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  • Authors: Fatimah, Fatimah; Indrati, Rini; Suroso, Adjie;

    The purpose of this research to find out the differences between T1-Weighted Image Fluid Attenuated Inversion Recovery (T1WI FLAIR) and T1-Weighted Image Spin Echo (T1WI SE) sequences, use with MRI Superconducting Modality 0,5 Tesla and to determine its superiority between those sequences, at low field strengths. This is experimental research. Twenty four patients with brain lesions underwent T1-Weighted Image Spin Echo and T1-Weighted FLAIR imaging during the same imaging session. T1-Weighted Spin Echo and T1-Weighted FLAIR Images were compared on the basis their SNR and CNR. Data were analysed statistically using t-test and Mann-Whitney test. Contrast to Noise Ratio (CNRs) obtained with T1-Weighted Image FLAIR were comparable but statistically superior to those obtained with T1-Weighted Spin Echo imaging whether on the CNR lesion- white matter with p value 0,043 or lesion-gray matter with p value 0,015.

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  • Authors: Dewi, Yuli Kusuma; Aulanni'am, Aulanni'am; Mahdi, Chanif;

    Methyl mercury (MeHg) has the highest toxicity among the derivative of the organic mercury compounds. Rate of accumulation of MeHg in the body is very high because it is soluble in lipids. The ability of methyl mercury binds to proteins in the body causing MeHg to penetrate the blood-brain barrier easily, so that it can quickly disrupt the central nervous system and speed up nerve cell damage. This paper reported the effect of methyl mercury on the number of microglia cells and expression of iNOS in the brains of Rattus norvegicus. In this study, rats were divided into two groups: a control group with no exposure of MeHg and groups of rats exposed with MeHg at a dose of 0.6 mg/kg BW/day given orally for 21 days. Number of microglia cells is investigated using silver nitrate staining method and iNOS expression is determined by immunohistochemistry methods. The results showed that exposure with MeHg in a dose of 0.6 mg/kgBW can increase the number of microglia cells and iNOS expression respectively as mush as 151.63% and 918.08% .

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The following results are related to Neuroinformatics. Are you interested to view more results? Visit OpenAIRE - Explore.
  • Authors: Fatimah, Fatimah; Indrati, Rini; Suroso, Adjie;

    The purpose of this research to find out the differences between T1-Weighted Image Fluid Attenuated Inversion Recovery (T1WI FLAIR) and T1-Weighted Image Spin Echo (T1WI SE) sequences, use with MRI Superconducting Modality 0,5 Tesla and to determine its superiority between those sequences, at low field strengths. This is experimental research. Twenty four patients with brain lesions underwent T1-Weighted Image Spin Echo and T1-Weighted FLAIR imaging during the same imaging session. T1-Weighted Spin Echo and T1-Weighted FLAIR Images were compared on the basis their SNR and CNR. Data were analysed statistically using t-test and Mann-Whitney test. Contrast to Noise Ratio (CNRs) obtained with T1-Weighted Image FLAIR were comparable but statistically superior to those obtained with T1-Weighted Spin Echo imaging whether on the CNR lesion- white matter with p value 0,043 or lesion-gray matter with p value 0,015.

    0
    citations0
    popularityAverage
    influenceAverage
    impulseAverage
    BIP!Powered by BIP!
    more_vert
  • Authors: Dewi, Yuli Kusuma; Aulanni'am, Aulanni'am; Mahdi, Chanif;

    Methyl mercury (MeHg) has the highest toxicity among the derivative of the organic mercury compounds. Rate of accumulation of MeHg in the body is very high because it is soluble in lipids. The ability of methyl mercury binds to proteins in the body causing MeHg to penetrate the blood-brain barrier easily, so that it can quickly disrupt the central nervous system and speed up nerve cell damage. This paper reported the effect of methyl mercury on the number of microglia cells and expression of iNOS in the brains of Rattus norvegicus. In this study, rats were divided into two groups: a control group with no exposure of MeHg and groups of rats exposed with MeHg at a dose of 0.6 mg/kg BW/day given orally for 21 days. Number of microglia cells is investigated using silver nitrate staining method and iNOS expression is determined by immunohistochemistry methods. The results showed that exposure with MeHg in a dose of 0.6 mg/kgBW can increase the number of microglia cells and iNOS expression respectively as mush as 151.63% and 918.08% .

    0
    citations0
    popularityAverage
    influenceAverage
    impulseAverage
    BIP!Powered by BIP!
    more_vert
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