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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yao-Ting eSung; Yao-Ting eSung; Jung-Yueh eTu; Jih-Ho eCha; +1 Authors

    The current study employed an eye-movement technique with an attempt to explore the reading patterns for the two types of Chinese relative clauses, subject-extracted relative clauses (SRCs) and object-extracted relative clauses (ORCs), by native speakers (L1), and Japanese learners (L2) of Chinese. The data were analyzed in terms of gaze duration, regression path duration, and regression rate on the two critical regions, head noun, and embedded verb. The results indicated that both the L1 and L2 participants spent less time on the head nouns in ORCs than in SRCs. Also, the L2 participants spent less time on the embedded verbs in ORCs than in SRCs and their regression rate for embedded verbs was generally lower in ORCs than in SRC. The findings showed that the participants experienced less processing difficulty in ORCs than SRCs. These results suggest an ORC preference in L1 and L2 speakers of Chinese, which provides evidence in support of linear distance hypothesis and implies that the syntactic nature of Chinese is at play in the RC processing.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Frontiers in Psychology
    Article . 2016
    Data sources: DOAJ-Articles
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    DOAJ
    Article . 2016
    Data sources: DOAJ
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Frontiers in Psychology
    Article . 2016 . Peer-reviewed
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Frontiers in Psychology
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Frontiers in Psychology
      Article . 2016
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      DOAJ
      Article . 2016
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Frontiers in Psychology
      Article . 2016 . Peer-reviewed
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Frontiers in Psychology
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Hu, YuanFeng; Zhou, Bin; Lu, YueHan; Zhang, JianPing; +5 Authors

    It remains debatable whether slash-and-burn practices were adopted in rice cultivation by the Neolithic Kuahuqiao culture in the Ningshao Plain, one of the birthplaces of rice farming. Here, we established charcoal-based indices to reconstruct the history of fire and vegetation in the Ningshao Plain since the last glacial period. We collected representative modern vegetation and conducted combustion and fragmentation experiments to simulate fire and depositional processes, respectively. Charcoals from modern vegetation show clear morphological differences between herbaceous and woody plants. In particular, the length to width ratios (L/W) of herbaceous charcoals were systematically higher than those of woody charcoals, and the associated end-member values were 4.50 and 1.94, respectively. These values were then applied to sediment cores (KHQ-14/15) collected in proximity to the Kuahuqiao archaeological site. Results show that the amount of combusted herbaceous plants increased sharply after the Holocene, and the most remarkable rise occurred around 8550 yr B.P. This observation may reflect local environment (sedimentary and/or climatic) changes or small-scale early human activities. During the Kuahuqiao cultural period (8250-7450 yr B.P.), the relative abundance of woody charcoals increased, but the overall fire intensity decreased. This finding suggests that the Kuahuqiao farming was restricted to a small geographic area and large-scale slash-and-burn farming activities were not adopted.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    PLoS ONE
    Article
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    DOAJ; PLoS ONE
    Article . 2020
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    PLoS ONE
    Article . 2020 . Peer-reviewed
    License: CC BY
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      PLoS ONE
      Article
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      DOAJ; PLoS ONE
      Article . 2020
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      PLoS ONE
      Article . 2020 . Peer-reviewed
      License: CC BY
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: A, Krogh; E, Lange;
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Biochemical Journalarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Europe PubMed Central
    Other literature type . 1930
    Data sources: PubMed Central
    Biochemical Journal
    Article . 1930 . Peer-reviewed
    Data sources: Crossref
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Biochemical Journalarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Europe PubMed Central
      Other literature type . 1930
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      Biochemical Journal
      Article . 1930 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Smith, MK; Moodie, SL; Bizzotto, R; E, Blaudez.; +33 Authors

    Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics. 1-3 Currently, models are encoded in a variety of computer languages and are shared through publications that rarely include original code and generally lack reproducibility. The DDMoRe Model Description Language (MDL) has been developed primarily as a language standard to facilitate sharing knowledge and understanding of models.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    CPT: Pharmacometrics & Systems Pharmacology
    Article . 2017 . Peer-reviewed
    License: CC BY NC
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      CPT: Pharmacometrics & Systems Pharmacology
      Article . 2017 . Peer-reviewed
      License: CC BY NC
      Data sources: Crossref
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Aoife Daly; Marta Domínguez-Delmás; Wendy van Duivenvoorde;

    Ocean-going ships were key to rising maritime economies of the Early Modern period, and understanding how they were built is critical to grasp the challenges faced by shipwrights and merchant seafarers. Shipwreck timbers hold material evidence of the dynamic interplay of wood supplies, craftmanship, and evolving ship designs that helped shape the Early Modern world. Here we present the results of dendroarchaeological research carried out on Batavia���s wreck timbers, currently on display at the Western Australian Shipwrecks Museum in Fremantle. Built in Amsterdam in 1628 CE and wrecked on its maiden voyage in June 1629 CE in Western Australian waters, Batavia epitomises Dutch East India Company (Verenigde Oostindische Compagnie, or VOC) shipbuilding. In the 17th century, the VOC grew to become the first multinational trading enterprise, prompting the rise of the stock market and modern capitalism. Oak (Quercus sp.) was the preferred material for shipbuilding in northern and western Europe, and maritime nations struggled to ensure sufficient supplies to meet their needs and sustain their ever-growing mercantile fleets and networks. Our research illustrates the compatibility of dendrochronological studies with musealisation of shipwreck assemblages, and the results demonstrate that the VOC successfully coped with timber shortages in the early 17th century through diversification of timber sources (mainly Baltic region, L��beck hinterland in northern Germany, and Lower Saxony in northwest Germany), allocation of sourcing regions to specific timber products (hull planks from the Baltic and L��beck, framing elements from Lower Saxony), and skillful woodworking craftmanship (sapwood was removed from all timber elements). These strategies, combined with an innovative hull design and the use of wind-powered sawmills, allowed the Dutch to produce unprecedented numbers of ocean-going ships for long-distance voyaging and interregional trade in Asia, proving key to their success in 17th-century world trade. Funding: WvD LP130100137 Australian Research Council https://www.arc.gov.au/ No MD-D 607545 FP7 People Programme (Marie Curie Actions) https://ec.europa.eu/research/mariecurieactions/ 016.Veni.195.502 Nederlandse Organisatie voor Wetenschappelijk Onderzoek https://www.nwo.nl/en AD 677152 European Research Council https://erc.europa.eu/

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ NARCIS; PLoS ONEarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    PLoS ONE
    Other literature type . Article . 2021 . Peer-reviewed
    License: CC BY
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Article . 2021
    License: CC BY
    Data sources: Datacite
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Article . 2021
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      Article . 2021
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    Authors: Wang, Yan; Jia, Peng; Liu, Luping; Huang, Cheng; +1 Authors

    Security vulnerabilities play a vital role in network security system. Fuzzing technology is widely used as a vulnerability discovery technology to reduce damage in advance. However, traditional fuzz testing faces many challenges, such as how to mutate input seed files, how to increase code coverage, and how to bypass the format verification effectively. Therefore machine learning techniques have been introduced as a new method into fuzz testing to alleviate these challenges. This paper reviews the research progress of using machine learning techniques for fuzz testing in recent years, analyzes how machine learning improves the fuzzing process and results, and sheds light on future work in fuzzing. Firstly, this paper discusses the reasons why machine learning techniques can be used for fuzzing scenarios and identifies five different stages in which machine learning has been used. Then this paper systematically studies machine learning-based fuzzing models from five dimensions of selection of machine learning algorithms, pre-processing methods, datasets, evaluation metrics, and hyperparameters setting. Secondly, this paper assesses the performance of the machine learning techniques in existing research for fuzz testing. The results of the evaluation prove that machine learning techniques have an acceptable capability of prediction for fuzzing. Finally, the capability of discovering vulnerabilities both traditional fuzzers and machine learning-based fuzzers is analyzed. The results depict that the introduction of machine learning techniques can improve the performance of fuzzing. We hope to provide researchers with a systematic and more in-depth understanding of fuzzing based on machine learning techniques and provide some references for this field through analysis and summarization of multiple dimensions.

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    Article . 2020
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    arXiv.org e-Print Archive
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    Authors: Ling, Lu; Joseph, Barbi; Fan, Pan;

    The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes. The expression of the transcription factor forkhead box protein P3 (FOXP3) is a well-recognized characteristic of Treg cells, and FOXP3 is centrally involved in the establishment and maintenance of the Treg cell phenotype. In this Review, we summarize how the expression and activity of FOXP3 are regulated across multiple layers by diverse factors. The therapeutic implications of these topics for cancer and autoimmunity are also discussed.

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    https://doi.org/10.1038/nri.20...
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      https://doi.org/10.1038/nri.20...
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    Authors: Hakak, Saqib; Kamsin, Amirrudin; Palaiahnakote, Shivakumara; Tayan, Omar; +2 Authors

    Arabic script is highly sensitive to changes in meaning with respect to the accurate arrangement of diacritics and other related symbols. The most sensitive Arabic text available online is the Digital Qur'an, the sacred book of Revelation in Islam that all Muslims including non-Arabs recite as part of their worship. Due to the different characteristics of the Arabic letters like diacritics (punctuation symbols), kashida (extended letters) and other symbols, it is written and available in different styles like Kufi, Naskh, Thuluth, Uthmani, etc. As social media has become part of our daily life, posting downloaded Qur'anic verses from the web is common. This leads to the problem of authenticating the selected Qur'anic passages available in different styles. This paper presents a residual approach for authenticating Uthmani and plain Qur'an verses using one common database. Residual (difference) is obtained by analyzing the differences between Uthmani and plain Quranic styles using XOR operation. Based on predefined data, the proposed approach converts Uthmani text into plain text. Furthermore, we propose to use the Tuned BM algorithm (BMT) exact pattern matching algorithm to verify the substituted Uthmani verse with a given database of plain Qur'anic style. Experimental results show that the proposed approach is useful and effective in authenticating multi-style texts of the Qur'an with 87.1% accuracy.

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    Authors: Luyao Chen; Junjie Wu; Yongben Fu; Huntae Kang; +1 Authors

    AbstractThe ability to use word category information (WCI) for syntactic structure building has been hypothesized to be the essence of human language faculty. The neural substrate of the ability of using the WCI for the complex syntactic hierarchical structure processing, however, is yet unknown. Therefore, we directly conducted an fMRI experiment by using a pseudo‐Chinese artificial language with syntactic structures containing a center‐embedded relative clause. Thirty non‐Chinese native (Korean) speakers were randomly divided into two groups: one acquired WCI and WCI‐based syntactic rules (the WCI group) before the scanning session, and the other did not (the non‐WCI group). Both groups were required to judge the grammaticality of the testing sentences, with critical long‐distance dependencies between two elements (the main verb and the relativizer). Behaviorally, the WCI group's accuracy was significantly higher and its reaction time was shorter. The scanning results showed that the left superior temporal gyrus (STG) and Broca's area were more strongly activated for the WCI group, and the dynamic causal modeling analyses revealed a distinct effective connectivity pattern for this group. Therefore, the present research, for the first time, reveals that the activation of and the functional connectivity between Broca's area and the left STG play a critical role in the ability of the rule‐based use of the WCI which is crucial for complex hierarchical structure building, and might be substantially corresponding to the “labeling competence” within the linguistic framework.

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    Europe PubMed Central
    Other literature type . 2018
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    MPG.PuRe
    Article . 2019
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    Human Brain Mapping
    Article . 2018 . Peer-reviewed
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    Article . 2019
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      Europe PubMed Central
      Other literature type . 2018
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      MPG.PuRe
      Article . 2019
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      Human Brain Mapping
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Jiajie Peng; Qianqian Li; Xuequn Shang;

    Abstract Background Although disease diagnosis has greatly benefited from next generation sequencing technologies, it is still difficult to make the right diagnosis purely based on sequencing technologies for many diseases with complex phenotypes and high genetic heterogeneity. Recently, calculating Human Phenotype Ontology (HPO)-based phenotype semantic similarity has contributed a lot for completing disease diagnosis. However, factors which affect the accuracy of HPO-based semantic similarity have not been evaluated systematically. Results In this study, we proposed a new framework called HPOFactor to evaluate these factors. Our model includes four components: (1) the size of annotation set, (2) the evidence code of annotations, (3) the quality of annotations and (4) the coverage of annotations respectively. Conclusions HPOFactor analyzes the four factors systematically based on two kinds of experiments: causative gene prediction and disease prediction. Furthermore, semantic similarity measurement could be designed based on the characteristic of these factors.

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    DOAJ
    Article . 2017
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    Journal of Biomedical Semantics
    Article . 2017 . Peer-reviewed
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    Journal of Biomedical Semantics
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      Journal of Biomedical Semantics
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yao-Ting eSung; Yao-Ting eSung; Jung-Yueh eTu; Jih-Ho eCha; +1 Authors

    The current study employed an eye-movement technique with an attempt to explore the reading patterns for the two types of Chinese relative clauses, subject-extracted relative clauses (SRCs) and object-extracted relative clauses (ORCs), by native speakers (L1), and Japanese learners (L2) of Chinese. The data were analyzed in terms of gaze duration, regression path duration, and regression rate on the two critical regions, head noun, and embedded verb. The results indicated that both the L1 and L2 participants spent less time on the head nouns in ORCs than in SRCs. Also, the L2 participants spent less time on the embedded verbs in ORCs than in SRCs and their regression rate for embedded verbs was generally lower in ORCs than in SRC. The findings showed that the participants experienced less processing difficulty in ORCs than SRCs. These results suggest an ORC preference in L1 and L2 speakers of Chinese, which provides evidence in support of linear distance hypothesis and implies that the syntactic nature of Chinese is at play in the RC processing.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Frontiers in Psychology
    Article . 2016
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    DOAJ
    Article . 2016
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    Frontiers in Psychology
    Article . 2016 . Peer-reviewed
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    Frontiers in Psychology
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      Frontiers in Psychology
      Article . 2016 . Peer-reviewed
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      Frontiers in Psychology
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    Authors: Hu, YuanFeng; Zhou, Bin; Lu, YueHan; Zhang, JianPing; +5 Authors

    It remains debatable whether slash-and-burn practices were adopted in rice cultivation by the Neolithic Kuahuqiao culture in the Ningshao Plain, one of the birthplaces of rice farming. Here, we established charcoal-based indices to reconstruct the history of fire and vegetation in the Ningshao Plain since the last glacial period. We collected representative modern vegetation and conducted combustion and fragmentation experiments to simulate fire and depositional processes, respectively. Charcoals from modern vegetation show clear morphological differences between herbaceous and woody plants. In particular, the length to width ratios (L/W) of herbaceous charcoals were systematically higher than those of woody charcoals, and the associated end-member values were 4.50 and 1.94, respectively. These values were then applied to sediment cores (KHQ-14/15) collected in proximity to the Kuahuqiao archaeological site. Results show that the amount of combusted herbaceous plants increased sharply after the Holocene, and the most remarkable rise occurred around 8550 yr B.P. This observation may reflect local environment (sedimentary and/or climatic) changes or small-scale early human activities. During the Kuahuqiao cultural period (8250-7450 yr B.P.), the relative abundance of woody charcoals increased, but the overall fire intensity decreased. This finding suggests that the Kuahuqiao farming was restricted to a small geographic area and large-scale slash-and-burn farming activities were not adopted.

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    PLoS ONE
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    DOAJ; PLoS ONE
    Article . 2020
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    PLoS ONE
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      Article . 2020
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      PLoS ONE
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    Authors: A, Krogh; E, Lange;
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    Europe PubMed Central
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    Authors: Smith, MK; Moodie, SL; Bizzotto, R; E, Blaudez.; +33 Authors

    Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics. 1-3 Currently, models are encoded in a variety of computer languages and are shared through publications that rarely include original code and generally lack reproducibility. The DDMoRe Model Description Language (MDL) has been developed primarily as a language standard to facilitate sharing knowledge and understanding of models.

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    CPT: Pharmacometrics & Systems Pharmacology
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    Authors: Aoife Daly; Marta Domínguez-Delmás; Wendy van Duivenvoorde;

    Ocean-going ships were key to rising maritime economies of the Early Modern period, and understanding how they were built is critical to grasp the challenges faced by shipwrights and merchant seafarers. Shipwreck timbers hold material evidence of the dynamic interplay of wood supplies, craftmanship, and evolving ship designs that helped shape the Early Modern world. Here we present the results of dendroarchaeological research carried out on Batavia���s wreck timbers, currently on display at the Western Australian Shipwrecks Museum in Fremantle. Built in Amsterdam in 1628 CE and wrecked on its maiden voyage in June 1629 CE in Western Australian waters, Batavia epitomises Dutch East India Company (Verenigde Oostindische Compagnie, or VOC) shipbuilding. In the 17th century, the VOC grew to become the first multinational trading enterprise, prompting the rise of the stock market and modern capitalism. Oak (Quercus sp.) was the preferred material for shipbuilding in northern and western Europe, and maritime nations struggled to ensure sufficient supplies to meet their needs and sustain their ever-growing mercantile fleets and networks. Our research illustrates the compatibility of dendrochronological studies with musealisation of shipwreck assemblages, and the results demonstrate that the VOC successfully coped with timber shortages in the early 17th century through diversification of timber sources (mainly Baltic region, L��beck hinterland in northern Germany, and Lower Saxony in northwest Germany), allocation of sourcing regions to specific timber products (hull planks from the Baltic and L��beck, framing elements from Lower Saxony), and skillful woodworking craftmanship (sapwood was removed from all timber elements). These strategies, combined with an innovative hull design and the use of wind-powered sawmills, allowed the Dutch to produce unprecedented numbers of ocean-going ships for long-distance voyaging and interregional trade in Asia, proving key to their success in 17th-century world trade. Funding: WvD LP130100137 Australian Research Council https://www.arc.gov.au/ No MD-D 607545 FP7 People Programme (Marie Curie Actions) https://ec.europa.eu/research/mariecurieactions/ 016.Veni.195.502 Nederlandse Organisatie voor Wetenschappelijk Onderzoek https://www.nwo.nl/en AD 677152 European Research Council https://erc.europa.eu/

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    Authors: Wang, Yan; Jia, Peng; Liu, Luping; Huang, Cheng; +1 Authors

    Security vulnerabilities play a vital role in network security system. Fuzzing technology is widely used as a vulnerability discovery technology to reduce damage in advance. However, traditional fuzz testing faces many challenges, such as how to mutate input seed files, how to increase code coverage, and how to bypass the format verification effectively. Therefore machine learning techniques have been introduced as a new method into fuzz testing to alleviate these challenges. This paper reviews the research progress of using machine learning techniques for fuzz testing in recent years, analyzes how machine learning improves the fuzzing process and results, and sheds light on future work in fuzzing. Firstly, this paper discusses the reasons why machine learning techniques can be used for fuzzing scenarios and identifies five different stages in which machine learning has been used. Then this paper systematically studies machine learning-based fuzzing models from five dimensions of selection of machine learning algorithms, pre-processing methods, datasets, evaluation metrics, and hyperparameters setting. Secondly, this paper assesses the performance of the machine learning techniques in existing research for fuzz testing. The results of the evaluation prove that machine learning techniques have an acceptable capability of prediction for fuzzing. Finally, the capability of discovering vulnerabilities both traditional fuzzers and machine learning-based fuzzers is analyzed. The results depict that the introduction of machine learning techniques can improve the performance of fuzzing. We hope to provide researchers with a systematic and more in-depth understanding of fuzzing based on machine learning techniques and provide some references for this field through analysis and summarization of multiple dimensions.

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    arXiv.org e-Print Archive
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    https://doi.org/10.48550/arxiv...
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      arXiv.org e-Print Archive
      Other literature type . Preprint . 2019
      https://doi.org/10.48550/arxiv...
      Article . 2019
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    Authors: Ling, Lu; Joseph, Barbi; Fan, Pan;

    The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes. The expression of the transcription factor forkhead box protein P3 (FOXP3) is a well-recognized characteristic of Treg cells, and FOXP3 is centrally involved in the establishment and maintenance of the Treg cell phenotype. In this Review, we summarize how the expression and activity of FOXP3 are regulated across multiple layers by diverse factors. The therapeutic implications of these topics for cancer and autoimmunity are also discussed.

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    Europe PubMed Central
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    https://doi.org/10.1038/nri.20...
    Article . 2017 . Peer-reviewed
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      Europe PubMed Central
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      https://doi.org/10.1038/nri.20...
      Article . 2017 . Peer-reviewed
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    Authors: Hakak, Saqib; Kamsin, Amirrudin; Palaiahnakote, Shivakumara; Tayan, Omar; +2 Authors

    Arabic script is highly sensitive to changes in meaning with respect to the accurate arrangement of diacritics and other related symbols. The most sensitive Arabic text available online is the Digital Qur'an, the sacred book of Revelation in Islam that all Muslims including non-Arabs recite as part of their worship. Due to the different characteristics of the Arabic letters like diacritics (punctuation symbols), kashida (extended letters) and other symbols, it is written and available in different styles like Kufi, Naskh, Thuluth, Uthmani, etc. As social media has become part of our daily life, posting downloaded Qur'anic verses from the web is common. This leads to the problem of authenticating the selected Qur'anic passages available in different styles. This paper presents a residual approach for authenticating Uthmani and plain Qur'an verses using one common database. Residual (difference) is obtained by analyzing the differences between Uthmani and plain Quranic styles using XOR operation. Based on predefined data, the proposed approach converts Uthmani text into plain text. Furthermore, we propose to use the Tuned BM algorithm (BMT) exact pattern matching algorithm to verify the substituted Uthmani verse with a given database of plain Qur'anic style. Experimental results show that the proposed approach is useful and effective in authenticating multi-style texts of the Qur'an with 87.1% accuracy.

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    PLoS ONE
    Article . 2018
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    PLoS ONE
    Article . 2018 . Peer-reviewed
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    Article . 2018
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      PLoS ONE
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    Authors: Luyao Chen; Junjie Wu; Yongben Fu; Huntae Kang; +1 Authors

    AbstractThe ability to use word category information (WCI) for syntactic structure building has been hypothesized to be the essence of human language faculty. The neural substrate of the ability of using the WCI for the complex syntactic hierarchical structure processing, however, is yet unknown. Therefore, we directly conducted an fMRI experiment by using a pseudo‐Chinese artificial language with syntactic structures containing a center‐embedded relative clause. Thirty non‐Chinese native (Korean) speakers were randomly divided into two groups: one acquired WCI and WCI‐based syntactic rules (the WCI group) before the scanning session, and the other did not (the non‐WCI group). Both groups were required to judge the grammaticality of the testing sentences, with critical long‐distance dependencies between two elements (the main verb and the relativizer). Behaviorally, the WCI group's accuracy was significantly higher and its reaction time was shorter. The scanning results showed that the left superior temporal gyrus (STG) and Broca's area were more strongly activated for the WCI group, and the dynamic causal modeling analyses revealed a distinct effective connectivity pattern for this group. Therefore, the present research, for the first time, reveals that the activation of and the functional connectivity between Broca's area and the left STG play a critical role in the ability of the rule‐based use of the WCI which is crucial for complex hierarchical structure building, and might be substantially corresponding to the “labeling competence” within the linguistic framework.

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    Europe PubMed Central
    Other literature type . 2018
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    MPG.PuRe
    Article . 2019
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    Human Brain Mapping
    Article . 2018 . Peer-reviewed
    License: Wiley Online Library User Agreement
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    Article . 2019
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      Human Brain Mapping
      Article . 2018 . Peer-reviewed
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    Authors: Jiajie Peng; Qianqian Li; Xuequn Shang;

    Abstract Background Although disease diagnosis has greatly benefited from next generation sequencing technologies, it is still difficult to make the right diagnosis purely based on sequencing technologies for many diseases with complex phenotypes and high genetic heterogeneity. Recently, calculating Human Phenotype Ontology (HPO)-based phenotype semantic similarity has contributed a lot for completing disease diagnosis. However, factors which affect the accuracy of HPO-based semantic similarity have not been evaluated systematically. Results In this study, we proposed a new framework called HPOFactor to evaluate these factors. Our model includes four components: (1) the size of annotation set, (2) the evidence code of annotations, (3) the quality of annotations and (4) the coverage of annotations respectively. Conclusions HPOFactor analyzes the four factors systematically based on two kinds of experiments: causative gene prediction and disease prediction. Furthermore, semantic similarity measurement could be designed based on the characteristic of these factors.

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    Article . 2017
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    Journal of Biomedical Semantics
    Article . 2017 . Peer-reviewed
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