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The first issue of Nature Reviews Neuroscience was published 20 years ago, in 2000. To mark this anniversary, in this Viewpoint article we asked a selection of researchers from across the field who have authored pieces published in the journal in recent years for their thoughts on notable and interesting developments in neuroscience, and particularly in their areas of the field, over the past two decades. They also provide some thoughts on current lines of research and questions that excite them.

Ocean-going ships were key to rising maritime economies of the Early Modern period, and understanding how they were built is critical to grasp the challenges faced by shipwrights and merchant seafarers. Shipwreck timbers hold material evidence of the dynamic interplay of wood supplies, craftmanship, and evolving ship designs that helped shape the Early Modern world. Here we present the results of dendroarchaeological research carried out on Batavia���s wreck timbers, currently on display at the Western Australian Shipwrecks Museum in Fremantle. Built in Amsterdam in 1628 CE and wrecked on its maiden voyage in June 1629 CE in Western Australian waters, Batavia epitomises Dutch East India Company (Verenigde Oostindische Compagnie, or VOC) shipbuilding. In the 17th century, the VOC grew to become the first multinational trading enterprise, prompting the rise of the stock market and modern capitalism. Oak (Quercus sp.) was the preferred material for shipbuilding in northern and western Europe, and maritime nations struggled to ensure sufficient supplies to meet their needs and sustain their ever-growing mercantile fleets and networks. Our research illustrates the compatibility of dendrochronological studies with musealisation of shipwreck assemblages, and the results demonstrate that the VOC successfully coped with timber shortages in the early 17th century through diversification of timber sources (mainly Baltic region, L��beck hinterland in northern Germany, and Lower Saxony in northwest Germany), allocation of sourcing regions to specific timber products (hull planks from the Baltic and L��beck, framing elements from Lower Saxony), and skillful woodworking craftmanship (sapwood was removed from all timber elements). These strategies, combined with an innovative hull design and the use of wind-powered sawmills, allowed the Dutch to produce unprecedented numbers of ocean-going ships for long-distance voyaging and interregional trade in Asia, proving key to their success in 17th-century world trade. Funding: WvD LP130100137 Australian Research Council https://www.arc.gov.au/ No MD-D 607545 FP7 People Programme (Marie Curie Actions) https://ec.europa.eu/research/mariecurieactions/ 016.Veni.195.502 Nederlandse Organisatie voor Wetenschappelijk Onderzoek https://www.nwo.nl/en AD 677152 European Research Council https://erc.europa.eu/

The articles presented in this issue constitute the second part of the special issue devoted to analyzing the links between culture, crisis, and renewal as part of the research project “Cultural Na...

Rather than being seen as citizens, the children of immigrants are portrayed as a population to be controlled and contained across Europe. In Italy today, debates about cultural ‘authenticity’ and renewed nationalism accompany waves of moral panic that depict a country under siege by illegal and unwanted immigrants. Specifically in cities, immigrants and their children are imagined and portrayed as alien and out of place. Drawing on fourteen months of ethnographic research in Turin, Italy, with children of immigrants aged between 16 and 21, De Martini Ugolotti and Moyer illustrate how these youth make use of their bodies through capoeira and parkour practices to contest and reappropriate public spaces, thereby challenging dominant visions about what constitutes the public, how it should be used and by whom. They analyse the ‘body in place’ to understand how the children of immigrants navigate unequal spatial relations and challenge dominant regimes of representation, while also attempting to improve their life conditions and reach their personal goals.

Une série de photos récemment redécouvertes, illustrant les sépultures de treize individus ensevelis dans les amas coquilliers mésolithiques de Poças de S. Bento et d'Arapouco fouillés en 1960 et en 1962 dans la vallée du Sado au Portugal, démontre le potentiel d'une réévaluation d'anciennes archives avec de nouvelles méthodes. L'examen des clichés, dans une perspective archéothanatologique et étayés par des recherches expérimentales en taphonomie, a révélé certains détails concernant le traitement des cadavres et offert de nouvelles perspectives sur des lieux de sépulture. Certains cadavres auraient été momifiés, un phénomène que les auteurs associent à la mise en valeur et au transport des défunts et qui souligne l'importance du corps et du lieu de sépulture pendant le Mésolithique dans le sud du Portugal. Translation by Madeleine Hummler Letztlich wiederentdeckte Fotos von dreizehn Individuen, welche in den mesolithischen Muschelhäufen von Poças de S. Bento and Arapouco im portugiesischen Sadotal in den Jahren 1960 und 1962 ausgegraben wurden, zeigen das Potenzial einer Neubewertung von Archivalien mit neuen Methoden. Die Auswertung der Bilder, aus einer archäothanatologischen Perspektive gesehen und von experimentellen taphonomischen Untersuchungen unterstützt, hat Aspekte der Behandlung der Leichen bestätigt und neue Einblicke in die Benutzung von Begräbnisstätten geliefert. Die Ergebnisse deuten auf eine mögliche Mumifizierung der Leichen, was vielleicht mit deren Erhaltung und Transport verbunden ist und die Bedeutung des physischen Körpers der Toten sowie der Bestattungsstätten im südportugiesischen Mesolithikum betont. Translation by Madeleine Hummler Recently rediscovered photographs of the remains of thirteen individuals buried in the Sado Valley Mesolithic shell middens of Poças de S. Bento and Arapouco, excavated in 1960 and 1962, show the potential of revisiting excavation archives with new methods. The analysis, which applies the principles of archaeothanatology and is enriched by experimental taphonomic research, confirmed details concerning the treatment of the dead body and provided new insights into the use of burial spaces. Some bodies may have been mummified prior to burial, a phenomenon possibly linked to their curation and transport, highlighting the significance of both the body and the burial place in Mesolithic south-western Portugal.

In European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the past 10,000 years1. Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions2,3. Here we provide detailed distributions of milk exploitation across Europe over the past 9,000 years using around 7,000 pottery fat residues from more than 550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Notably, LP selection varying with levels of prehistoric milk exploitation is no better at explaining LP allele frequency trajectories than uniform selection since the Neolithic period. In the UK Biobank4,5 cohort of 500,000 contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests that other reasons for the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available but, under conditions of famine and/or increased pathogen exposure, this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitation—proxies for these drivers—provide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution. 336-345 200