- home
- Advanced Search
- Digital Humanities and Cultural Heritage
- Publications
- Other research products
- European Commission
- EU
- DE
- Europe PubMed Central
- Digital Humanities and Cultural Heritage
- Publications
- Other research products
- European Commission
- EU
- DE
- Europe PubMed Central
Loading
description Publicationkeyboard_double_arrow_right Preprint , Other literature type 2023Publisher:Cold Spring Harbor Laboratory Funded by:EC | SHARE-COHESION, SNSF | Cardiovascular diseases a..., EC | SERISS +17 projectsEC| SHARE-COHESION ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,EC| SERISS ,NIH| ESTABLISH POPULATIONS FOR EPIDEMIOLOGICAL STUDIES ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,EC| DASISH ,EC| SHARE_LEAP ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,NIH| PATHOLOGY MONITORING OF NIH AGED HYBRID RODENT COLONIES ,NIH| Health and Retirement Study Yrs 23-28 ,NIH| End of Life in the Very Old ,NIH| Peripheral Nerve Function Decline in an Aged Cohort ,EC| SHARE-COVID19 ,EC| SHARE-PREP ,SNSF| Family study of specific subthreshold and threshold mood, anxiety, substance use and schizophrenia spectrum syndromes in the general population ,EC| SSHOC ,NIH| SELECTION PROD CHARACT. &DIST OF GENE. MARKED CELLS ,EC| SHARE_M4 ,EC| SHARE-DEV3 ,SNSF| Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based surveyValerie Aponte Ribero; Heba Alwan; Orestis Efthimiou; Nazanin Abolhassani; Douglas C Bauer; Séverine Henrard; Antoine Christiaens; Gérard Waeber; Nicolas Rodondi; Baris Gencer; Cinzia Del Giovane;ABSTRACTIntroductionOlder and multimorbid adults with type 2 diabetes (T2D) are at high risk of cardiovascular disease (CVD) and chronic kidney disease (CKD). Estimating risk and preventing CVD is a challenge in this population notably because it is underrepresented in clinical trials. Our study aims to (1) assess if T2D and haemoglobin A1c (HbA1c) are associated with the risk of CVD events and mortality in older adults, (2) develop a risk score for CVD events and mortality for older adults with T2D, (3) evaluate the comparative efficacy and safety of novel antidiabetics.Methods and analysisFor Aim 1, we will analyse individual participant data on individuals aged ≥65 years from five cohort studies: the Optimising Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older People study; the Cohorte Lausannoise study; the Health, Aging and Body Composition study; the Health and Retirement Study; and the Survey of Health, Ageing and Retirement in Europe. We will fit flexible parametric survival models (FPSM) to assess the association of T2D and HbA1c with CVD events and mortality. For Aim 2, we will use data on individuals aged ≥65 years with T2D from the same cohorts to develop risk prediction models for CVD events and mortality using FPSM. We will assess model performance, perform internal-external cross validation, and derive a point-based risk score. For Aim 3, we will systematically search randomized controlled trials of novel antidiabetics. Network meta-analysis will be used to determine comparative efficacy in terms of CVD, CKD, and retinopathy outcomes, and safety of these drugs. Confidence in results will be judged using the CINeMA tool.Ethics and disseminationAims 1 and 2 were approved by the local ethics committee (Kantonale Ethikkommission Bern); no approval is required for Aim 3. Results will be published in peer-reviewed journals and presented in scientific conferences.STRENGTHS AND LIMITATIONSWe will analyse individual participant data from multiple cohort studies of older adults who are often not well represented in large clinical trials.By using flexible survival parametric models, we will be able to capture the potentially complex shapes of the baseline hazard functions of cardiovascular disease (CVD) and mortality.Our network meta-analysis will include recently published randomised controlled trials on novel anti-diabetic drugs that have not been included in previous network meta-analysis and results will be stratified by age and baseline HbA1cAlthough we plan to use several international cohorts, the external validity of our findings and particularly of our prediction model will need to be assessed in independent studiesOur study will help guide CVD risk estimation and prevention among older adults with type 2 diabetes
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.03.13.23287105&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.03.13.23287105&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2023 France, United StatesPublisher:Cold Spring Harbor Laboratory Funded by:EC | SHARE-COHESION, ANR | FrontCog, ANR | NeurATRIS +13 projectsEC| SHARE-COHESION ,ANR| FrontCog ,ANR| NeurATRIS ,EC| SSHOC ,NIH| English Longitudinal Study of Ageing ,NIH| Advancing Psychosocial and Biobehavioral Stress Measurement to Understanding Aging ,EC| DASISH ,EC| SHARE-DEV3 ,EC| SHARE_LEAP ,EC| SERISS ,NIH| Mega Meta Data Set of the Health and Retirement Surveys Around the World ,EC| SHARE_M4 ,EC| SHARE-PREP ,NIH| Integrating Information about Aging Surveys ,NIH| FINANCIAL STATUS--RETIREMENT SAVING PROGRAMS ,NIH| Archiving & Creating User Friendly Data: the Longitudinal Aging Survey in IndiaAmin Gharbi-Meliani; François Husson; Henri Vandendriessche; Eleonore Bayen; Kristine Yaffe; Anne-Catherine Bachoud-Lévi; Laurent Cleret de Langavant;pmc: PMC9980227 , PMC10688099
Abstract Background Dementia is defined as a cognitive decline that affects functional status. Longitudinal ageing surveys often lack a clinical diagnosis of dementia though measure cognition and daily function over time. We used unsupervised machine learning and longitudinal data to identify transition to probable dementia. Methods Multiple Factor Analysis was applied to longitudinal function and cognitive data of 15,278 baseline participants (aged 50 years and more) from the Survey of Health, Ageing, and Retirement in Europe (SHARE) (waves 1, 2 and 4–7, between 2004 and 2017). Hierarchical Clustering on Principal Components discriminated three clusters at each wave. We estimated probable or “Likely Dementia” prevalence by sex and age, and assessed whether dementia risk factors increased the risk of being assigned probable dementia status using multistate models. Next, we compared the “Likely Dementia” cluster with self-reported dementia status and replicated our findings in the English Longitudinal Study of Ageing (ELSA) cohort (waves 1–9, between 2002 and 2019, 7840 participants at baseline). Results Our algorithm identified a higher number of probable dementia cases compared with self-reported cases and showed good discriminative power across all waves (AUC ranged from 0.754 [0.722–0.787] to 0.830 [0.800–0.861]). “Likely Dementia” status was more prevalent in older people, displayed a 2:1 female/male ratio, and was associated with nine factors that increased risk of transition to dementia: low education, hearing loss, hypertension, drinking, smoking, depression, social isolation, physical inactivity, diabetes, and obesity. Results were replicated in ELSA cohort with good accuracy. Conclusions Machine learning clustering can be used to study dementia determinants and outcomes in longitudinal population ageing surveys in which dementia clinical diagnosis is lacking. International audience
eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2023Data sources: eScholarship - University of CaliforniaAlzheimer’s Research & TherapyArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.02.17.23286078&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2023Data sources: eScholarship - University of CaliforniaAlzheimer’s Research & TherapyArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.02.17.23286078&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2023 United KingdomPublisher:Elsevier BV Funded by:NIH | The Neurobiology of Socia..., EC | RISKYREWARDS, WT | Neuronal reward mechanism... +1 projectsNIH| The Neurobiology of Social Decision-Making ,EC| RISKYREWARDS ,WT| Neuronal reward mechanisms. ,WT| Neuronal reward mechanismsAuthors: Mark Burrell; Alexandre Pastor-Bernier; Wolfram Schultz;Mark Burrell; Alexandre Pastor-Bernier; Wolfram Schultz;AbstractAll life must solve how to allocate limited energy resources to maximise benefits from scarce opportunities. Economic theory posits decision makers optimise choice by maximising the subjective benefit (utility) of reward minus the subjective cost (disutility) of the required effort. While successful in many settings, this model does not fully account for how experience can alter reward-effort trade-offs. Here we test how well the subtractive model of effort disutility explains the behavior of two non-human primates (Macaca mulatta) in a binary choice task in which reward quantity and physical effort to obtain were varied.Applying random utility modelling to independently estimate reward utility and effort disutility, we show the subtractive effort model better explains out-of-sample choice behavior when compared to parabolic and exponential effort discounting. Furthermore, we demonstrate that effort disutility is dependent on previous experience of effort: in analogy to work from behavioral labour economics, we develop a model of reference-dependent effort disutility to explain the increased willingness to expend effort following previous experience of effortful options in a session. The result of this analysis suggests that monkeys discount reward by an effort cost that is measured relative to an expected effort learned from previous trials. When this subjective cost of effort, a function of context and experience, is accounted for, trial-by-trial choice behavior can be explained by the subtractive cost model of effort.Therefore, in searching for net utility signals that may underpin effort-based decision-making in the brain, careful measurement of subjective effort costs is an essential first step.SignificanceAll decision-makers need to consider how much effort they need to expend when evaluating potential options. Economic theories suggest that the optimal way to choose is by cost-benefit analysis of reward against effort. To be able to do this efficiently over many decision contexts, this needs to be done flexibly, with appropriate adaptation to context and experience. Therefore, in aiming to understand how this might be achieved in the brain, it is important to first carefully measure the subjective cost of effort. Here we show monkeys make reward-effort cost-benefit decisions, subtracting the subjective cost of effort from the subjective value of rewards. Moreover, the subjective cost of effort is dependent on the monkeys’ experience of effort in previous trials.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4321740&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 32visibility views 32 download downloads 3 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4321740&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2023Publisher:Elsevier BV Funded by:NIH | The Neurobiology of Socia..., EC | RISKYREWARDS, WT | Neuronal reward mechanism... +1 projectsNIH| The Neurobiology of Social Decision-Making ,EC| RISKYREWARDS ,WT| Neuronal reward mechanisms ,WT| Neuronal reward mechanisms.Leo Chi U Seak; Simone Ferrari-Toniolo; Ritesh Jain; Kirby Nielsen; Wolfram Schultz;AbstractThe past decades have seen tremendous progress in fundamental studies on economic choice in humans. However, elucidation of the underlying neuronal processes requires invasive neurophysiological studies that are met with difficulties in humans. Monkeys as evolutionary closest relatives offer a solution. The animals display sophisticated and well-controllable behavior that allows to implement key constructs of proven economic choice theories. However, the similarity of economic choice between the two species has never been systematically investigated. We investigated compliance with the independence axiom (IA) of expected utility theory as one of the most demanding choice tests and compared IA violations between humans and monkeys. Using generalized linear modeling and cumulative prospect theory (CPT), we found that humans and monkeys made comparable risky choices, although their subjective values (utilities) differed. These results suggest similar fundamental choice mechanism across these primate species and encourage to study their underlying neurophysiological mechanisms.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4350946&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4350946&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022Publisher:Springer Science and Business Media LLC Funded by:NIH | Neuro-immune regulation o..., NIH | Regulation of mucosal imm..., NIH | Microbiota-derived metabo... +6 projectsNIH| Neuro-immune regulation of intestinal inflammation ,NIH| Regulation of mucosal immunity by neuronal pathways ,NIH| Microbiota-derived metabolites and the regulation of host immunity and inflammation ,NIH| Regulation and function of innate lymphoid cells in the gut ,NIH| Infectious Diseases Training Program ,SNSF| Intestinal tuft cells as a component of host-defense mechanisms ,NIH| Microbiota-dependent regulation of the gut-brain axis ,NIH| Structure-based design of novel Lassa virus glycoproteins for vaccine development ,EC| ENTRIAuthors: Alexandra, Flemming;Alexandra, Flemming;Protective immunity relies on the interplay of innate and adaptive immune cells with complementary and redundant functions. Innate lymphoid cells (ILCs) have recently emerged as tissue-resident, innate mirror images of the T cell system with which they share lineage-specifying transcription factors and effector machinery(1). Located at barrier surfaces, ILCs are among the first responders against invading pathogens and might thus determine the outcome of the immune response(2). However, it has been impossible until now to dissect the unique contributions of ILCs to protective immunity due to limitations in specifically targeting ILC subsets. Thus, all of the available data have either been generated in mice lacking the adaptive immune system or with tools that also affect other immune cell subsets. In addition, it was proposed that ILCs might be dispensable for a proper immune response because other immune cells could compensate for their absence(3–7). Here, we report the generation of a new mouse model based on the Nmurl promoter as a driver for simultaneous expression of Cre recombinase and green fluorescent protein (GFP), which allows gene targeting in ILC2s without affecting other innate and adaptive immune cells. By removing Id2 and Gata-3 using Cre-mediated gene deletion in Nmur1-expressing cells, we have generated mice with selective and specific deficiency in ILC2s. ILC2-deficient mice have decreased eosinophil counts in steady state and are unable to recruit eosinophils in the airways in models of allergic asthma. Further, ILC2-deficient mice fail to mount an appropriate immune and epithelial type 2 response resulting in a profound defect in worm expulsion and a non-protective type 3 immune response. In total, our data establish non-redundant functions for ILC2s in the presence of adaptive immune cells at steady state and during diseases and argue for a multilayered organization of the immune system based on a spatiotemporal division of labor.
Europe PubMed Centra... arrow_drop_down Nature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41577-022-00807-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Nature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41577-022-00807-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022Publisher:Wiley Funded by:EC | SHARE-COHESION, EC | DASISH, EC | SSHOC +9 projectsEC| SHARE-COHESION ,EC| DASISH ,EC| SSHOC ,NIH| FINANCIAL STATUS--RETIREMENT SAVING PROGRAMS ,NIH| Large-Scale Selection of Genomic Loci ,EC| SHARE_LEAP ,EC| SERISS ,EC| SHARE-PREP ,EC| SHARE_M4 ,EC| SHARE-DEV3 ,NIH| Understanding Cross-National Health Differences at Older Ages and Their Causes ,NIH| RAND CENTER FOR THE STUDY OF AGINGAuthors: Rebecca Groh; Luzia M. Weiss; Martina Börsch‐Supan; Axel Börsch‐Supan;Rebecca Groh; Luzia M. Weiss; Martina Börsch‐Supan; Axel Börsch‐Supan;AbstractObjectivesThe quality of blood values analyzed from survey‐collected dried blood spot (DBS) samples is affected by fieldwork conditions, particularly spot size. We offer an image‐based algorithm that accurately measures the area of field‐collected DBS and we investigate the impact of spot size on the analyzed blood marker values.MethodsSHARE, a pan‐European study, collected 24 000 DBS samples in 12 countries in its sixth wave. Our new algorithm uses photographs of the DBS samples to calculate the number of pixels of the blood‐covered area to measure the spot sizes accurately. We ran regression models to examine the association of spot size and seven DBS analytes. We then compared the application of our new spot‐size measures to common spot‐size estimation.ResultsUsing automated spot‐size measurement, we found that spot size has a significant effect on all markers. Smaller spots are associated with lower measured levels, except for HbA1c, for which we observe a negative effect. Our precisely measured spot sizes explain substantially more variance of DBS analytes compared to commonly used spot‐size estimation.ConclusionThe new algorithm accurately measures the size of field‐collected DBS in an automated way. This methodology can be applied to surveys even with very large numbers of observations. The measured spot sizes improve the accuracy of conversion formulae that translate blood marker values derived from DBS into venous blood values. The significance of the spot‐size effects on biomarkers in DBS should also incentivize the improvement of fieldwork training and monitoring.
MediaTUM arrow_drop_down American Journal of Human BiologyArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ajhb.23777&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert MediaTUM arrow_drop_down American Journal of Human BiologyArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ajhb.23777&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022Publisher:Informa UK Limited Funded by:EC | ECHO, NIH | Demographic models and hy..., NIH | LAMBdA: The Latin America... +6 projectsEC| ECHO ,NIH| Demographic models and hypothesis testing of delayed effects on adult mortality ,NIH| LAMBdA: The Latin American Mortality Database ,NIH| INTERNATIONAL TRAINING IN POPULATION HEALTH ,NIH| HEALTH CONDITIONS OF ELDERLY PUERTO RICANS ,NIH| CENTER FOR DEMOGRAPHY OF HEALTH AND AGING ,NIH| Health Conditions Among Elderly in Latin America ,NIH| Center for Demography and Ecology ,NIH| The Mexican Health and Aging Study - IIAuthors: Aktar, Rengin; Palloni, Alberto;Aktar, Rengin; Palloni, Alberto;We test a conjecture to explain Turkey’s decades long underachievement in early child mortality improvements. We argue that it is largely a consequence of cultural barriers to embrace available modern medical technology and health care practices. The empirical test rests on a reformulation of Coale’s Ready-Willing-Able (RWA) framework (1973) to explain fertility changes making it suitable to understand mortality changes. We employ a Structural Equation Model (SEM) and Demographic and Health Surveys (DHS) spanning 1993 to 2013, and estimate basic parameters of the reformulated framework. These are then used to classify mothers into four categories representing subgroups with different configurations of RWA dimensions and different probabilities of adopting modern medical practices. We find that observed behaviors in these subgroups are consistent with RWA expectations. In addition, we find that an important contributor to Turkey’s lagging mortality decline is a population distribution biased toward groups more reticent to adopt modern health care, not to their availability or accessibility.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/00324728.2022.2058596&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/00324728.2022.2058596&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United Kingdom, NetherlandsPublisher:Elsevier BV Funded by:EC | TRAIN-OLD, NIH | Aging and dysfunction of ..., NIH | IL-22, Immune Plasticity,... +1 projectsEC| TRAIN-OLD ,NIH| Aging and dysfunction of progenitor niches: Role of Del-1 ,NIH| IL-22, Immune Plasticity, and Autotherapy in the Periodontium ,NIH| Trained innate immunity and periodontitis-associated comorbiditiesXiaofei Li; Hui Wang; Xiang Yu; Gundappa Saha; Lydia Kalafati; Charalampos Ioannidis; Ioannis Mitroulis; Mihai G. Netea; Triantafyllos Chavakis; George Hajishengallis;pmc: PMC9106933
Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid progeny. We show here that maladaptive BM-mediated TII underlies inflammatory comorbidities, as exemplified by the periodontitis-arthritis axis. Experimental-periodontitis-related systemic inflammation in mice induced epigenetic rewiring of HSPC and led to sustained enhancement of production of myeloid cells with increased inflammatory preparedness. The periodontitis-induced trained phenotype was transmissible by BM transplantation to naive recipients, which exhibited increased inflammatory responsiveness and disease severity when subjected to inflammatory arthritis. IL-1 signaling in HSPC was essential for their maladaptive training by periodontitis. Therefore, maladaptive innate immune training of myelopoiesis underlies inflammatory comorbidities and may be pharmacologically targeted to treat them via a holistic approach.
Europe PubMed Centra... arrow_drop_down Radboud Repository; Cell; METIS Research Information SystemArticle . 2022 . Peer-reviewedLicense: Elsevier Non-CommercialNature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2022.03.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 87 citations 87 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Radboud Repository; Cell; METIS Research Information SystemArticle . 2022 . Peer-reviewedLicense: Elsevier Non-CommercialNature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2022.03.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022Publisher:Elsevier BV Funded by:NIH | Uncovering Population-Lev..., NIH | MULTIREGIONAL ELECTRICAL ..., NIH | Dissecting and modifying ... +3 projectsNIH| Uncovering Population-Level Cellular Relationships to Behavior via Mesoscale Networks ,NIH| MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION ,NIH| Dissecting and modifying temporal dynamics underlying major depressive disorder ,NIH| A novel neural circuit analysis paradigm to model autism in mice ,EC| InsularAnxiety ,NIH| Environmental Toxins and Microglia-Synapse Interactions in AutismAuthors: Stephen D, Mague; Austin, Talbot; Cameron, Blount; Kathryn K, Walder-Christensen; +15 AuthorsStephen D, Mague; Austin, Talbot; Cameron, Blount; Kathryn K, Walder-Christensen; Lara J, Duffney; Elise, Adamson; Alexandra L, Bey; Nkemdilim, Ndubuizu; Gwenaëlle E, Thomas; Dalton N, Hughes; Yael, Grossman; Rainbo, Hultman; Saurabh, Sinha; Alexandra M, Fink; Neil M, Gallagher; Rachel L, Fisher; Yong-Hui, Jiang; David E, Carlson; Kafui, Dzirasa;pmc: PMC9126093
The architecture whereby activity across many brain regions integrates to encode individual appetitive social behavior remains unknown. Here we measure electrical activity from eight brain regions as mice engage in a social preference assay. We then use machine learning to discover a network that encodes the extent to which individual mice engage another mouse. This network is organized by theta oscillations leading from prelimbic cortex and amygdala that converge on the ventral tegmental area. Network activity is synchronized with cellular firing, and frequency-specific activation of a circuit within this network increases social behavior. Finally, the network generalizes, on a mouse-by-mouse basis, to encode individual differences in social behavior in healthy animals but fails to encode individual behavior in a 'high confidence' genetic model of autism. Thus, our findings reveal the architecture whereby the brain integrates distributed activity across timescales to encode an appetitive brain state underlying individual differences in social behavior.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuron.2022.02.016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuron.2022.02.016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 NetherlandsPublisher:The Royal Society Funded by:UKRI | Plasma Functionalisation ..., NSF | Shifted Baselines: Quanti..., EC | ALPHA +1 projectsUKRI| Plasma Functionalisation of Recovered Carbon Black & Graphene for Multifunctional Elastomers (ElastoPlas) ,NSF| Shifted Baselines: Quantifying Past Human Influences on Andean Landscapes ,EC| ALPHA ,NSF| FESD Type I: The Dynamics of Mountains, Landscapes and Climate in the Distribution and Generation of Biodiversity of the Amazon/Andean ForestMajoi N. Nascimento; Britte M. Heijink; Mark B. Bush; William D. Gosling; Crystal N. H. McMichael;pmc: PMC8899618 , PMC10577023
Humans have been present in Amazonia throughout the Holocene, with the earliest archaeological sites dating to 12 000 years ago. The earliest inhabitants began managing landscapes through fire and plant domestication, but the total extent of vegetation modification remains relatively unknown. Here, we compile palaeoecological records from lake sediments containing charcoal and from pollen analyses to understand how human land-use affected vegetation during the early to mid-Holocene, and place our results in the context of previous archaeological work. We identified gradual, rather than abrupt changes in forest openness, disturbance and enrichment, with useful species at almost all sites. Early human occupations occurred in peripheral sites of Amazonia, where natural fires are part of the vegetation dynamics, so human-made fires did not exert a novel form of disturbance. Synchronicity between evidence of the onset of human occupation in lake records and archaeological sites was found for eastern Amazonia. For southwestern and western Amazonia and the Guiana Shield, the timing of the onset of human occupation differed by thousands of years between lake records and archaeological sites. Plant cultivation showed a different spatio-temporal pattern, appearing ca 2000 years earlier in western Amazonia than in other regions. Our findings highlight the spatial–temporal heterogeneity of Amazonia and indicate that the region cannot be treated as one entity when assessing ecological or cultural history. This article is part of the theme issue ‘Tropical forests in the deep human past’.
Europe PubMed Centra... arrow_drop_down Philosophical Transactions of the Royal Society B Biological SciencesArticle . 2023 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: CrossrefPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2022 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2022Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0498&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Philosophical Transactions of the Royal Society B Biological SciencesArticle . 2023 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: CrossrefPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2022 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2022Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0498&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
Loading
description Publicationkeyboard_double_arrow_right Preprint , Other literature type 2023Publisher:Cold Spring Harbor Laboratory Funded by:EC | SHARE-COHESION, SNSF | Cardiovascular diseases a..., EC | SERISS +17 projectsEC| SHARE-COHESION ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,EC| SERISS ,NIH| ESTABLISH POPULATIONS FOR EPIDEMIOLOGICAL STUDIES ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,EC| DASISH ,EC| SHARE_LEAP ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,NIH| PATHOLOGY MONITORING OF NIH AGED HYBRID RODENT COLONIES ,NIH| Health and Retirement Study Yrs 23-28 ,NIH| End of Life in the Very Old ,NIH| Peripheral Nerve Function Decline in an Aged Cohort ,EC| SHARE-COVID19 ,EC| SHARE-PREP ,SNSF| Family study of specific subthreshold and threshold mood, anxiety, substance use and schizophrenia spectrum syndromes in the general population ,EC| SSHOC ,NIH| SELECTION PROD CHARACT. &DIST OF GENE. MARKED CELLS ,EC| SHARE_M4 ,EC| SHARE-DEV3 ,SNSF| Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based surveyValerie Aponte Ribero; Heba Alwan; Orestis Efthimiou; Nazanin Abolhassani; Douglas C Bauer; Séverine Henrard; Antoine Christiaens; Gérard Waeber; Nicolas Rodondi; Baris Gencer; Cinzia Del Giovane;ABSTRACTIntroductionOlder and multimorbid adults with type 2 diabetes (T2D) are at high risk of cardiovascular disease (CVD) and chronic kidney disease (CKD). Estimating risk and preventing CVD is a challenge in this population notably because it is underrepresented in clinical trials. Our study aims to (1) assess if T2D and haemoglobin A1c (HbA1c) are associated with the risk of CVD events and mortality in older adults, (2) develop a risk score for CVD events and mortality for older adults with T2D, (3) evaluate the comparative efficacy and safety of novel antidiabetics.Methods and analysisFor Aim 1, we will analyse individual participant data on individuals aged ≥65 years from five cohort studies: the Optimising Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older People study; the Cohorte Lausannoise study; the Health, Aging and Body Composition study; the Health and Retirement Study; and the Survey of Health, Ageing and Retirement in Europe. We will fit flexible parametric survival models (FPSM) to assess the association of T2D and HbA1c with CVD events and mortality. For Aim 2, we will use data on individuals aged ≥65 years with T2D from the same cohorts to develop risk prediction models for CVD events and mortality using FPSM. We will assess model performance, perform internal-external cross validation, and derive a point-based risk score. For Aim 3, we will systematically search randomized controlled trials of novel antidiabetics. Network meta-analysis will be used to determine comparative efficacy in terms of CVD, CKD, and retinopathy outcomes, and safety of these drugs. Confidence in results will be judged using the CINeMA tool.Ethics and disseminationAims 1 and 2 were approved by the local ethics committee (Kantonale Ethikkommission Bern); no approval is required for Aim 3. Results will be published in peer-reviewed journals and presented in scientific conferences.STRENGTHS AND LIMITATIONSWe will analyse individual participant data from multiple cohort studies of older adults who are often not well represented in large clinical trials.By using flexible survival parametric models, we will be able to capture the potentially complex shapes of the baseline hazard functions of cardiovascular disease (CVD) and mortality.Our network meta-analysis will include recently published randomised controlled trials on novel anti-diabetic drugs that have not been included in previous network meta-analysis and results will be stratified by age and baseline HbA1cAlthough we plan to use several international cohorts, the external validity of our findings and particularly of our prediction model will need to be assessed in independent studiesOur study will help guide CVD risk estimation and prevention among older adults with type 2 diabetes
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.03.13.23287105&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.03.13.23287105&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2023 France, United StatesPublisher:Cold Spring Harbor Laboratory Funded by:EC | SHARE-COHESION, ANR | FrontCog, ANR | NeurATRIS +13 projectsEC| SHARE-COHESION ,ANR| FrontCog ,ANR| NeurATRIS ,EC| SSHOC ,NIH| English Longitudinal Study of Ageing ,NIH| Advancing Psychosocial and Biobehavioral Stress Measurement to Understanding Aging ,EC| DASISH ,EC| SHARE-DEV3 ,EC| SHARE_LEAP ,EC| SERISS ,NIH| Mega Meta Data Set of the Health and Retirement Surveys Around the World ,EC| SHARE_M4 ,EC| SHARE-PREP ,NIH| Integrating Information about Aging Surveys ,NIH| FINANCIAL STATUS--RETIREMENT SAVING PROGRAMS ,NIH| Archiving & Creating User Friendly Data: the Longitudinal Aging Survey in IndiaAmin Gharbi-Meliani; François Husson; Henri Vandendriessche; Eleonore Bayen; Kristine Yaffe; Anne-Catherine Bachoud-Lévi; Laurent Cleret de Langavant;pmc: PMC9980227 , PMC10688099
Abstract Background Dementia is defined as a cognitive decline that affects functional status. Longitudinal ageing surveys often lack a clinical diagnosis of dementia though measure cognition and daily function over time. We used unsupervised machine learning and longitudinal data to identify transition to probable dementia. Methods Multiple Factor Analysis was applied to longitudinal function and cognitive data of 15,278 baseline participants (aged 50 years and more) from the Survey of Health, Ageing, and Retirement in Europe (SHARE) (waves 1, 2 and 4–7, between 2004 and 2017). Hierarchical Clustering on Principal Components discriminated three clusters at each wave. We estimated probable or “Likely Dementia” prevalence by sex and age, and assessed whether dementia risk factors increased the risk of being assigned probable dementia status using multistate models. Next, we compared the “Likely Dementia” cluster with self-reported dementia status and replicated our findings in the English Longitudinal Study of Ageing (ELSA) cohort (waves 1–9, between 2002 and 2019, 7840 participants at baseline). Results Our algorithm identified a higher number of probable dementia cases compared with self-reported cases and showed good discriminative power across all waves (AUC ranged from 0.754 [0.722–0.787] to 0.830 [0.800–0.861]). “Likely Dementia” status was more prevalent in older people, displayed a 2:1 female/male ratio, and was associated with nine factors that increased risk of transition to dementia: low education, hearing loss, hypertension, drinking, smoking, depression, social isolation, physical inactivity, diabetes, and obesity. Results were replicated in ELSA cohort with good accuracy. Conclusions Machine learning clustering can be used to study dementia determinants and outcomes in longitudinal population ageing surveys in which dementia clinical diagnosis is lacking. International audience
eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2023Data sources: eScholarship - University of CaliforniaAlzheimer’s Research & TherapyArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.02.17.23286078&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert eScholarship - Unive... arrow_drop_down eScholarship - University of CaliforniaArticle . 2023Data sources: eScholarship - University of CaliforniaAlzheimer’s Research & TherapyArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.02.17.23286078&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2023 United KingdomPublisher:Elsevier BV Funded by:NIH | The Neurobiology of Socia..., EC | RISKYREWARDS, WT | Neuronal reward mechanism... +1 projectsNIH| The Neurobiology of Social Decision-Making ,EC| RISKYREWARDS ,WT| Neuronal reward mechanisms. ,WT| Neuronal reward mechanismsAuthors: Mark Burrell; Alexandre Pastor-Bernier; Wolfram Schultz;Mark Burrell; Alexandre Pastor-Bernier; Wolfram Schultz;AbstractAll life must solve how to allocate limited energy resources to maximise benefits from scarce opportunities. Economic theory posits decision makers optimise choice by maximising the subjective benefit (utility) of reward minus the subjective cost (disutility) of the required effort. While successful in many settings, this model does not fully account for how experience can alter reward-effort trade-offs. Here we test how well the subtractive model of effort disutility explains the behavior of two non-human primates (Macaca mulatta) in a binary choice task in which reward quantity and physical effort to obtain were varied.Applying random utility modelling to independently estimate reward utility and effort disutility, we show the subtractive effort model better explains out-of-sample choice behavior when compared to parabolic and exponential effort discounting. Furthermore, we demonstrate that effort disutility is dependent on previous experience of effort: in analogy to work from behavioral labour economics, we develop a model of reference-dependent effort disutility to explain the increased willingness to expend effort following previous experience of effortful options in a session. The result of this analysis suggests that monkeys discount reward by an effort cost that is measured relative to an expected effort learned from previous trials. When this subjective cost of effort, a function of context and experience, is accounted for, trial-by-trial choice behavior can be explained by the subtractive cost model of effort.Therefore, in searching for net utility signals that may underpin effort-based decision-making in the brain, careful measurement of subjective effort costs is an essential first step.SignificanceAll decision-makers need to consider how much effort they need to expend when evaluating potential options. Economic theories suggest that the optimal way to choose is by cost-benefit analysis of reward against effort. To be able to do this efficiently over many decision contexts, this needs to be done flexibly, with appropriate adaptation to context and experience. Therefore, in aiming to understand how this might be achieved in the brain, it is important to first carefully measure the subjective cost of effort. Here we show monkeys make reward-effort cost-benefit decisions, subtracting the subjective cost of effort from the subjective value of rewards. Moreover, the subjective cost of effort is dependent on the monkeys’ experience of effort in previous trials.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4321740&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 32visibility views 32 download downloads 3 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4321740&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2023Publisher:Elsevier BV Funded by:NIH | The Neurobiology of Socia..., EC | RISKYREWARDS, WT | Neuronal reward mechanism... +1 projectsNIH| The Neurobiology of Social Decision-Making ,EC| RISKYREWARDS ,WT| Neuronal reward mechanisms ,WT| Neuronal reward mechanisms.Leo Chi U Seak; Simone Ferrari-Toniolo; Ritesh Jain; Kirby Nielsen; Wolfram Schultz;AbstractThe past decades have seen tremendous progress in fundamental studies on economic choice in humans. However, elucidation of the underlying neuronal processes requires invasive neurophysiological studies that are met with difficulties in humans. Monkeys as evolutionary closest relatives offer a solution. The animals display sophisticated and well-controllable behavior that allows to implement key constructs of proven economic choice theories. However, the similarity of economic choice between the two species has never been systematically investigated. We investigated compliance with the independence axiom (IA) of expected utility theory as one of the most demanding choice tests and compared IA violations between humans and monkeys. Using generalized linear modeling and cumulative prospect theory (CPT), we found that humans and monkeys made comparable risky choices, although their subjective values (utilities) differed. These results suggest similar fundamental choice mechanism across these primate species and encourage to study their underlying neurophysiological mechanisms.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4350946&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2139/ssrn.4350946&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022Publisher:Springer Science and Business Media LLC Funded by:NIH | Neuro-immune regulation o..., NIH | Regulation of mucosal imm..., NIH | Microbiota-derived metabo... +6 projectsNIH| Neuro-immune regulation of intestinal inflammation ,NIH| Regulation of mucosal immunity by neuronal pathways ,NIH| Microbiota-derived metabolites and the regulation of host immunity and inflammation ,NIH| Regulation and function of innate lymphoid cells in the gut ,NIH| Infectious Diseases Training Program ,SNSF| Intestinal tuft cells as a component of host-defense mechanisms ,NIH| Microbiota-dependent regulation of the gut-brain axis ,NIH| Structure-based design of novel Lassa virus glycoproteins for vaccine development ,EC| ENTRIAuthors: Alexandra, Flemming;Alexandra, Flemming;Protective immunity relies on the interplay of innate and adaptive immune cells with complementary and redundant functions. Innate lymphoid cells (ILCs) have recently emerged as tissue-resident, innate mirror images of the T cell system with which they share lineage-specifying transcription factors and effector machinery(1). Located at barrier surfaces, ILCs are among the first responders against invading pathogens and might thus determine the outcome of the immune response(2). However, it has been impossible until now to dissect the unique contributions of ILCs to protective immunity due to limitations in specifically targeting ILC subsets. Thus, all of the available data have either been generated in mice lacking the adaptive immune system or with tools that also affect other immune cell subsets. In addition, it was proposed that ILCs might be dispensable for a proper immune response because other immune cells could compensate for their absence(3–7). Here, we report the generation of a new mouse model based on the Nmurl promoter as a driver for simultaneous expression of Cre recombinase and green fluorescent protein (GFP), which allows gene targeting in ILC2s without affecting other innate and adaptive immune cells. By removing Id2 and Gata-3 using Cre-mediated gene deletion in Nmur1-expressing cells, we have generated mice with selective and specific deficiency in ILC2s. ILC2-deficient mice have decreased eosinophil counts in steady state and are unable to recruit eosinophils in the airways in models of allergic asthma. Further, ILC2-deficient mice fail to mount an appropriate immune and epithelial type 2 response resulting in a profound defect in worm expulsion and a non-protective type 3 immune response. In total, our data establish non-redundant functions for ILC2s in the presence of adaptive immune cells at steady state and during diseases and argue for a multilayered organization of the immune system based on a spatiotemporal division of labor.
Europe PubMed Centra... arrow_drop_down Nature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41577-022-00807-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Nature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41577-022-00807-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022Publisher:Wiley Funded by:EC | SHARE-COHESION, EC | DASISH, EC | SSHOC +9 projectsEC| SHARE-COHESION ,EC| DASISH ,EC| SSHOC ,NIH| FINANCIAL STATUS--RETIREMENT SAVING PROGRAMS ,NIH| Large-Scale Selection of Genomic Loci ,EC| SHARE_LEAP ,EC| SERISS ,EC| SHARE-PREP ,EC| SHARE_M4 ,EC| SHARE-DEV3 ,NIH| Understanding Cross-National Health Differences at Older Ages and Their Causes ,NIH| RAND CENTER FOR THE STUDY OF AGINGAuthors: Rebecca Groh; Luzia M. Weiss; Martina Börsch‐Supan; Axel Börsch‐Supan;Rebecca Groh; Luzia M. Weiss; Martina Börsch‐Supan; Axel Börsch‐Supan;AbstractObjectivesThe quality of blood values analyzed from survey‐collected dried blood spot (DBS) samples is affected by fieldwork conditions, particularly spot size. We offer an image‐based algorithm that accurately measures the area of field‐collected DBS and we investigate the impact of spot size on the analyzed blood marker values.MethodsSHARE, a pan‐European study, collected 24 000 DBS samples in 12 countries in its sixth wave. Our new algorithm uses photographs of the DBS samples to calculate the number of pixels of the blood‐covered area to measure the spot sizes accurately. We ran regression models to examine the association of spot size and seven DBS analytes. We then compared the application of our new spot‐size measures to common spot‐size estimation.ResultsUsing automated spot‐size measurement, we found that spot size has a significant effect on all markers. Smaller spots are associated with lower measured levels, except for HbA1c, for which we observe a negative effect. Our precisely measured spot sizes explain substantially more variance of DBS analytes compared to commonly used spot‐size estimation.ConclusionThe new algorithm accurately measures the size of field‐collected DBS in an automated way. This methodology can be applied to surveys even with very large numbers of observations. The measured spot sizes improve the accuracy of conversion formulae that translate blood marker values derived from DBS into venous blood values. The significance of the spot‐size effects on biomarkers in DBS should also incentivize the improvement of fieldwork training and monitoring.
MediaTUM arrow_drop_down American Journal of Human BiologyArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ajhb.23777&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert MediaTUM arrow_drop_down American Journal of Human BiologyArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ajhb.23777&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022Publisher:Informa UK Limited Funded by:EC | ECHO, NIH | Demographic models and hy..., NIH | LAMBdA: The Latin America... +6 projectsEC| ECHO ,NIH| Demographic models and hypothesis testing of delayed effects on adult mortality ,NIH| LAMBdA: The Latin American Mortality Database ,NIH| INTERNATIONAL TRAINING IN POPULATION HEALTH ,NIH| HEALTH CONDITIONS OF ELDERLY PUERTO RICANS ,NIH| CENTER FOR DEMOGRAPHY OF HEALTH AND AGING ,NIH| Health Conditions Among Elderly in Latin America ,NIH| Center for Demography and Ecology ,NIH| The Mexican Health and Aging Study - IIAuthors: Aktar, Rengin; Palloni, Alberto;Aktar, Rengin; Palloni, Alberto;We test a conjecture to explain Turkey’s decades long underachievement in early child mortality improvements. We argue that it is largely a consequence of cultural barriers to embrace available modern medical technology and health care practices. The empirical test rests on a reformulation of Coale’s Ready-Willing-Able (RWA) framework (1973) to explain fertility changes making it suitable to understand mortality changes. We employ a Structural Equation Model (SEM) and Demographic and Health Surveys (DHS) spanning 1993 to 2013, and estimate basic parameters of the reformulated framework. These are then used to classify mothers into four categories representing subgroups with different configurations of RWA dimensions and different probabilities of adopting modern medical practices. We find that observed behaviors in these subgroups are consistent with RWA expectations. In addition, we find that an important contributor to Turkey’s lagging mortality decline is a population distribution biased toward groups more reticent to adopt modern health care, not to their availability or accessibility.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/00324728.2022.2058596&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/00324728.2022.2058596&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United Kingdom, NetherlandsPublisher:Elsevier BV Funded by:EC | TRAIN-OLD, NIH | Aging and dysfunction of ..., NIH | IL-22, Immune Plasticity,... +1 projectsEC| TRAIN-OLD ,NIH| Aging and dysfunction of progenitor niches: Role of Del-1 ,NIH| IL-22, Immune Plasticity, and Autotherapy in the Periodontium ,NIH| Trained innate immunity and periodontitis-associated comorbiditiesXiaofei Li; Hui Wang; Xiang Yu; Gundappa Saha; Lydia Kalafati; Charalampos Ioannidis; Ioannis Mitroulis; Mihai G. Netea; Triantafyllos Chavakis; George Hajishengallis;pmc: PMC9106933
Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid progeny. We show here that maladaptive BM-mediated TII underlies inflammatory comorbidities, as exemplified by the periodontitis-arthritis axis. Experimental-periodontitis-related systemic inflammation in mice induced epigenetic rewiring of HSPC and led to sustained enhancement of production of myeloid cells with increased inflammatory preparedness. The periodontitis-induced trained phenotype was transmissible by BM transplantation to naive recipients, which exhibited increased inflammatory responsiveness and disease severity when subjected to inflammatory arthritis. IL-1 signaling in HSPC was essential for their maladaptive training by periodontitis. Therefore, maladaptive innate immune training of myelopoiesis underlies inflammatory comorbidities and may be pharmacologically targeted to treat them via a holistic approach.
Europe PubMed Centra... arrow_drop_down Radboud Repository; Cell; METIS Research Information SystemArticle . 2022 . Peer-reviewedLicense: Elsevier Non-CommercialNature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2022.03.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 87 citations 87 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Radboud Repository; Cell; METIS Research Information SystemArticle . 2022 . Peer-reviewedLicense: Elsevier Non-CommercialNature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2022.03.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022Publisher:Elsevier BV Funded by:NIH | Uncovering Population-Lev..., NIH | MULTIREGIONAL ELECTRICAL ..., NIH | Dissecting and modifying ... +3 projectsNIH| Uncovering Population-Level Cellular Relationships to Behavior via Mesoscale Networks ,NIH| MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION ,NIH| Dissecting and modifying temporal dynamics underlying major depressive disorder ,NIH| A novel neural circuit analysis paradigm to model autism in mice ,EC| InsularAnxiety ,NIH| Environmental Toxins and Microglia-Synapse Interactions in AutismAuthors: Stephen D, Mague; Austin, Talbot; Cameron, Blount; Kathryn K, Walder-Christensen; +15 AuthorsStephen D, Mague; Austin, Talbot; Cameron, Blount; Kathryn K, Walder-Christensen; Lara J, Duffney; Elise, Adamson; Alexandra L, Bey; Nkemdilim, Ndubuizu; Gwenaëlle E, Thomas; Dalton N, Hughes; Yael, Grossman; Rainbo, Hultman; Saurabh, Sinha; Alexandra M, Fink; Neil M, Gallagher; Rachel L, Fisher; Yong-Hui, Jiang; David E, Carlson; Kafui, Dzirasa;pmc: PMC9126093
The architecture whereby activity across many brain regions integrates to encode individual appetitive social behavior remains unknown. Here we measure electrical activity from eight brain regions as mice engage in a social preference assay. We then use machine learning to discover a network that encodes the extent to which individual mice engage another mouse. This network is organized by theta oscillations leading from prelimbic cortex and amygdala that converge on the ventral tegmental area. Network activity is synchronized with cellular firing, and frequency-specific activation of a circuit within this network increases social behavior. Finally, the network generalizes, on a mouse-by-mouse basis, to encode individual differences in social behavior in healthy animals but fails to encode individual behavior in a 'high confidence' genetic model of autism. Thus, our findings reveal the architecture whereby the brain integrates distributed activity across timescales to encode an appetitive brain state underlying individual differences in social behavior.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuron.2022.02.016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuron.2022.02.016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 NetherlandsPublisher:The Royal Society Funded by:UKRI | Plasma Functionalisation ..., NSF | Shifted Baselines: Quanti..., EC | ALPHA +1 projectsUKRI| Plasma Functionalisation of Recovered Carbon Black & Graphene for Multifunctional Elastomers (ElastoPlas) ,NSF| Shifted Baselines: Quantifying Past Human Influences on Andean Landscapes ,EC| ALPHA ,NSF| FESD Type I: The Dynamics of Mountains, Landscapes and Climate in the Distribution and Generation of Biodiversity of the Amazon/Andean ForestMajoi N. Nascimento; Britte M. Heijink; Mark B. Bush; William D. Gosling; Crystal N. H. McMichael;pmc: PMC8899618 , PMC10577023
Humans have been present in Amazonia throughout the Holocene, with the earliest archaeological sites dating to 12 000 years ago. The earliest inhabitants began managing landscapes through fire and plant domestication, but the total extent of vegetation modification remains relatively unknown. Here, we compile palaeoecological records from lake sediments containing charcoal and from pollen analyses to understand how human land-use affected vegetation during the early to mid-Holocene, and place our results in the context of previous archaeological work. We identified gradual, rather than abrupt changes in forest openness, disturbance and enrichment, with useful species at almost all sites. Early human occupations occurred in peripheral sites of Amazonia, where natural fires are part of the vegetation dynamics, so human-made fires did not exert a novel form of disturbance. Synchronicity between evidence of the onset of human occupation in lake records and archaeological sites was found for eastern Amazonia. For southwestern and western Amazonia and the Guiana Shield, the timing of the onset of human occupation differed by thousands of years between lake records and archaeological sites. Plant cultivation showed a different spatio-temporal pattern, appearing ca 2000 years earlier in western Amazonia than in other regions. Our findings highlight the spatial–temporal heterogeneity of Amazonia and indicate that the region cannot be treated as one entity when assessing ecological or cultural history. This article is part of the theme issue ‘Tropical forests in the deep human past’.
Europe PubMed Centra... arrow_drop_down Philosophical Transactions of the Royal Society B Biological SciencesArticle . 2023 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: CrossrefPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2022 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2022Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0498&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Philosophical Transactions of the Royal Society B Biological SciencesArticle . 2023 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: CrossrefPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2022 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2022Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2020.0498&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu