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description Publicationkeyboard_double_arrow_right Article 2019 Norway, Denmark, United Kingdom, France, United States, France, Norway, United KingdomPublisher:The Royal Society Funded by:UKRI | Animals, Lifeways and Lif..., UKRI | Deciphering dog domestica..., NSF | Genetic Analysis of Indig... +7 projectsUKRI| Animals, Lifeways and Lifeworlds in Yup'ik Archaeology (ALLY): Subsistence, Technologies, and Communities of Change ,UKRI| Deciphering dog domestication through a combined ancient DNA and geometric morphometric approach ,NSF| Genetic Analysis of Indigenous Dogs from Siberia to Greenland: Implications for Interaction among their Human Companions ,EC| WhereWolf ,UKRI| Deciphering dog domestication through a combined ancient DNA and geometric morphometric approach ,NSF| Genetic Analysis of Prehistoric Canis Remains from Across the North American Arctic: Implications for Interactions Among their Human Companions ,EC| UNDEAD ,UKRI| Understanding Cultural Resilience and Climate Change on the Bering Sea through Yup'ik Ecological Knowledge, Lifeways, Learning and Archaeology (ELLA) ,WT| Domestic animals as a model to understand the relationship between deleterious mutations, demography and disease ,EC| ArchSci2020Carly Ameen; Tatiana R. Feuerborn; Sarah K. Brown; Anna Linderholm; Ardern Hulme-Beaman; Ophélie Lebrasseur; Mikkel-Holger S. Sinding; Zachary T. Lounsberry; Audrey T. Lin; Martin Appelt; Lutz Bachmann; Matthew W. Betts; Kate Britton; John Darwent; Rune Dietz; Merete Fredholm; Shyam Gopalakrishnan; Olga I. Goriunova; Bjarne Grønnow; James Haile; Jón Hallsteinn Hallsson; Ramona Harrison; Mads Peter Heide-Jørgensen; Rick Knecht; Robert J. Losey; Edouard Masson-MacLean; Thomas H. McGovern; Ellen McManus-Fry; Morten Meldgaard; Åslaug Midtdal; Madonna L. Moss; Iurii G. Nikitin; Tatiana Nomokonova; Albína Hulda Pálsdóttir; Angela R. Perri; Aleksandr N. Popov; Lisa Rankin; Joshua D. Reuther; Mikhail Sablin; Anne Lisbeth Schmidt; Scott Shirar; Konrad Smiarowski; Christian Sonne; Mary C. Stiner; Mitya Vasyukov; Catherine F. West; Gro Birgit Ween; Sanne Eline Wennerberg; Øystein Wiig; James Woollett; Love Dalén; Anders J. Hansen; M. Thomas P. Gilbert; Benjamin N. Sacks; Laurent A. F. Frantz; Greger Larson; Keith Dobney; Christyann M. Darwent; Allowen Evin;pmid: 31771471
pmc: PMC6939252
Domestic dogs have been central to life in the North American Arctic for millennia. The ancestors of the Inuit were the first to introduce the widespread usage of dog sledge transportation technology to the Americas, but whether the Inuit adopted local Palaeo-Inuit dogs or introduced a new dog population to the region remains unknown. To test these hypotheses, we generated mitochondrial DNA and geometric morphometric data of skull and dental elements from a total of 922 North American Arctic dogs and wolves spanning over 4500 years. Our analyses revealed that dogs from Inuit sites dating from 2000 BP possess morphological and genetic signatures that distinguish them from earlier Palaeo-Inuit dogs, and identified a novel mitochondrial clade in eastern Siberia and Alaska. The genetic legacy of these Inuit dogs survives today in modern Arctic sledge dogs despite phenotypic differences between archaeological and modern Arctic dogs. Together, our data reveal that Inuit dogs derive from a secondary pre-contact migration of dogs distinct from Palaeo-Inuit dogs, and probably aided the Inuit expansion across the North American Arctic beginning around 1000 BP. Domestic dogs have been central to life in the North American Arctic for millennia. The ancestors of the Inuit were the first to introduce the widespread usage of dog sledge transportation technology to the Americas, but whether the Inuit adopted local Palaeo-Inuit dogs or introduced a new dog population to the region remains unknown. To test these hypotheses, we generated mitochondrial DNA and geometric morphometric data of skull and dental elements from a total of 922 North American Arctic dogs and wolves spanning over 4500 years. Our analyses revealed that dogs from Inuit sites dating from 2000 BP possess morphological and genetic signatures that distinguish them from earlier Palaeo-Inuit dogs, and identified a novel mitochondrial clade in eastern Siberia and Alaska. The genetic legacy of these Inuit dogs survives today in modern Arctic sledge dogs despite phenotypic differences between archaeological and modern Arctic dogs. Together, our data reveal that Inuit dogs derive from a secondary pre-contact migration of dogs distinct from Palaeo-Inuit dogs, and probably aided the Inuit expansion across the North American Arctic beginning around 1000 BP.
Mémoires en Sciences... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6939252Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaDigitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2019 . Peer-reviewedOxford University Research ArchiveArticle . 2019License: CC BYData sources: Oxford University Research ArchiveProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallBergen Open Research Archive - UiBArticle . 2019 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBProceedings of the Royal Society B Biological SciencesOther literature type . Article . 2019 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 45 citations 45 popularity Top 10% influence Average impulse Top 1% Powered by BIP!visibility 17visibility views 17 download downloads 17 Powered bymore_vert Mémoires en Sciences... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6939252Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaDigitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2019 . Peer-reviewedOxford University Research ArchiveArticle . 2019License: CC BYData sources: Oxford University Research ArchiveProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallBergen Open Research Archive - UiBArticle . 2019 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBProceedings of the Royal Society B Biological SciencesOther literature type . Article . 2019 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Netherlands, Croatia, United Kingdom, United Kingdom, SpainPublisher:Springer Science and Business Media LLC Funded by:NIH | Advanced tools for using ..., WT | Human Adaptation to Chang..., FCT | LA 14 +4 projectsNIH| Advanced tools for using ancient DNA to study biology and history ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,FCT| LA 14 ,UKRI| Urban-Air Port | "Air-One" [Rapidly Deployable Vertiport For Drone-Delivery, Air-Taxi, Disaster Management] ,EC| COREX ,EC| COMMIOS ,NIH| Population mixture in evolutionary and medical geneticsNick Patterson; Michael Isakov; Thomas Booth; Lindsey Büster; Claire-Elise Fischer; Iñigo Olalde; Harald Ringbauer; Ali Akbari; Olivia Cheronet; Madeleine Bleasdale; Nicole Adamski; Eveline Altena; Rebecca Bernardos; Selina Brace; Nasreen Broomandkhoshbacht; Kimberly Callan; Francesca Candilio; Brendan Culleton; Elizabeth Curtis; Lea Demetz; Kellie Sara Duffett Carlson; Ceiridwen J. Edwards; Daniel M. Fernandes; M. George B. Foody; Suzanne Freilich; Helen Goodchild; Aisling Kearns; Ann Marie Lawson; Iosif Lazaridis; Matthew Mah; Swapan Mallick; Kirsten Mandl; Adam Micco; Megan Michel; Guillermo Bravo Morante; Jonas Oppenheimer; Kadir Toykan Özdoğan; Lijun Qiu; Constanze Schattke; Kristin Stewardson; J. Noah Workman; Fatma Zalzala; Zhao Zhang; Bibiana Agustí; Tim Allen; Katalin Almássy; Luc Amkreutz; Abigail Ash; Christèle Baillif-Ducros; Alistair Barclay; László Bartosiewicz; Katherine Baxter; Zsolt Bernert; Jan Blažek; Mario Bodružić; Philippe Boissinot; Clive Bonsall; Pippa Bradley; Marcus Brittain; Alison Brookes; Fraser Brown; Lisa Brown; Richard Brunning; Chelsea Budd; Josip Burmaz; Sylvain Canet; Silvia Carnicero-Cáceres; Morana Čaušević-Bully; Andrew Chamberlain; Sébastien Chauvin; Sharon Clough; Natalija Čondić; Alfredo Coppa; Oliver Craig; Matija Črešnar; Vicki Cummings; Szabolcs Czifra; Alžběta Danielisová; Robin Daniels; Alex Davies; Philip de Jersey; Jody Deacon; Csilla Deminger; Peter W. Ditchfield; Marko Dizdar; Miroslav Dobeš; Miluše Dobisíková; László Domboróczki; Gail Drinkall; Ana Đukić; Michal Ernée; Christopher Evans; Jane Evans; Manuel Fernández-Götz; Slavica Filipović; Andrew Fitzpatrick; Harry Fokkens; Chris Fowler; Allison Fox; Zsolt Gallina; Michelle Gamble; Manuel R. González Morales; Borja González-Rabanal; Adrian Green; Katalin Gyenesei; Diederick Habermehl; Tamás Hajdu; Derek Hamilton; James Harris; Chris Hayden; Joep Hendriks; Bénédicte Hernu; Gill Hey; Milan Horňák; Gábor Ilon; Eszter Istvánovits; Andy M. Jones; Martina Blečić Kavur; Kevin Kazek; Robert A. Kenyon; Amal Khreisheh; Viktória Kiss; Jos Kleijne; Mark Knight; Lisette M. Kootker; Péter F. Kovács; Anita Kozubová; Gabriella Kulcsár; Valéria Kulcsár; Christophe Le Pennec; Michael Legge; Matt Leivers; Louise Loe; Olalla López-Costas; Tom Lord; Dženi Los; James Lyall; Ana B. Marín-Arroyo; Philip Mason; Damir Matošević; Andy Maxted; Lauren McIntyre; Jacqueline McKinley; Kathleen McSweeney; Bernard Meijlink; Balázs G. Mende; Marko Menđušić; Milan Metlička; Sophie Meyer; Kristina Mihovilić; Lidija Milasinovic; Steve Minnitt; Joanna Moore; Geoff Morley; Graham Mullan; Margaréta Musilová; Benjamin Neil; Rebecca Nicholls; Mario Novak; Maria Pala; Martin Papworth; Cécile Paresys; Ricky Patten; Domagoj Perkić; Krisztina Pesti; Alba Petit; Katarína Petriščáková; Coline Pichon; Catriona Pickard; Zoltán Pilling; T. Douglas Price; Siniša Radović; Rebecca Redfern; Branislav Resutík; Daniel T. Rhodes; Martin B. Richards; Amy Roberts; Jean Roefstra; Pavel Sankot; Alena Šefčáková; Alison Sheridan; Sabine Skae; Miroslava Šmolíková; Krisztina Somogyi; Ágnes Somogyvári; Mark Stephens; Géza Szabó; Anna Szécsényi-Nagy; Tamás Szeniczey; Jonathan Tabor; Károly Tankó; Clenis Tavarez Maria; Rachel Terry; Biba Teržan; Maria Teschler-Nicola; Jesús F. Torres-Martínez; Julien Trapp; Ross Turle; Ferenc Ujvári; Menno van der Heiden; Petr Veleminsky; Barbara Veselka; Carles Lalueza-Fox; Peter de Knijff; Ian Barnes; Mark G. Thomas; Douglas J. Kennett; Malcolm Lillie; Ron Pinhasi; David Reich;pmc: PMC8889665
This work was funded in part by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 834087; the COMMIOS Project to I.A.). M.N. was supported by the Croatian Science Fund grant (HRZZ IP-2016-06-1450). P.V., M.Dobeš and Z.V. were supported by the Ministry of Culture of the Czech Republic (DKRVO 2019-2023/7.I.c, 00023272). M.E. was supported by Czech Academy of Sciences award Praemium Academiae. M.Dobisíková and A.Danielisová were supported by the grant RVO 67985912 of the Institute of Archaeology of the Czech Academy of Sciences. M.G.B.F. was funded by The Leverhulme Trust via a Doctoral Scholarship scheme awarded to M.Pala and M.B.R. Support to M.Legge came from the South, West & Wales Doctoral Training Partnership. M.G.’s osteological analyses were funded by Culture Vannin. A.S.-N. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. T.H., T.S. and K.K.’s work was supported by a grant from the Hungarian Research, Development and Innovation Office (project number: FK128013). We acknowledge support for radiocarbon dating and stable isotope analyses as well as access to skeletal material from Manx National Heritage and A. Fox. Dating analysis was funded by Leverhulme Trust grant RPG-388. M.G.T. and I.B. were supported by a Wellcome Trust Investigator Award (project 100713/Z/12/Z). I.O. was supported by a Ramón y Cajal grant from Ministerio de Ciencia e Innovación, Spanish Government (RYC2019-027909-I). The research directed at Harvard was funded by NIH grants GM100233 and HG012287, by John Templeton Foundation grant 61220, by a gift from Jean-François Clin, and by the Allen Discovery Center program, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. D.R. is also an Investigator of the Howard Hughes Medical Institute. Present-day people from England and Wales have more ancestry derived from early European farmers (EEF) than did people of the Early Bronze Age1. To understand this, here we generated genome-wide data from 793 individuals, increasing data from the Middle to the Late Bronze Age and Iron Age in Britain by 12-fold, and western and central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of people of England and Wales from the Iron Age, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to the Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and the independent genetic trajectory in Britain is also reflected in the rise of the allele conferring lactase persistence to approximately 50% by this time compared to approximately 7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period. Peer reviewed
CORE (RIOXX-UK Aggre... arrow_drop_down NARCIS; Nature; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional RepositoryArticle . 2021 . 2022NARCIS; NatureArticle . 2021 . 2022Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Springer TDMLeiden University Scholarly Publications RepositoryArticle . 2021Data sources: Leiden University Scholarly Publications Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 72 citations 72 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 216visibility views 216 download downloads 1,655 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down NARCIS; Nature; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional RepositoryArticle . 2021 . 2022NARCIS; NatureArticle . 2021 . 2022Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Springer TDMLeiden University Scholarly Publications RepositoryArticle . 2021Data sources: Leiden University Scholarly Publications Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2013 Italy, Croatia, Spain, United States, United Kingdom, Argentina, ArgentinaPublisher:Cold Spring Harbor Laboratory Funded by:NSERC, WT, NSF | XSEDE: eXtreme Science an... +7 projectsNSERC ,WT ,NSF| XSEDE: eXtreme Science and Engineering Discovery Environment ,NIH| Human Genome Structural Variation ,NSF| Collaborative Research: Genetic Bases for the Evolution of Human Diet ,NIH| Population mixture in evolutionary and medical genetics ,NSF| A new history and geography of human genes informed by ancient DNA ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,EC| MALADAPTED ,NIH| Models of Complex Genetic SystemsIosif Lazaridis; Nick Patterson; Alissa Mittnik; Gabriel Renaud; Swapan Mallick; Karola Kirsanow; Peter H. Sudmant; Joshua G. Schraiber; Sergi Castellano; Mark Lipson; Bonnie Berger; Christos Economou; Ruth Bollongino; Qiaomei Fu; Kirsten I. Bos; Susanne Nordenfelt; Heng Li; Cesare de Filippo; Kay Prüfer; Susanna Sawyer; Cosimo Posth; Wolfgang Haak; Fredrik Hallgren; Elin Fornander; Nadin Rohland; Dominique Delsate; Michael Francken; Jean-Michel Guinet; Joachim Wahl; George Ayodo; Hamza A. Babiker; Graciela Bailliet; Elena Balanovska; Oleg Balanovsky; Ramiro Barrantes; Gabriel Bedoya; Haim Ben-Ami; Judit Bene; Fouad Berrada; Claudio M. Bravi; Francesca Brisighelli; George B.J. Busby; Francesco Calì; Mikhail Churnosov; David E. C. Cole; Daniel Corach; Larissa Damba; George van Driem; Stanislav Dryomov; Jean-Michel Dugoujon; Sardana A. Fedorova; Irene Gallego Romero; Marina Gubina; Michael F. Hammer; Brenna M. Henn; Tor Hervig; Ugur Hodoglugil; Aashish R. Jha; Sena Karachanak-Yankova; Rita Khusainova; Elza Khusnutdinova; Rick A. Kittles; Toomas Kivisild; William Klitz; Vaidutis Kučinskas; Alena Kushniarevich; Leila Laredj; Sergey Litvinov; Theologos Loukidis; Robert W. Mahley; Béla Melegh; Ene Metspalu; Julio Molina; Joanna L. Mountain; Klemetti Näkkäläjärvi; Desislava Nesheva; Thomas B. Nyambo; Ludmila P. Osipova; Jüri Parik; Fedor Platonov; Olga L. Posukh; Valentino Romano; Francisco Rothhammer; Igor Rudan; Ruslan Ruizbakiev; Hovhannes Sahakyan; Antti Sajantila; Antonio Salas; Elena B. Starikovskaya; Ayele Tarekegn; Draga Toncheva; Shahlo Turdikulova; Ingrida Uktveryte; Olga Utevska; René Vasquez; Mercedes Villena; Mikhail Voevoda; Cheryl A. Winkler; Levon Yepiskoposyan; Pierre Zalloua; Tatijana Zemunik; Alan Cooper; Cristian Capelli; Mark G. Thomas; Andres Ruiz-Linares; Sarah A. Tishkoff; Lalji Singh; Kumarasamy Thangaraj; Richard Villems; David Comas; Rem I. Sukernik; Mait Metspalu; Matthias Meyer; Evan E. Eichler; Joachim Burger; Montgomery Slatkin; Svante Pääbo; Janet Kelso; David Reich; Johannes Krause;J. Kr., A.M. and C.P. are grateful for support from DFG grant number KR 4015/1-1, the Carl-Zeiss Foundation and the Baden Württemberg Foundation. S. P., G. R., Q. F., C. F., K. P., S.C. and J.Ke. acknowledge support from the Presidential Innovation Fund of the Max Planck Society. G.R. was supported by an NSERC fellowship. J.G.S. acknowledges use of the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF grant number OCI-1053575. E.B. and O.B. were supported by RFBR grants 13-06-00670, 13-04-01711, 13-04-90420. B.M. was supported by grants OTKA 73430 and 103983. A.Saj. was supported by a Finnish Professor Pool (Paulo Foundation) Grant. The Lithuanian sampling was supported by the LITGEN project (VP1-3.1-ŠMM-07-K-01-013), funded by the European Social Fund under the Global Grant Measure. A.S. was supported by Spanish grants SAF2011-26983 and EM 2012/045. O.U. was supported by Ukrainian SFFS grant F53.4/071. S.A.T. was supported by NIH Pioneer Award 8DP1ES022577-04 and NSF HOMINID award BCS-0827436. K.T. was supported by an Indian CSIR Network Project (GENESIS: BSC0121). L.S. was supported by an Indian CSIR Bhatnagar Fellowship. R.V., M.M., J.P. and E.M. were supported by the European Union Regional Development Fund through the Centre of Excellence in Genomics to the Estonian Biocentre and University of Tartu and by an Estonian Basic Research grant SF0270177As08. M.M. was additionally supported by Estonian Science Foundation grant number 8973. J.G.S. and M.S. were supported by NIH grant GM40282. P.H.S. and E.E.E. were supported by NIH grants HG004120 and HG002385. D.R. and N.P. were supported by NSF HOMINID award BCS-1032255 and NIH grant GM100233. This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN26120080001E. This Research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.
bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4170574Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; NatureArticle . 2014 . Peer-reviewedLicense: Springer TDMarXiv.org e-Print ArchiveOther literature type . Preprint . 2013Data sources: arXiv.org e-Print ArchiveCroatian Scientific Bibliography - CROSBIArticle . 2014Data sources: Croatian Scientific Bibliography - CROSBIServicio de Difusión de la Creación IntelectualArticle . 2014Data sources: Servicio de Difusión de la Creación Intelectualhttps://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 1K citations 1,096 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 24visibility views 24 download downloads 297 Powered bymore_vert bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4170574Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; NatureArticle . 2014 . Peer-reviewedLicense: Springer TDMarXiv.org e-Print ArchiveOther literature type . Preprint . 2013Data sources: arXiv.org e-Print ArchiveCroatian Scientific Bibliography - CROSBIArticle . 2014Data sources: Croatian Scientific Bibliography - CROSBIServicio de Difusión de la Creación IntelectualArticle . 2014Data sources: Servicio de Difusión de la Creación Intelectualhttps://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 France, United Kingdom, France, Italy, United States, CroatiaPublisher:Springer Science and Business Media LLC Funded by:WT | Human Adaptation to Chang..., NIH | Integrative nutrigenomic ..., WT | Wellcome Trust Sanger Ins... +9 projectsWT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,NIH| Integrative nutrigenomic and metabolomic analyses of Africans with variable diets ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,ARC| The origin of the first Australians ,ANR| OCEOADAPTO ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,EC| NEFREX ,EC| LocalAdaptation ,NIH| Integrative Genomics of Body Size and Metabolism in Ethnically Diverse Africans ,EC| ePerMed ,ARC| Discovery Projects - Grant ID: DP140101405 ,EC| MALADAPTEDLuca Pagani; Daniel Lawson; Evelyn Jagoda; Alexander Mörseburg; Anders Eriksson; Mario Mitt; Florian Clemente; Georgi Hudjashov; Michael DeGiorgio; Lauri Saag; Jeffrey D. Wall; Alexia Cardona; Reedik Mägi; Melissa A. Wilson Sayres; Sarah Kaewert; Charlotte E. Inchley; Christiana L. Scheib; Mari Järve; Monika Karmin; Guy S. Jacobs; Tiago Antao; Florin Mircea Iliescu; Alena Kushniarevich; Qasim Ayub; Chris Tyler-Smith; Yali Xue; Bayazit Yunusbayev; Kristiina Tambets; Chandana Basu Mallick; Lehti Saag; Elvira Pocheshkhova; George Andriadze; Craig Muller; Michael C. Westaway; David M. Lambert; Grigor Zoraqi; Shahlo Turdikulova; Dilbar Dalimova; Zhaxylyk Sabitov; Gazi Nurun Nahar Sultana; Joseph Lachance; Sarah A. Tishkoff; Kuvat T. Momynaliev; Jainagul Isakova; Larisa Damba; Marina Gubina; Pagbajabyn Nymadawa; Irina Evseeva; L. A. Atramentova; Olga Utevska; François-Xavier Ricaut; Nicolas Brucato; Herawati Sudoyo; Thierry Letellier; Murray P. Cox; Nikolay A. Barashkov; Vedrana Škaro; Lejla Mulahasanovic; Dragan Primorac; Hovhannes Sahakyan; Maru Mormina; Christina A. Eichstaedt; Daria V. Lichman; S M Abdullah; Gyaneshwer Chaubey; Joseph Wee; Evelin Mihailov; A. S. Karunas; Sergei Litvinov; Rita Khusainova; N. V. Ekomasova; V. L. Akhmetova; I. M. Khidiyatova; Damir Marjanović; Levon Yepiskoposyan; Doron M. Behar; Elena Balanovska; Andres Metspalu; Miroslava Derenko; Boris Malyarchuk; Mikhail Voevoda; Sardana A. Fedorova; Ludmila P. Osipova; Marta Mirazón Lahr; Pascale Gerbault; Matthew Leavesley; Andrea Bamberg Migliano; Michael D. Petraglia; Oleg Balanovsky; Elza Khusnutdinova; Ene Metspalu; Mark G. Thomas; Andrea Manica; Rasmus Nielsen; Richard Villems; Eske Willerslev; Toomas Kivisild; Mait Metspalu;pmc: PMC5164938
High-coverage whole-genome sequence studies have so far focused on a limited number1 of geographically restricted populations2, 3, 4, 5, or been targeted at specific diseases, such as cancer6. Nevertheless, the availability of high- resolution genomic data has led to the development of new methodologies for inferring population history7, 8, 9 and refuelled the debate on the mutation rate in humans10. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record11, and admixture between AMHs and Neanderthals predating the main Eurasian expansion12, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75, 000 years ago.
Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5164938Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature19792&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 329 citations 329 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 19visibility views 19 download downloads 93 Powered bymore_vert Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5164938Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2018Publisher:Cold Spring Harbor Laboratory Funded by:WT | Human Adaptation to Chang..., NSF | A new history and geograp...WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,NSF| A new history and geography of human genes informed by ancient DNASelina Brace; Yoan Diekmann; Thomas J. Booth; Zuzana Faltyskova; Nadin Rohland; Swapan Mallick; Matthew Ferry; Megan Michel; Jonas Oppenheimer; Nasreen Broomandkhoshbacht; Kristin Stewardson; Susan Walsh; Manfred Kayser; Rick Schulting; Oliver E. Craig; J A Sheridan; Mike Parker Pearson; Chris Stringer; David Reich; Mark G. Thomas; Ian Barnes;doi: 10.1101/267443
The roles of migration, admixture and acculturation in the European transition to farming have been debated for over 100 years. Genome-wide ancient DNA studies indicate predominantly Anatolian ancestry for continental Neolithic farmers, but also variable admixture with local Mesolithic hunter-gatherers1–9. Neolithic cultures first appear in Britain c. 6000 years ago (kBP), a millennium after they appear in adjacent areas of northwestern continental Europe. However, the pattern and process of the British Neolithic transition remains unclear10–15. We assembled genome-wide data from six Mesolithic and 67 Neolithic individuals found in Britain, dating from 10.5-4.5 kBP, a dataset that includes 22 newly reported individuals and the first genomic data from British Mesolithic hunter-gatherers. Our analyses reveals persistent genetic affinities between Mesolithic British and Western European hunter-gatherers over a period spanning Britain’s separation from continental Europe. We find overwhelming support for agriculture being introduced by incoming continental farmers, with small and geographically structured levels of additional hunter-gatherer introgression. We find genetic affinity between British and Iberian Neolithic populations indicating that British Neolithic people derived much of their ancestry from Anatolian farmers who originally followed the Mediterranean route of dispersal and likely entered Britain from northwestern mainland Europe.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu19 citations 19 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/267443&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Croatia, United Kingdom, United Kingdom, United Kingdom, Netherlands, United Kingdom, Germany, United KingdomPublisher:Springer Science and Business Media LLC Funded by:WT, FCT | D4, UKRI | Study of common and rare ...WT ,FCT| D4 ,UKRI| Study of common and rare genetic variants in respiratory health: the UK Biobank Lung Exome Evaluation (UK BiLEVE) consoertiumLouise V. Wain; Nick Shrine; María Soler Artigas; A. Mesut Erzurumluoglu; Boris Noyvert; Lara Bossini-Castillo; Ma'en Obeidat; Amanda P. Henry; Michael A. Portelli; Robert J. Hall; Charlotte K. Billington; Tracy L. Rimington; Anthony G. Fenech; Catherine John; Tineka Blake; Victoria E. Jackson; Richard J. Allen; Bram P. Prins; Archie Campbell; David J. Porteous; Marjo-Riitta Järvelin; Matthias Wielscher; Alan James; Jennie Hui; Nicholas J. Wareham; Jing Hua Zhao; James F. Wilson; Peter K. Joshi; Beate Stubbe; Rajesh Rawal; Holger Schulz; Medea Imboden; Nicole Probst-Hensch; Stefan Karrasch; Christian Gieger; Ian J. Deary; Sarah E. Harris; Jonathan Marten; Igor Rudan; Stefan Enroth; Ulf Gyllensten; Shona M. Kerr; Ozren Polasek; Mika Kähönen; Ida Surakka; Veronique Vitart; Caroline Hayward; Terho Lehtimäki; Olli T. Raitakari; David M. Evans; A. John Henderson; Craig E. Pennell; Carol A. Wang; Peter D. Sly; Emily S. Wan; Robert Busch; Brian D. Hobbs; Augusto A. Litonjua; David Sparrow; Amund Gulsvik; Per Bakke; James D. Crapo; Terri H. Beaty; Nadia N. Hansel; Rasika A. Mathias; Ingo Ruczinski; Kathleen C. Barnes; Yohan Bossé; Philippe Joubert; Maarten van den Berge; Corry-Anke Brandsma; Peter D. Paré; Don D. Sin; David C. Nickle; Ke Hao; Omri Gottesman; Frederick E. Dewey; Shannon Bruse; David J. Carey; H. Lester Kirchner; Stefan Jonsson; Gudmar Thorleifsson; Ingileif Jonsdottir; Thorarinn Gislason; Kari Stefansson; Claudia Schurmann; Girish N. Nadkarni; Erwin P. Bottinger; Ruth J. F. Loos; Robin G. Walters; Zhengming Chen; Iona Y Millwood; Julien Vaucher; Om P Kurmi; Liming Li; Anna Hansell; Christopher E. Brightling; Eleftheria Zeggini; Michael H. Cho; Edwin K. Silverman; Ian Sayers; Gosia Trynka; Andrew P. Morris; David P. Strachan; Ian P. Hall; Martin D. Tobin;Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (similar to 6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 x 10(-49)), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications.
CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5326681Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositoryPublication Server of Helmholtz Zentrum München (PuSH)Article . 2017Data sources: Publication Server of Helmholtz Zentrum München (PuSH)Croatian Scientific Bibliography - CROSBIArticle . 2017Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ng.3787&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 256 citations 256 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 38visibility views 38 download downloads 437 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5326681Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositoryPublication Server of Helmholtz Zentrum München (PuSH)Article . 2017Data sources: Publication Server of Helmholtz Zentrum München (PuSH)Croatian Scientific Bibliography - CROSBIArticle . 2017Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2019 Norway, Denmark, United Kingdom, France, United States, France, Norway, United KingdomPublisher:The Royal Society Funded by:UKRI | Animals, Lifeways and Lif..., UKRI | Deciphering dog domestica..., NSF | Genetic Analysis of Indig... +7 projectsUKRI| Animals, Lifeways and Lifeworlds in Yup'ik Archaeology (ALLY): Subsistence, Technologies, and Communities of Change ,UKRI| Deciphering dog domestication through a combined ancient DNA and geometric morphometric approach ,NSF| Genetic Analysis of Indigenous Dogs from Siberia to Greenland: Implications for Interaction among their Human Companions ,EC| WhereWolf ,UKRI| Deciphering dog domestication through a combined ancient DNA and geometric morphometric approach ,NSF| Genetic Analysis of Prehistoric Canis Remains from Across the North American Arctic: Implications for Interactions Among their Human Companions ,EC| UNDEAD ,UKRI| Understanding Cultural Resilience and Climate Change on the Bering Sea through Yup'ik Ecological Knowledge, Lifeways, Learning and Archaeology (ELLA) ,WT| Domestic animals as a model to understand the relationship between deleterious mutations, demography and disease ,EC| ArchSci2020Carly Ameen; Tatiana R. Feuerborn; Sarah K. Brown; Anna Linderholm; Ardern Hulme-Beaman; Ophélie Lebrasseur; Mikkel-Holger S. Sinding; Zachary T. Lounsberry; Audrey T. Lin; Martin Appelt; Lutz Bachmann; Matthew W. Betts; Kate Britton; John Darwent; Rune Dietz; Merete Fredholm; Shyam Gopalakrishnan; Olga I. Goriunova; Bjarne Grønnow; James Haile; Jón Hallsteinn Hallsson; Ramona Harrison; Mads Peter Heide-Jørgensen; Rick Knecht; Robert J. Losey; Edouard Masson-MacLean; Thomas H. McGovern; Ellen McManus-Fry; Morten Meldgaard; Åslaug Midtdal; Madonna L. Moss; Iurii G. Nikitin; Tatiana Nomokonova; Albína Hulda Pálsdóttir; Angela R. Perri; Aleksandr N. Popov; Lisa Rankin; Joshua D. Reuther; Mikhail Sablin; Anne Lisbeth Schmidt; Scott Shirar; Konrad Smiarowski; Christian Sonne; Mary C. Stiner; Mitya Vasyukov; Catherine F. West; Gro Birgit Ween; Sanne Eline Wennerberg; Øystein Wiig; James Woollett; Love Dalén; Anders J. Hansen; M. Thomas P. Gilbert; Benjamin N. Sacks; Laurent A. F. Frantz; Greger Larson; Keith Dobney; Christyann M. Darwent; Allowen Evin;pmid: 31771471
pmc: PMC6939252
Domestic dogs have been central to life in the North American Arctic for millennia. The ancestors of the Inuit were the first to introduce the widespread usage of dog sledge transportation technology to the Americas, but whether the Inuit adopted local Palaeo-Inuit dogs or introduced a new dog population to the region remains unknown. To test these hypotheses, we generated mitochondrial DNA and geometric morphometric data of skull and dental elements from a total of 922 North American Arctic dogs and wolves spanning over 4500 years. Our analyses revealed that dogs from Inuit sites dating from 2000 BP possess morphological and genetic signatures that distinguish them from earlier Palaeo-Inuit dogs, and identified a novel mitochondrial clade in eastern Siberia and Alaska. The genetic legacy of these Inuit dogs survives today in modern Arctic sledge dogs despite phenotypic differences between archaeological and modern Arctic dogs. Together, our data reveal that Inuit dogs derive from a secondary pre-contact migration of dogs distinct from Palaeo-Inuit dogs, and probably aided the Inuit expansion across the North American Arctic beginning around 1000 BP. Domestic dogs have been central to life in the North American Arctic for millennia. The ancestors of the Inuit were the first to introduce the widespread usage of dog sledge transportation technology to the Americas, but whether the Inuit adopted local Palaeo-Inuit dogs or introduced a new dog population to the region remains unknown. To test these hypotheses, we generated mitochondrial DNA and geometric morphometric data of skull and dental elements from a total of 922 North American Arctic dogs and wolves spanning over 4500 years. Our analyses revealed that dogs from Inuit sites dating from 2000 BP possess morphological and genetic signatures that distinguish them from earlier Palaeo-Inuit dogs, and identified a novel mitochondrial clade in eastern Siberia and Alaska. The genetic legacy of these Inuit dogs survives today in modern Arctic sledge dogs despite phenotypic differences between archaeological and modern Arctic dogs. Together, our data reveal that Inuit dogs derive from a secondary pre-contact migration of dogs distinct from Palaeo-Inuit dogs, and probably aided the Inuit expansion across the North American Arctic beginning around 1000 BP.
Mémoires en Sciences... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6939252Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaDigitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2019 . Peer-reviewedOxford University Research ArchiveArticle . 2019License: CC BYData sources: Oxford University Research ArchiveProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallBergen Open Research Archive - UiBArticle . 2019 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBProceedings of the Royal Society B Biological SciencesOther literature type . Article . 2019 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rspb.2019.1929&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 45 citations 45 popularity Top 10% influence Average impulse Top 1% Powered by BIP!visibility 17visibility views 17 download downloads 17 Powered bymore_vert Mémoires en Sciences... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6939252Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2019Data sources: eScholarship - University of CaliforniaDigitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2019 . Peer-reviewedOxford University Research ArchiveArticle . 2019License: CC BYData sources: Oxford University Research ArchiveProceedings of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallBergen Open Research Archive - UiBArticle . 2019 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBProceedings of the Royal Society B Biological SciencesOther literature type . Article . 2019 . Peer-reviewedLicense: Royal Society Data Sharing and Accessibilityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Netherlands, Croatia, United Kingdom, United Kingdom, SpainPublisher:Springer Science and Business Media LLC Funded by:NIH | Advanced tools for using ..., WT | Human Adaptation to Chang..., FCT | LA 14 +4 projectsNIH| Advanced tools for using ancient DNA to study biology and history ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,FCT| LA 14 ,UKRI| Urban-Air Port | "Air-One" [Rapidly Deployable Vertiport For Drone-Delivery, Air-Taxi, Disaster Management] ,EC| COREX ,EC| COMMIOS ,NIH| Population mixture in evolutionary and medical geneticsNick Patterson; Michael Isakov; Thomas Booth; Lindsey Büster; Claire-Elise Fischer; Iñigo Olalde; Harald Ringbauer; Ali Akbari; Olivia Cheronet; Madeleine Bleasdale; Nicole Adamski; Eveline Altena; Rebecca Bernardos; Selina Brace; Nasreen Broomandkhoshbacht; Kimberly Callan; Francesca Candilio; Brendan Culleton; Elizabeth Curtis; Lea Demetz; Kellie Sara Duffett Carlson; Ceiridwen J. Edwards; Daniel M. Fernandes; M. George B. Foody; Suzanne Freilich; Helen Goodchild; Aisling Kearns; Ann Marie Lawson; Iosif Lazaridis; Matthew Mah; Swapan Mallick; Kirsten Mandl; Adam Micco; Megan Michel; Guillermo Bravo Morante; Jonas Oppenheimer; Kadir Toykan Özdoğan; Lijun Qiu; Constanze Schattke; Kristin Stewardson; J. Noah Workman; Fatma Zalzala; Zhao Zhang; Bibiana Agustí; Tim Allen; Katalin Almássy; Luc Amkreutz; Abigail Ash; Christèle Baillif-Ducros; Alistair Barclay; László Bartosiewicz; Katherine Baxter; Zsolt Bernert; Jan Blažek; Mario Bodružić; Philippe Boissinot; Clive Bonsall; Pippa Bradley; Marcus Brittain; Alison Brookes; Fraser Brown; Lisa Brown; Richard Brunning; Chelsea Budd; Josip Burmaz; Sylvain Canet; Silvia Carnicero-Cáceres; Morana Čaušević-Bully; Andrew Chamberlain; Sébastien Chauvin; Sharon Clough; Natalija Čondić; Alfredo Coppa; Oliver Craig; Matija Črešnar; Vicki Cummings; Szabolcs Czifra; Alžběta Danielisová; Robin Daniels; Alex Davies; Philip de Jersey; Jody Deacon; Csilla Deminger; Peter W. Ditchfield; Marko Dizdar; Miroslav Dobeš; Miluše Dobisíková; László Domboróczki; Gail Drinkall; Ana Đukić; Michal Ernée; Christopher Evans; Jane Evans; Manuel Fernández-Götz; Slavica Filipović; Andrew Fitzpatrick; Harry Fokkens; Chris Fowler; Allison Fox; Zsolt Gallina; Michelle Gamble; Manuel R. González Morales; Borja González-Rabanal; Adrian Green; Katalin Gyenesei; Diederick Habermehl; Tamás Hajdu; Derek Hamilton; James Harris; Chris Hayden; Joep Hendriks; Bénédicte Hernu; Gill Hey; Milan Horňák; Gábor Ilon; Eszter Istvánovits; Andy M. Jones; Martina Blečić Kavur; Kevin Kazek; Robert A. Kenyon; Amal Khreisheh; Viktória Kiss; Jos Kleijne; Mark Knight; Lisette M. Kootker; Péter F. Kovács; Anita Kozubová; Gabriella Kulcsár; Valéria Kulcsár; Christophe Le Pennec; Michael Legge; Matt Leivers; Louise Loe; Olalla López-Costas; Tom Lord; Dženi Los; James Lyall; Ana B. Marín-Arroyo; Philip Mason; Damir Matošević; Andy Maxted; Lauren McIntyre; Jacqueline McKinley; Kathleen McSweeney; Bernard Meijlink; Balázs G. Mende; Marko Menđušić; Milan Metlička; Sophie Meyer; Kristina Mihovilić; Lidija Milasinovic; Steve Minnitt; Joanna Moore; Geoff Morley; Graham Mullan; Margaréta Musilová; Benjamin Neil; Rebecca Nicholls; Mario Novak; Maria Pala; Martin Papworth; Cécile Paresys; Ricky Patten; Domagoj Perkić; Krisztina Pesti; Alba Petit; Katarína Petriščáková; Coline Pichon; Catriona Pickard; Zoltán Pilling; T. Douglas Price; Siniša Radović; Rebecca Redfern; Branislav Resutík; Daniel T. Rhodes; Martin B. Richards; Amy Roberts; Jean Roefstra; Pavel Sankot; Alena Šefčáková; Alison Sheridan; Sabine Skae; Miroslava Šmolíková; Krisztina Somogyi; Ágnes Somogyvári; Mark Stephens; Géza Szabó; Anna Szécsényi-Nagy; Tamás Szeniczey; Jonathan Tabor; Károly Tankó; Clenis Tavarez Maria; Rachel Terry; Biba Teržan; Maria Teschler-Nicola; Jesús F. Torres-Martínez; Julien Trapp; Ross Turle; Ferenc Ujvári; Menno van der Heiden; Petr Veleminsky; Barbara Veselka; Carles Lalueza-Fox; Peter de Knijff; Ian Barnes; Mark G. Thomas; Douglas J. Kennett; Malcolm Lillie; Ron Pinhasi; David Reich;pmc: PMC8889665
This work was funded in part by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 834087; the COMMIOS Project to I.A.). M.N. was supported by the Croatian Science Fund grant (HRZZ IP-2016-06-1450). P.V., M.Dobeš and Z.V. were supported by the Ministry of Culture of the Czech Republic (DKRVO 2019-2023/7.I.c, 00023272). M.E. was supported by Czech Academy of Sciences award Praemium Academiae. M.Dobisíková and A.Danielisová were supported by the grant RVO 67985912 of the Institute of Archaeology of the Czech Academy of Sciences. M.G.B.F. was funded by The Leverhulme Trust via a Doctoral Scholarship scheme awarded to M.Pala and M.B.R. Support to M.Legge came from the South, West & Wales Doctoral Training Partnership. M.G.’s osteological analyses were funded by Culture Vannin. A.S.-N. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. T.H., T.S. and K.K.’s work was supported by a grant from the Hungarian Research, Development and Innovation Office (project number: FK128013). We acknowledge support for radiocarbon dating and stable isotope analyses as well as access to skeletal material from Manx National Heritage and A. Fox. Dating analysis was funded by Leverhulme Trust grant RPG-388. M.G.T. and I.B. were supported by a Wellcome Trust Investigator Award (project 100713/Z/12/Z). I.O. was supported by a Ramón y Cajal grant from Ministerio de Ciencia e Innovación, Spanish Government (RYC2019-027909-I). The research directed at Harvard was funded by NIH grants GM100233 and HG012287, by John Templeton Foundation grant 61220, by a gift from Jean-François Clin, and by the Allen Discovery Center program, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. D.R. is also an Investigator of the Howard Hughes Medical Institute. Present-day people from England and Wales have more ancestry derived from early European farmers (EEF) than did people of the Early Bronze Age1. To understand this, here we generated genome-wide data from 793 individuals, increasing data from the Middle to the Late Bronze Age and Iron Age in Britain by 12-fold, and western and central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of people of England and Wales from the Iron Age, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to the Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and the independent genetic trajectory in Britain is also reflected in the rise of the allele conferring lactase persistence to approximately 50% by this time compared to approximately 7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period. Peer reviewed
CORE (RIOXX-UK Aggre... arrow_drop_down NARCIS; Nature; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional RepositoryArticle . 2021 . 2022NARCIS; NatureArticle . 2021 . 2022Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Springer TDMLeiden University Scholarly Publications RepositoryArticle . 2021Data sources: Leiden University Scholarly Publications Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 72 citations 72 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 216visibility views 216 download downloads 1,655 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down NARCIS; Nature; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional RepositoryArticle . 2021 . 2022NARCIS; NatureArticle . 2021 . 2022Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: Springer TDMLeiden University Scholarly Publications RepositoryArticle . 2021Data sources: Leiden University Scholarly Publications Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2013 Italy, Croatia, Spain, United States, United Kingdom, Argentina, ArgentinaPublisher:Cold Spring Harbor Laboratory Funded by:NSERC, WT, NSF | XSEDE: eXtreme Science an... +7 projectsNSERC ,WT ,NSF| XSEDE: eXtreme Science and Engineering Discovery Environment ,NIH| Human Genome Structural Variation ,NSF| Collaborative Research: Genetic Bases for the Evolution of Human Diet ,NIH| Population mixture in evolutionary and medical genetics ,NSF| A new history and geography of human genes informed by ancient DNA ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,EC| MALADAPTED ,NIH| Models of Complex Genetic SystemsIosif Lazaridis; Nick Patterson; Alissa Mittnik; Gabriel Renaud; Swapan Mallick; Karola Kirsanow; Peter H. Sudmant; Joshua G. Schraiber; Sergi Castellano; Mark Lipson; Bonnie Berger; Christos Economou; Ruth Bollongino; Qiaomei Fu; Kirsten I. Bos; Susanne Nordenfelt; Heng Li; Cesare de Filippo; Kay Prüfer; Susanna Sawyer; Cosimo Posth; Wolfgang Haak; Fredrik Hallgren; Elin Fornander; Nadin Rohland; Dominique Delsate; Michael Francken; Jean-Michel Guinet; Joachim Wahl; George Ayodo; Hamza A. Babiker; Graciela Bailliet; Elena Balanovska; Oleg Balanovsky; Ramiro Barrantes; Gabriel Bedoya; Haim Ben-Ami; Judit Bene; Fouad Berrada; Claudio M. Bravi; Francesca Brisighelli; George B.J. Busby; Francesco Calì; Mikhail Churnosov; David E. C. Cole; Daniel Corach; Larissa Damba; George van Driem; Stanislav Dryomov; Jean-Michel Dugoujon; Sardana A. Fedorova; Irene Gallego Romero; Marina Gubina; Michael F. Hammer; Brenna M. Henn; Tor Hervig; Ugur Hodoglugil; Aashish R. Jha; Sena Karachanak-Yankova; Rita Khusainova; Elza Khusnutdinova; Rick A. Kittles; Toomas Kivisild; William Klitz; Vaidutis Kučinskas; Alena Kushniarevich; Leila Laredj; Sergey Litvinov; Theologos Loukidis; Robert W. Mahley; Béla Melegh; Ene Metspalu; Julio Molina; Joanna L. Mountain; Klemetti Näkkäläjärvi; Desislava Nesheva; Thomas B. Nyambo; Ludmila P. Osipova; Jüri Parik; Fedor Platonov; Olga L. Posukh; Valentino Romano; Francisco Rothhammer; Igor Rudan; Ruslan Ruizbakiev; Hovhannes Sahakyan; Antti Sajantila; Antonio Salas; Elena B. Starikovskaya; Ayele Tarekegn; Draga Toncheva; Shahlo Turdikulova; Ingrida Uktveryte; Olga Utevska; René Vasquez; Mercedes Villena; Mikhail Voevoda; Cheryl A. Winkler; Levon Yepiskoposyan; Pierre Zalloua; Tatijana Zemunik; Alan Cooper; Cristian Capelli; Mark G. Thomas; Andres Ruiz-Linares; Sarah A. Tishkoff; Lalji Singh; Kumarasamy Thangaraj; Richard Villems; David Comas; Rem I. Sukernik; Mait Metspalu; Matthias Meyer; Evan E. Eichler; Joachim Burger; Montgomery Slatkin; Svante Pääbo; Janet Kelso; David Reich; Johannes Krause;J. Kr., A.M. and C.P. are grateful for support from DFG grant number KR 4015/1-1, the Carl-Zeiss Foundation and the Baden Württemberg Foundation. S. P., G. R., Q. F., C. F., K. P., S.C. and J.Ke. acknowledge support from the Presidential Innovation Fund of the Max Planck Society. G.R. was supported by an NSERC fellowship. J.G.S. acknowledges use of the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF grant number OCI-1053575. E.B. and O.B. were supported by RFBR grants 13-06-00670, 13-04-01711, 13-04-90420. B.M. was supported by grants OTKA 73430 and 103983. A.Saj. was supported by a Finnish Professor Pool (Paulo Foundation) Grant. The Lithuanian sampling was supported by the LITGEN project (VP1-3.1-ŠMM-07-K-01-013), funded by the European Social Fund under the Global Grant Measure. A.S. was supported by Spanish grants SAF2011-26983 and EM 2012/045. O.U. was supported by Ukrainian SFFS grant F53.4/071. S.A.T. was supported by NIH Pioneer Award 8DP1ES022577-04 and NSF HOMINID award BCS-0827436. K.T. was supported by an Indian CSIR Network Project (GENESIS: BSC0121). L.S. was supported by an Indian CSIR Bhatnagar Fellowship. R.V., M.M., J.P. and E.M. were supported by the European Union Regional Development Fund through the Centre of Excellence in Genomics to the Estonian Biocentre and University of Tartu and by an Estonian Basic Research grant SF0270177As08. M.M. was additionally supported by Estonian Science Foundation grant number 8973. J.G.S. and M.S. were supported by NIH grant GM40282. P.H.S. and E.E.E. were supported by NIH grants HG004120 and HG002385. D.R. and N.P. were supported by NSF HOMINID award BCS-1032255 and NIH grant GM100233. This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN26120080001E. This Research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.
bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4170574Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; NatureArticle . 2014 . Peer-reviewedLicense: Springer TDMarXiv.org e-Print ArchiveOther literature type . Preprint . 2013Data sources: arXiv.org e-Print ArchiveCroatian Scientific Bibliography - CROSBIArticle . 2014Data sources: Croatian Scientific Bibliography - CROSBIServicio de Difusión de la Creación IntelectualArticle . 2014Data sources: Servicio de Difusión de la Creación Intelectualhttps://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 1K citations 1,096 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 24visibility views 24 download downloads 297 Powered bymore_vert bioRxiv arrow_drop_down bioRxivPreprint . 2013Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4170574Data sources: PubMed CentralCONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas; NatureArticle . 2014 . Peer-reviewedLicense: Springer TDMarXiv.org e-Print ArchiveOther literature type . Preprint . 2013Data sources: arXiv.org e-Print ArchiveCroatian Scientific Bibliography - CROSBIArticle . 2014Data sources: Croatian Scientific Bibliography - CROSBIServicio de Difusión de la Creación IntelectualArticle . 2014Data sources: Servicio de Difusión de la Creación Intelectualhttps://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 France, United Kingdom, France, Italy, United States, CroatiaPublisher:Springer Science and Business Media LLC Funded by:WT | Human Adaptation to Chang..., NIH | Integrative nutrigenomic ..., WT | Wellcome Trust Sanger Ins... +9 projectsWT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,NIH| Integrative nutrigenomic and metabolomic analyses of Africans with variable diets ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,ARC| The origin of the first Australians ,ANR| OCEOADAPTO ,NIH| African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits ,EC| NEFREX ,EC| LocalAdaptation ,NIH| Integrative Genomics of Body Size and Metabolism in Ethnically Diverse Africans ,EC| ePerMed ,ARC| Discovery Projects - Grant ID: DP140101405 ,EC| MALADAPTEDLuca Pagani; Daniel Lawson; Evelyn Jagoda; Alexander Mörseburg; Anders Eriksson; Mario Mitt; Florian Clemente; Georgi Hudjashov; Michael DeGiorgio; Lauri Saag; Jeffrey D. Wall; Alexia Cardona; Reedik Mägi; Melissa A. Wilson Sayres; Sarah Kaewert; Charlotte E. Inchley; Christiana L. Scheib; Mari Järve; Monika Karmin; Guy S. Jacobs; Tiago Antao; Florin Mircea Iliescu; Alena Kushniarevich; Qasim Ayub; Chris Tyler-Smith; Yali Xue; Bayazit Yunusbayev; Kristiina Tambets; Chandana Basu Mallick; Lehti Saag; Elvira Pocheshkhova; George Andriadze; Craig Muller; Michael C. Westaway; David M. Lambert; Grigor Zoraqi; Shahlo Turdikulova; Dilbar Dalimova; Zhaxylyk Sabitov; Gazi Nurun Nahar Sultana; Joseph Lachance; Sarah A. Tishkoff; Kuvat T. Momynaliev; Jainagul Isakova; Larisa Damba; Marina Gubina; Pagbajabyn Nymadawa; Irina Evseeva; L. A. Atramentova; Olga Utevska; François-Xavier Ricaut; Nicolas Brucato; Herawati Sudoyo; Thierry Letellier; Murray P. Cox; Nikolay A. Barashkov; Vedrana Škaro; Lejla Mulahasanovic; Dragan Primorac; Hovhannes Sahakyan; Maru Mormina; Christina A. Eichstaedt; Daria V. Lichman; S M Abdullah; Gyaneshwer Chaubey; Joseph Wee; Evelin Mihailov; A. S. Karunas; Sergei Litvinov; Rita Khusainova; N. V. Ekomasova; V. L. Akhmetova; I. M. Khidiyatova; Damir Marjanović; Levon Yepiskoposyan; Doron M. Behar; Elena Balanovska; Andres Metspalu; Miroslava Derenko; Boris Malyarchuk; Mikhail Voevoda; Sardana A. Fedorova; Ludmila P. Osipova; Marta Mirazón Lahr; Pascale Gerbault; Matthew Leavesley; Andrea Bamberg Migliano; Michael D. Petraglia; Oleg Balanovsky; Elza Khusnutdinova; Ene Metspalu; Mark G. Thomas; Andrea Manica; Rasmus Nielsen; Richard Villems; Eske Willerslev; Toomas Kivisild; Mait Metspalu;pmc: PMC5164938
High-coverage whole-genome sequence studies have so far focused on a limited number1 of geographically restricted populations2, 3, 4, 5, or been targeted at specific diseases, such as cancer6. Nevertheless, the availability of high- resolution genomic data has led to the development of new methodologies for inferring population history7, 8, 9 and refuelled the debate on the mutation rate in humans10. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record11, and admixture between AMHs and Neanderthals predating the main Eurasian expansion12, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75, 000 years ago.
Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5164938Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 329 citations 329 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 19visibility views 19 download downloads 93 Powered bymore_vert Nature arrow_drop_down NatureArticle . 2016Full-Text: http://europepmc.org/articles/PMC5164938Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2016Data sources: eScholarship - University of CaliforniaNature; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2018Publisher:Cold Spring Harbor Laboratory Funded by:WT | Human Adaptation to Chang..., NSF | A new history and geograp...WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,NSF| A new history and geography of human genes informed by ancient DNASelina Brace; Yoan Diekmann; Thomas J. Booth; Zuzana Faltyskova; Nadin Rohland; Swapan Mallick; Matthew Ferry; Megan Michel; Jonas Oppenheimer; Nasreen Broomandkhoshbacht; Kristin Stewardson; Susan Walsh; Manfred Kayser; Rick Schulting; Oliver E. Craig; J A Sheridan; Mike Parker Pearson; Chris Stringer; David Reich; Mark G. Thomas; Ian Barnes;doi: 10.1101/267443
The roles of migration, admixture and acculturation in the European transition to farming have been debated for over 100 years. Genome-wide ancient DNA studies indicate predominantly Anatolian ancestry for continental Neolithic farmers, but also variable admixture with local Mesolithic hunter-gatherers1–9. Neolithic cultures first appear in Britain c. 6000 years ago (kBP), a millennium after they appear in adjacent areas of northwestern continental Europe. However, the pattern and process of the British Neolithic transition remains unclear10–15. We assembled genome-wide data from six Mesolithic and 67 Neolithic individuals found in Britain, dating from 10.5-4.5 kBP, a dataset that includes 22 newly reported individuals and the first genomic data from British Mesolithic hunter-gatherers. Our analyses reveals persistent genetic affinities between Mesolithic British and Western European hunter-gatherers over a period spanning Britain’s separation from continental Europe. We find overwhelming support for agriculture being introduced by incoming continental farmers, with small and geographically structured levels of additional hunter-gatherer introgression. We find genetic affinity between British and Iberian Neolithic populations indicating that British Neolithic people derived much of their ancestry from Anatolian farmers who originally followed the Mediterranean route of dispersal and likely entered Britain from northwestern mainland Europe.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu19 citations 19 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Croatia, United Kingdom, United Kingdom, United Kingdom, Netherlands, United Kingdom, Germany, United KingdomPublisher:Springer Science and Business Media LLC Funded by:WT, FCT | D4, UKRI | Study of common and rare ...WT ,FCT| D4 ,UKRI| Study of common and rare genetic variants in respiratory health: the UK Biobank Lung Exome Evaluation (UK BiLEVE) consoertiumLouise V. Wain; Nick Shrine; María Soler Artigas; A. Mesut Erzurumluoglu; Boris Noyvert; Lara Bossini-Castillo; Ma'en Obeidat; Amanda P. Henry; Michael A. Portelli; Robert J. Hall; Charlotte K. Billington; Tracy L. Rimington; Anthony G. Fenech; Catherine John; Tineka Blake; Victoria E. Jackson; Richard J. Allen; Bram P. Prins; Archie Campbell; David J. Porteous; Marjo-Riitta Järvelin; Matthias Wielscher; Alan James; Jennie Hui; Nicholas J. Wareham; Jing Hua Zhao; James F. Wilson; Peter K. Joshi; Beate Stubbe; Rajesh Rawal; Holger Schulz; Medea Imboden; Nicole Probst-Hensch; Stefan Karrasch; Christian Gieger; Ian J. Deary; Sarah E. Harris; Jonathan Marten; Igor Rudan; Stefan Enroth; Ulf Gyllensten; Shona M. Kerr; Ozren Polasek; Mika Kähönen; Ida Surakka; Veronique Vitart; Caroline Hayward; Terho Lehtimäki; Olli T. Raitakari; David M. Evans; A. John Henderson; Craig E. Pennell; Carol A. Wang; Peter D. Sly; Emily S. Wan; Robert Busch; Brian D. Hobbs; Augusto A. Litonjua; David Sparrow; Amund Gulsvik; Per Bakke; James D. Crapo; Terri H. Beaty; Nadia N. Hansel; Rasika A. Mathias; Ingo Ruczinski; Kathleen C. Barnes; Yohan Bossé; Philippe Joubert; Maarten van den Berge; Corry-Anke Brandsma; Peter D. Paré; Don D. Sin; David C. Nickle; Ke Hao; Omri Gottesman; Frederick E. Dewey; Shannon Bruse; David J. Carey; H. Lester Kirchner; Stefan Jonsson; Gudmar Thorleifsson; Ingileif Jonsdottir; Thorarinn Gislason; Kari Stefansson; Claudia Schurmann; Girish N. Nadkarni; Erwin P. Bottinger; Ruth J. F. Loos; Robin G. Walters; Zhengming Chen; Iona Y Millwood; Julien Vaucher; Om P Kurmi; Liming Li; Anna Hansell; Christopher E. Brightling; Eleftheria Zeggini; Michael H. Cho; Edwin K. Silverman; Ian Sayers; Gosia Trynka; Andrew P. Morris; David P. Strachan; Ian P. Hall; Martin D. Tobin;Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (similar to 6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 x 10(-49)), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications.
CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5326681Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositoryPublication Server of Helmholtz Zentrum München (PuSH)Article . 2017Data sources: Publication Server of Helmholtz Zentrum München (PuSH)Croatian Scientific Bibliography - CROSBIArticle . 2017Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 256 citations 256 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 38visibility views 38 download downloads 437 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5326681Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositoryPublication Server of Helmholtz Zentrum München (PuSH)Article . 2017Data sources: Publication Server of Helmholtz Zentrum München (PuSH)Croatian Scientific Bibliography - CROSBIArticle . 2017Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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