Olivia; Pencheon, David; Rabbaniha, Mahnaz; Robinson, Elizabeth; Rocklöv, Joacim; Salas, Renee; Semenza, Jan; Sherman, Jodi; Shi, Liuhua; Springmann, Marco; Tabatabaei, Meisam; Taylor, J; Trinanes, Joaquin; Shumake-Guillemot, Joy; Vu, Bryan; Wagner, Fabian; Wilkinson, Paul; Winning, Matthew; Yglesias, Marisol; Zhang, S; Gong, Peng; Montgomery, Hugh; Costello, Anthony; Hamilton, Ian;The Lancet Countdown is an international collaboration that independently monitors the health consequences of a changing climate. Publishing updated, new, and improved indicators each year, the Lancet Countdown represents the consensus of leading researchers from 43 academic institutions and UN agencies. The 44 indicators of this report expose an unabated rise in the health impacts of climate change and the current health consequences of the delayed and inconsistent response of countries around the globe—providing a clear imperative for accelerated action that puts the health of people and planet above all else.\ud \ud The 2021 report coincides with the UN Framework Convention on Climate Change 26th Conference of the Parties (COP26), at which countries are facing pressure to realise the ambition of the Paris Agreement to keep the global average temperature rise to 1·5°C and to mobilise the financial resources required for all countries to have an effective climate response. These negotiations unfold in the context of the COVID-19 pandemic—a global health crisis that has claimed millions of lives, affected livelihoods and communities around the globe, and exposed deep fissures and inequities in the world's capacity to cope with, and respond to, health emergencies. Yet, in its response to both crises, the world is faced with an unprecedented opportunity to ensure a healthy future for all.
CORE (RIOXX-UK Aggre... arrow_drop_down Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 222 citations 222 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 117visibility views 117 download downloads 995 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United States, Netherlands, DenmarkPublisher:Hindawi Limited Funded by:WT | Studies in Co-creating As...WT| Studies in Co-creating Assisted Living Solutions.Jose L. Jimenez; Linsey C. Marr; Katherine Randall; Edward Thomas Ewing; Zeynep Tufekci; Trish Greenhalgh; Raymond Tellier; Julian W. Tang; Yuguo Li; Lidia Morawska; Jonathan Mesiano‐Crookston; David Fisman; Orla Hegarty; Stephanie J. Dancer; Philomena M. Bluyssen; Giorgio Buonanno; Marcel G. L. C. Loomans; William P. Bahnfleth; Maosheng Yao; Chandra Sekhar; Pawel Wargocki; Arsen K. Melikov; Kimberly A. Prather;Abstract The question of whether SARS-CoV-2 is mainly transmitted by droplets or aerosols has been highly controversial. We sought to explain this controversy through a historical analysis of transmission research in other diseases. For most of human history, the dominant paradigm was that many diseases were carried by the air, often over long distances and in a phantasmagorical way. This miasmatic paradigm was challenged in the mid to late 19th century with the rise of germ theory, and as diseases such as cholera, puerperal fever, and malaria were found to actually transmit in other ways. Motivated by his views on the importance of contact/droplet infection, and the resistance he encountered from the remaining influence of miasma theory, prominent public health official Charles Chapin in 1910 helped initiate a successful paradigm shift, deeming airborne transmission most unlikely. This new paradigm became dominant. However, the lack of understanding of aerosols led to systematic errors in the interpretation of research evidence on transmission pathways. For the next five decades, airborne transmission was considered of negligible or minor importance for all major respiratory diseases, until a demonstration of airborne transmission of tuberculosis (which had been mistakenly thought to be transmitted by droplets) in 1962. The contact/droplet paradigm remained dominant, and only a few diseases were widely accepted as airborne before COVID-19: those that were clearly transmitted to people not in the same room. The acceleration of interdisciplinary research inspired by the COVID-19 pandemic has shown that airborne transmission is a major mode of transmission for this disease, and is likely to be significant for many respiratory infectious diseases. Indoor Environment
NARCIS arrow_drop_down Online Research Database In TechnologyArticle . 2022Data sources: Online Research Database In TechnologyeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 33 citations 33 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 8visibility views 8 download downloads 35 Powered bymore_vert NARCIS arrow_drop_down Online Research Database In TechnologyArticle . 2022Data sources: Online Research Database In TechnologyeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 France, United Kingdom, France, Italy, United States, CroatiaPublisher:Springer Science and Business Media LLC Funded by:WT | Human Adaptation to Chang..., NIH | Integrative nutrigenomic ..., WT | Wellcome Trust Sanger Ins... +9 projectsWT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,NIH| Integrative nutrigenomic and metabolomic analyses of Africans with variable diets ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,ARC| The origin of the first Australians ,ANR| OCEOADAPTO ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,EC| NEFREX ,EC| LocalAdaptation ,NIH| Integrative Genomics of Body Size and Metabolism in Ethnically Diverse Africans ,EC| ePerMed ,ARC| Discovery Projects - Grant ID: DP140101405 ,EC| MALADAPTEDLuca Pagani; Daniel Lawson; Evelyn Jagoda; Alexander Mörseburg; Anders Eriksson; Mario Mitt; Florian Clemente; Georgi Hudjashov; Michael DeGiorgio; Lauri Saag; Jeffrey D. Wall; Alexia Cardona; Reedik Mägi; Melissa A. Wilson Sayres; Sarah Kaewert; Charlotte E. Inchley; Christiana L. Scheib; Mari Järve; Monika Karmin; Guy S. Jacobs; Tiago Antao; Florin Mircea Iliescu; Alena Kushniarevich; Qasim Ayub; Chris Tyler-Smith; Yali Xue; Bayazit Yunusbayev; Kristiina Tambets; Chandana Basu Mallick; Lehti Saag; Elvira Pocheshkhova; George Andriadze; Craig Muller; Michael C. Westaway; David M. Lambert; Grigor Zoraqi; Shahlo Turdikulova; Dilbar Dalimova; Zhaxylyk Sabitov; Gazi Nurun Nahar Sultana; Joseph Lachance; Sarah A. Tishkoff; Kuvat T. Momynaliev; Jainagul Isakova; Larisa Damba; Marina Gubina; Pagbajabyn Nymadawa; Irina Evseeva; L. A. Atramentova; Olga Utevska; François-Xavier Ricaut; Nicolas Brucato; Herawati Sudoyo; Thierry Letellier; Murray P. Cox; Nikolay A. Barashkov; Vedrana Škaro; Lejla Mulahasanovic; Dragan Primorac; Hovhannes Sahakyan; Maru Mormina; Christina A. Eichstaedt; Daria V. Lichman; S M Abdullah; Gyaneshwer Chaubey; Joseph Wee; Evelin Mihailov; A. S. Karunas; Sergei Litvinov; Rita Khusainova; N. V. Ekomasova; V. L. Akhmetova; I. M. Khidiyatova; Damir Marjanović; Levon Yepiskoposyan; Doron M. Behar; Elena Balanovska; Andres Metspalu; Miroslava Derenko; Boris Malyarchuk; Mikhail Voevoda; Sardana A. Fedorova; Ludmila P. Osipova; Marta Mirazón Lahr; Pascale Gerbault; Matthew Leavesley; Andrea Bamberg Migliano; Michael D. Petraglia; Oleg Balanovsky; Elza Khusnutdinova; Ene Metspalu; Mark G. Thomas; Andrea Manica; Rasmus Nielsen; Richard Villems; Eske Willerslev; Toomas Kivisild; Mait Metspalu;pmc: PMC5164938
High-coverage whole-genome sequence studies have so far focused on a limited number1 of geographically restricted populations2, 3, 4, 5, or been targeted at specific diseases, such as cancer6. Nevertheless, the availability of high- resolution genomic data has led to the development of new methodologies for inferring population history7, 8, 9 and refuelled the debate on the mutation rate in humans10. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record11, and admixture between AMHs and Neanderthals predating the main Eurasian expansion12, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75, 000 years ago.
Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5164938Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 329 citations 329 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 19visibility views 19 download downloads 93 Powered bymore_vert Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5164938Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Review , Article 2014Publisher:Springer Science and Business Media LLC Funded by:WTWTAuthors: Gan, Victor C.;Gan, Victor C.;Opinion statement Treatment of dengue remains supportive in the absence of targeted antiviral therapy or approved vaccines. Responsive fluid management is key to preventing progression to shock or other severe manifestations. The dynamic natural history of dengue infection and its influence on hemodynamic homeostasis needs to be carefully considered in the planning of individualized therapy. Though largely self-limiting, the sheer burden of dengue disease on the global population will result in atypical manifestations especially in children, older adults, and comorbid patients. Management of these has not yet been systematized. The failure of recent randomized controlled trials to show utility for antiviral and immunomodulatory agents in dengue is disappointing. Vaccine candidates hold promise, but growing outbreaks require more robust, evidence-based management guidelines to inform clinicians, especially in novel epidemic situations.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4431705Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s40506-014-0025-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 22 citations 22 popularity Top 10% influence Top 10% impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4431705Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United Kingdom, Germany, Australia, Germany, United Kingdom, Sweden, United Kingdom, Netherlands, Australia, Italy, Poland, United Kingdom, Sweden, SwedenPublisher:Elsevier BV Publicly fundedFunded by:FCT | SFRH/BPD/92934/2013, WT | Defining the population a..., SNSF | Morbidity and cost of hel...FCT| SFRH/BPD/92934/2013 ,WT| Defining the population at risk and burden of disease of Plasmodium vivax malaria. ,SNSF| Morbidity and cost of helminth infections: fitting existing and investigating missing pieces of evidenceAuthors: Zulfiqar A Bhutta; Matthew M Coates; Khassoum Diallo; Elisabeth Barboza França; +331 AuthorsZulfiqar A Bhutta; Matthew M Coates; Khassoum Diallo; Elisabeth Barboza França; Simon I. Hay; Yohannes Kinfu; Xie Rachel Kulikoff; Heidi J. Larson; Xiaofeng Liang; Margaret Lind; Rafael Lozano; George A. Mensah; Ali H. Mokdad; Meghan D. Mooney; Grant Nguyen; Ivo Rakovac; Joshua A. Salomon; Naris Silpakit; Amber Sligar; Amanuel Alemu Abajobir; Foad Abd-Allah; Semaw Ferede Abera; Victor Aboyans; Biju Abraham; Ibrahim Abubakar; Laith J. Abu-Raddad; Gebre Yitayih Abyu; Tom Achoki; Akindele Olupelumi Adebiyi; Ademola Lukman Adelekan; Oluremi N Ajala; Khurshid Alam; Noore Alam; Deena Alasfoor; Robert W Aldridge; Miguel Angel Alegretti; Zewdie Aderaw Alemu; Ala'a Alkerwi; François Alla; Rajaa Al-Raddadi; Ubai Alsharif; Khalid A Altirkawi; Nelson Alvis-Guzman; Walid Ammar; Hjalte Holm Andersen; Carl Abelardo T. Antonio; Johan Ärnlöv; Al Artaman; Hamid Asayesh; Rana Jawad Asghar; Reza Assadi; Suleman Atique; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Kalpana Balakrishnan; Amitava Banerjee; Aleksandra Barac; Lope H Barrero; Yibeltal Tebekaw Bayou; Justin Beardsley; Neeraj Bedi; Aminu K. Bello; Derrick A Bennett; Isabela M. Benseñor; Adugnaw Berhane; Eduardo Bernabé; Balem Demtsu Betsu; Samir Bhatt; Sibhatu Biadgilign; Boris Bikbov; Sait Mentes Birlik; Rupert R A Bourne; Michael Brainin; Alexandra Brazinova; Nicholas J K Breitborde; Geoffrey Buckle; Daniel C Casey; Carlos A Castañeda-Orjuela; Jacqueline Castillo Rivas; Ruben Castro; Ferrán Catalá-López; Jung-Chen Chang; Chioma Ezinne Chibueze; Vesper Hichilombwe Chisumpa; Rajiv Chowdhury; Devasahayam J. Christopher; Liliana G Ciobanu; Samantha M. Colquhoun; Leslie Cornaby; Solomon Abrha Damtew; Rakhi Dandona; José Neves; Pieter de Jager; Diego De Leo; Louisa Degenhardt; Kebede Deribe; Amare Deribew; Preet K Dhillon; Eric L. Ding; Kerrie E. Doyle; Manisha Dubey; Hedyeh Ebrahimi; Iqbal R. F. Elyazar; Aman Yesuf Endries; Sergey Petrovich Ermakov; Alireza Esteghamati; Carla Sofia e Sa Farinha; Maryam S. Farvid; Farshad Farzadfar; Florian Fischer; Nataliya Foigt; Richard C. Franklin; Amiran Gamkrelidze; Parthasarathi Ganguly; Tsegaye Tewelde Gebrehiwot; Amanuel Tesfay Gebremedhin; Johanna M. Geleijnse; Bradford D. Gessner; Ibrahim Abdelmageem Mohamed Ginawi; Melkamu Dedefo Gishu; Philimon Gona; Amador Goodridge; Sameer Vali Gopalani; Atsushi Goto; Hebe N. Gouda; Yuming Guo; Bishal Gyawali; Juanita A. Haagsma; Gessessew Bugssa Hailu; Samer Hamidi; Graeme J. Hankey; Sivadasanpillai Harikrishnan; Ileana Heredia-Pi; Hans W. Hoek; H. Dean Hosgood; Damian G Hoy; Mohamed Hsairi; Guoqing Hu; John J Huang; Laetitia Huiart; Chantal Huynh; Kaire Innos; Kathryn H. Jacobsen; Nader Jahanmehr; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Vivekanand Jha; Zubair Kabir; Yogeshwar Kalkonde; Ritul Kamal; Haidong Kan; Gagandeep Kang; André Karch; Corine Karema; Amir Kasaeian; Norito Kawakami; Jeanne Françoise Kayibanda; Peter Njenga Keiyoro; Andrew H. Kemp; Andre Pascal Kengne; Maia Kereselidze; Yousef Khader; Ejaz Ahmad Khan; Young-Ho Khang; Jagdish Khubchandani; Daniel Kim; Yun Jin Kim; Niranjan Kissoon; Miia Kivipelto; Luke D. Knibbs; Yoshihiro Kokubo; Soewarta Kosen; Parvaiz A Koul; Ai Koyanagi; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Andreas A Kudom; Michael Kutz; Ratilal Lalloo; Van C. Lansingh; Anders Larsson; Ricky Leung; Yichong Li; Shiwei Liu; Belinda K Lloyd; Warren D. Lo; Giancarlo Logroscino; Nicola Low; Raimundas Lunevicius; Ronan A Lyons; Hassan Magdy Abd El Razek; Mahdi Mahdavi; Marek Majdan; Azeem Majeed; Jose Martinez-Raga; John J. McGrath; Man Mohan Mehndiratta; Alemayehu B. Mekonnen; Yohannes Adama Melaku; Atte Meretoja; Francis Apolinary Mhimbira; Ted R. Miller; Edward J Mills; Charles N Mock; Alireza Mohammadi; Shafiu Mohammed; Lorenzo Monasta; Julio Cesar Montañez Hernandez; Marcella Montico; Ami R. Moore; Maziar Moradi-Lakeh; Lidia Morawska; Rintaro Mori; Georgina A. V. Murphy; Srinivas Murthy; Jean B. Nachega; Aliya Naheed; Luigi Naldi; Devina Nand; Subas Neupane; John N Newton; Marie Ng; Peter Nguhiu; Quyen Nguyen; Muhammad Imran Nisar; Ole Frithjof Norheim; Rosana E. Norman; Pedro R. Olivares; Bolajoko O. Olusanya; Jacob Olusegun Olusanya; Eyal Oren; Erika Ota; Padukudru Anand Mahesh; Mahboubeh Parsaeian; João Mário Pedro; David M. Pereira; Norberto Perico; Konrad Pesudovs; Michael R. Phillips; Julian David Pillay; Farhad Pishgar; Suzanne Polinder; Mostafa Qorbani; Vafa Rahimi-Movaghar; Mahfuzar Rahman; Mohammad Hifz Ur Rahman; Sajjad Ur Rahman; Rajesh Kumar Rai; Giuseppe Remuzzi; Gholamreza Roshandel; Gregory A. Roth; Ambuj Roy; George Mugambage Ruhago; Rajesh Sagar; Muhammad Muhammad Saleh; Maria Dolores Sanchez-Niño; Itamar S. Santos; João Vasco Santos; Rodrigo Sarmiento-Suarez; Benn Sartorius; Maheswar Satpathy; Ione Jayce Ceola Schneider; Ben Schöttker; Soraya Seedat; Edson Serván-Mori; Tesfaye Setegn; Marina Shakh-Nazarova; Rajesh Sharma; Jun She; Sara Sheikhbahaei; Jiabin Shen; Kenji Shibuya; Min-Jeong Shin; Rahman Shiri; Ivy Shuie; Inga Dora Sigfusdottir; Diego Augusto Santos Silva; Jonathan I. Silverberg; Shireen Sindi; Abhishek Singh; Om Prakash Singh; Joan B. Soriano; Sergey Soshnikov; Chandrashekhar T Sreeramareddy; Nicholas Steel; Konstantinos Stroumpoulis; Lela Sturua; Bruno F. Sunguya; Soumya Swaminathan; Cassandra Szoeke; Rafael Tabarés-Seisdedos; Bineyam Taye; Bemnet Amare Tedla; Abdullah Sulieman Terkawi; Fisaha Haile Tesfay; Gizachew Assefa Tessema; Andrew L. Thorne-Lyman; Ruoyan Tobe-Gai; Marcello Tonelli; Fotis Topouzis; Bach Xuan Tran; Christopher Troeger; Zacharie Tsala Dimbuene; Stefanos Tyrovolas; Kingsley N. Ukwaja; Chigozie Jesse Uneke; Olalekan A. Uthman; Tommi Vasankari; Ana Maria Nogales Vasconcelos; Raj Kumar Verma; Vasiliy Victorovich Vlassov; Scott Weichenthal; Elisabete Weiderpass; Daniel J. Weiss; Ronny Westerman; Tissa Wijeratne; Charles Shey Wiysonge; Charles D.A. Wolfe; Ingrid Wolfe; Sungho Won; Mamo Wubshet; Gelin Xu; Bereket Yakob; Yuichiro Yano; Mehdi Yaseri; Pengpeng Ye; Henock Yebyo; Paul S. F. Yip; Seok Jun Yoon; Mustafa Z. Younis; Zoubida Zaidi; Maysaa El Sayed Zaki; Hajo Zeeb; Maigeng Zhou; Sanjay Zodpey;pmc: PMC5224696
BACKGROUND: Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time. METHODS: Drawing from analytical approaches developed and refined in previous iterations of the GBD study, we generated updated estimates of child mortality by age group (neonatal, post-neonatal, ages 1-4 years, and under 5) for 195 countries and territories and selected subnational geographies, from 1980-2015. We also estimated numbers and rates of stillbirths for these geographies and years. Gaussian process regression with data source adjustments for sampling and non-sampling bias was applied to synthesise input data for under-5 mortality for each geography. Age-specific mortality estimates were generated through a two-stage age-sex splitting process, and stillbirth estimates were produced with a mixed-effects model, which accounted for variable stillbirth definitions and data source-specific biases. For GBD 2015, we did a series of novel analyses to systematically quantify the drivers of trends in child mortality across geographies. First, we assessed observed and expected levels and annualised rates of decrease for under-5 mortality and stillbirths as they related to the Soci-demographic Index (SDI). Second, we examined the ratio of recorded and expected levels of child mortality, on the basis of SDI, across geographies, as well as differences in recorded and expected annualised rates of change for under-5 mortality. Third, we analysed levels and cause compositions of under-5 mortality, across time and geographies, as they related to rising SDI. Finally, we decomposed the changes in under-5 mortality to changes in SDI at the global level, as well as changes in leading causes of under-5 deaths for countries and territories. We documented each step of the GBD 2015 child mortality estimation process, as well as data sources, in accordance with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). FINDINGS: Globally, 5·8 million (95% uncertainty interval [UI] 5·7-6·0) children younger than 5 years died in 2015, representing a 52·0% (95% UI 50·7-53·3) decrease in the number of under-5 deaths since 1990. Neonatal deaths and stillbirths fell at a slower pace since 1990, decreasing by 42·4% (41·3-43·6) to 2·6 million (2·6-2·7) neonatal deaths and 47·0% (35·1-57·0) to 2·1 million (1·8-2·5) stillbirths in 2015. Between 1990 and 2015, global under-5 mortality decreased at an annualised rate of decrease of 3·0% (2·6-3·3), falling short of the 4·4% annualised rate of decrease required to achieve MDG4. During this time, 58 countries met or exceeded the pace of progress required to meet MDG4. Between 2000, the year MDG4 was formally enacted, and 2015, 28 additional countries that did not achieve the 4·4% rate of decrease from 1990 met the MDG4 pace of decrease. However, absolute levels of under-5 mortality remained high in many countries, with 11 countries still recording rates exceeding 100 per 1000 livebirths in 2015. Marked decreases in under-5 deaths due to a number of communicable diseases, including lower respiratory infections, diarrhoeal diseases, measles, and malaria, accounted for much of the progress in lowering overall under-5 mortality in low-income countries. Compared with gains achieved for infectious diseases and nutritional deficiencies, the persisting toll of neonatal conditions and congenital anomalies on child survival became evident, especially in low-income and low-middle-income countries. We found sizeable heterogeneities in comparing observed and expected rates of under-5 mortality, as well as differences in observed and expected rates of change for under-5 mortality. At the global level, we recorded a divergence in observed and expected levels of under-5 mortality starting in 2000, with the observed trend falling much faster than what was expected based on SDI through 2015. Between 2000 and 2015, the world recorded 10·3 million fewer under-5 deaths than expected on the basis of improving SDI alone. INTERPRETATION: Gains in child survival have been large, widespread, and in many places in the world, faster than what was anticipated based on improving levels of development. Yet some countries, particularly in sub-Saharan Africa, still had high rates of under-5 mortality in 2015. Unless these countries are able to accelerate reductions in child deaths at an extraordinary pace, their achievement of proposed SDG targets is unlikely. Improving the evidence base on drivers that might hasten the pace of progress for child survival, ranging from cost-effective intervention packages to innovative financing mechanisms, is vital to charting the pathways for ultimately ending preventable child deaths by 2030. FUNDING: Bill & Melinda Gates Foundation. Erratum: Department of Error, The Lancet,Volume 389, Issue 10064, 2017, Page e1. DOI: 10.1016/S0140-6736(16)32608-3
CORE (RIOXX-UK Aggre... arrow_drop_down Helmholtz Zentrum für Infektionsforschung RepositoryArticle . 2016License: CC BY NC SAData sources: Helmholtz Zentrum für Infektionsforschung RepositorySpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryFachrepositorium LebenswissenschaftenArticle . 2016Data sources: Fachrepositorium LebenswissenschaftenRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTAOxford University Research ArchiveArticle . 2018License: CC BYData sources: Oxford University Research ArchiveNARCIS; The LancetArticle . 2016UniSA Research Outputs RepositoryArticle . 2016 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0140-6736(16)31575-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 533 citations 533 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 24visibility views 24 download downloads 57 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Helmholtz Zentrum für Infektionsforschung RepositoryArticle . 2016License: CC BY NC SAData sources: Helmholtz Zentrum für Infektionsforschung RepositorySpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryFachrepositorium LebenswissenschaftenArticle . 2016Data sources: Fachrepositorium LebenswissenschaftenRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTAOxford University Research ArchiveArticle . 2018License: CC BYData sources: Oxford University Research ArchiveNARCIS; The LancetArticle . 2016UniSA Research Outputs RepositoryArticle . 2016 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2007 Italy, GermanyPublisher:Springer Science and Business Media LLC Funded by:NIH | A Core Database of Intera..., WTNIH| A Core Database of Interacting Proteins ,WTSamuel Kerrien; Sandra Orchard; Luisa Montecchi-Palazzi; Bruno Aranda; Antony F. Quinn; Nisha Vinod; Gary D. Bader; Ioannis Xenarios; Jérôme Wojcik; David James Sherman; Mike Tyers; John J. Salama; Susan Moore; Arnaud Ceol; Andrew Chatr-aryamontri; Matthias Oesterheld; Volker Stümpflen; Lukasz Salwinski; Jason Nerothin; Ethan Cerami; Michael E. Cusick; Marc Vidal; Michael K. Gilson; John Armstrong; Peter Woollard; Christopher W. V. Hogue; David Eisenberg; Gianni Cesareni; Rolf Apweiler; Henning Hermjakob;Abstract Background Molecular interaction Information is a key resource in modern biomedical research. Publicly available data have previously been provided in a broad array of diverse formats, making access to this very difficult. The publication and wide implementation of the Human Proteome Organisation Proteomics Standards Initiative Molecular Interactions (HUPO PSI-MI) format in 2004 was a major step towards the establishment of a single, unified format by which molecular interactions should be presented, but focused purely on protein-protein interactions. Results The HUPO-PSI has further developed the PSI-MI XML schema to enable the description of interactions between a wider range of molecular types, for example nucleic acids, chemical entities, and molecular complexes. Extensive details about each supported molecular interaction can now be captured, including the biological role of each molecule within that interaction, detailed description of interacting domains, and the kinetic parameters of the interaction. The format is supported by data management and analysis tools and has been adopted by major interaction data providers. Additionally, a simpler, tab-delimited format MITAB2.5 has been developed for the benefit of users who require only minimal information in an easy to access configuration. Conclusion The PSI-MI XML2.5 and MITAB2.5 formats have been jointly developed by interaction data producers and providers from both the academic and commercial sector, and are already widely implemented and well supported by an active development community. PSI-MI XML2.5 enables the description of highly detailed molecular interaction data and facilitates data exchange between databases and users without loss of information. MITAB2.5 is a simpler format appropriate for fast Perl parsing or loading into Microsoft Excel.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2007Full-Text: http://europepmc.org/articles/PMC2189715Data sources: PubMed CentralPublication Server of Helmholtz Zentrum München (PuSH)Article . 2007Data sources: Publication Server of Helmholtz Zentrum München (PuSH)BMC Biology; Archivio della Ricerca - Università di Roma Tor vergataArticle . 2007 . Peer-reviewedLicense: CC BYArchivio della Ricerca - Università di Roma Tor vergataArticle . 2007Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 265 citations 265 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2007Full-Text: http://europepmc.org/articles/PMC2189715Data sources: PubMed CentralPublication Server of Helmholtz Zentrum München (PuSH)Article . 2007Data sources: Publication Server of Helmholtz Zentrum München (PuSH)BMC Biology; Archivio della Ricerca - Università di Roma Tor vergataArticle . 2007 . Peer-reviewedLicense: CC BYArchivio della Ricerca - Università di Roma Tor vergataArticle . 2007Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Denmark, United Kingdom, Italy, PeruPublisher:Elsevier BV Funded by:WT | Health and economic impac..., UKRI | UK Centre for Research on..., WT | Lancet Countdown: Trackin... +5 projectsWT| Health and economic impacts of urban heat islands and greenspace ,UKRI| UK Centre for Research on Energy Demand ,WT| Lancet Countdown: Tracking Progress on Health and Climate Change ,WT| Complex Urban Systems for Sustainability and Health (London Hub) ,UKRI| Developing integrated environmental indicators for sustainable global food production and trade ,UKRI| UK Energy Research Centre Phase 4 ,UKRI| Human health in an increasingly urbanized and warming world ,WT| Sustainable and Healthy Food Systems (SHEFS)Romanello, Marina; McGushin, Alice; Di Napoli, Claudia; Drummond, Paul; Hughes, Nick; Jamart, Louis; Kennard, Harry; Lampard, Pete; Rodriguez, Baltazar Solano; Arnell, Nigel; Ayeb-Karlsson, Sonja; Belesova, Kristine; Cai, Wenjia; Campbell-Lendrum, Diarmid; Capstick, Stuart; Chambers, Jonathan; Chu, Lingzhi; Ciampi, Luisa; Dalin, Carole; Dasandi, Niheer; Dasgupta, Shoura; Davies, Michael; Dominguez-Salas, Paula; Dubrow, Robert; Ebi, Kristie; Eckelman, Matthew; Ekins, Paul; Escobar, Luis; Georgeson, Lucien; Grace, Delia; Graham, Hilary; Gunther, Samuel; Hartinger, Stella; He, Kehan; Heaviside, C.; Hess, Jeremy; Hsu, Shih-Che; Jankin, Slava; Jimenez, Marcia; Kelman, Ilan; Kiesewetter, Gregor; Kinney, Patrick; Kjellstrom, Tord; Kniveton, Dominic; Lee, J.; Lemke, Bruno; Liu, Y; Liu, Z.; Lott, Melissa; Lowe, Rachel; Martinez-Urtaza, Jaime; Maslin, Mark; McAllister, Lucy; McMichael, Celia; Mi, Zhifu; Milner, James; Minor, Kelton; Mohajeri, Nahid; Moradi-Lakeh, Maziar; Morrissey, Karyn; Munzert, Simon; Murray, Kris; Neville, Tara; Nilsson, Maria; Obradovich, Nick; Odhiambo Sewe, Maquins; Oreszczyn, Tadj; Otto, Matthias; Owfi, Fereidoon; Pearman, Olivia; Pencheon, David; Rabbaniha, Mahnaz; Robinson, Elizabeth; Rocklöv, Joacim; Salas, Renee; Semenza, Jan; Sherman, Jodi; Shi, Liuhua; Springmann, Marco; Tabatabaei, Meisam; Taylor, J; Trinanes, Joaquin; Shumake-Guillemot, Joy; Vu, Bryan; Wagner, Fabian; Wilkinson, Paul; Winning, Matthew; Yglesias, Marisol; Zhang, S; Gong, Peng; Montgomery, Hugh; Costello, Anthony; Hamilton, Ian;The Lancet Countdown is an international collaboration that independently monitors the health consequences of a changing climate. Publishing updated, new, and improved indicators each year, the Lancet Countdown represents the consensus of leading researchers from 43 academic institutions and UN agencies. The 44 indicators of this report expose an unabated rise in the health impacts of climate change and the current health consequences of the delayed and inconsistent response of countries around the globe—providing a clear imperative for accelerated action that puts the health of people and planet above all else.\ud \ud The 2021 report coincides with the UN Framework Convention on Climate Change 26th Conference of the Parties (COP26), at which countries are facing pressure to realise the ambition of the Paris Agreement to keep the global average temperature rise to 1·5°C and to mobilise the financial resources required for all countries to have an effective climate response. These negotiations unfold in the context of the COVID-19 pandemic—a global health crisis that has claimed millions of lives, affected livelihoods and communities around the globe, and exposed deep fissures and inequities in the world's capacity to cope with, and respond to, health emergencies. Yet, in its response to both crises, the world is faced with an unprecedented opportunity to ensure a healthy future for all.
CORE (RIOXX-UK Aggre... arrow_drop_down Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 222 citations 222 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 117visibility views 117 download downloads 995 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United States, Netherlands, DenmarkPublisher:Hindawi Limited Funded by:WT | Studies in Co-creating As...WT| Studies in Co-creating Assisted Living Solutions.Jose L. Jimenez; Linsey C. Marr; Katherine Randall; Edward Thomas Ewing; Zeynep Tufekci; Trish Greenhalgh; Raymond Tellier; Julian W. Tang; Yuguo Li; Lidia Morawska; Jonathan Mesiano‐Crookston; David Fisman; Orla Hegarty; Stephanie J. Dancer; Philomena M. Bluyssen; Giorgio Buonanno; Marcel G. L. C. Loomans; William P. Bahnfleth; Maosheng Yao; Chandra Sekhar; Pawel Wargocki; Arsen K. Melikov; Kimberly A. Prather;Abstract The question of whether SARS-CoV-2 is mainly transmitted by droplets or aerosols has been highly controversial. We sought to explain this controversy through a historical analysis of transmission research in other diseases. For most of human history, the dominant paradigm was that many diseases were carried by the air, often over long distances and in a phantasmagorical way. This miasmatic paradigm was challenged in the mid to late 19th century with the rise of germ theory, and as diseases such as cholera, puerperal fever, and malaria were found to actually transmit in other ways. Motivated by his views on the importance of contact/droplet infection, and the resistance he encountered from the remaining influence of miasma theory, prominent public health official Charles Chapin in 1910 helped initiate a successful paradigm shift, deeming airborne transmission most unlikely. This new paradigm became dominant. However, the lack of understanding of aerosols led to systematic errors in the interpretation of research evidence on transmission pathways. For the next five decades, airborne transmission was considered of negligible or minor importance for all major respiratory diseases, until a demonstration of airborne transmission of tuberculosis (which had been mistakenly thought to be transmitted by droplets) in 1962. The contact/droplet paradigm remained dominant, and only a few diseases were widely accepted as airborne before COVID-19: those that were clearly transmitted to people not in the same room. The acceleration of interdisciplinary research inspired by the COVID-19 pandemic has shown that airborne transmission is a major mode of transmission for this disease, and is likely to be significant for many respiratory infectious diseases. Indoor Environment
NARCIS arrow_drop_down Online Research Database In TechnologyArticle . 2022Data sources: Online Research Database In TechnologyeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 33 citations 33 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 8visibility views 8 download downloads 35 Powered bymore_vert NARCIS arrow_drop_down Online Research Database In TechnologyArticle . 2022Data sources: Online Research Database In TechnologyeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 France, United Kingdom, France, Italy, United States, CroatiaPublisher:Springer Science and Business Media LLC Funded by:WT | Human Adaptation to Chang..., NIH | Integrative nutrigenomic ..., WT | Wellcome Trust Sanger Ins... +9 projectsWT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,NIH| Integrative nutrigenomic and metabolomic analyses of Africans with variable diets ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,ARC| The origin of the first Australians ,ANR| OCEOADAPTO ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,EC| NEFREX ,EC| LocalAdaptation ,NIH| Integrative Genomics of Body Size and Metabolism in Ethnically Diverse Africans ,EC| ePerMed ,ARC| Discovery Projects - Grant ID: DP140101405 ,EC| MALADAPTEDLuca Pagani; Daniel Lawson; Evelyn Jagoda; Alexander Mörseburg; Anders Eriksson; Mario Mitt; Florian Clemente; Georgi Hudjashov; Michael DeGiorgio; Lauri Saag; Jeffrey D. Wall; Alexia Cardona; Reedik Mägi; Melissa A. Wilson Sayres; Sarah Kaewert; Charlotte E. Inchley; Christiana L. Scheib; Mari Järve; Monika Karmin; Guy S. Jacobs; Tiago Antao; Florin Mircea Iliescu; Alena Kushniarevich; Qasim Ayub; Chris Tyler-Smith; Yali Xue; Bayazit Yunusbayev; Kristiina Tambets; Chandana Basu Mallick; Lehti Saag; Elvira Pocheshkhova; George Andriadze; Craig Muller; Michael C. Westaway; David M. Lambert; Grigor Zoraqi; Shahlo Turdikulova; Dilbar Dalimova; Zhaxylyk Sabitov; Gazi Nurun Nahar Sultana; Joseph Lachance; Sarah A. Tishkoff; Kuvat T. Momynaliev; Jainagul Isakova; Larisa Damba; Marina Gubina; Pagbajabyn Nymadawa; Irina Evseeva; L. A. Atramentova; Olga Utevska; François-Xavier Ricaut; Nicolas Brucato; Herawati Sudoyo; Thierry Letellier; Murray P. Cox; Nikolay A. Barashkov; Vedrana Škaro; Lejla Mulahasanovic; Dragan Primorac; Hovhannes Sahakyan; Maru Mormina; Christina A. Eichstaedt; Daria V. Lichman; S M Abdullah; Gyaneshwer Chaubey; Joseph Wee; Evelin Mihailov; A. S. Karunas; Sergei Litvinov; Rita Khusainova; N. V. Ekomasova; V. L. Akhmetova; I. M. Khidiyatova; Damir Marjanović; Levon Yepiskoposyan; Doron M. Behar; Elena Balanovska; Andres Metspalu; Miroslava Derenko; Boris Malyarchuk; Mikhail Voevoda; Sardana A. Fedorova; Ludmila P. Osipova; Marta Mirazón Lahr; Pascale Gerbault; Matthew Leavesley; Andrea Bamberg Migliano; Michael D. Petraglia; Oleg Balanovsky; Elza Khusnutdinova; Ene Metspalu; Mark G. Thomas; Andrea Manica; Rasmus Nielsen; Richard Villems; Eske Willerslev; Toomas Kivisild; Mait Metspalu;pmc: PMC5164938
High-coverage whole-genome sequence studies have so far focused on a limited number1 of geographically restricted populations2, 3, 4, 5, or been targeted at specific diseases, such as cancer6. Nevertheless, the availability of high- resolution genomic data has led to the development of new methodologies for inferring population history7, 8, 9 and refuelled the debate on the mutation rate in humans10. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record11, and admixture between AMHs and Neanderthals predating the main Eurasian expansion12, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75, 000 years ago.
Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5164938Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 329 citations 329 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 19visibility views 19 download downloads 93 Powered bymore_vert Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5164938Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature19792&type=result"></script>'); --> </script>
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