- home
- Advanced Search
Filters
Clear AllYear range
-chevron_right GO
- Digital Humanities and Cultural Heritage
- NL
- Cell
- Digital Humanities and Cultural Heritage
- NL
- Cell
Loading
description Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United Kingdom, NetherlandsPublisher:Elsevier BV Funded by:EC | TRAIN-OLD, NIH | Aging and dysfunction of ..., NIH | IL-22, Immune Plasticity,... +1 projectsEC| TRAIN-OLD ,NIH| Aging and dysfunction of progenitor niches: Role of Del-1 ,NIH| IL-22, Immune Plasticity, and Autotherapy in the Periodontium ,NIH| Trained innate immunity and periodontitis-associated comorbiditiesXiaofei Li; Hui Wang; Xiang Yu; Gundappa Saha; Lydia Kalafati; Charalampos Ioannidis; Ioannis Mitroulis; Mihai G. Netea; Triantafyllos Chavakis; George Hajishengallis;pmc: PMC9106933
Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid progeny. We show here that maladaptive BM-mediated TII underlies inflammatory comorbidities, as exemplified by the periodontitis-arthritis axis. Experimental-periodontitis-related systemic inflammation in mice induced epigenetic rewiring of HSPC and led to sustained enhancement of production of myeloid cells with increased inflammatory preparedness. The periodontitis-induced trained phenotype was transmissible by BM transplantation to naive recipients, which exhibited increased inflammatory responsiveness and disease severity when subjected to inflammatory arthritis. IL-1 signaling in HSPC was essential for their maladaptive training by periodontitis. Therefore, maladaptive innate immune training of myelopoiesis underlies inflammatory comorbidities and may be pharmacologically targeted to treat them via a holistic approach.
Europe PubMed Centra... arrow_drop_down Radboud Repository; Cell; METIS Research Information SystemArticle . 2022 . Peer-reviewedLicense: Elsevier Non-CommercialNature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2022.03.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 87 citations 87 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Radboud Repository; Cell; METIS Research Information SystemArticle . 2022 . Peer-reviewedLicense: Elsevier Non-CommercialNature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2022.03.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, Italy, United Kingdom, TurkeyPublisher:Elsevier BV Authors: Eirini Skourtanioti; Yılmaz Selim Erdal; Marcella Frangipane; Francesca Balossi Restelli; +25 AuthorsEirini Skourtanioti; Yılmaz Selim Erdal; Marcella Frangipane; Francesca Balossi Restelli; K. Aslıhan Yener; Frances Pinnock; Paolo Matthiae; Rana Özbal; Ulf-Dietrich Schoop; Farhad Guliyev; Tufan I. Akhundov; Bertille Lyonnet; Emily Hammer; Selin Nugent; Marta Burri; Gunnar U. Neumann; Sandra Penske; Tara Ingman; Murat Akar; Rula Shafiq; Giulio Palumbi; Stefanie Eisenmann; Marta D’Andrea; Adam Ben Rohrlach; Christina Warinner; Choongwon Jeong; Philipp W. Stockhammer; Wolfgang Haak; Johannes Krause;Here, we report genome-wide data analyses from 110 ancient Near Eastern individuals spanning the Late Neolithic to Late Bronze Age, a period characterized by intense interregional interactions for the Near East. We find that 6th millennium BCE populations of North/Central Anatolia and the Southern Caucasus shared mixed ancestry on a genetic cline that formed during the Neolithic between Western Anatolia and regions in today’s Southern Caucasus/Zagros. During the Late Chalcolithic and/or the Early Bronze Age, more than half of the Northern Levantine gene pool was replaced, while in the rest of Anatolia and the Southern Caucasus, we document genetic continuity with only transient gene flow. Additionally, we reveal a genetically distinct individual within the Late Bronze Age Northern Levant. Overall, our study uncovers multiple scales of population dynamics through time, from extensive admixture during the Neolithic period to long-distance mobility within the globalized societies of the Late Bronze Age. Video Abstract - Introduction - Results -- Sample Corpus and Data Compilation -- The Late Neolithic/Early Chalcolithic Genetic Structure in Anatolia, Northern Levant, and Caucasian Lowlands -- Neolithic Admixture and a Common Genetic Profile of Chalcolithic and Bronze Age Groups -- Admixture Modeling of the Chalcolithic and Bronze Age Groups -- Genetic Turnover in the Bronze Age Northern Levant -- Evidence for Individual Mobility in Alalakh - Discussion -- Genetic Homogenization across Anatolia and the Southern Caucasus prior to the Bronze Age -- Population and Territorial State Dynamics in the Northern Levant -- Conclusions STAR★Methods
Edinburgh Research E... arrow_drop_down Ibn Haldun University Institutional RepositoryArticle . 2020Data sources: Ibn Haldun University Institutional RepositoryArchivio della ricerca- Università di Roma La Sapienza; CellArticle . 2020 . Peer-reviewedLicense: Elsevier Non-CommercialArchivio della ricerca- Università di Roma La SapienzaArticle . 2020Data sources: Archivio della ricerca- Università di Roma La SapienzaMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-03041651/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2020.04.044&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 74 citations 74 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 111visibility views 111 download downloads 38 Powered bymore_vert Edinburgh Research E... arrow_drop_down Ibn Haldun University Institutional RepositoryArticle . 2020Data sources: Ibn Haldun University Institutional RepositoryArchivio della ricerca- Università di Roma La Sapienza; CellArticle . 2020 . Peer-reviewedLicense: Elsevier Non-CommercialArchivio della ricerca- Università di Roma La SapienzaArticle . 2020Data sources: Archivio della ricerca- Università di Roma La SapienzaMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-03041651/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2020.04.044&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Singapore, NetherlandsPublisher:Elsevier BV Degang Wu; Jinzhuang Dou; Xiaoran Chai; Claire Bellis; Andreas Wilm; Chih Chuan Shih; Wendy Wei Jia Soon; Nicolas Bertin; Clarabelle Bitong Lin; Chiea Chuen Khor; Michael DeGiorgio; Shanshan Cheng; Li Bao; Neerja Karnani; William Ying Khee Hwang; Sonia Davila; Patrick Tan; Asim Shabbir; Angela Moh; Eng-King Tan; Jia Nee Foo; Liuh Ling Goh; Khai Pang Leong; Roger S.Y. Foo; Carolyn Su Ping Lam; Arthur Mark Richards; Ching-Yu Cheng; Tin Aung; Tien Yin Wong; Huck Hui Ng; Jianjun Liu; Chaolong Wang; Matthew Andrew Ackers-Johnson; Edita Aliwarga; Kenneth Hon Kim Ban; Denis Bertrand; John C. Chambers; Dana Leng Hui Chan; Cheryl Xue Li Chan; Miao Li Chee; Miao Ling Chee; Pauline Chen; Yunxin Chen; Elaine Guo Yan Chew; Wen Jie Chew; Lynn Hui Yun Chiam; Jenny Pek Ching Chong; Ivan Chua; Stuart A. Cook; Wei Dai; Rajkumar Dorajoo; Chuan-Sheng Foo; Rick Siow Mong Goh; Axel M. Hillmer; Ishak D. Irwan; Fazlur Jaufeerally; Asif Javed; Justin Jeyakani; John Tat Hung Koh; Jia Yu Koh; Pavitra Krishnaswamy; Jyn Ling Kuan; Neelam Kumari; Ai Shan Lee; Seow Eng Lee; Sheldon Lee; Yen Ling Lee; See Ting Leong; Zheng Li; Peter Yiqing Li; Jun Xian Liew; Oi Wah Liew; Su Chi Lim; Weng Khong Lim; Chia Wei Lim; Tingsen Benson Lim; Choon Kiat Lim; Seet Yoong Loh; Au Wing Lok; Calvin W.L. Chin; Shivani Majithia; Sebastian Maurer-Stroh; Wee Yang Meah; Shi Qi Mok; Niranjan Nargarajan; Pauline Ng; Sarah B. Ng; Zhenyuan Ng; Jessica Yan Xia Ng; Ebonne Ng; Shi Ling Ng; Simon Nusinovici; Chin Thing Ong; Bangfen Pan; Vincent Pedergnana; Stanley Poh; Shyam Prabhakar; Kumar M. Prakash; Ivy Quek; Charumathi Sabanayagam; Wei Qiang See; Yee Yen Sia; Xueling Sim; Wey Cheng Sim; Jimmy So; Dinna K.N. Soon; E. Shyong Tai; Nicholas Y. Tan; Louis C.S. Tan; Hong Chang Tan; Wilson Lek Wen Tan; Moses Tandiono; Amanda Tay; Sahil Thakur; Yih Chung Tham; Zenia Tiang; Grace Li-Xian Toh; Pi Kuang Tsai; Lavanya Veeravalli; Chandra S. Verma; Ling Wang; Min Rui Wang; Wing-Cheong Wong; Zhicheng Xie; Khung Keong Yeo; Liang Zhang; Weiwei Zhai; Yi Zhao;Underrepresentation of Asian genomes has hindered population and medical genetics research on Asians, leading to population disparities in precision medicine. By whole-genome sequencing of 4,810 Singapore Chinese, Malays, and Indians, we found 98.3 million SNPs and small insertions or deletions, over half of which are novel. Population structure analysis demonstrated great representation of Asian genetic diversity by three ethnicities in Singapore and revealed a Malay-related novel ancestry component. Furthermore, demographic inference suggested that Malays split from Chinese ∼24,800 years ago and experienced significant admixture with East Asians ∼1,700 years ago, coinciding with the Austronesian expansion. Additionally, we identified 20 candidate loci for natural selection, 14 of which harbored robust associations with complex traits and diseases. Finally, we show that our data can substantially improve genotype imputation in diverse Asian and Oceanian populations. These results highlight the value of our data as a resource to empower human genetics discovery across broad geographic regions. Agency for Science, Technology and Research (A*STAR) National Medical Research Council (NMRC) National Research Foundation (NRF) Accepted version We acknowledge H.M. Kang, S. Das, A. Tan, F. Zhang, J. Terhorst, P.-R. Loh, and G. Hellenthal for helpful discussions and support from all participants and clinical research coordinators of the contributing cohorts and studies: the TTSH Healthy Control Workgroup, the SEED cohort, the Asian Sudden Cardiac Death in Heart Failure Study, the Singapore Heart Failure Outcomes and Phenotypes (SHOP) cohort, the Asian neTwork for Translational Research and Cardiovascular Trials (ATTRaCT), the Parkinson’s Disease Study, the Peranakan Genome Study, the Platinum Asian Genomes Project, the Bariatric Surgery Study, the National Heart Centre Singapore Biobank and SingHEART cohorts, and the GUSTO and S-PRESTO study groups. This study was supported by Singapore’s A*STAR (core funding and IAF-PP H17/01/a0/007), BMRC (SPF2014/001, SPF2013/002, SPF2014/003, SPF2014/004, and SPF2014/005), NMRC (CIRG/1371/2013, CIRG/1417/2015, CIRG/1488/ 2018, CSA-SI/0012/2017, CG/017/2013, CG/M006/2017_NHCS, TCR/013- NNI/2014, STaR/0011/2012, STaR2013/001, STaR/014/2013, STaR/0026/ 2015, TCR/006-NUHS/2013, TCR/012-NUHS/2014, TCR/004-NUS/2008, TCR/012-NUHS/2014, and center grants 2010-13 and 2013-2017), NRF (NRFF2016-03), National University of Singapore, SingHealth and DukeNUS, and Alexandra Health small innovative grant SIGII/15203 and funding from Huazhong University of Science and Technology, the Tanoto Foundation, the Lee Foundation, the Boston Scientific Investigator Sponsored Research Program and Bayer, the NSF (DEB-1753489), and the Alfred P. Sloan Foundation. The computation was partially performed on resources of the National Supercomputing Centre, Singapore (https://www.nscc.sg).
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2019.09.019&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 120 citations 120 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2019.09.019&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
Loading
description Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United Kingdom, NetherlandsPublisher:Elsevier BV Funded by:EC | TRAIN-OLD, NIH | Aging and dysfunction of ..., NIH | IL-22, Immune Plasticity,... +1 projectsEC| TRAIN-OLD ,NIH| Aging and dysfunction of progenitor niches: Role of Del-1 ,NIH| IL-22, Immune Plasticity, and Autotherapy in the Periodontium ,NIH| Trained innate immunity and periodontitis-associated comorbiditiesXiaofei Li; Hui Wang; Xiang Yu; Gundappa Saha; Lydia Kalafati; Charalampos Ioannidis; Ioannis Mitroulis; Mihai G. Netea; Triantafyllos Chavakis; George Hajishengallis;pmc: PMC9106933
Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid progeny. We show here that maladaptive BM-mediated TII underlies inflammatory comorbidities, as exemplified by the periodontitis-arthritis axis. Experimental-periodontitis-related systemic inflammation in mice induced epigenetic rewiring of HSPC and led to sustained enhancement of production of myeloid cells with increased inflammatory preparedness. The periodontitis-induced trained phenotype was transmissible by BM transplantation to naive recipients, which exhibited increased inflammatory responsiveness and disease severity when subjected to inflammatory arthritis. IL-1 signaling in HSPC was essential for their maladaptive training by periodontitis. Therefore, maladaptive innate immune training of myelopoiesis underlies inflammatory comorbidities and may be pharmacologically targeted to treat them via a holistic approach.
Europe PubMed Centra... arrow_drop_down Radboud Repository; Cell; METIS Research Information SystemArticle . 2022 . Peer-reviewedLicense: Elsevier Non-CommercialNature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2022.03.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 87 citations 87 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Radboud Repository; Cell; METIS Research Information SystemArticle . 2022 . Peer-reviewedLicense: Elsevier Non-CommercialNature Reviews ImmunologyArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2022.03.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, Italy, United Kingdom, TurkeyPublisher:Elsevier BV Authors: Eirini Skourtanioti; Yılmaz Selim Erdal; Marcella Frangipane; Francesca Balossi Restelli; +25 AuthorsEirini Skourtanioti; Yılmaz Selim Erdal; Marcella Frangipane; Francesca Balossi Restelli; K. Aslıhan Yener; Frances Pinnock; Paolo Matthiae; Rana Özbal; Ulf-Dietrich Schoop; Farhad Guliyev; Tufan I. Akhundov; Bertille Lyonnet; Emily Hammer; Selin Nugent; Marta Burri; Gunnar U. Neumann; Sandra Penske; Tara Ingman; Murat Akar; Rula Shafiq; Giulio Palumbi; Stefanie Eisenmann; Marta D’Andrea; Adam Ben Rohrlach; Christina Warinner; Choongwon Jeong; Philipp W. Stockhammer; Wolfgang Haak; Johannes Krause;Here, we report genome-wide data analyses from 110 ancient Near Eastern individuals spanning the Late Neolithic to Late Bronze Age, a period characterized by intense interregional interactions for the Near East. We find that 6th millennium BCE populations of North/Central Anatolia and the Southern Caucasus shared mixed ancestry on a genetic cline that formed during the Neolithic between Western Anatolia and regions in today’s Southern Caucasus/Zagros. During the Late Chalcolithic and/or the Early Bronze Age, more than half of the Northern Levantine gene pool was replaced, while in the rest of Anatolia and the Southern Caucasus, we document genetic continuity with only transient gene flow. Additionally, we reveal a genetically distinct individual within the Late Bronze Age Northern Levant. Overall, our study uncovers multiple scales of population dynamics through time, from extensive admixture during the Neolithic period to long-distance mobility within the globalized societies of the Late Bronze Age. Video Abstract - Introduction - Results -- Sample Corpus and Data Compilation -- The Late Neolithic/Early Chalcolithic Genetic Structure in Anatolia, Northern Levant, and Caucasian Lowlands -- Neolithic Admixture and a Common Genetic Profile of Chalcolithic and Bronze Age Groups -- Admixture Modeling of the Chalcolithic and Bronze Age Groups -- Genetic Turnover in the Bronze Age Northern Levant -- Evidence for Individual Mobility in Alalakh - Discussion -- Genetic Homogenization across Anatolia and the Southern Caucasus prior to the Bronze Age -- Population and Territorial State Dynamics in the Northern Levant -- Conclusions STAR★Methods
Edinburgh Research E... arrow_drop_down Ibn Haldun University Institutional RepositoryArticle . 2020Data sources: Ibn Haldun University Institutional RepositoryArchivio della ricerca- Università di Roma La Sapienza; CellArticle . 2020 . Peer-reviewedLicense: Elsevier Non-CommercialArchivio della ricerca- Università di Roma La SapienzaArticle . 2020Data sources: Archivio della ricerca- Università di Roma La SapienzaMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-03041651/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2020.04.044&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 74 citations 74 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 111visibility views 111 download downloads 38 Powered bymore_vert Edinburgh Research E... arrow_drop_down Ibn Haldun University Institutional RepositoryArticle . 2020Data sources: Ibn Haldun University Institutional RepositoryArchivio della ricerca- Università di Roma La Sapienza; CellArticle . 2020 . Peer-reviewedLicense: Elsevier Non-CommercialArchivio della ricerca- Università di Roma La SapienzaArticle . 2020Data sources: Archivio della ricerca- Università di Roma La SapienzaMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-03041651/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2020.04.044&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Singapore, NetherlandsPublisher:Elsevier BV Degang Wu; Jinzhuang Dou; Xiaoran Chai; Claire Bellis; Andreas Wilm; Chih Chuan Shih; Wendy Wei Jia Soon; Nicolas Bertin; Clarabelle Bitong Lin; Chiea Chuen Khor; Michael DeGiorgio; Shanshan Cheng; Li Bao; Neerja Karnani; William Ying Khee Hwang; Sonia Davila; Patrick Tan; Asim Shabbir; Angela Moh; Eng-King Tan; Jia Nee Foo; Liuh Ling Goh; Khai Pang Leong; Roger S.Y. Foo; Carolyn Su Ping Lam; Arthur Mark Richards; Ching-Yu Cheng; Tin Aung; Tien Yin Wong; Huck Hui Ng; Jianjun Liu; Chaolong Wang; Matthew Andrew Ackers-Johnson; Edita Aliwarga; Kenneth Hon Kim Ban; Denis Bertrand; John C. Chambers; Dana Leng Hui Chan; Cheryl Xue Li Chan; Miao Li Chee; Miao Ling Chee; Pauline Chen; Yunxin Chen; Elaine Guo Yan Chew; Wen Jie Chew; Lynn Hui Yun Chiam; Jenny Pek Ching Chong; Ivan Chua; Stuart A. Cook; Wei Dai; Rajkumar Dorajoo; Chuan-Sheng Foo; Rick Siow Mong Goh; Axel M. Hillmer; Ishak D. Irwan; Fazlur Jaufeerally; Asif Javed; Justin Jeyakani; John Tat Hung Koh; Jia Yu Koh; Pavitra Krishnaswamy; Jyn Ling Kuan; Neelam Kumari; Ai Shan Lee; Seow Eng Lee; Sheldon Lee; Yen Ling Lee; See Ting Leong; Zheng Li; Peter Yiqing Li; Jun Xian Liew; Oi Wah Liew; Su Chi Lim; Weng Khong Lim; Chia Wei Lim; Tingsen Benson Lim; Choon Kiat Lim; Seet Yoong Loh; Au Wing Lok; Calvin W.L. Chin; Shivani Majithia; Sebastian Maurer-Stroh; Wee Yang Meah; Shi Qi Mok; Niranjan Nargarajan; Pauline Ng; Sarah B. Ng; Zhenyuan Ng; Jessica Yan Xia Ng; Ebonne Ng; Shi Ling Ng; Simon Nusinovici; Chin Thing Ong; Bangfen Pan; Vincent Pedergnana; Stanley Poh; Shyam Prabhakar; Kumar M. Prakash; Ivy Quek; Charumathi Sabanayagam; Wei Qiang See; Yee Yen Sia; Xueling Sim; Wey Cheng Sim; Jimmy So; Dinna K.N. Soon; E. Shyong Tai; Nicholas Y. Tan; Louis C.S. Tan; Hong Chang Tan; Wilson Lek Wen Tan; Moses Tandiono; Amanda Tay; Sahil Thakur; Yih Chung Tham; Zenia Tiang; Grace Li-Xian Toh; Pi Kuang Tsai; Lavanya Veeravalli; Chandra S. Verma; Ling Wang; Min Rui Wang; Wing-Cheong Wong; Zhicheng Xie; Khung Keong Yeo; Liang Zhang; Weiwei Zhai; Yi Zhao;Underrepresentation of Asian genomes has hindered population and medical genetics research on Asians, leading to population disparities in precision medicine. By whole-genome sequencing of 4,810 Singapore Chinese, Malays, and Indians, we found 98.3 million SNPs and small insertions or deletions, over half of which are novel. Population structure analysis demonstrated great representation of Asian genetic diversity by three ethnicities in Singapore and revealed a Malay-related novel ancestry component. Furthermore, demographic inference suggested that Malays split from Chinese ∼24,800 years ago and experienced significant admixture with East Asians ∼1,700 years ago, coinciding with the Austronesian expansion. Additionally, we identified 20 candidate loci for natural selection, 14 of which harbored robust associations with complex traits and diseases. Finally, we show that our data can substantially improve genotype imputation in diverse Asian and Oceanian populations. These results highlight the value of our data as a resource to empower human genetics discovery across broad geographic regions. Agency for Science, Technology and Research (A*STAR) National Medical Research Council (NMRC) National Research Foundation (NRF) Accepted version We acknowledge H.M. Kang, S. Das, A. Tan, F. Zhang, J. Terhorst, P.-R. Loh, and G. Hellenthal for helpful discussions and support from all participants and clinical research coordinators of the contributing cohorts and studies: the TTSH Healthy Control Workgroup, the SEED cohort, the Asian Sudden Cardiac Death in Heart Failure Study, the Singapore Heart Failure Outcomes and Phenotypes (SHOP) cohort, the Asian neTwork for Translational Research and Cardiovascular Trials (ATTRaCT), the Parkinson’s Disease Study, the Peranakan Genome Study, the Platinum Asian Genomes Project, the Bariatric Surgery Study, the National Heart Centre Singapore Biobank and SingHEART cohorts, and the GUSTO and S-PRESTO study groups. This study was supported by Singapore’s A*STAR (core funding and IAF-PP H17/01/a0/007), BMRC (SPF2014/001, SPF2013/002, SPF2014/003, SPF2014/004, and SPF2014/005), NMRC (CIRG/1371/2013, CIRG/1417/2015, CIRG/1488/ 2018, CSA-SI/0012/2017, CG/017/2013, CG/M006/2017_NHCS, TCR/013- NNI/2014, STaR/0011/2012, STaR2013/001, STaR/014/2013, STaR/0026/ 2015, TCR/006-NUHS/2013, TCR/012-NUHS/2014, TCR/004-NUS/2008, TCR/012-NUHS/2014, and center grants 2010-13 and 2013-2017), NRF (NRFF2016-03), National University of Singapore, SingHealth and DukeNUS, and Alexandra Health small innovative grant SIGII/15203 and funding from Huazhong University of Science and Technology, the Tanoto Foundation, the Lee Foundation, the Boston Scientific Investigator Sponsored Research Program and Bayer, the NSF (DEB-1753489), and the Alfred P. Sloan Foundation. The computation was partially performed on resources of the National Supercomputing Centre, Singapore (https://www.nscc.sg).
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2019.09.019&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 120 citations 120 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cell.2019.09.019&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu