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In this paper, we investigate the stationary profiles of a nonlinear Fokker–Planck equation with small diffusion and nonlinear inflow and outflow boundary conditions. We consider corridors with a bottleneck whose width has a unique global nondegenerate minimum in the interior. In the small diffusion limit, the profiles are obtained constructively by using methods from geometric singular perturbation theory (GSPT). We identify three main types of profiles corresponding to: (i) high density in the domain and a boundary layer at the entrance, (ii) low density in the domain and a boundary layer at the exit, and (iii) transitions from high density to low density inside the bottleneck with boundary layers at the entrance and exit. Interestingly, solutions of the last type involve canard solutions generated at the narrowest point of the bottleneck. We obtain a detailed bifurcation diagram of these solutions in terms of the inflow and outflow rates. The analytic results based on GSPT are further corroborated by computational experiments investigating corridors with bottlenecks of variable width. published

Summary By introducing compulsory antiseptic measures in 1881, the Austrian Empire became a trendsetter in European midwifery legislation. Starting with the focus on puerperal infection in the 1870s, this article investigates the process from the first proposal of antiseptic regimes within a clinical setting to the dissemination of antiseptic knowledge among the midwifery profession. Competition between the leading medical men throughout the Austrian territories played a major role and influenced the way in which antiseptic measures were propagated. The article identifies the antiseptic collectives active at the leading universities of Prague and Vienna. As practical instruction during midwifery education was not regarded as sufficient, the late 1870s and 1880s saw the emergence of several instruction textbooks. Changing birth attendance routines and the innovative materials that entered midwifery practice are explored and discussed, based on these manuals, alongside evidence of midwives’ reactions as published in the Austrian Midwifery Newspaper.

Abstract. Sub-orbital-scale climate variability of the last glacial period provides important insights into the rates at which the climate can change state, the mechanisms that drive such changes, and the leads, lags, and synchronicity occurring across different climate zones. Such short-term climate variability has previously been investigated using δ18O from speleothems ( δ18O calc ) that grew along the northern rim of the Alps (NALPS), enabling direct chronological comparisons with δ18O records from Greenland ice cores ( δ18O ice ). In this study, we present NALPS19, which includes a revision of the last glacial NALPS δ18O calc chronology over the interval 118.3 to 63.7 ka using 11, newly available, clean, precisely dated stalagmites from five caves. Using only the most reliable and precisely dated records, this period is now 90 % complete and is comprised of 16 stalagmites from seven caves. Where speleothems grew synchronously, the timing of major transitional events in δ18O calc between stadials and interstadials (and vice versa) are all in agreement on multi-decadal timescales. Ramp-fitting analysis further reveals that, except for one abrupt change, the timing of δ18O transitions occurred synchronously within centennial-scale dating uncertainties between the NALPS19 δ18O calc record and the Asian monsoon composite speleothem δ18O calc record. Due to the millennial-scale uncertainties in the ice core chronologies, a comprehensive comparison with the NALPS19 chronology is difficult. Generally, however, we find that the absolute timing of transitions in the Greenland Ice Core Chronology (GICC) 05 modelext and Antarctic Ice Core Chronology (AICC) 2012 are in agreement on centennial scales. The exception to this is during the interval of 100 to 115 ka, where transitions in the AICC2012 chronology occurred up to 3000 years later than in NALPS19. In such instances, the transitions in the revised AICC2012 chronology of Extier et al. (2018) are in agreement with NALPS19 on centennial scales, supporting the hypothesis that AICC2012 appears to be considerably too young between 100 and 115 ka. Using a ramp-fitting function to objectively identify the onset and the end of abrupt transitions, we show that δ18O shifts took place on multi-decadal to multi-centennial timescales in the North Atlantic-sourced regions (northern Alps and Greenland) as well as the Asian monsoon. Given the near-complete record of δ18O calc variability during the last glacial period in the northern Alps, we also offer preliminary considerations regarding the controls on mean δ18O calc for given stadials and interstadials. We find that, as expected, δ18O calc values became increasingly lighter with distance from the oceanic source regions, and increasingly lighter with increasing altitude. Exceptions were found for some high-elevation sites that locally display δ18O calc values that are heavier than expected in comparison to lower-elevation sites, possibly caused by a summer bias in the recorded signal of the high-elevation site, or a winter bias in the low-elevation site. Finally, we propose a new mechanism for the centennial-scale stadial-level depletions in δ18O such as the Greenland Stadial (GS)-16.2, GS-17.2, GS-21.2, and GS-23.2 “precursor” events, as well as the “within-interstadial” GS-24.2 cooling event. Our new high-precision chronology shows that each of these δ18O depletions occurred in the decades and centuries following rapid rises in sea level associated with increased ice-rafted debris and southward shifts of the Intertropical Convergence Zone, suggesting that influxes of meltwater from moderately sized ice sheets may have been responsible for the cold reversals causing the Atlantic Meridional Overturning Circulation to slow down similar to the Preboreal Oscillation and Older Dryas deglacial events.

Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ). Autoantibodies target key molecules at the NMJ, such as the nicotinic acetylcholine receptor (AChR), muscle-specific kinase (MuSK), and low-density lipoprotein receptor-related protein 4 (Lrp4), that lead by a range of different pathogenic mechanisms to altered tissue architecture and reduced densities or functionality of AChRs, reduced neuromuscular transmission, and therefore a severe fatigable skeletal muscle weakness. In this review, we give an overview of the history and clinical aspects of MG, with a focus on the structure and function of myasthenic autoantigens at the NMJ and how they are affected by the autoantibodies’ pathogenic mechanisms. Furthermore, we give a short overview of the cells that are implicated in the production of the autoantibodies and briefly discuss diagnostic challenges and treatment strategies.

ABSTRACT This article offers a “feminist critical discourse analysis” of the Saturday Night Live sketch “Melanianade.” It argues that the comical video reinforces and essentializes negative stereotypes of Eastern European women to depict Melania Trump, seeking to delegitimize white hegemonic masculinity and female complicity. The fictitious Melania Trump’s appearance needs to be understood in her co-construction with her white hegemonic husband and otherwise racialized women in the comedy sketch. These women are the African-American women of Beyoncé’s video “Sorry,” which “Melanianade” copies/satirizes. “Sorry” represents Black female US-American experience, and was broadly understood as Black feminist art/activism. Taking Beyoncé’s place in the video, the fictitious Melania Trump is co-constructed to the absent black feminist bodies as white non-feminist Eastern European Other. Using Beyoncé’s video as a template, “Melanianade” re-affirms a discourse of Otherness that re-establishes the enlightened and emancipated educated (white) feminist American non-immigrant woman as norm, while it also whitewashes the Black American experience, which “Sorry” stands for.

AbstractShulgan-Tash (also known as Kapova) cave located on the western slope of the Ural Mountains (Russia) is the easternmost European cave art monument of late Palaeolithic age. Radiocarbon dates from cultural layers in the cave suggest an age of about 16.3 to 19.6 ka (cal BP), but dates directly on the paintings were not obtained. In order to constrain the age of this art using an independent method, we performed detailed 230Th-U dating of calcite flowstone underlying and overgrowing the paintings at 22 sites in three halls of the cave. The youngest age for the underlying calcite (i.e., the maximum age of the cave art) is 36.4 ± 0.1 ka, and the oldest overlying calcite (constraining the minimum age of the cave art) is 14.5 ± 0.04 ka. The ca. 21.9 ka-long hiatus in calcite deposition during which the paintings were made is attributed to regional permafrost conditions and sub-zero temperatures inside the cave during Marine Isotope Stage (MIS) 2. This is supported by samples of cryogenic cave calcite, which document seven episodes of freezing and thawing of permafrost associated with stadials and interstadials of MIS 3, respectively.

Abstract Early Bronze Age and early medieval inhumation graves in (central) Europe had often been re-opened a short time after burial and, in most cases, grave goods were removed. To improve the understanding of the archaeological evidence of these graves, one re-opened grave from a large early Bronze Age (Wieselburg/Gata culture) cemetery in Weiden am See, eastern Austria, was excavated using a microstratigraphic protocol to maximize data collection for the reconstruction of the context formation process and, consequently, the interpretation of the re-opening process. In this article the results of the soil thin section analyses are presented and discussed.

In this study, we investigated the microbial community (bacteria and fungi) colonising an oil painting on canvas, which showed visible signs of biodeterioration. A combined strategy, comprising culture-dependent and -independent techniques, was selected. The results derived from the two techniques were disparate. Most of the isolated bacterial strains belonged to related species of the phylum Firmicutes, as Bacillus sp. and Paenisporosarcina sp., whereas the majority of the non-cultivable members of the bacterial community were shown to be related to species of the phylum Proteobacteria, as Stenotrophomonas sp. Fungal communities also showed discrepancies: the isolated fungal strains belonged to different genera of the order Eurotiales, as Penicillium and Eurotium, and the non-cultivable belonged to species of the order Pleosporales and Saccharomycetales. The cultivable microorganisms, which exhibited enzymatic activities related to the deterioration processes, were selected to evaluate their biodeteriorative potential on canvas paintings; namely Arthrobacter sp. as the representative bacterium and Penicillium sp. as the representative fungus. With this aim, a sample taken from the painting studied in this work was examined to determine the stratigraphic sequence of its cross-section. From this information, “mock paintings,” simulating the structure of the original painting, were prepared, inoculated with the selected bacterial and fungal strains, and subsequently examined by micro-Fourier Transform Infrared spectroscopy, in order to determine their potential susceptibility to microbial degradation. The FTIR-spectra revealed that neither Arthrobacter sp. nor Penicillium sp. alone, were able to induce chemical changes on the various materials used to prepare “mock paintings.” Only when inoculated together, could a synergistic effect on the FTIR-spectra be observed, in the form of a variation in band position on the spectrum. The FTIR analyses performed in this study were financed by the Junta de Andalucía (RNM-325 group). The molecular analyses performed in this study were financed by the Austrian Science Fund (FWF) project ‘Hertha-Firnberg T137’ and the Spanish Ministry of Science and Innovation (Project CTQ2008-06727-C03-03). G. Piñar also thanks the “Elise-Richter V194-B20” projects.